Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9101 - 9150 OF 15217 RESULTS

Microtubule amplification in the assembly of mitotic spindle and the maturation of kinetochore fibers
Communicative and Integrative Biology, ISSN: 19420889
Hui Zhu; Kayleen Fang; Guowei Fang
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Some notable properties of the standard oncology phase i design
Journal of Biopharmaceutical Statistics, ISSN: 10543406 15205711
Gregory J. Hather; Howard M. Mackey
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High-throughput generation of tagged stable cell lines for proteomic analysis
Proteomics, ISSN: 16159853 16159861
Jorge Z. Torres; Julie J. Miller; Peter K Jackson
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Atg5-independent sequestration of ubiquitinated mycobacteria
PLoS Pathogens, ISSN: 15537366 15537374
Cathleen A. Collins; Ann De Mazière; Suzanne Van Dijk; Fredric Carlsson; Judith Klumperman; Eric J. Brown
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Plk1 and aurora A regulate the depolymerase activity and the cellular localization of Kif2a
Journal of Cell Science, ISSN: 00219533
Chang-Young Jang; Judith A. Coppinger; Akiko Seki; John R. Yates; Guowei Fang
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Estimating glomerular filtration rate: Cockcroft-gault and modification of diet in renal disease formulas compared to renal inulin clearance
Clinical Journal of the American Society of Nephrology, ISSN: 15559041 1555905X
Rossini Botev; Jean-Pierre Mallié; Cecilé Couchoud; Otto Schück; Jean-Pierre Fauvel; Jack F. M. Wetzels; Nelson Lee; Natale G. De Santo; Massimo Cirillo
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Second International Conference on Accelerating Biopharmaceutical Development: March 9-12, 2009, Coronado, CA USA
mAbs, ISSN: 19420862
Janice M. Reichert; Nitya M. Jacob; Ashraf Amanullah
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Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Jing Qing; Xiangnan Du; Yongmei Chen; Pamela Chan; Hao Li; Ping Wu; Scot A. Marsters; Scott Stawicki; Janet Y. Tien; Klara Totpal; Ross; Susanna Y. Stinson; David Dornan; French; Qian-Rena Wang; Jean-Philippe Stephan; Yan Wu; Wiesmann; Avi Ashkenazi
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Regulating laboratory-developed tests
Nature Biotechnology, ISSN: 10870156 15461696
Hal V. Barron
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Molecular mechanisms of mTOR-mediated translational control
Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080
Xiaoju Max Ma; John Blenis
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How can we improve the translational landscape for a faster cure of type 1 diabetes?
Journal of Clinical Investigation, ISSN: 00219738 15588238
Matthias von Herrath; Andrew Chan
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Increasing IgG concentration modulates the conformational heterogeneity and bonding network that influence solution properties
Journal of Physical Chemistry B, ISSN: 15206106
Tim J. Kamerzell; Sonoko Kanai; Jun Liu; Steven J. Shire; Y. John Wang
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Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
Oncogene, ISSN: 09509232 14765594
Kwek; Roy; Zhou; Climent; Martinez-Climent; Jane Fridlyand; Albertson
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Crystal structure of full-length KcsA in its closed conformation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Serdar Uysal; Valeria Vásquez; Valentina Tereshko; Kaori Esaki; Frederic A. Fellouse; Sachdev S. Sidhu; Shohei Koide; Eduardo Perozo; Anthony A. Kossiakoff
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High-throughput, high-accuracy array-based resequencing
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jianbiao Zheng; Martin Moorhead; Li Weng; Farooq Siddiqui; Victoria E. H. Carlton; James S. Ireland; Liana Lee; Joseph Peterson; Jennifer Wilkins; Sean Lin; Zhengyan Kan; Somasekar Seshagiri; Ronald W. Davis; Malek Faham
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G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Farbod Shojaei; Xiumin Wu; Xueping Qu; Marcin Kowanetz; Lanlan Yu; Martha Tan; Meng; Napoleone Ferrara
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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
Immunity, ISSN: 10747613
Paul G. Thomas; Pradyot Dash; Jerry R. Aldridge Jr.; Ali H. Ellebedy; Cory Reynolds; Amy J. Funk; William J. Martin; Lamkanfi; Richard Webby; Kelli L. Boyd; Peter C. Doherty; Thirumala-Devi Kanneganti
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Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kenneth J. Katschke Jr.; Scott Stawicki; Micah Steffek; Jianping Yin; Hongkang Xi; Lizette Sturgeon; Hass; Kelly M. Loyet; Laura DeForge; Yan Wu; Menno Van Lookeren Campagne; Wiesmann
