Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9201 - 9250 OF 15491 RESULTS

Multivariate analysis of the sequence dependence of asparagine deamidation rates in peptides
Pharmaceutical Research, ISSN: 07248741 1573904X
Andrew Kosky; Vasumathi Dharmavaram; Gayathri Ratnaswamy; Mark C. Manning
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Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism
mAbs, ISSN: 19420862
Claire L. Dobson; Sarah Main; Philip Newton; Matthieu Chodorge; Karen Cadwallader; Robin Humphreys; Albert; Tristan J. Vaughan; Ralph R. Minter; Bryan M. Edwards
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Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4- (methylsulfonyl)benzamide), an orally bioavailable systemic hedgehog signalling pathway inhibitor
Xenobiotica, ISSN: 00498254 13665928
Harvey Wong; Jacob Z. Chen; Bilin Chou; Jason S Halladay; Jane R. Kenny; Hank La; James C. Marsters Jr.; Emile G. Plise; Patrick J. Rudewicz; Kirk D. Robarge; Young G. Shin; Susan C. Wong; Chenghong Zhang; S. Cyrus Khojasteh
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Human immunodeficiency virus type 1 protease-correlated cleavage site mutations enhance inhibitor resistance
Journal of Virology, ISSN: 0022538X
Madhavi Kolli; Eric Stawiski; Colombe Chappey; Celia A. Schiffer
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Targeting inhibitor of apoptosis proteins for therapeutic intervention
Future Medicinal Chemistry, ISSN: 17568919
Chudi O. Ndubaku; Frederick Cohen; Eugene Varfolomeev; Domagoj Vucic
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Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung
Pediatric Pulmonology, ISSN: 87556863 10990496
Fernando Urrego; Mario Scuri; Alexander Auais; Lida Mohtasham; Giovanni Piedimonte
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Economic outcomes in patients diagnosed with systemic lupus erythematosus with versus without nephritis: Results from an analysis of data from a US claims database
Clinical Therapeutics, ISSN: 01492918 1879114X
Elise M. Pelletier; Sarika Ogale; Elaine B. Yu; Paul Brunetta; Jay Garg
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Retinoic Acid from the Meninges Regulates Cortical Neuron Generation
Cell, ISSN: 00928674
Julie A. Siegenthaler; Amir M. Ashique; Konstantinos Zarbalis; Katelin P. Patterson; Jonathan H. Hecht; Maureen A. Kane; Alexandra E. Folias; Youngshik Choe; Scott R. May; Tsutomu Kume; Joseph L. Napoli; Andrew S. Peterson; Samuel J. Pleasure
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Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors
Journal of Medicinal Chemistry, ISSN: 00222623
Michael B. Plewe; Scott L. Butler; Klaus R. Dress; Qiyue Hu; Ted W. Johnson; Jon E. Kuehler; Atsuo Kuki; Hieu Lam; Wen Liu; Dawn Nowlin; Qinghai Peng; Sadayappan V. Rahavendran; Steven P. Tanis; Khanh T. Tran; Hai Wang; Anle Yang; Junhu Zhang
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Masking MALT1: The paracaspase's potential for cancer therapy
Journal of Experimental Medicine, ISSN: 00221007 15409538
Domagoj Vucic; Vishva M. Dixit
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Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
Journal of Experimental Medicine, ISSN: 00221007 15409538
David K. Finlay; Linda V. Sinclair; Carmen Feijoo; Caryll M. Waugh; Thijs Hagenbeek; Hergen Spits; Doreen A. Cantrell
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Smoothened mutation confers resistance to a hedgehog pathway inhibitor in medulloblastoma
Science, ISSN: 00368075 10959203
Robert Yauch; Gerrit J. P. Dijkgraaf; Bruno Alicke; Thomas Januario; Christina Ahn; Thomas Holcomb; Kanan Pujara; Stinson; Christopher Callahan; Tracy Tzu-Ling Tang; J.Fernando Bazan; Zhengyan Kan; Somasekar Seshagiri; Christine L. Hann; Stephen Gould; Low; Charles M. Rudin; Frederic J. De Sauvage
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The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta
