Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8151 - 8200 OF 15217 RESULTS

April 15, 2011

Discovery and SAR of spirochromane Akt inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Nicholas C. Kallan; Keith L. Spencer; James F. Blake; Rui Xu; Justin Heizer; Josef R. Bencsik; Ian S. Mitchell; Susan L. Gloor; Matthew Martinson; Tyler Risom; Stefan Gross; Tony Morales; Wen-I. Wu; Guy Vigers; Barbara J. Brandhuber; Nicholas J. Skelton

April 15, 2011

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Rui Xu; Anna L. Banka; James F. Blake; Ian S. Mitchell; Eli M. Wallace; Josef R. Bencsik; Nicholas C. Kallan; Keith L. Spencer; Susan L. Gloor; Matthew Martinson; Tyler Risom; Stefan Gross; Tony Morales; Wen-I. Wu; Guy Vigers; Barbara J. Brandhuber; Nicholas J. Skelton

April 15, 2011

DDA3 associates with MCAK and controls chromosome congression

Biochemical and Biophysical Research Communications, ISSN: 0006291X 10902104

Chang-Young Jang; Guowei Fang

April 15, 2011

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors

Clinical Cancer Research, ISSN: 10780432 15573265

Patricia M. LoRusso; Charles M. Rudin; Josina C. Reddy; Raoul Tibes; Glen J. Weiss; Mitesh J. Borad; Christine L. Hann; Julie Brahmer; Ilsung Chang; Darbonne; Richard A. Graham; Kenn Zerivitz; Low; Daniel D. Von Hoff

April 15, 2011

Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: The role of alpha-1-acid glycoprotein binding

Clinical Cancer Research, ISSN: 10780432 15573265

Richard A. Graham; Bert L. Lum; Sravanthi Cheeti; Jin Y. Jin; Karin Jorga; Daniel D. Von Hoff; Charles M. Rudin; Josina C. Reddy; Low; Patricia M. LoRusso

April 15, 2011

Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime

Analytical Biochemistry, ISSN: 10960309 00032697

Sandeep Yadav; Thomas M. Scherer; Steven J. Shire; Devendra S. Kalonia

April 14, 2011

Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S

Blood, ISSN: 15280020 00064971

Felicity N. E. Gavins; Janice Russell; Elena L. Senchenkova; Lidiana De Almeida Paula; Amílcar S. Damazo; Charles T. Esmon; Daniel Kirchhofer; Robert P. Hebbel; D. Neil Granger

April 11, 2011

Genome-wide survey of post-meiotic segregation during yeast recombination

Genome Biology, ISSN: 14747596 1474760X

Eugenio Mancera; Richard Bourgon; Wolfgang Huber; Lars M. Steinmetz

April 4, 2011

A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells

Journal of Cell Biology, ISSN: 00219525 00219525

Stephen S. Francis; Jeff Sfakianos; Bryan Lo; Ira Mellman

April 1, 2011

BioBeat: ICBE explores biology at the molecular level

Chemical Engineering Progress, ISSN: 03607275

Deshayes

April 1, 2011

Integrated cytogenetic and high-resolution array CGH analysis of genomic alterations associated with MYCN amplification

Cytogenetic and Genome Research, ISSN: 14248581

Ajay Pandita; Bayani; Paderova; Marrano; Graham; Barrett; Prasad; Zielenska; Squire

April 1, 2011

Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocytespecific deletion of JAK2

Journal of Clinical Investigation, ISSN: 15588238 00219738

Brandon C. Sos; Charles Harris; Sarah M. Nordstrom; Jennifer L. Tran; Mercedesz Balazs; Patrick Caplazi; Maria Febbraio; Milana A. B. Applegate; Kay-Uwe Wagner; Ethan J. Weiss

April 1, 2011

A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes

British Journal of Pharmacology, ISSN: 00071188 14765381

Stefanich; Dimitry Danilenko; Hong Wang; Sharon O'Byrne; Erickson; Thomas R. Gelzleichter; Hajime Hiraragi; Chiu; Ivelja; Surinc Er Jeet; Gadkari; Hwang; Franklin Fuh; Looney; Howell; Albert; Mercedesz Balazs; Refino; Fong; Suhasini Iyer; Marna Williams

April 1, 2011

NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling

Cell, ISSN: 00928674

Sharon Biton; Avi Ashkenazi

April 1, 2011

Functional characterization of putative cilia genes by high-content analysis

Molecular Biology of the Cell, ISSN: 10591524 19394586

Cary K. Lai; Nidhi Gupta; Xiaohui Wen; Linda Rangell; Ben Chih; Andrew S. Peterson; J.Fernando Bazan; Li Li; Suzie J. Scales

April 1, 2011

Do cilia put brakes on the cell cycle?

