Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9251 - 9300 OF 15217 RESULTS

January 1, 2009

The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue

Genetics, ISSN: 00166731 00166731

Georg L. Bauer; Christian Praetorius; Kristín Bergsteinsdóttir; Jón H. Hallsson; Bryndís K. Gísladóttir; Alexander Schepsky; Deborah A. Swing; T. Norene O'Sullivan; Heinz Arnheiter; Keren Bismuth; Julien Debbache; Colin Fletcher; Søren Warming; Neal G. Copeland; Nancy A. Jenkins; Eiríkur Steingrímsson

January 1, 2009

Second- and third-line treatment of patients with non-small-cell lung cancer with erlotinib in the community setting: Retrospective study of patient healthcare utilization and symptom burden

Clinical Lung Cancer, ISSN: 15257304

Edward J. Stepanski; Arthur C. Houts; Lee S. Schwartzberg; Mark S. Walker; Carolina Reyes; Johnetta Blakely

January 1, 2009

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Junyan A. Ji; Boyan Zhang; Wilson Cheng; Y. John Wang

January 1, 2009

Viable tumor tissue detection in murine metastatic breast cancer by whole-body MRI and multispectral analysis

Magnetic Resonance in Medicine, ISSN: 15222594 07403194

Kai H. Barck; Brandon Willis; Ross; French; Ellen H. Filvaroff; Richard A. D. Carano

January 1, 2009

Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Frank-Peter Theil

January 1, 2009

Targeting the purinome.

Methods in Molecular Biology, ISSN: 19406029

Jeremy Murray; Dirksen Bussiere

January 1, 2009

Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma

Blood, ISSN: 15280020 00064971

David Dornan; Bennett; Chen; Dennis; Dan L. Eaton; Kristi Elkins; French; MaryAnn Go; Andrew S. Jack; Jagath R. Junutula; Koeppen; Jeffrey Lau; Jacqueline McBride; Andy Rawstron; Xiaoyan Shi; Nancy Yu; Shang-Fan Yu; Peng Yue; Bing Zheng; Allen Ebens; Andrew G. Polson

January 1, 2009

Prediction of the possibility of the secondary peaks of iv bolus drug plasma concentration time curve by the model that directly takes into account the transit time through the organ

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Leonid M. Berezhkovskiy

January 1, 2009

Consistently very poorly controlled asthma, as defined by the impairment domain of the Expert Panel Report 3 guidelines, increases risk for future severe asthma exacerbations in The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Tmirah Haselkorn; James E. Fish; Robert S. Zeiger; Stanley J. Szefler; Dave P. Miller; Bradley E. Chipps; F. Estelle R. Simons; Weiss; Sally E. Wenzel; Larry Borish; Eugene R. Bleecker

January 1, 2009

Design and construction of synthetic phage-displayed Fab libraries.

Methods in Molecular Biology, ISSN: 10643745

Jenny Bostrom; Fuh

January 1, 2009

Orphan disease gains second treatment option

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2009

Expanded availability of isotope boon to neuroblastoma diagnosis

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2009

Transgenic goats are key to antithrombin production

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2009

Sensitivity of administrative claims to identify incident cases of lung cancer: A comparison of 3 health plans

Journal of Managed Care Pharmacy, ISSN: 10834087

Scott D. Ramsey; John F. Scoggins; David Blough; Cara L. McDermott; Carolina Reyes

January 1, 2009

A stepwise increase in recombinant human growth hormone dosing during puberty achieves improved pubertal growth: A national cooperative growth study report

Journal of Pediatric Endocrinology and Metabolism, ISSN: 0334018X

Linda Riddick; Craig Alter; Daniel Aaron Davis; James W. Frane; Barbara M. Lippe; Bert Bakker

January 1, 2009

Viscoelastic characterization of high concentration antibody formulations using quartz crystal microbalance with dissipation monitoring

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Ankit Patel; Bruce A. Kerwin; Sekhar R. Kanapuram

January 1, 2009

Baseline characteristics of patients enrolled in EXCELS: A cohort study

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

Aidan Long; James E. Fish; Abdelkader Rahmaoui; Mary K. Miller; Mary S. Bradley; Hassan N. Taki; Anthony N. Demeo; Stephen A. Tilles; Stanley J. Szefler

January 1, 2009

Root UV-B sensitive2 acts with root UV-B sensitive1 in a root ultraviolet B-sensing pathway

Plant Physiology, ISSN: 15322548 00320889

Colin D. Leasure; Hongyun Tong; Gigi Yuen; Xuewen Hou; Xuefeng Sun; Zheng-Hui He

January 1, 2009

Prasugrel, new platelet inhibitor, subject of formulary debates.