Developmental Cell, ISSN: 15345807
Boris Strilić; Tomáš Kučera; Jan Eglinger; Michael R. Hughes; Kelly M. McNagny; Sachiko Tsukita; Elisabetta Dejana; Napoleone Ferrara; Eckhard Lammert
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A Role for C. elegans Eph RTK Signaling in PTEN Regulation
Developmental Cell, ISSN: 15345807
Sarah Brisbin; Jun Liu; Jeff Boudreau; Jimmy Peng; Marie Evangelista; Ian Chin-Sang
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The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Richard G. Jenner; Michael J. Townsend; Ian Jackson; Kaiming Sun; Russell D. Bouwman; Richard A. Young; Laurie H. Glimcher; Graham M. Lord
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Promising bone-related therapeutic targets for rheumatoid arthritis
Nature Reviews Rheumatology, ISSN: 17594790 17594804
Yongwon Choi; Joseph R. Arron; Michael J. Townsend
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TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling
Cell, ISSN: 00928674
Harald Junge; Stacey Yang; Jeremy B. Burton; Kim Paes; Xiao Shu; French; Michael Costa; Dennis S. Rice; Weilan Ye
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Revving the throttle on an oncogene: CDK8 takes the driver seat
Cancer Research, ISSN: 00085472 15387445
Ron Firestein; William C. Hahn
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Arcuate nucleus expression of NKX2.1 and DLX and lineages expressing these transcription factors in neuropeptide Y+, proopiomelanocortin+, and tyrosine hydroxylase+ neurons in neonatal and adult mice
Journal of Comparative Neurology, ISSN: 00219967 10969861
Cindy Yee; Yanling Wang; Stewart Anderson; Marc Ekker; John L. R. Rubenstein
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Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
PLoS ONE, ISSN: 19326203
Junichi Soh; Naoki Okumura; William W. Lockwood; Hiromasa Yamamoto; Hisayuki Shigematsu; Wei Zhang; Raj Chari; David S. Shames; Ximing Tang; Calum MacAulay; Marileila Varella-Garcia; Tõnu Vooder; Ignacio I. Wistuba; Stephen Lam; Rolf Brekken; Shinichi Toyooka; Minna; Wan L. Lam; Adi Gazdar
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Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: A validation study
Arthritis and Rheumatism, ISSN: 00043591 15290131
Jason W. Bauer; Michelle Petri; Franak Batliwalla; Thearith Koeuth; Joseph Wilson; Catherine A. Slattery; Angela Panoskaltsis-Mortari; Peter K. Gregersen; Timothy W. Behrens; Emily C. Baechler
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Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors-Insight into Heterotrimeric IL-1 Signaling Complexes
Structure, ISSN: 09692126
Andreas Lingel; Thomas M. Weiss; Marc Niebuhr; Borlan Pan; Brent A. Appleton; Wiesmann; J.Fernando Bazan; Wayne J. Fairbrother
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Engineering surfaces for substrate-mediated gene delivery using recombinant proteins
Biomacromolecules, ISSN: 15257797
Jennifer C. Rea; Romie F. Gibly; Nicolynn E. Davis; Annelise E. Barron; Lonnie D. Shea
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DNA spike studies for demonstrating improved clearance on chromatographic media
Journal of Chromatography A, ISSN: 00219673
Michelle D. Butler; Brian Kluck; Tracy Bentley
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Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus
Lupus, ISSN: 09612033
Michelle Petri; Singh; Tesfasyone; Russell L Dedrick; Fry; Preeti Lal; Williams; Jason W. Bauer; Peter K. Gregersen; Timothy W. Behrens; Emily C. Baechler
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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Journal of Cell Biology, ISSN: 00219525 00219525
Lamkanfi; James L. Mueller; Alberto C. Vitari; Shahram Misaghi; Anna V. Fedorova; Deshayes; Wyne P. Lee; Hal M. Hoffman; Vishva M. Dixit
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The N-terminal domain of DDA3 regulates the spindle-association of the microtubule depolymerase Kif2a and controls the mitotic function of DDA3
