Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8101 - 8150 OF 15217 RESULTS

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions
Blood, ISSN: 15280020 00064971
David Yao; Yuanshuai Huang; Xiaoran Huang; Weihuan Wang; Quanjian Yan; Lebing L. Wei; Wei Xin; Stanton Gerson; Pamela Stanley; John Lowe; Lan Zhou
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A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
Science Translational Medicine, ISSN: 19466234 19466242
Jasvinder K. Atwal; Yongmei Chen; Cecilia Chiu; Deborah L. Mortensen; William J. Meilandt; Yichin Liu; Christopher E. Heise; Kwame Hoyte; Wilman Luk; Yanmei Lu; Kun Peng; Ping Wu; Lionel Rouge; Yingnan Zhang; Lazarus; Kimberly Scearce-Levie; Weiru Wang; Yan Wu; Marc Tessier-Lavigne; Ryan J. Watts
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Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
Science Translational Medicine, ISSN: 19466234 19466242
Y. Joy Yu; Yin Zhang; Margaret Kenrick; Kwame Hoyte; Wilman Luk; Yanmei Lu; Jasvinder K. Atwal; J. Michael Elliott; Saileta Prabhu; Ryan J. Watts; Dennis
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Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry
Molecular Cell, ISSN: 10972765 10974164
Xiaodong Huang; Matthew K. Summers; Victoria Pham; Jennie R. Lill; Jinfeng Liu; Gwanghee Lee; Donald S. Kirkpatrick; Peter K Jackson; Guowei Fang; Vishva M. Dixit
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Crystal structures of two aminoglycoside kinases bound with a Eukaryotic protein kinase inhibitor
PLoS ONE, ISSN: 19326203
Desiree H. Fong; Bing Xiong; Jiyoung Hwang; Albert M. Berghuis
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Toward understanding molecular heterogeneity of polysorbates by application of liquid chromatography-mass spectrometry with computer-aided data analysis
Analytical Chemistry, ISSN: 00032700
Oleg V. Borisov; Junyan A. Ji; Y. John Wang; Felix Vega; Victor Ling
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Targeting superficial or nodular basal cell carcinoma with topically formulated small molecule inhibitor of smoothened
Clinical Cancer Research, ISSN: 10780432 15573265
Tracy Tzu-Ling Tang; Jean Y. Tang; Dongwei Li; Mike Reich; Christopher Callahan; Ling Fu; Robert Yauch; Frank Wang; Karen Kotkow; Kris Chang; Elana Shpall; Angela Wu; Lee L. Rubin; James C. Marsters Jr.; Ervin H. Epstein Jr.; Ivor Caro; Frederic J. De Sauvage
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Changes in18F-fluorodeoxyglucose and 18F-fluorodeoxythymidine positron emission tomography imaging in patients with non-small cell lung cancer treated with erlotinib
Clinical Cancer Research, ISSN: 10780432 15573265
Linda Mileshkin; Rodney Hicks; Brett Hughes; Paul Mitchell; Veena Charu; Barbara Gitlitz; David Macfarlane; Benjamin Solomon; Lukas Amler; Wei Yu; Andrea Pirzkall; Bernard M. Fine
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AMP-activated protein kinase (AMPK) activation and glycogen synthase kinase-3β(GSK-3β) inhibition induce Ca2+-independent deposition of tight junction components at the plasma membrane
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Li Zhang; Francois Jouret; Jesse Rinehart; Jeff Sfakianos; Ira Mellman; Richard P. Lifton; Lawrence H. Young; Michael J. Caplan
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Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways
Cell, ISSN: 00928674
Liyun Sang; Julie J. Miller; Kevin C. Corbit; Rachel H. Giles; Matthew J. Brauer; Edgar A. Otto; Lisa M. Baye; Xiaohui Wen; Suzie J. Scales; Mandy Kwong; Erik G. Huntzicker; Mindan K. Sfakianos; Wendy N. Sandoval; J.Fernando Bazan; Priya Kulkarni; Francesc R. Garcia-Gonzalo; Allen D. Seol; John F. O'Toole; Susanne Held; Heiko M. Reutter; William Lane; Muhammad Arshad Rafiq; Abdul Noor; Muhammad Ansar; Akella Radha Rama Devi; Val C. Sheffield; Diane C. Slusarski; John B. Vincent; Daniel A. Doherty; Friedhelm Hildebrandt; Jeremy Reiter; Peter K Jackson
