Genentech: Publications

January 1, 2011

The corrected traditional equations for calculation of hepatic clearance that account for the difference in drug ionization in extracellular and intracellular tissue water and the corresponding corrected PBPK equation

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

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January 1, 2011

Pregnancy outcomes after maternal exposure to rituximab

Blood, ISSN: 15280020 00064971

Eliza F. Chakravarty; Elaine R. Murray; Ariella Kelman; Pamela Farmer

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January 1, 2011

Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development

Molecular and Cellular Neuroscience, ISSN: 10447431

Viola Maier; Christine Jolicoeur; Helen Rayburn; Noriko Takegahara; Atsushi Kumanogoh; Hitoshi Kikutani; Marc Tessier-Lavigne; Wolfgang Wurst; Roland H. Friedel

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January 1, 2011

An observational retrospective subgroup analysis of verteporfin photodynamic therapy-naive and previously treated patients in the focus trial

Retina, ISSN: 0275004X

Rajendra S. Apte; Sherri L. Alexander; Erin C. Henry; Pamela Wong; Lisa Tuomi

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January 1, 2011

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis

Nature Chemical Biology, ISSN: 15524469 15524450

Julie Di Paolo; Tao Huang; Mercedesz Balazs; Jim Barbosa; Kai H. Barck; Brandon Bravo; Richard A. D. Carano; James Darrow; Douglas R. Davies; Laura DeForge; Laurie Diehl; Ron Ferrando; Steven L. Gallion; Anthony M. Giannetti; Gribling; Vincent Hurez; Sarah G. Hymowitz; Randall Jones; Jeffrey E. Kropf; Wyne P. Lee; Patricia M. MacIejewski; Scott A. Mitchell; Hong Rong; Bart L. Staker; J. Andrew Whitney; Sherry Yeh; Wendy B. Young; Christine Yu; Juan Zhang; Karin Reif; Kevin S. Currie

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January 1, 2011

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned?

mAbs, ISSN: 19420862 19420870

Rong Deng; Suhasini Iyer; Frank-Peter Theil; Deborah L. Mortensen; Fielder; Saileta Prabhu

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January 1, 2011

The societal impact of age-related macular degeneration: Use of social support resources differs by the severity of the impairment

Journal of Visual Impairment and Blindness, ISSN: 0145482X

Mark Brennan; Amy Horowitz; Joann P. Reinhardt; Cynthia Stuen; Roman G. Rubio; Nina Oestreicher

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January 1, 2011

Trastuzumab emtansine (T-DM1): A novel agent for targeting HER2+ breast cancer

Clinical Breast Cancer, ISSN: 19380666 15268209

Howard A. Burris; Jay Tibbitts; Scott N. Holden; Mark X. Sliwkowski; Gail L. Phillips

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January 1, 2011

Response as a predictor of survival in patients with recurrent glioblastoma treated with bevacizumab

Neuro-Oncology, ISSN: 15228517 15235866

Michael D. Prados; Timothy Cloughesy; Meghna Samant; Liang Fang; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; James Vredenburgh; Asha Das; Henry S. Friedman

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January 1, 2011

Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: The IMAGE trial

Annals of the Rheumatic Diseases, ISSN: 00034967 14682060

Paul P. Tak; William F. Rigby; Rubbert-Roth; Charles G. Peterfy; Ronald Van Vollenhoven; Stohl W.; Eva W. Hessey; Annie Chen; Helen Tyrrell; Tim Shaw

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January 1, 2011

Quinolones as HCV NS5B polymerase inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Dange V. Kumar; Roopa Rai; Ken A. Brameld; John R. Somoza; Ravi Rajagopalan; James W. Janc; Yu M. Xia; Tony L. Ton; Michael B. Shaghafi; Huiyong Hu; Isabelle Lehoux; Nhat To; Wendy B. Young; Michael J. Green

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January 1, 2011

Evaluation of eml4-alk fusion proteins in non-small cell lung cancer using small molecule inhibitors