Nature Cell Biology, ISSN: 14657392

Peter K Jackson

April 1, 2011

International consensus for a definition of disease flare in lupus

Lupus, ISSN: 09612033

Nicolino Ruperto; Hanrahan; Graciela S. Alarcõn; Belmont; Brey; Paul Brunetta; Jill P. Buyon; Costner; Cronin; Dooley; Filocamo; Fiorentino; Fortin; Franks; Gary S. Gilkeson; Ginzler; Gordon; Grossman; Hahn; David A. Isenberg; Kenneth C. Kalunian; Michelle Petri; Sammaritano; Sánchez-Guerrero; Sontheimer; Vibeke Strand; Urowitz; Von Feldt; Werth; Merrill

April 1, 2011

Improving prescribing safety in patients with renal insufficiency in the ambulatory setting: The Drug Renal Alert Pharmacy (DRAP) program

Pharmacotherapy, ISSN: 02770008

Bharati Bhardwaja; Nikki M. Carroll; Marsha A. Raebel; Elizabeth A. Chester; Korner; Bob E. Rocho; David W. Brand; David J. Magid

April 1, 2011

Genetic and molecular analysis of nematode-microbe interactions

Cellular Microbiology, ISSN: 14625814 14625822

Man-Wah Tan; Michael Shapira

April 1, 2011

DNA markers linked to eastern filbert blight resistance in "Ratoli" hazelnut (Corylus avellana L.)

Tree Genetics and Genomes, ISSN: 16142942 16142950

Sathuvalli; Chen; Mehlenbacher; Smith

April 1, 2011

In vitro stability and compatibility of tenecteplase in central venous access devices

Hemodialysis International, ISSN: 14927535 15424758

Yvonne Lentz; Michael Joyce; Lam

April 1, 2011

Compliance with PET acquisition protocols for therapeutic monitoring of erlotinib therapy in an international trial for patients with non-small cell lung cancer

European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197070

David S. Binns; Andrea Pirzkall; Wei Yu; Jason Callahan; Linda Mileshkin; Peter Conti; Andrew M. Scott; David Macfarlane; Bernard M. Fine; Rodney Hicks

April 1, 2011

A distinct subset of glioma cell lines with stem cell-like properties reflects the transcriptional phenotype of glioblastomas and overexpresses CXCR4 as therapeutic target

GLIA, ISSN: 08941491 10981136

Alexander Schulte; Hauke S. Günther; Phillips; Dirk Kemming; Tobias Martens; Samir Kharbanda; Robert Soriano; Zora Modrusan; Svenja Zapf; Manfred Westphal; Katrin Lamszus

April 1, 2011

AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme

Advances in Therapy, ISSN: 0741238X 18658652

Olivier L. Chinot; De La Motte Rouge; Moore; Zeaiter; Asha Das; Phillips; Zora Modrusan; Timothy Cloughesy

April 1, 2011

A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes

British Journal of Pharmacology, ISSN: 00071188 14765381

Stefanich; Dimitry Danilenko; Hong Wang; Sharon O'Byrne; Erickson; Thomas R. Gelzleichter; Hajime Hiraragi; Chiu; Ivelja; Surinc Er Jeet; Gadkari; Hwang; Franklin Fuh; Looney; Howell; Albert; Mercedesz Balazs; Refino; Sherman Fong; Suhasini Iyer; Marna Williams

April 1, 2011

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Cell Death and Differentiation, ISSN: 13509047 14765403

Nele Vanlangenakker; Vanden Berghe; Bogaert; Bram Laukens; Zobel; Deshayes; Domagoj Vucic; Fulda; Vandenabeele; Mathieu J.M. Bertrand

April 1, 2011

Preclinical absorption, distribution, metabolism, excretion, and pharmacokinetic-pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3- fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl) -2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide, a novel MET kinase inhibitor

Xenobiotica, ISSN: 00498254 13665928

Bianca M. Liederer; Leonid M. Berezhkovskiy; Brian J. Dean; Victoria Dinkel; Jing Peng; Mark Merchant; Emile G. Plise; Harvey Wong; Xingrong Liu

