Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8651 - 8700 OF 15217 RESULTS

Detection of protein-RNA complexes in Xenopus oocytes
Methods, ISSN: 10462023 10959130
Paul W. Huber; Wei-meng Zhao
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A20: From ubiquitin editing to tumour suppression
Nature Reviews Cancer, ISSN: 1474175X 14741768
Sarah G. Hymowitz; Ingrid E. Wertz
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Host-detrimental role of Esx-1-mediated inflammasome activation in Mycobacterial infection
PLoS Pathogens, ISSN: 15537366 15537374
Fredric Carlsson; Janice Kim; Calin Dumitru; Kai H. Barck; Richard A. D. Carano; Mei Sun; Laurie Diehl; Eric J. Brown
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Detecting low level sequence variants in recombinant monoclonal antibodies
mAbs, ISSN: 19420862
Yi Yang; Alex Strahan; Charlene Li; Amy Shen; Hongbin Liu; Jun Ouyang; Viswanatham Katta; Kathleen Francissen; Boyan Zhang
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Signalling lessons from death receptors: The importance of cleavage
Nature Cell Biology, ISSN: 14657392
Vishva M. Dixit
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Efficacy and safety of retreatment in patients with rheumatoid arthritis with previous inadequate response to tumor necrosis factor inhibitors: Results from the SUNRISE trial
Journal of Rheumatology, ISSN: 0315162X
Philip J. Mease; Stanley B. Cohen; Norman B. Gaylis; Andrew Chubick; Alan T. Kaell; Maria Greenwald; Sunil Agarwal; Ming Yin; Ariella Kelman
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Physical activity and change in mammographic density
American Journal of Epidemiology, ISSN: 00029262 14766256
Shannon M. Conroy; Lesley Butler; Danielle Harvey; Ellen B. Gold; Barbara Sternfeld; Nina Oestreicher; Gail A. Greendale; Laurel A. Habel
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Strategies for developing design spaces for viral clearance by anion exchange chromatography during monoclonal antibody production
Biotechnology Progress, ISSN: 87567938 15206033
Daniel M. Strauss; Tony Cano; Nick Cai; Heather Delucchi; Magdalena Plancarte; Daniel A. Coleman; Gregory S. Blank; Qi Chen; Bin Yang
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Role of myeloid cells in vascular endothelial growth factor-independent tumor angiogenesis
Current Opinion in Hematology, ISSN: 10656251 15317048
Napoleone Ferrara
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Recent advances in the genetics of systemic lupus erythematosus
Expert Review of Clinical Immunology, ISSN: 1744666X
Donna Thibault Flesher; Xin Sun; Timothy W. Behrens; Robert R. Graham; Lindsey A. Criswell
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Assembly and biological and immunological properties of Newcastle disease virus-like particles
Journal of Virology, ISSN: 0022538X
Lori W. McGinnes; Homer Pantua; Jason P. Laliberte; Kathryn A. Gravel; Surbhi Jain; Trudy G. Morrison
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Protein tyrosine phosphatase SHP-1 positively regulates TLR-induced IL-12p40 production in macrophages through inhibition of phosphatidylinositol 3-kinase
Journal of Leukocyte Biology, ISSN: 07415400
Delu Zhou; Cathleen A. Collins; Ping Wu; Eric J. Brown
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Hepatocyte growth factor activator (HGFA): Molecular structure and interactions with HGFA inhibitor-1 (HAI-1)
FEBS Journal, ISSN: 1742464X 17424658
Eigenbrot; Rajkumar Ganesan; Daniel Kirchhofer
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Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Ashraf Amanullah; Jose Manuel Otero; Mark Mikola; Amy Hsu; Jinyou Zhang; John Aunins; H. Brett Schreyer; James A. Hope; A. Peter Russo
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Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy
Clinical Cancer Research, ISSN: 10780432
Jiping Zha; Lackner
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The flexibility, quality and cost of single use recovery systems in bio-pharmaceutical drug production
American Pharmaceutical Review, ISSN: 10998012
Lindsay Leveen
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Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis
Nature, ISSN: 00280836 14764687
Sergio E. Baranzini; Joann Mudge; Jennifer C. Van Velkinburgh; Pouya Khankhanian; Irina Khrebtukova; Neil A. Miller; Lu Zhang; Andrew D. Farmer; Callum J. Bell; Ryan W. Kim; Gregory D. May; Jimmy E. Woodward; Stacy J. Caillier; Joseph P. McElroy; Refujia Gomez; Marcelo J. Pando; Leonda E. Clendenen; Elena E. Ganusova; Faye D. Schilkey; Thiruvarangan Ramaraj; Omar A. Khan; Jim J. Huntley; Shujun Luo; Pui-Yan Kwok; Thomas D Wu; Gary P. Schroth; Jorge R. Oksenberg; Stephen L. Hauser; Stephen F. Kingsmore
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Reply to W. Wick et al
Journal of Clinical Oncology, ISSN: 0732183X 15277755
Henry S. Friedman; Michael D. Prados; Patrick Y. Wen; Tom Mikkelsen; David Schiff; Lauren E. Abrey; Alfred Yung; Nina Paleologos; Martin K. Nicholas; Randy Jensen; James Vredenburgh; Jane E. Huang; Maoxia Zheng; Timothy Cloughesy
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Ladder polyether synthesis via epoxide-opening cascades directed by a disappearing trimethylsilyl group