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Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: Reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism
Toxicological Sciences, ISSN: 10966080 10960929
Lloyd Lecureux; Matthew Z. Dieter; David M. Nelson; Linda Watson; Harvey Wong; Brian Gemzik; Curtis D. Klaassen; Lois D. Lehman-McKeeman
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Efficient error determination in sequential clinical trial design
Journal of Computational and Graphical Statistics, ISSN: 10618600
Jiaqiao Hu; Zheng Su
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Small molecule clearance in ultrafiltration/diafiltration in relation to protein interactions: Study of citrate binding to a fab
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Chithkala Harinarayan; Ken Skidmore; Kao; Andrew Zydney; Robert Van Reis
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Comment on "Reassessment of the role of mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching"
Journal of Immunology, ISSN: 00221767 15506606
Hideharu Sekine; Ricardo C. Ferreira; Qiang Pan-Hammarström; Lennart Hammarström; Gary S. Gilkeson; Timothy W. Behrens
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The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf
Development (Cambridge), ISSN: 09501991 14779129
Idit Eshkar-Oren; Sergey V. Viukov; Sharbel Salameh; Sharon Krief; Chun-Do Oh; Haruhiko Akiyama; Hans-Peter Gerber; Napoleone Ferrara; Elazar Zelzer
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Characterization and regulation of Bv8 in human blood cells
Clinical Cancer Research, ISSN: 10780432
Cuiling Zhong; Xueping Qu; Martha Tan; Meng; Napoleone Ferrara
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VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Fan Zhang; Zhongshu Tang; Xu Hou; Johan Lennartsson; Yang Li; Alexander W. Koch; Pierre Scotney; Chunsik Lee; Pachiappan Arjunan; Lijin Dong; Anil Kumar; Tuomas T. Rissanen; Bin Wang; Nobuo Nagai; Pierre Fons; Robert Fariss; Yongqing Zhang; Eric Wawrousek; Ginger Tansey; James Raber; Guo-Hua Fong; Hao Ding; David A. Greenberg; Kevin G. Becker; Jean-Marc Herbert; Andrew Nash; Seppo Yla-Herttuala; Yihai Cao; Ryan J. Watts; Xuri Lia
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Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nature Chemical Biology, ISSN: 15524469 15524450
Yingnan Zhang; Brent A. Appleton; Wiesmann; Ted Lau; Michael Costa; Rami N. Hannoush; Sachdev S. Sidhu
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Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAF V600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression
Cancer Research, ISSN: 00085472 15387445
Klaus P. Hoeflich; Sylvia Herter; Janet Y. Tien; Leo Wong; Berry; Jocelyn Chan; Carol O'Brien; Zora Modrusan; Somasekar Seshagiri; Lackner; Howard M. Stern; Edna F. Choo; Lesley J. Murray; Lori S. Friedman; Marcia Belvin
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Follow: The Raptiva (efalizumab) Pregnancy Registry
Journal of the American Academy of Dermatology, ISSN: 01909622
David Margolis; Elizabeth Andrews; Winifred Werther
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A Novel, Q-PCR based approach to measuring endogenous retroviral clearance by capture protein a chromatography
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Min Zhang; Scott Lute; Lenore A Norling; Connie Hong; Aurelia Safta; Deborah O'Connor; Lisa J. Bernstein; Hua Wang; Gregory S. Blank; Kurt Brorson; Qi Chen
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Autophagy, an Achilles′ heel AKTing against cancer?
Autophagy, ISSN: 15548635 15548627
Michael Degtyarev; Ann De Mazière; Judith Klumperman; Kui Lin
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Genetic alterations and oncogenic pathways associated with breast cancer subtypes
Molecular Cancer Research, ISSN: 15417786
Hu; Howard M. Stern; Lin Ge; Carol O'Brien; Lauren Haydu; Cynthia D. Honchell; Matthias Peter; Brock A. Peters; Thomas D Wu; Lukas Amler; John Chant; David Stokoe; Lackner; Guy Cavet
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Association of C-terminal ubiquitin hydrolase BRCAl-associated protein 1 with cell cycle regulator host cell factor 1
Molecular and Cellular Biology, ISSN: 02707306
Shahram Misaghi; Søren Ottosen; Anita Izrael-Tomasevic; David Arnott; Lamkanfi; James Lee; Jinfeng Liu; Karen M. O'Rourke; Vishva M. Dixit; Angus C. Wilson
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Interleukin-22-producing innate immune cells: New players in mucosal immunity and tissue repair?