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Computational design of proteins targeting the conserved stem region of influenza hemagglutinin
Science, ISSN: 00368075 10959203
Sarel J. Fleishman; Timothy A. Whitehead; Damian C. Ekiert; Cyrille Dreyfus; Jacob E. Corn; Eva-Maria Strauch; Ian A. Wilson; David Baker
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Pyrazolopyridine inhibitors of B-RafV600E. Part 1: The development of selective, orally bioavailable, and efficacious inhibitors
ACS Medicinal Chemistry Letters, ISSN: 19485875
Steve Wenglowsky; Li Ren; Kateri Ahrendt; Ellen R. Laird; Ignacio Aliagas; Bruno Alicke; Alexandre J. Buckmelter; Edna F. Choo; Victoria Dinkel; Bainian Feng; Susan L. Gloor; Stephen Gould; Stefan Gross; Janet Gunzner; Joshua D. Hansen; Georgia Hatzivassiliou; Bonnie Liu; Kim Malesky; Simon Mathieu; Bradley J. Newhouse; Nicholas J. Raddatz; Yingqing Ran; Sumeet Rana; Nikole Randolph; Tyler Risom; Joachim Rudolph; Scott Savage; Leann T. Selby; Michael Shrag; Kyung Song; Hillary L. Sturgis; Walter C. Voegtli; Zhaoyang Wen; Brandon S. Willis; Richard D. Woessner; Wen-I. Wu; Wendy B. Young; Jonas Grina
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Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Frederick Cohen; Philippe Bergeron; Elizabeth M. Blackwood; Krista K. Bowman; Huifen Chen; Antonio G. DiPasquale; Jennifer A. Epler; Michael F. T. Koehler; Kevin Lau; Lewis; Lichuan Liu; Cuong Q. Ly; Shiva Malek; Jim Nonomiya; Daniel F. Ortwine; Zhonghua Pei; Kirk D. Robarge; Steve Sideris; Lan Trinh; Tom Truong; Jiansheng Wu; Xianrui Zhao; Joseph P. Lyssikatos
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TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma
PLoS ONE, ISSN: 19326203
Kui Lin; James R. Taylor Jr.; Thomas D Wu; Johnny Gutierrez; J. Michael Elliott; Jean-Michel Vernes; Koeppen; Phillips; Frederic J. De Sauvage; Meng
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Facile synthesis of spiro oxindoles, azaoxindoles, and dihydroisoquinolone
Synthetic Communications, ISSN: 00397911 15322432
Sharada Labadie; Christa Parmer
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Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Pranav Parikh; Yuhan Hao; Mohsen Hosseinkhani; Shekhar B. Patil; George W. Huntley; Marc Tessier-Lavigne; Hongyan Zou
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Modulation of K11-linkage formation by variable loop residues within UbcH5A
Journal of Molecular Biology, ISSN: 00222836
Ivan Bosanac; Lilian Phu; Borlan Pan; Inna Zilberleyb; Brigitte Maurer; Vishva M. Dixit; Sarah G. Hymowitz; Donald S. Kirkpatrick
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Bevacizumab treatment to progression after chemotherapy: Outcomes from a U.S. community practice network
Oncologist, ISSN: 10837159 1549490X
Eric Nadler; Elaine B. Yu; Arliene Ravelo; Amy Sing; Michael Forsyth; Stephen Gruschkus
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Comparing protein VEGF inhibitors: In vitro biological studies
Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104
Lanlan Yu; Xiao Huan Liang; Napoleone Ferrara
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High affinity antigen recognition of the dual specific variants of Herceptin is entropy-driven in spite of structural plasticity
PLoS ONE, ISSN: 19326203
Jenny Bostrom; Lauric Haber; Patrick Koenig; Robert F. Kelley; Fuh
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Gelatin Capsule Shell Cross-Linking: Tier II Dissolution Method Development in the Presence of Sodium Lauryl Sulfate
Pharmaceutical Technology, ISSN: 15432521 21507376
Xiling Song; Yong Cui; Minli Xie
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Is this the end of painful injections?