Managed Care, ISSN: 10623388

Thomas Morrow

January 1, 2009

Enhanced expression of p210BCR/ABL and aberrant expression of Zfp423/ZNF423 induce blast crisis of chronic myelogenous leukemia

Blood, ISSN: 15280020 00064971

Kazuko Miyazaki; Norimasa Yamasaki; Hideaki Oda; Takeshi Kuwata; Yohei Kanno; Masaki Miyazaki; Yukiko Komeno; Jiro Kitaura; Zen-Ichiro Honda; Søren Warming; Nancy A. Jenkins; Neal G. Copeland; Toshio Kitamura; Takuro Nakamura; Hiroaki Honda

January 1, 2009

Assessing Medical Information Needs via an Internet-Based Survey

Therapeutic Innovation and Regulatory Science, ISSN: 21684790

Stacey M. Fung; Laura Merriman; Maureen Cawley

December 30, 2008

Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Dongguang Wei; Snezana Levic; Liping Nie; Gao; Christine Petit; Edward G. Jones; Ebenezer N. Yamoah

December 30, 2008

Quantifying the usefulness of PD biomarkers in Phase 2 screening trials of oncology drugs

Statistics in Medicine, ISSN: 02776715 10970258

Holmgren

December 26, 2008

Quantitation of polysorbate 20 in protein solutions using mixed-mode chromatography and evaporative light scattering detection

Journal of Chromatography A, ISSN: 00219673

Daniel Hewitt; Taylor Zhang; Kao

December 19, 2008

Mass spectrometric analysis of type 1 inositol 1,4,5-trisphosphate receptor ubiquitination

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Danielle A. Sliter; Kazuishi Kubota; Donald S. Kirkpatrick; Kamil J. Alzayady; Steven P. Gygi; Richard J. H. Wojcikiewicz

December 16, 2008

Near infrared spectroscopic characterisation of secondary structure content of proteins

Journal of Near Infrared Spectroscopy, ISSN: 09670335

Leon N. Hsu; Tanya P. Lin; Samir Sane

December 15, 2008

Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Gopi Shankar; Viswanath Devanarayan; Lakshmi Amaravadi; Yu Chen Barrett; Ronald Bowsher; Deborah Finco-Kent; Michele Fiscella; Boris Gorovits; Susan Kirschner; Michael Moxness; Thomas Parish; Quarmby; Holly W. Smith; Wendell Smith; Linda A. Zuckerman; Koren

December 12, 2008

The Filamentous Actin Cross-Linking/Bundling Activity of Mammalian Formins

Journal of Molecular Biology, ISSN: 00222836

Osigwe Esue; Elizabeth S. Harris; Henry N. Higgs; Denis Wirtz

December 11, 2008

Generation of a prostate from a single adult stem cell

Nature, ISSN: 00280836 14764679

Kevin G. Leong; Bu-Er Wang; Leisa Johnson; Gao

December 9, 2008

Distinct Thresholds Govern Myc's Biological Output In Vivo

Cancer Cell, ISSN: 15356108

Daniel J. Murphy; Melissa Junttila; Laurent Pouyet; Anthony N. Karnezis; Ksenya Shchors; Duyen A. Bui; Lamorna Brown Swigart; Leisa Johnson; Gerard I. Evan

December 9, 2008

A BBSome Subunit Links Ciliogenesis, Microtubule Stability, and Acetylation

Developmental Cell, ISSN: 15345807

Alexander V. Loktev; Qihong Zhang; John S. Beck; Charles C. Searby; Todd E. Scheetz; J.Fernando Bazan; Diane C. Slusarski; Val C. Sheffield; Peter K Jackson; Maxence V. Nachury

December 8, 2008

The conjugate addition-Peterson olefination reaction for the preparation of cross-conjugated cyclopentenone, PPAR-γ ligands

Organic and Biomolecular Chemistry, ISSN: 14770520

Mazhar Iqbal; Patricia Duffy; Paul Evans; George Cloughley; Bernard B. Allan; Agustí Lledó; Xavier Verdaguer; Antoni Riera

December 2, 2008

Validation of column-based chromatograhy processes for the purification of proteins

PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440

Brandeth; Chris Bussineau; Michelle D. Butler; Tony Christensen; Doris Conrad; Becky Devine; Ranga Godavarti; Eric Grund; Norbert Hentschel; Philip M. Lester; Jennifer McNay; Michael Muegge; Stephen Notarnicola; Rahul Patel; Laurie Scaggs