Neoplasia (United States), ISSN: 14765586 15228002

Li; Ye; Jinfeng Liu; Jiping Zha; Lin Pei

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January 1, 2011

Investigational antibody-drug conjugates for hematological malignancies

Expert Opinion on Investigational Drugs, ISSN: 13543784

Andrew G. Polson; William Y. Ho; Vanitha Ramakrishnan

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January 1, 2011

The pathologist's slide reveals more than meets the eye: Loss of heterozygosity and cancer biology

Veterinary Pathology, ISSN: 03009858 15442217

Suzana Couto

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January 1, 2011

Ankylosing spondylitis: Patterns of radiographic involvement-a re-examination of accepted principles in a cohort of 769 patients

Radiology, ISSN: 00338419 15271315

Jennifer H. Jang; Michael M. Ward; Adam N. Rucker; John D. Reveille; John C. Davis; Michael Weisman; Thomas J. Learch

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January 1, 2011

BRIDGE: An open-label phase II trial evaluating the safety of bevacizumab + carboplatin/paclitaxel as first-line treatment for patients with advanced, previously untreated, squamous non-small cell lung cancer

Journal of Thoracic Oncology, ISSN: 15561380 15560864

John Hainsworth; Liang Fang; Jane E. Huang; David A. Karlin; Kenneth Russell; Leonardo Faoro; Christopher Azzoli

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January 1, 2011

Improvement of hemodialysis catheter function with tenecteplase: A phase III, Open-label study: TROPICS 4

Journal of Thrombosis and Thrombolysis, ISSN: 09295305

Steven Fishbane; Samuel L. Milligan; Kenneth D. Lempert; Joachim E. W. Hertel; James B. Wetmore; Matthew J. Oliver; Martha Blaney; Barbara S. Gillespie; Joan R. Jacobs; Susan M. Begelman

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January 1, 2011

Towards BioDBcore: A community-defined information specification for biological databases

Nucleic Acids Research, ISSN: 03051048 13624962

Pascale Gaudet; Amos Bairoch; Dawn Field; Susanna-Assunta Sansone; Chris Taylor; Teresa K. Attwood; Alex Bateman; Judith A. Blake; Carol J. Bult; J. Michael Cherry; Rex L. Chisholm; Guy Cochrane; Charles E. Cook; Janan T. Eppig; Michael Y. Galperin; Robert Gentleman; Carole A. Goble; Takashi Gojobori; John M. Hancock; Douglas G. Howe; Tadashi Imanishi; Janet Kelso; David Landsman; Suzanna E. Lewis; Ilene Karsch-Mizrachi; Sandra Orchard; B.F. Francis Ouellette; Shoba Ranganathan; Lorna Richardson; Philippe Rocca-Serra; Paul N. Schofield; Damian Smedley; Christopher Southan; Tin W. Tan; Tatiana Tatusova; Patricia L. Whetzel; Owen White; Chisato Yamasaki

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January 1, 2011

Deubiquitinases in the regulation of NF-κB signaling

Cell Research, ISSN: 10010602 17487838

Edward W. Harhaj; Vishva M. Dixit

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January 1, 2011

The IL-17 pathway as a major therapeutic target in autoimmune diseases

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Yan Hu; Fang Shen; Natasha K Crellin; Wenjun Ouyang

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January 1, 2011

Monitoring spatial learning and memory in Alzheimer's disease mouse models using the morris water maze

Methods in Molecular Biology, ISSN: 10643745

Kimberly Scearce-Levie

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January 1, 2011

A technical feasibility study of dornase alfa delivery with eflow® vibrating membrane nebulizers: Aerosol characteristics and physicochemical stability

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Thomas M. Scherer; David E. Geller; Laura Owyang; Marcus Tservistas; Manfred Keller; Norbert Boden; Kenneth C. Kesser; Steven J. Shire

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January 1, 2011

A 2-week, polysomnographic, safety study of sodium oxybate in obstructive sleep apnea syndrome

Sleep and Breathing, ISSN: 15209512 15221709

Charles F. P. George; Neil Feldman; Yanping Zheng; Teresa L. Steininger; Susanna M. Grzeschik; Chinglin Lai; Neil Inhaber