Managed Care, ISSN: 10623388
Thomas Morrow
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Journey Forward: The new face of cancer survivorship care
Journal of Oncology Practice, ISSN: 15547477 1935469X
Jennifer Hausman; Patricia A. Ganz; Thomas P. Sellers; Joel Rosenquist
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Journey forward: The new face of cancer survivorship care
American Journal of Managed Care, ISSN: 10880224
Jennifer Hausman; Patricia A. Ganz; Thomas P. Sellers; Joel Rosenquist
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Investigation of the HIN200 Locus in UK SLE Families Identifies Novel Copy Number Variants
Annals of Human Genetics, ISSN: 00034800 14691809
Michelle M.A. Fernando; Adam J. de Smith; Lachlan Coin; David L. Morris; Philippe Froguel; Jonathan Mangion; Alexandra I. F. Blakemore; Robert R. Graham; Timothy W. Behrens; Timothy J. Vyse
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Inhibitor of apoptosis proteins: Fascinating biology leads to attractive tumor therapeutic targets
Future Oncology, ISSN: 14796694 17448301
Eugene Varfolomeev; Domagoj Vucic
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PHOENIX: A randomized controlled trial of peginterferon alfa-2a plus ribavirin as a prophylactic treatment after liver transplantation for hepatitis C virus
Liver Transplantation, ISSN: 15276465 15276473
Natalie Bzowej; David R. Nelson; Terrault; Gregory T. Everson; Lichen L. Teng; Avinash Prabhakar; Michael R. Charlton
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Gelatin capsule shell cross-linking
Pharmaceutical Technology Europe, ISSN: 01646826
Xiling Song; Yong Cul; Minli Xie
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Improved quantitative mass spectrometry methods for characterizing complex ubiquitin signals
Molecular and Cellular Proteomics, ISSN: 15359476 15359484
Lilian Phu; Anita Izrael-Tomasevic; Marissa L. Matsumoto; Daisy J. Bustos; Jasmin N. Dynek; Anna V. Fedorova; Corey Bakalarski; David Arnott; Deshayes; Vishva M. Dixit; Robert F. Kelley; Domagoj Vucic; Donald S. Kirkpatrick
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Effect of rituximab on physical function and quality of life in patients with rheumatoid arthritis previously untreated with methotrexate
Arthritis Care and Research, ISSN: 21514658 15290131
William F. Rigby; Gianfranco Ferraccioli; Maria Greenwald; Beatriz Zazueta-Montiel; Roy Fleischmann; Siegfried Wassenberg; Sarika Ogale; Gillian Armstrong; Angelika Jahreis; Laura Burke; Christopher Mela; Annie Chen
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Human prostate cancer stem cells: New features unveiled
Asian Journal of Andrology, ISSN: 1008682X 17457262
Yuting Sun; Gao
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Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Marcella Yu; Zhilan Hu; Efren Pacis; Natarajan Vijayasankaran; Amy Shen; Feng Li
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Molecular determinants of origin discrimination by Orc1 initiators in archaea
Nucleic Acids Research, ISSN: 03051048 13624962
Erin C. Dueber; Alessandro Costa; Jacob E. Corn; Stephen D. Bell; James M. Berger
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A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase
Nature Genetics, ISSN: 10614036 15461718
Trevor Hinkley; João Martins; Colombe Chappey; Mojgan Haddad; Eric Stawiski; Jeannette M. Whitcomb; Christos J. Petropoulos; Sebastian Bonhoeffer
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Validation of the national eye institute Visual Function Questionnaire-25 (NEI VFQ-25) in age-related macular degeneration
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Peggy Orr; Anne M. Rentz; Mary Kay Margolis; Dennis A. Revicki; Chantal M. Dolan; Shoshana Colman; Jennifer T. Fine; Neil M. Bressler
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Characterization of intact antibody-drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography-mass spectrometry
Analytical Biochemistry, ISSN: 10960309 00032697
