Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8451 - 8500 OF 15217 RESULTS

A novel homogeneous Biotin-digoxigenin based assay for the detection of human anti-therapeutic antibodies in autoimmune serum
Journal of Immunological Methods, ISSN: 00221759
Zhihua Julia Qiu; Yong Ying; Michael Fox; Kun Peng; Sock-Cheng Lewin-Koh; Daniel A. Coleman; Jeremy Good; John Lowe; Amena Rahman; Yang; Jenny Jiang; Quarmby; An Song
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Designing vaccines based on biology of human dendritic cell subsets
Immunity, ISSN: 10747613
A. Karolina Palucka; Jacques Banchereau; Ira Mellman
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Diffusion and sedimentation interaction parameters for measuring the second virial coefficient and their utility as predictors of protein aggregation
Biophysical Journal, ISSN: 15420086 00063495
Atul Saluja; R. Matthew Fesinmeyer; Sabine Hogan; David N. Brems; Yatin Gokarn
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Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes
Developmental Cell, ISSN: 15345807
Diego Correa; Eric Hesse; Dutmanee Seriwatanachai; Riku Kiviranta; Hiroaki Saito; Kei Yamana; Lynn Neff; Azeddine Atfi; Lucie Coillard; Despina Sitara; Yukiko Maeda; Søren Warming; Nancy A. Jenkins; Neal G. Copeland; William C. Horne; Beate Lanske; Roland Baron
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Genome-wide inference of regulatory networks in Streptomyces coelicolor
BMC Genomics, ISSN: 14712164
Marlene Castro-Melchor; Salim Charaniya; George Karypis; Eriko Takano; Hu
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Monocyte-derived dendritic cells exhibit increased levels of lysosomal proteolysis as compared to other human dendritic cell populations
PLoS ONE, ISSN: 19326203
Nathanael Mccurley; Ira Mellman
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Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models
Statistics in Medicine, ISSN: 02776715 10970258
Kingshuk Roy Choudhury; Ian Kasman; Greg D. Plowman
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Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Thomas M. Scherer; Jun Liu; Steven J. Shire; Allen P. Minton
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Incidence of progressive multifocal leukoencephalopathy in patients without HIV
Neurology, ISSN: 1526632X 00283878
Amend; Turnbull; Foskett; Pavel Napalkov; Kurth; Seeger
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ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
Oncogene, ISSN: 09509232 14765594
Sheryl R. Krig; Miller; Frietze; Beckett; Richard M. Neve; Farnham; Paul Yaswen; Colleen A. Sweeney
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Chromatography-Advances and Applications in Pharmaceutical Analysis in the Corporate Sector
Chromatography: A Science of Discovery,
Pat Noland; Terry N. Hopper; Michael W. Dong; Yong Guo; Todd D. Maloney; Raymond N. Xu
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Wnts influence the timing and efficiency of oligodendrocyte precursor cell generation in the telencephalon
Journal of Neuroscience, ISSN: 02706474 15292401
Abraham J. Langseth; Roeben N. Munji; Youngshik Choe; Trung Huynh; Christine D. Pozniak; Samuel J. Pleasure
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Development and evaluation of a novel method for preclinical measurement of tissue vascular volume
Molecular Pharmaceutics, ISSN: 15438384 15438392
C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Michelle G. Schweiger; Jan Marik; Mike Reich; Frank-Peter Theil; Fielder; Leslie A. Khawli
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Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis
Inflammatory Bowel Diseases, ISSN: 10780998 15364844
Colin L. Noble; Abbas Alexander; Charles W. Lees; Jennine Cornelius; Toy; Zora Modrusan; Hilary F. Clark; Ian D. Arnott; Ian D. Penman; Jack Satsangi; Laurie Diehl