Journal of Organic Chemistry, ISSN: 00223263 15206904
Timothy P. Heffron; Graham L. Simpson; Estibaliz Merino; Timothy F. Jamison
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Therapeutic antibody targeting of individual Notch receptors
Nature, ISSN: 00280836 14764687
Yan Wu; Carol Cain-Hom; Lisa Choy; Thijs Hagenbeek; Gladys P. De Leon; Yongmei Chen; David Finkle; Rayna Venook; Xiumin Wu; John B.B. Ridgway; Dorreyah Schahin-Reed; Graham J. Dow; Amy Shelton; Scott Stawicki; Ryan J. Watts; Jeff Zhang; Robert Choy; Peter Howard; Lisa Kadyk; Minhong Yan; Jiping Zha; Christopher Callahan; Sarah G. Hymowitz; Christian W. Siebel
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A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life
Cancer Research, ISSN: 00085472 15387445
Yik Andy Yeung; Xiumin Wu; Arthur Reyes; Jean-Michel Vernes; Samantha Lien; John Lowe; Mauricio Maia; William F. Forrest; Meng; Lisa A. Damico; Napoleone Ferrara; Henry B. Lowman
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Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Timothy P. Heffron; Megan Berry; Georgette M. Castanedo; Christine Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Janet Gunzner; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Daniel P. Sutherlin; Vickie Tsui; Nan Chi Wan; Shumei Wang; Susan C. Wong; Bing-Yan Zhu
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IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis
Journal of Immunology, ISSN: 00221767 15506606
Yan Hu; Naruhisa Ota; Ivan Peng; Refino; Dimitry Danilenko; Patrick Caplazi; Wenjun Ouyang
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Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons
Journal of Neuroscience, ISSN: 02706474 15292401
Yanling Wang; Catherine A. Dye; Vikaas Sohal; Jason E. Long; Rosanne C. Estrada; Tomas Roztocil; Thomas Lufkin; Karl Deisseroth; Scott C. Baraban; John L. R. Rubenstein
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A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
Cancer Cell, ISSN: 15356108
Ruihuan Chen; Merry C. Nishimura; Stephanie M. Bumbaca; Samir Kharbanda; William F. Forrest; Ian Kasman; Joan M. Greve; Robert Soriano; Laurie L. Gilmour; Rivers; Zora Modrusan; Serban Nacu; Steve Guerrero; Kyle A. Edgar; Jeffery J. Wallin; Katrin Lamszus; Manfred Westphal; Susanne Heim; C. David James; Scott R. VandenBerg; Joseph F. Costello; Scott Moorefield; Cynthia J. Cowdrey; Michael D. Prados; Phillips
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Differential effects of divalent manganese and magnesium on the kinase activity of Leucine-Rich Repeat Kinase 2 (LRRK2)
Biochemistry, ISSN: 00062960 15204995
Brian Lovitt; Erica Vanderporten; Zejuan Sheng; Haitao Zhu; Jake Drummond; Yichin Liu
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Cancer therapy reform
Science, ISSN: 00368075 10959203
Levinson
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Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Laetitia Malphettes; Yevgeniy Freyvert; Chang; Pei-Qi Liu; Edmond Chan; Jeffrey C. Miller; Zhe Zhou; Nguyen; Christina Tsai; Andrew Snowden; Trevor N. Collingwood; Philip D. Gregory; Gregory J. Cost
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Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions
Nature Methods, ISSN: 15487091 15491676
Anita A. Koshy; Ashley Fouts; Melissa B. Lodoen; Ozan Alkan; Helen M. Blau; John C. Boothroyd
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Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-α antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Rong Deng; Kelly M. Loyet; Samantha Lien; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Henry B. Lowman; Fielder; Saileta Prabhu
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Kinetics of Hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation
Molecular and Cellular Biology, ISSN: 02707306
Xiaohui Wen; Cary K. Lai; Marie Evangelista; Hongo; Frederic J. De Sauvage; Suzie J. Scales
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A phase III, randomized, double-blind, placebo-controlled study of tenecteplase for improvement of hemodialysis catheter function: TROPICS 3
Clinical Journal of the American Society of Nephrology, ISSN: 15559041 1555905X
James Tumlin; Jesse Goldman; David M. Spiegel; David Roer; K. Adu Ntoso; Martha Blaney; Joan R. Jacobs; Barbara S. Gillespie; Susan M. Begelman
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Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin e for the treatment of melanoma and breast cancer
Current Opinion in Molecular Therapeutics, ISSN: 14648431
Louie Naumovski; Jagath R. Junutula
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Cross-species comparison of the metabolism and excretion of zoniporide: Contribution of aldehyde oxidase to interspecies differences
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Deepak Dalvie; Chenghong Zhang; Weichao Chen; Teresa Smolarek; R. Scott Obach; Cho-Ming Loi
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Spatial control of EGF receptor activation by reversible dimerization on living cells
Nature, ISSN: 00280836 14764687
Inhee Chung; Robert W. Akita; Richard L. Vandlen; Derek Toomre; Schlessinger; Ira Mellman
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Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?