Cell Cycle, ISSN: 15514005 15384101
Chang-Young Jang; Guowei Fang
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Understanding the mechanism of virus removal by Q sepharose fast flow chromatography during the purification of CHO-cell derived biotherapeutics
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Daniel M. Strauss; Scott Lute; Zinaida Tebaykina; Douglas D. Frey; Cintia Ho; Gregory S. Blank; Kurt Brorson; Qi Chen; Bin Yang
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Multiplex RT Q-PCR assay for simultaneous quantification of three viruses used for validation of virus clearance by biopharmaceutical production
Biologicals, ISSN: 10451056 10958320
Scott Lute; Hua Wang; Davonie Sanchez; Janet Barletta; Qi Chen; Kurt Brorson
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Biomanufacturing process analytical technology (PAT) application for downstream processing: Using dissolved oxygen as an indicator of product quality for a protein refolding reaction
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Shelly A. Pizarro; Rachel Dinges; Rachel Adams; Ailen M. Sánchez; Charles Winter
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In vivo effects of targeting CD79b with antibodies and antibody-drug conjugates
Molecular Cancer Therapeutics, ISSN: 15357163
Bing Zheng; Reina N. Fuji; Kristi Elkins; Shang-Fan Yu; Franklin Fuh; Josefa Chuh; Christine Tan; Hongo; Helga Raab; Katherine R. Kozak; Marna Williams; Elena McDorman; Dan L. Eaton; Allen Ebens; Andrew G. Polson
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Systematic genetic nomenclature for type VII secretion systems
PLoS Pathogens, ISSN: 15537366 15537374
Wilbert Bitter; Edith N. G. Houben; Daria Bottai; Priscille Brodin; Eric J. Brown; Jeffery S. Cox; Keith Derbyshire; Sarah M. Fortune; Lian-Yong Gao; Jun Liu; Nicolaas C. Gey Van Pittius; Alexander S. Pym; Eric J. Rubin; David R. Sherman; Stewart T. Cole; Roland Brosch
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GDC-0449-A potent inhibitor of the hedgehog pathway
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Kirk D. Robarge; Shirley A. Brunton; Georgette M. Castanedo; Yong Cui; Dina; Richard Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner; Jason S Halladay; Wei Jia; S. Cyrus Khojasteh; Michael F. T. Koehler; Karen Kotkow; Hank La; Rebecca L. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James C. Marsters Jr.; Lesley J. Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark S. Stanley; John H.A. Stibbard; Daniel P. Sutherlin; Savita Ubhayakar; Shumei Wang; Susan C. Wong; Minli Xie
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Axl as a potential therapeutic target in cancer: Role of Axl in tumor growth, metastasis and angiogenesis
Oncogene, ISSN: 09509232 14765594
Li; Ye; Christine Tan; Hongo; Jiping Zha; Liu; Dara Y. Kallop; Mary J. C. Ludlam; Lin Pei
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High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions
PLoS Genetics, ISSN: 15537390 15537404
Lisa F. Barcellos; Suzanne L. May; Ramsay; Hong L. Quach; Lane; Joanne Nititham; Janelle A. Noble; Kimberly E. Taylor; Diana L. Quach; Sharon A. Chung; Jennifer A. Kelly; Kathy L. Moser; Timothy W. Behrens; Michael F. Seldin; Glenys Thomson; John B. Harley; Patrick M. Gaffney; Lindsey A. Criswell
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Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins
PLoS Biology, ISSN: 15449173 15457885
Raffi Tonikian; Xiaofeng Xin; Christopher P. Toret; David Gfeller; Christiane Landgraf; Simona Panni; Serena Paoluzi; Luisa Castagnoli; Bridget Currell; Somasekar Seshagiri; Haiyuan Yu; Barbara Winsor; Marc Vidal; Mark Gerstein; Gary D. Bader; Rudolf Volkmer; Gianni Cesareni; Drubin; Philip M. Kim; Sachdev S. Sidhu; Charles Boone