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Diagnosis and differential diagnosis of multiple sclerosis
CONTINUUM Lifelong Learning in Neurology, ISSN: 10802371
Bruce A. C. Cree
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Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer
Clinical Cancer Research, ISSN: 10780432 15573265
Jagath R. Junutula; Kelly Flagella; Richard A. Graham; Kathryn Parsons; Edward Ha; Helga Raab; Sunil Bhakta; Trung Nguyen; Dugger; Guangmin Li; Elaine Mai; Gail L. Phillips; Hajime Hiraragi; Reina N. Fuji; Jay Tibbitts; Richard L. Vandlen; Spencer; Richard H. Scheller; Paul G. Polakis; Mark X. Sliwkowski
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TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia
Genes and Development, ISSN: 08909369 15495477
Saikat Mukhopadhyay; Xiaohui Wen; Ben Chih; Nelson; William Lane; Suzie J. Scales; Peter K Jackson
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Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Guozhi Tang; Denis J. Kertesz; Minmin Yang; Xianfeng Lin; Zhanguo Wang; Wentao Li; Zongxing Qiu; Junli Chen; Jianghua Mei; Li Chen; Taraneh Mirzadegan; Seth F. Harris; Armando G. Villaseñor; Jennifer Fretland; William L. Fitch; Julie Qi Hang; Gabrielle Heilek; Klumpp
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Safety and efficacy of erlotinib in first-relapse glioblastoma: A phase II open-label study
Neuro-Oncology, ISSN: 15228517 15235866
Alfred Yung; James Vredenburgh; Timothy Cloughesy; Phioanh L. Nghiemphu; Barbara Klencke; Mark R. Gilbert; David A. Reardon; Michael D. Prados
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Mri in multiple sclerosis
CONTINUUM Lifelong Learning in Neurology, ISSN: 10802371
Robert A. Bermel; Robert J. Fox
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Anatomical benefit from ranibizumab treatment of predominantly classic neovascular age-related macular degeneration in the 2-year ANCHOR study
Retina, ISSN: 0275004X
Srinivas Sadda; Glenn Stoller; David S. Boyer; Barbara A. Blodi; Howard Shapiro; Tsontcho Ianchulev
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APC/CCdc20 targets E2F1 for degradation in prometaphase
Cell Cycle, ISSN: 15514005 15384101
Melissa J. Peart; Masha V. Poyurovsky; Elizabeth M. Kass; Marshall Urist; Emmy W. Verschuren; Matthew K. Summers; Peter K Jackson; Carol Prives
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Dosing regimen and the frequency of macular hemorrhages in neovascular age-related macular degeneration treated with ranibizumab
Retina, ISSN: 0275004X
Irene Barbazetto; Namrata Saroj; Howard Shapiro; Pamela Wong; K. Bailey Freund
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Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy
Nature Genetics, ISSN: 10614036 15461718
Edgar A. Otto; Toby W Hurd; Rannar Airik; Moumita Chaki; Weibin Zhou; Corinne Stoetzel; Suresh B Patil; Shawn Levy; Amiya K Ghosh; Carlos A Murga-Zamalloa; Jeroen Van Reeuwijk; Stef J F Letteboer; Liyun Sang; Rachel H. Giles; Qin Liu; Karlien L M Coene; Alejandro Estrada-Cuzcano; Rob W J Collin; Heather M McLaughlin; Susanne Held; Jennifer M Kasanuki; Gokul Ramaswami; Jinny Conte; Irma Lopez; Joseph Washburn; James MacDonald; Jinghua Hu; Yukiko Yamashita; Eamonn R Maher; Lisa M Guay-Woodford; Hartmut P H Neumann; Nicholas Obermüller; Robert K Koenekoop; Carsten Bergmann; Xiaoshu Bei; Richard A Lewis; Nicholas Katsanis; Vanda Lopes; David S Williams; Robert H Lyons; Chi V. Dang; Daniela A Brito; M'nica Bettencourt Dias; Xinmin Zhang; James D Cavalcoli; Gudrun Nürnberg; Peter Nürnberg; Eric A. Pierce; Peter K Jackson; Corinne Antignac; Sophie Saunier; Ronald Roepman; Helene Dollfus; Hemant Khanna; Friedhelm Hildebrandt
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Discovery of pyrrolopyrimidine inhibitors of Akt
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