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January 1, 2011

Costs associated with second-line therapies for lung cancer

American Journal of Pharmacy Benefits, ISSN: 19454481

Stephen Lash; April Teitelbaum; Henry J. Henk; Carolina Reyes; Lucinda Benn

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January 1, 2011

Sphingolipids and expression regulation of genes in cancer

Progress in Lipid Research, ISSN: 01637827

Gauri A. Patwardhan; Yong-Yu Liu

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January 1, 2011

Developmental immunotoxicology assessment of rituximab in cynomolgus monkeys

Toxicological Sciences, ISSN: 10960929 10966080

Anu Vaidyanathan; Kathleen McKeever; Banmeet S. Anand; Stephen M. Eppler; Gerhard F. Weinbauer; Joseph Beyer

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January 1, 2011

Estimating area under the curve and relative exposure in a pharmacokinetic study with data below quantification limit

Journal of Biopharmaceutical Statistics, ISSN: 10543406 15205711

Liang Fang; Peng Chen; Chunlei Ke; Edward Lee

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January 1, 2011

Characterization of the basic charge variants of a human IgG1: Effect of copper concentration in cell culture media

mAbs, ISSN: 19420870 19420862

Timothy Kaschak; Daniel Boyd; Franklin Lu; Gayle E. Derfus; Brian Kluck; Bartek Nogal; Craig Emery; Christie Summers; Kai Zheng; Robert Bayer; Ashraf Amanullah; Boxu Yan

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January 1, 2011

Trehalose: Current use and future applications

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Satoshi Ohtake; Y. John Wang

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January 1, 2011

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles

Genes and Immunity, ISSN: 14664879 14765470

Budarf; Philippe Goyette; Boucher; Lian; Robert R. Graham; Claudio; Hudson; Gladman; Clarke; Janet E. Pope; Peschken; Smith; Hanly; Rich; Boire; Barr; Zummer; Fortin; Joan E. Wither; John D. Rioux

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January 1, 2011

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL

Cancer Cell, ISSN: 18783686 15356108

Raghuveer Singh Mali; Baskar Ramdas; Peilin Ma; Jianjian Shi; Veerendra Munugalavadla; Emily Sims; Lei Wei; Sasidhar Vemula; Sarah Nabinger; Charles B. Goodwin; Rebecca J. Chan; Fabiola Traina; Valeria Visconte; Ramon V. Tiu; Timothy A. Lewis; Andrew M. Stern; Qiang Wen; John D. Crispino; H. Scott Boswell; Reuben Kapur

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January 1, 2011

Root cause investigation of rubber seal cracking in pre-filled cartridges: Ozone and packaging effects

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

Edwin K. Chan; Aaron Hubbard; Chung C. Hsu; Lionel Vedrine; Maa

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January 1, 2011

Reprogrammed quiescent B cells provide an effective cellular therapy against chronic experimental autoimmune encephalomyelitis

European Journal of Immunology, ISSN: 15214141 00142980

Elisabeth Calderón-Gómez; Vicky Lampropoulou; Ping Shen; Patricia Neves; Toralf Roch; Ulrik Stervbo; Sascha Rutz; Anja A. Kühl; Frank L. Heppner; Christoph Loddenkemper; Stephen M. Anderton; Jean M. Kanellopoulos; Pierre Charneau; Simon Fillatreau

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January 1, 2011

New prostate cancer drug encourages development of treatment pathway

Managed Care, ISSN: 10623388

Thomas Morrow

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January 1, 2011

Symptom burden and quality of life in patients with follicular lymphoma undergoing maintenance treatment with rituximab compared with observation

Therapeutic Advances in Hematology, ISSN: 20406215 20406207

Mark S. Walker; Edward J. Stepanski; Arthur C. Houts; Carolina Reyes; Sacha Satram-Hoang; Lee S. Schwartzberg

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January 1, 2011

Effect of protein and solution properties on the donnan effect during the ultrafiltration of proteins

Biotechnology Progress, ISSN: 87567938 15206033

Glen Bolton; Austin W. Boesch; Jonida Basha; Daniel P. LaCasse; Kelley; Hari Acharya