Annals of Neurology, ISSN: 03645134 15318249
Amit Bar-Or; Lama Fawaz; Boli Fan; Peter J. Darlington; Aja Rieger; Christine Ghorayeb; Peter A Calabresi; Waubant; Stephen L. Hauser; Jiameng Zhang; Craig H. Smith
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Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET
Nuclear Medicine and Biology, ISSN: 09698051
Jeff N. Tinianow; Herman S. Gill; Annie Ogasawara; Judith E. Flores; Alexander N. Vanderbilt; Luis; Richard L. Vandlen; Martine Darwish; Jagath R. Junutula; Simon P. Williams; Jan Marik
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Estimating duration in partnership studies: Issues, methods and examples
Sexually Transmitted Infections, ISSN: 13684973 14723263
Bart Burington; James P. Hughes; William L. H. Whittington; Brad Stoner; Geoff Garnett; Sevgi O. Aral; King K. Holmes
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Cytosol as battleground: Ubiquitin as a weapon for both host and pathogen
Trends in Cell Biology, ISSN: 09628924
Cathleen A. Collins; Eric J. Brown
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Novel method for genotyping hepatitis B virus on the basis of taqMan real-time PCR
Journal of Clinical Microbiology, ISSN: 00951137
Sebastian Malmström; Ida Enquist; Magnus Lindh
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Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother
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A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice
Developmental Biology, ISSN: 1095564X 00121606
Setsu Endoh-Yamagami; Kameel M. Karkar; Scott R. May; Inma Cobos; Myo T. Thwin; Jason E. Long; Amir M. Ashique; Konstantinos Zarbalis; John L. R. Rubenstein; Andrew S. Peterson
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An intracellular traffic jam: Fc receptor-mediated transport of immunoglobulin G
Current Opinion in Structural Biology, ISSN: 0959440X
Devin B. Tesar; Pamela J. Bjorkman
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Characteristics of rhVEGF release from topical hydrogel formulations
Pharmaceutical Research, ISSN: 07248741 1573904X
Junyan A. Ji; Jun Liu; Steven J. Shire; Tim J. Kamerzell; Sung Hong; Karen L Billeci; Ye Shen; Y. John Wang
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Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A
Nature Cell Biology, ISSN: 14657392
Yaron Pereg; Bob Y. Liu; Karen M. O'Rourke; Meredith Sagolla; Anwesha Dey; László Kömüves; French; Vishva M. Dixit
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The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility
Journal of Immunology, ISSN: 00221767 15506606
Sharon Celeste Morley; Chen Wang; Wan-Lin Lo; Chan-Wang J. Lio; Bernd H. Zinselmeyer; Mark J. Miller; Eric J. Brown; Paul M. Allen
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Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jin I. Lee; Damien M. O'Halloran; Jeffrey Eastham-Anderson; Bi-Tzen Juang; Julia A. Kaye; O. Scott Hamilton; Bluma Lesch; Andrei Goga; Noelle D. L'Etoile
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Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Desiree H. Fong; Christopher T. Lemke; Jiyoung Hwang; Bing Xiong; Albert M. Berghuis
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Reconstitution of a Frizzled8·Wnt3a·LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eric Bourhis; Christine Tam; Yvonne Franke; J.Fernando Bazan; James A. Ernst; Jiyoung Hwang; Michael Costa; Andrea G Cochran; Rami N. Hannoush
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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
Nature, ISSN: 00280836 14764687
Georgia Hatzivassiliou; Kyung Song; Ivana Yen; Barbara J. Brandhuber; Daniel J Anderson; Ryan Alvarado; Mary J. C. Ludlam; David Stokoe; Susan L. Gloor; Guy Vigers; Tony Morales; Ignacio Aliagas; Bonnie Liu; Steve Sideris; Klaus P. Hoeflich; Bijay S. Jaiswal; Somasekar Seshagiri; Koeppen; Marcia Belvin; Lori S. Friedman; Shiva Malek
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