James F. Blake; Nicholas C. Kallan; Dengming Xiao; Rui Xu; Josef R. Bencsik; Nicholas J. Skelton; Keith L. Spencer; Ian S. Mitchell; Richard D. Woessner; Susan L. Gloor; Tyler Risom; Stefan Gross; Matthew Martinson; Tony Morales; Guy Vigers; Barbara J. Brandhuber
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Use and evaluation of a CD-ROM-based decision aid for prostate cancer treatment decisions
Behavioral Medicine, ISSN: 08964289 19404026
Kathryn L. Taylor; Kimberly M. Davis; Tara Lamond; Randi M. Williams; Marc D. Schwartz; William Lawrence; Shibao Feng; Susan Brink; Amy Birney; John Lynch; James Regan; Anatoly Dritschilo
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Pharmacokinetic, pharmacodynamic and immunogenicity comparability assessment strategies for monoclonal antibodies
Trends in Biotechnology, ISSN: 01677799
Wendy Putnam; Saileta Prabhu; Zheng; Subramanyam; Yow-Ming C. Wang
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Pediatric multiple sclerosis
CONTINUUM Lifelong Learning in Neurology, ISSN: 10802371
Ellen M. Mowry; Waubant
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Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven T. Staben; Timothy P. Heffron; Daniel P. Sutherlin; Seema R. Bhat; Georgette M. Castanedo; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Alan G. Olivero; Emile G. Plise; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Weismann; Ping Wu; Bing-Yan Zhu
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Bioequivalence studies for three formulations of a recombinant human growth hormone: Challenges and lessons learned
Growth Hormone and IGF Research, ISSN: 10966374 15322238
Dao; Joan R. Jacobs; Peter Kuebler; Bert Bakker; Barbara M. Lippe
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Bioavailability and population pharmacokinetics of voriconazole in lung transplant recipients
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Kelong Han; Blair Capitano; Robert Bies; Potoski; Husain; Gilbert; Paterson; McCurry; Raman Venkataramanan
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Peginterferon α-2a plus ribavirin in latino and non-latino whites with HCV genotype 1: Histologic outcomes and tolerability from the LATINO study
American Journal of Gastroenterology, ISSN: 00029270 15720241
Luis Balart; Mauricio Lisker-Melman; Hamzeh; Ambrose Kwok; Lentz; Maribel Rodriguez-Torres
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Histologic Outcomes in Hepatitis C–Infected Patients with Varying Degrees of Virologic Response to Interferon-Based Treatments
Hepatology, ISSN: 02709139
Pockros; Hamzeh; Martin; Lentz; Zhou; Sugantha Govindarajan; Anna S. Lok
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Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages
European Journal of Immunology, ISSN: 00142980 15214141
Andrea J. McCoy; Yukiko Koizumi; Claudia Toma; Naomi Higa; Vishva M. Dixit; Shun'ichiro Taniguchi; Jurg Tschopp; Toshihiko Suzuki
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Antibody purification: Drivers of change
Pharmaceutical Formulation and Quality, ISSN: 15312135 19363435
Narahari Pujar; Duncan Low; O'Leary
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Coevolution of PDZ domain-ligand interactions analyzed by high-throughput phage display and deep sequencing
Molecular BioSystems, ISSN: 1742206X 17422051
Andreas Ernst; David Gfeller; Zhengyan Kan; Somasekar Seshagiri; Philip M. Kim; Gary D. Bader; Sachdev S. Sidhu
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Connecting vascular and nervous system development: Angiogenesis and the blood-brain barrier
Annual Review of Neuroscience, ISSN: 0147006X 15454126
Stephen Tam; Ryan J. Watts
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Toxicogenomics and cancer risk assessment: A framework for key event analysis and dose-response assessment for nongenotoxic carcinogens
Regulatory Toxicology and Pharmacology, ISSN: 02732300 10960295