December 1, 2008

Vascular endothelial growth factor antibodies for anti-angiogenic therapy

Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy,

Hans-Peter Gerber; Megan E. Baldwin; Farbod Shojaei

December 1, 2008

Overview and clinical applications of VEGF-A

Angiogenesis: An Integrative Approach From Science to Medicine,

Napoleone Ferrara

December 1, 2008

Gene therapy offers HD patients relief from some symptoms

Managed Care, ISSN: 10623388

Thomas Morrow

December 1, 2008

The development of avastin

Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy,

Robert Mass

December 1, 2008

Meniscectomy alters the dynamic deformational behavior and cumulative strain of tibial articular cartilage in knee joints subjected to cyclic loads

Osteoarthritis and Cartilage, ISSN: 10634584

Song; Joan M. Greve; Carter; Giori

December 1, 2008

Crucial roles of robo proteins in midline crossing of cerebellofugal axons and lack of their up-regulation after midline crossing

Neural Development, ISSN: 17498104

Atsushi Tamada; Tatsuro Kumada; Yan Zhu; Tomoko Matsumoto; Yumiko Hatanaka; Keiko Muguruma; Zhe Chen; Yasuto Tanabe; Makio Torigoe; Kenta Yamauchi; Hiroshi Oyama; Kazuhiko Nishida; Fujio Murakami

December 1, 2008

Recent developments in microwave-assisted protein chemistries - can this be integrated into the drug discovery and validation process?

Drug Discovery Today, ISSN: 13596446

Wendy N. Sandoval; Victoria Pham; Jennie R. Lill

December 1, 2008

Bayesian adaptive design for targeted therapy development in lung cancer - A step toward personalized medicine

Clinical Trials, ISSN: 17407745 17407753

Xian Zhou; Suyu Liu; Edward S. Kim; Roy S. Herbst; J. Jack J. Lee

December 1, 2008

Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways

PLoS Medicine, ISSN: 15491277 15491676

Charles W. Lees; William J. Zacharias; Mark Tremelling; Colin L. Noble; Elaine R. Nimmo; Albert Tenesa; Jennine Cornelius; Leif Torkvist; John Kao; Susan Farrington; Hazel E. Drummond; Gwo-Tzer Ho; Ian Arnott; Henry D. Appelman; Laurie Diehl; Harry Campbell; Malcolm G. Dunlop; Miles Parkes; Sarah Howie; Deborah L. Gumucio; Jack Satsangi

December 1, 2008

Pathophysiology and clinical implications of vascular endothelial growth factor

Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy,

Napoleone Ferrara

December 1, 2008

MFAM29A promotes microtubule amplification via recruitment of the NEDDI-γ-tubuIin complex to the mitotic spindle

Journal of Cell Biology, ISSN: 00219525 00219525

Hui Zhu; Judith A. Coppinger; Chang-Young Jang; John R. Yates; Guowei Fang

December 1, 2008

Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies

Drug Resistance Updates, ISSN: 13687646

Farbod Shojaei; Napoleone Ferrara

December 1, 2008

Proteomic analysis of breast cancer molecular subtypes and biomarkers of response to targeted kinase inhibitors using reverse-phase protein microarrays

Molecular Cancer Therapeutics, ISSN: 15357163

Zachary Boyd; Jenny Q. Wu; Carol O'Brien; Jill M. Spoerke; Heidi Savage; Fielder; Lukas Amler; Yibing Yan; Lackner

December 1, 2008

Establishing the credibility of a biotech simulation model

Proceedings - Winter Simulation Conference, ISSN: 08917736

Lenrick Johnston; Lee Schruben; Arden Yang; David Zhang

December 1, 2008

Triple light chain antibodies in thiomabs

AIChE Annual Meeting, Conference Proceedings,

Natalia Gomez; Abigail R Vinson; Jun Ouyang; Inn H. Yuk

December 1, 2008

Harnessing the power of statistical design and the efficiency of a high throughput system for Cho media development

AIChE Annual Meeting, Conference Proceedings,

Sonali Nigam; Robb Shawley; Martin Gawlitzek; Louis Cheung; Christina Bevilacqua

December 1, 2008

Automated de novo protein sequencing of monoclonal antibodies

Nature Biotechnology, ISSN: 10870156 15461696

Nuno Bandeira; Victoria Pham; Pavel A. Pevzner; David Arnott; Jennie R. Lill

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