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January 1, 2011

BOLD MRI Applied to a Murine Model of Peripheral Artery Disease

Methods in Molecular Biology, ISSN: 19406029 10643745

Joan M. Greve

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January 1, 2011

The BOLD Effect

Methods in Molecular Biology, ISSN: 19406029 10643745

Joan M. Greve

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December 27, 2010

Ganciclovir pharmacokinetic parameters do not change when extending valganciclovir cytomegalovirus prophylaxis from 100 to 200 days

Transplantation, ISSN: 00411337

Horst Welker; Mahdi Farhan; Atul Humar; Carla Washington

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December 22, 2010

UNCovering the Molecular Machinery of Dependence Receptor Signaling

Molecular Cell, ISSN: 10972765 10974164

Anil Bagri; Avi Ashkenazi

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December 20, 2010

IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

Journal of Experimental Medicine, ISSN: 00221007 15409538

Marcel Batten; Nandhini Ramamoorthi; Noelyn Kljavin; Cindy S. Ma; Jennifer Cox; Hart S. Dengler; Dimitry Danilenko; Patrick Caplazi; Melanie Wong; David A. Fulcher; Matthew C. Cook; Cecile King; Stuart G. Tangye; Frederic J. De Sauvage; Nico Ghilardi

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December 20, 2010

Clinical experience with hedgehog pathway inhibitors

Journal of Clinical Oncology, ISSN: 0732183X 15277755

Low; Frederic J. De Sauvage

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December 17, 2010

Allosteric peptide activators of pro-hepatocyte growth factor stimulate Met signaling

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Kyle E. Landgraf; Santell; Karen L Billeci; Quan; Judy Young; Henry R. Maun; Daniel Kirchhofer; Lazarus

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December 15, 2010

Effects of charge on antibody tissue distribution and pharmacokinetics

Bioconjugate Chemistry, ISSN: 15204812 10431802

C. Andrew Boswell; Devin B. Tesar; Kiran Mukhyala; Frank-Peter Theil; Fielder; Leslie A. Khawli

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December 15, 2010

Estimating recurrences prevented from using trastuzumab in HER-2/neu-positive adjuvant breast cancer in the United States

Cancer, ISSN: 0008543X 10970142

Mark Danese; Deepa Lalla; Melissa Brammer; Quan Doan; Kevin Knopf

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December 15, 2010

Actin-bundling protein L-plastin regulates T cell activation

Journal of Immunology, ISSN: 00221767 15506606

Wang Chen; Sharon Celeste Morley; David Donermeyer; Ivan Peng; Wyne P. Lee; Jason Devoss; Dimitry Danilenko; Zhonghua Lin; Juan Zhang; Zhou Jie; Paul M. Allen; Eric J. Brown

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December 15, 2010

C-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

EMBO Journal, ISSN: 02614189 14602075

Jasmin N. Dynek; Tatiana Goncharov; Erin C. Dueber; Anna V. Fedorova; Anita Izrael-Tomasevic; Lilian Phu; Elizabeth Helgason; Wayne J. Fairbrother; Deshayes; Donald S. Kirkpatrick; Domagoj Vucic

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December 14, 2010

Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christine D. Pozniak; Abraham J. Langseth; Gerrit J. P. Dijkgraaf; Youngshik Choe; Zena Werb; Samuel J. Pleasure

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December 14, 2010

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Marcin Kowanetz; Xiumin Wu; John Lee; Martha Tan; Thijs Hagenbeek; Xueping Qu; Lanlan Yu; Ross; Nina Korsisaari; Tim C. Cao; Hani Bou-Reslan; Dara Y. Kallop; Robby M. Weimer; Mary J. C. Ludlam; Joshua S. Kaminker; Zora Modrusan; Nicholas Van Bruggen; Franklin V. Peale Jr.; Richard A. D. Carano; Meng; Napoleone Ferrara

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December 8, 2010

Allosteric activation mechanism of the mycobacterium tuberculosis receptor Ser/Thr protein Kinase, PknB

Structure, ISSN: 09692126

T. Noelle Lombana; Nathaniel Echols; Matthew C. Good; Nathan D. Thomsen; Ho-Leung Ng; Andrew E. Greenstein; Arnold M. Falick; David S. King; Tom Alber

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