Joel P. Bercu; Robert A. Jolly; Kelly Flagella; Thomas K. Baker; Pedro Romero; James L. Stevens
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Display of peptides on the surface of tobacco mosaic virus particles
Current Topics in Microbiology and Immunology, ISSN: 0070217X
Smith; Fitzmaurice; Turpen; Palmer
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Vegf regulates embryonic erythroid development through Gata1 modulation
Blood, ISSN: 15280020 00064971
Benjamin Drogat; Joanna Kalucka; Laura Gutiérrez; Hamida Hammad; Steven Goossens; Morvarid Farhang Ghahremani; Sonia Bartunkova; Katharina Haigh; Kim Deswarte; Omar Nyabi; Michael Naessens; Napoleone Ferrara; Ursula Klingmüller; Bart N. Lambrecht; Andras Nagy; Sjaak Philipsen; Jody Haigh
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An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
Oncogene, ISSN: 09509232 14765594
Ye; Li; Scott Stawicki; Suzana Couto; Jeffrey Eastham-Anderson; Dara Y. Kallop; Robby M. Weimer; Yan Wu; Lin Pei
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Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: A case-control association study
Arthritis Research and Therapy, ISSN: 14786354 14786362
Aya Kawasaki; Satoshi Ito; Hiroshi Furukawa; Taichi Hayashi; Daisuke Goto; Isao Matsumoto; Makio Kusaoi; Jun Ohashi; Robert R. Graham; Kunio Matsuta; Timothy W. Behrens; Shigeto Tohma; Yoshinari Takasaki; Hiroshi Hashimoto; Takayuki Sumida; Naoyuki Tsuchiya
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Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments
Blood, ISSN: 15280020 00064971
Markus Moll; Sofia K. Andersson; Anna Smed-Sörensen; Johan K. Sandberg
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A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity
Journal of Immunology, ISSN: 00221767 15506606
Kate H. Gartlan; Gabrielle T Belz; Jacqueline M. Tarrant; Gabriela Minigo; Maria Katsara; Kuo-Ching Sheng; Mariam Sofi; Annemiek B. Van Spriel; Vasso Apostolopoulos; Magdalena Plebanski; Lorraine Robb; Mark D. Wright
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Physicochemical stability of the antibody - Drug conjugate trastuzumab-DM1: Changes due to modification and conjugation processes
Bioconjugate Chemistry, ISSN: 15204812 10431802
Aditya A. Wakankar; Maria B. Feeney; Javier Rivera; Yan Chen; Michael Kim; Vikas Sharma; Y. John Wang
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Interactions between Hedgehog proteins and their binding partners come into view
Genes and Development, ISSN: 15495477 08909369
Philip A. Beachy; Sarah G. Hymowitz; Lazarus; Daniel J. Leahy; Christian Siebold
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Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II
PLoS ONE, ISSN: 19326203
Rachael E. Hawtin; David E. Stockett; Jo Ann W. Byl; Robert S. McDowell; Nguyen Tan; Michelle R. Arkin; Andrew Conroy; Wenjin Yang; Neil Osheroff; Judy Fox
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Simultaneous determination of positive and negative pharmaceutical counterions using mixed-mode chromatography coupled with charged aerosol detector
Journal of Chromatography A, ISSN: 00219673
Kelly Zhang; Lulu Dai; Nik P. Chetwyn
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Nuclear phospho-Akt increase predicts synergy of PI3K inhibition and doxorubicin in breast and ovarian cancer
Science Translational Medicine, ISSN: 19466234 19466242
Jeffery J. Wallin; Zhengyu Guan; Wei Wei Prior; Kyle A. Edgar; Robert Kassees; Deepak Sampath; Marcia Belvin; Lori S. Friedman
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Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN: 10400605 15221504
Silvia Cardenas; Mario Scuri; Lennie Samsell; Barbara Ducatman; Pablo Bejarano; Alexander Auais; Melissa Doud; Kalai Mathee; Giovanni Piedimonte
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