April 1, 2011

Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial

Journal of Rheumatology, ISSN: 0315162X 14992752

Jin-Shei Lai; Jennifer L. Beaumont; Sarika Ogale; Paul Brunetta; Cella

April 1, 2011

A candidate gene study of the type i interferon pathway implicates IKBKE and IL8 as risk loci for SLE

European Journal of Human Genetics, ISSN: 10184813 14765438

Johanna K. Sandling; Sophie Garnier; Snaevar Sigurdsson; Chuan Wang; Gunnel Nordmark; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders A. Bengtsson; Lennart Truedsson; Catharina Eriksson; Solbritt Rantapää-Dahlqvist; Anders Mälarstig; Rona J. Strawbridge; Anders Hamsten; Lindsey A. Criswell; Robert R. Graham; Timothy W. Behrens; Maija-Leena Eloranta; Gunnar Alm; Lars Rönnblom; Ann-Christine Syvänen

April 1, 2011

Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK Inhibitors in BRAF mutant cancers

Oncotarget, ISSN: 19492553

Ryan B. Corcoran; Jeffrey Settleman; Jeff A. Engelman

March 31, 2011

An observational study of outcomes after initial infused therapy in Medicare patients diagnosed with chronic lymphocytic leukemia

Blood, ISSN: 15280020 00064971

Mark Danese; Robert I. Griffiths; Michelle Gleeson; Sacha Satram-Hoang; Kevin Knopf; Joseph Mikhael; Carolina Reyes

March 30, 2011

A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice

Science Translational Medicine, ISSN: 19466234 19466242

Natalya Lyubynska; Matthew F. Gorman; Jennifer O. Lauchle; Wan Xing Hong; Jon Akutagawa; Kevin Shannon; Benjamin S. Braun

March 25, 2011

Advancing translational research

Science, ISSN: 10959203 00368075

Brad Bolon; Bruce Altrock; Stephen W. Barthold; Nicole Baumgarth; David Besselsen; Gregory Boivin; Kelli L. Boyd; Cory Brayton; Robert D. Cardiff; Suzana Couto; Kathryn A. Eaton; Oded Foreman; Stephen M. Griffey; la Perle; Michael D. Lairmore; Chen Liu; David K. Meyerholz; Alexander Yu. Nikitin; Trenton R. Schoeb; Denise Schwahn; Rani Sellers; John P. Sundberg; Ravi Tolwani; Victor E. Valli; M. Christine Zink

March 24, 2011

Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cell

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Stephanie M. Stanford; Divya Krishnamurthy; Matthew D. Falk; Rossella Messina; Bikash Debnath; Sheng Li; Tong Liu; Roza Kazemi; Russell Dahl; Yantao He; Xiao Yu; Andrew A. Chan; Zhong-Yin Zhang; Amy M. Barrios; Virgil L. Woods Jr.; Nouri Neamati; Nunzio Bottini

March 24, 2011

FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

PLoS ONE, ISSN: 19326203

Ai-Luen Wu; Sally Coulter; Christopher Liddle; Anne Wong; Jeffrey Eastham-Anderson; French; Andrew S. Peterson; Junichiro Sonoda

March 24, 2011

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Brad E Sleebs; Czabotar; Wayne J. Fairbrother; Fairlie; Flygare; David C.S. Huang; Wilhelmus J A Kersten; Michael F. T. Koehler; Guillaume Lessene; Kym N Lowes; John P Parisot; Brian J. Smith; Morey L. Smith; Andrew J. Souers; Ian P Street; Hong Yang; Jonathan B Baell

March 23, 2011

Matrix metalloproteinase-9 predicts pulmonary status declines in α1-antitrypsin deficiency

Respiratory Research, ISSN: 1465993X 14659921

Theodore A. Omachi; Mark D. Eisner; Alexis Rames; Lada Markovtsova; Paul D. Blanc

March 21, 2011

Effects of anti-VEGF on predicted antibody biodistribution: Roles of vascular volume, interstitial volume, and blood flow

PLoS ONE, ISSN: 19326203

C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Daniela Bumbaca; Michelle G. Schweiger; Frank-Peter Theil; Fielder; Leslie A. Khawli

March 21, 2011

Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes

PLoS ONE, ISSN: 19326203

Rezaul Karim; Craig Meyers; Claude Backendorf; Kristina Ludigs; Rienk Offringa; Gert-Jan B. van Ommen; Cornelis J. M. Melief; Sjoerd H. van der Burg; Judith M. Boer