Keyang Xu; Luna Liu; Ola M. Saad; Jakub Baudys; Lara Williams; Douglas Leipold; Shen; Helga Raab; Jagath R. Junutula; Amy H. Kim; Surinder Kaur
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Aβ1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
Nature Neuroscience, ISSN: 10976256
Jihoon Jo; Daniel J. Whitcomb; Kimberly Moore Olsen; Talitha L. Kerrigan; Shih-Ching Lo; Gilles Bru-Mercier; Bryony Dickinson; Sarah Scullion; Morgan Sheng; Graham Collingridge; Kwangwook Cho
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Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2
Journal of Pharmacological and Toxicological Methods, ISSN: 10568719
Susan P. Rhodes; Jennifer N. Otten; Gary P. Hingorani; Dylan P. Hartley; Ronald B. Franklin
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Analysis of tumor burden versus progression-free survival for Phase II decision making
Contemporary Clinical Trials, ISSN: 15517144
Jane Fridlyand; Lee D. Kaiser; Gwendolyn Fyfe
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Studying the drift of in line pH measurements in cell culture
Biotechnology Progress, ISSN: 87567938 15206033
Victor Saucedo; Bradley Wolk; Adeyma Arroyo; Feng
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Mitotic kinases regulate MT-polymerizing/MT-bundling activity of DDA3
Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104
Chang-Young Jang; Judith A. Coppinger; John R. Yates; Guowei Fang
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Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449)
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Anthony M. Giannetti; Harvey Wong; Gerrit J. P. Dijkgraaf; Erin C. Dueber; Daniel F. Ortwine; Brandon Bravo; Stephen Gould; Emile G. Plise; Bert L. Lum; Vikram Malhi; Richard A. Graham
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PSD-95 is required to sustain the molecular organization of the postsynaptic density
Journal of Neuroscience, ISSN: 02706474 15292401
Xiaobing Chen; Nelson; Xiang Li; Christine A. Winters; Rita Azzam; Alioscka A. Sousa; Richard D. Leapman; Harold Gainer; Morgan Sheng; Thomas S. Reese
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Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christy C. Ong; Adrian M. Jubb; Matthias Peter; Wei Zhou; Victoria Tran; Tom Truong; Helen Turley; Thomas O'Brien; Domagoj Vucic; Adrian L. Harris; Marcia Belvin; Lori S. Friedman; Elizabeth M. Blackwood; Koeppen; Klaus P. Hoeflich
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[Targeted cytotoxic drugs emerging for cancer therapy]. Vasta-aineisiin konjugoidut solunsalpaajat tulossa syövän hoitoon.
Duodecim; lääketieteellinen aikakauskirja, ISSN: 00127183
Teemu T. Junttila; Minna Tanner; Jorma Isola
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Regulation and functions of the IL-10 family of cytokines in inflammation and disease
Annual Review of Immunology, ISSN: 07320582
Wenjun Ouyang; Sascha Rutz; Natasha K Crellin; Patricia A. Valdez; Sarah G. Hymowitz
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Jürg Tschopp (1951-2011).
Nature, ISSN: 14764687
Vishva M. Dixit
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Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases
Journal of Biotechnology, ISSN: 01681656
Meixia Zhou; Yongping Crawford; Domingos Ng; Jack Tung; Abigail F.J. Pynn; Angela Meier; Inn H. Yuk; Natarajan Vijayasankaran; Kimberly D. Leach; John C. Joly; Snedecor; Amy Shen
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P85α regulates osteoblast differentiation by cross-talking with the MAPK pathway
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Xiaohua Wu; Shi Chen; Selina A. Orlando; Jin Yuan; Edward T. Kim; Veerendra Munugalavadla; Raghuveer Singh Mali; Reuben Kapur; Feng-Chun Yang
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Mixed-mode and reversed-phase liquid chromatography-tandem mass spectrometry methodologies to study composition and base hydrolysis of polysorbate 20 and 80
Journal of Chromatography A, ISSN: 00219673
Daniel Hewitt; Melissa Alvarez; Kathryn Robinson; Junyan A. Ji; Y. John Wang; Kao; Taylor Zhang
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