Nature Reviews Immunology, ISSN: 14741733
Eric Vivier; Hergen Spits; Tom Cupedo
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Pharmacodynamics of 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]- 3-(pyridine-4-yl)-1H-pyrazol-1-yl}ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: Understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Harvey Wong; Marcia Belvin; Sylvia Herter; Klaus P. Hoeflich; Lesley J. Murray; Leo Wong; Edna F. Choo
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Inhibitory properties of trapping agents: Glutathione, potassium cyanide, and methoxylamine, against major human cytochrome p450 isoforms
Drug Metabolism Letters, ISSN: 18723128
Chenghong Zhang; Susan C. Wong; Erlie Marie Delarosa; Jane R. Kenny; Jason S. Hallday; Cornelis E. Hop; S. Cyrus Khojasteh
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A census of human transcription factors: Function, expression and evolution
Nature Reviews Genetics, ISSN: 14710056 14710064
Juan M. Vaquerizas; Sarah K. Kummerfeld; Sarah A. Teichmann; Nicholas M. Luscombe
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PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
Journal of Immunology, ISSN: 00221767 15506606
Julie Zikherman; Michelle Hermiston; David Steiner; Kiminori Hasegawa; Andrew A. Chan; Arthur Weiss
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Tissue factor-dependent coagulation contributes to α- naphthylisothiocyanate-induced cholestatic liver injury in mice
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 01931857 15221547
James P. Luyendyk; Glenn H. Cantor; Daniel Kirchhofer; Nigel Mackman; Bryan L. Copple; Ruipeng Wang
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Genetic alterations and oncogenic pathways associated with breast cancer subtypes
Molecular Cancer Research, ISSN: 15417786
Xiaolan Hu; Howard M. Stern; Lin Ge; Carol O'Brien; Lauren Haydu; Cynthia D. Honchell; Matthias Peter; Brock A. Peters; Thomas D Wu; Lukas Amler; John Chant; David Stokoe; Lackner; Guy Cavet
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The art of making an exit
Science, ISSN: 00368075 10959203
Fredric Carlsson; Eric J. Brown
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Death receptor signal transducers: Nodes of coordination in immune signaling networks
Nature Immunology, ISSN: 15292908 15292916
Nicholas S. Wilson; Vishva M. Dixit; Avi Ashkenazi
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Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
Journal of Medicinal Chemistry, ISSN: 00222623
Frederick Cohen; Bruno Alicke; Linda O. Elliott; Flygare; Tatiana Goncharov; Stephen F. Keteltas; Matthew C Franklin; Stacy Frankovitz; Jean-Philippe Stephan; Vickie Tsui; Domagoj Vucic; Harvey Wong; Wayne J. Fairbrother
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Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, ISSN: 00368075 10959203
Jenny Bostrom; Shang-Fan Yu; David Kan; Brent A. Appleton; Chingwei V. Lee; Karen L Billeci; Wenyan Man; Franklin V. Peale Jr.; Ross; Wiesmann; Fuh
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Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with carboplatin and paclitaxel plus bevacizumab
Journal of Clinical Oncology, ISSN: 0732183X
Alan Sandler; Joan H. Schiller; Robert Gray; Isaiah Dimery; Julie Brahmer; Meghna Samant; Lisa I. Wang; David H. Johnson
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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Hua Tian; Christopher Callahan; Kelly J. DuPree; Darbonne; Christina Ahn; Suzie J. Scales; Frederic J. De Sauvage
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Neuropilins in tumor biology
Clinical Cancer Research, ISSN: 10780432
Anil Bagri; Marc Tessier-Lavigne; Ryan J. Watts
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Chitin is a size-dependent regulator of macrophage TNF and IL-10 production
Journal of Immunology, ISSN: 00221767 15506606
Carla A. Da Silva; Cecile Chalouni; Adam Williams; Dominik Hartl; Chun G. Lee; Jack A. Elias
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Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection
Cancer Research, ISSN: 00085472 15387445
Andrew G. Polson; Jill Calemine-Fenaux; Pamela Chan; Wesley S. Chang; Erin Christensen; Suzanna Clark; Frederic J. De Sauvage; Dan L. Eaton; Kristi Elkins; J. Michael Elliott; Gretchen D. Frantz; Reina N. Fuji; Gray; Kristin Harden; Gladys S. Ingle; Noelyn Kljavin; Koeppen; Nelson; Saileta Prabhu; Helga Raab; Ross; Jean-Philippe Stephan; Suzie J. Scales; Spencer; Richard L. Vandlen; Bernd Wranik; Shang-Fan Yu; Bing Zheng; Allen Ebens
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Yas3p, an opi1 family transcription factor, regulates Cytochrome P450 expression in response to n-alkanes inYarrowia lipolytica
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kiyoshi Hirakawa; Satoshi Kobayashi; Takuro Inoue; Setsu Endoh-Yamagami; Ryouichi Fukuda; Akinori Ohta
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Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5, 7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5, 6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
Journal of Medicinal Chemistry, ISSN: 00222623
Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Tanya Jewell; Leena Patel; Sarah Ludlum; Matthew Drowns; Sadayappan V. Rahavendran; Heather Skor; Robert Hunter; Stephanie Shi; Koleen J. Herlihy; Hans Parge; Michael Hickey; Xiu Yu; Fannie Chau; Jim Nonomiya; Lewis
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