March 16, 2011

CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma

Science Translational Medicine, ISSN: 19466234 19466242

Bart Burington; Peng Yue; Xiaoyan Shi; Ranjana H. Advani; Jeffrey Lau; Jenille Tan; Susanna Y. Stinson; Stinson; Thomas Januario; Sven De Vos; Stephen Ansell; Andres Forero; Grazyna Fedorowicz; Teddy T. C. Yang; Kristi Elkins; Du; Sankar Mohan; Nancy Yu; Zora Modrusan; Somasekar Seshagiri; Shang-Fan Yu; Ajay Pandita; Koeppen; French; Andrew G. Polson; Rienk Offringa; Nancy Whiting; Allen Ebens; David Dornan

March 15, 2011

Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells

Cancer Research, ISSN: 00085472 15387445

Yong-Yu Liu; Gauri A. Patwardhan; Kaustubh Bhinge; Vineet Gupta; Xin Gu; S. Michal Jazwinski

March 15, 2011

Effect of CC chemokine receptor 2 CCR2 blockade on serum C-reactive protein in individuals at atherosclerotic risk and with a single nucleotide polymorphism of the monocyte chemoattractant protein-1 promoter region

American Journal of Cardiology, ISSN: 00029149

Jim Gilbert; Julie Lekstrom-Himes; Debra Donaldson; Yih Lee; Mingxiu Hu; Jing Xu; Tim Wyant; Michael Davidson

March 15, 2011

Identification of isomerization and racemization of aspartate in the Asp-Asp motifs of a therapeutic protein

Analytical Biochemistry, ISSN: 10960309 00032697

Jennifer Zhang; Holly Yip; Viswanatham Katta

March 15, 2011

Navitoclax enhances the efficacy of taxanes in non-small cell lung cancer models

Clinical Cancer Research, ISSN: 10780432 15573265

Nguyen Tan; Mehnaz Malek; Jiping Zha; Peng Yue; Robert Kassees; Berry; Wayne J. Fairbrother; Deepak Sampath; Lisa D. Belmont

March 15, 2011

Remote functionalisation via sodium alkylamidozincate intermediates: Access to unusual fluorenone and pyridyl ketone reactivity patterns

Chemical Communications, ISSN: 1364548X 13597345

James J. Crawford; Ben J. Fleming; Kennedy; Charles T. O’Hara; Samantha A. Orr

March 15, 2011

Remote functionalisation via sodium alkylamidozincate intermediates: Access to unusual fluorenone and pyridyl ketone reactivity patterns

Chemical Communications, ISSN: 1364548X 13597345

James J. Crawford; Ben J. Fleming; Alan R. Kennedy; Charles T. O’Hara; Samantha A. Orr

March 14, 2011

Mitochondrial reactive oxygen species drive proinflammatory cytokine production

Journal of Experimental Medicine, ISSN: 00221007 15409538

Naik; Vishva M. Dixit

March 10, 2011

Impact of β2 integrin deficiency on mouse natural killer cell development and function

Blood, ISSN: 15280020 00064971

Karine Crozat; Celine Eidenschenk; Baptiste N. Jaeger; Philippe Krebs; Sophie Guia; Bruce Beutler; Eric Vivier; Sophie Ugolini

March 7, 2011

Development of a multi-product leached protein A assay for bioprocess samples containing recombinant human monoclonal antibodies

Journal of Immunological Methods, ISSN: 00221759

Diya Ren; Maria R. Darlucio; Judy H. Chou

March 3, 2011

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Nature, ISSN: 00280836 14764687

Ingrid E. Wertz; Saritha Kusam; Cynthia Lam; Toru Okamoto; Wendy N. Sandoval; Daniel J Anderson; Elizabeth Helgason; James A. Ernst; Mike Eby; Jinfeng Liu; Lisa D. Belmont; Joshua S. Kaminker; Karen M. O'Rourke; Kanan Pujara; Pawan Bir Kohli; Adam R. Johnson; Mark L. Chiu; Jennie R. Lill; Peter K Jackson; Wayne J. Fairbrother; Somasekar Seshagiri; Mary J. C. Ludlam; Kevin G. Leong; Erin C. Dueber; Heather Maecker; David C.S. Huang; Vishva M. Dixit

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