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The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Hiroaki Uranishi; Andrei S. Zolotukhin; Susan Lindtner; Søren Warming; Gen-Mu Zhang; Jenifer Bear; Neal G. Copeland; Nancy A. Jenkins; George N. Pavlakis; Barbara K. Felber
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Structural Ties between Cholesterol Transport and Morphogen Signaling
Cell, ISSN: 00928674
J.Fernando Bazan; Frederic J. De Sauvage
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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
New England Journal of Medicine, ISSN: 15334406 00284793
Daniel D. Von Hoff; Patricia M. LoRusso; Charles M. Rudin; Josina C. Reddy; Robert Yauch; Raoul Tibes; Glen J. Weiss; Mitesh J. Borad; Christine L. Hann; Julie Brahmer; Howard M. Mackey; Bert L. Lum; Darbonne; James C. Marsters Jr.; Frederic J. De Sauvage; Low
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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
New England Journal of Medicine, ISSN: 15334406 00284793
Charles M. Rudin; Christine L. Hann; John Laterra; Robert Yauch; Christopher Callahan; Ling Fu; Thomas Holcomb; Stinson; Stephen Gould; Barbara Coleman; Patricia M. LoRusso; Daniel D. Von Hoff; Frederic J. De Sauvage; Low
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Local Guidance of Emerging Vessel Sprouts Requires Soluble Flt-1
Developmental Cell, ISSN: 15345807
John C. Chappell; Sarah M. Taylor; Napoleone Ferrara; Victoria L. Bautch
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Genomic DNA microarray comparison of gene expression patterns in Paracoccidioides brasiliensis mycelia and yeasts in vitro
Microbiology, ISSN: 13500872
Jomar P. Monteiro; Karl V. Clemons; Laurence F. Mirels; John A. Coller Jr.; Thomas D Wu; Jata Shankar; Catalina R. Lopes; David A. Stevens
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Estimating variance parameters from multivariate normal variables subject to limits of detection: MLE, REML, or Bayesian approaches?
Statistics in Medicine, ISSN: 02776715 10970258
Lei Nie; Haitao Chu; Shibao Feng
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A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2
Journal of Medicinal Chemistry, ISSN: 00222623
Herman S. Gill; Jeff N. Tinianow; Annie Ogasawara; Judith E. Flores; Alexander N. Vanderbilt; Helga Raab; Justin M. Scheer; Richard L. Vandlen; Simon P. Williams; Jan Marik
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Rapid evolution of functional complexity in a domain family
Science Signaling, ISSN: 19450877 19379145
Andreas Ernst; Stephen L. Sazinsky; Shirley Hui; Bridget Currell; Moyez Dharsee; Somasekar Seshagiri; Gary D. Bader; Sachdev S. Sidhu
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Science signaling podcast: 8 September 2009
Science Signaling, ISSN: 19450877 19379145
Sachdev S. Sidhu; Annalisa M. VanHook
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Single-use technology and the carbon and water footprints of biopharm manufacturing
American Pharmaceutical Review, ISSN: 10998012
Lindsay Leveen
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Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents
British Journal of Pharmacology, ISSN: 00071188 14765381
Florio; Christine Loh; Huang; Iwamaye; Kitto; Fowler; Treiberg; Hayflick; Walker; Fairbanks; Lai
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A Phase IIIb Study to Evaluate the Safety of Ranibizumab in Subjects with Neovascular Age-related Macular Degeneration
Ophthalmology, ISSN: 01616420
David S. Boyer; Jeffrey S. Heier; David M. Brown; Steve Francom; Tsontcho Ianchulev; Roman G. Rubio
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The prioritization of cancer antigens: A National Cancer Institute pilot project for the acceleration of translational research
Clinical Cancer Research, ISSN: 10780432
Martin A. Cheever; James P. Allison; Andrea Stern Ferris; Olivera J. Finn; Benjamin M. Hastings; Toby T. Hecht; Ira Mellman; Sheila A. Prindiville; Jaye L. Viner; Louis M. Weiner; Lynn M. Matrisian
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