Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9351 - 9400 OF 15217 RESULTS

Fluorescence in situ hybridization subgroup analysis of TRIBUTE, a phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer
Clinical Cancer Research, ISSN: 10780432
Fred R. Hirsch; Marileila Varella-Garcia; Rafal Dziadziuszko; Yun Xiao; Sujatha Gajapathy; Margaret Skokan; Ming Lin; Vincent O'Neill; Paul A. Bunn Jr.
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A coordinated approach to cutaneous wound healing: Vibrational microscopy and molecular biology
Journal of Cellular and Molecular Medicine, ISSN: 15821838
K. L. Andrew Chan; Guojin Zhang; Marjana Tomic-Canic; Olivera Stojadinovic; Brian Lee; Carol R. Flach; Richard Mendelsohn
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The C-terminal region of Ge-1 presents conserved structural features required for P-body localization
RNA, ISSN: 13558382 14699001
Martin Jinek; Ana Eulalio; Andreas Lingel; Sigrun Helms; Elena Conti; Elisa Izaurralde
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Validation of Treatment Benefit Scale for Assessing Subjective Outcomes in Treatment of Overactive Bladder
Urology, ISSN: 00904295 15279995
Shoshana Colman; Chapple; Nitti; Haag-Molkenteller; Hastedt; Massow
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Reactive hyperemia and BOLD MRI demonstrate that VEGF inhibition, age, and atherosclerosis adversely affect functional recovery in a murine model of peripheral artery disease
Journal of Magnetic Resonance Imaging, ISSN: 10531807 15222586
Joan M. Greve; Simon P. Williams; Lisa J. Bernstein; Hope Goldman; Franklin V. Peale Jr.; Bunting; Nicholas Van Bruggen
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Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis
Gut, ISSN: 00175749
Colin L. Noble; Abbas Alexander; Jennine Cornelius; Charles W. Lees; Gwo-Tzer Ho; Toy; Zora Modrusan; Pal; Zhong; Sreedevi Chalasani; Hilary F. Clark; Ian D. Arnott; Ian D. Penman; Jack Satsangi; Laurie Diehl
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Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis
Gut, ISSN: 00175749
Colin L. Noble; Abbas Alexander; Jennine Cornelius; Charles W. Lees; Gwo-Tzer Ho; Toy; Zora Modrusan; Pal; Fiona Zhong; Sreedevi Chalasani; Hilary F. Clark; Ian D. Arnott; Ian D. Penman; Jack Satsangi; Laurie Diehl
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Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Nancy Dumont; Matthew B. Wilson; Yongping Crawford; Paul A. Reynolds; Mahvash Sigaroudinia; Thea D. Tlsty
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Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction
Science Signaling, ISSN: 19450877 19379145
Marie Evangelista; Tze Yang Lim; James Lee; Leon Parker; Amir M. Ashique; Andrew S. Peterson; Weilan Ye; David P. Davis; Frederic J. De Sauvage
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Robustness of virus removal by protein A chromatography is independent of media lifetime
Journal of Chromatography A, ISSN: 00219673
Scott Lute; Lenore A Norling; Michael Hanson; Rachel Emery; Denise Stinson; Kevin Padua; Gregory S. Blank; Qi Chen; Kurt Brorson
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The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
Journal of Medicinal Chemistry, ISSN: 00222623
Adrian J. Folkes; Khatereh Ahmadi; Wendy K. Alderton; Sonia Alix; Stewart Baker; Gary Box; Irina Chuckowree; Paul A. Clarke; Paul Depledge; Suzanne A. Eccles; Lori S. Friedman; Angela Hayes; Timothy Hancox; Arumugam Kugendradas; Letitia Lensun; Pauline Moore; Alan G. Olivero; Jodie Pang; Sonal Patel; Giles H. Pergl-Wilson; Florence I. Raynaud; Anthony Robson; Nahid Saghir; Laurent Salphati; Sukhjit Sohal; Ultsch; Melanie Valenti; Heidi J. A. Wallweber; Chi Wan Nan; Wiesmann; Paul Workman; Alexander Zhyvoloup; Marketa J. Zvelebil; Stephen Shuttleworth
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Inducible BRAF Suppression Models for Melanoma Tumorigenesis
Methods in Enzymology, ISSN: 00766879
Klaus P. Hoeflich; Bijay S. Jaiswal; David P. Davis; Somasekar Seshagiri
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Two-stage randomization designs in drug development
Statistics in Medicine, ISSN: 02776715 10970258
Marcel Wolbers; Jeffrey D. Helterbrand
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Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: A case-control association study of the STAT1-STAT4 region
Arthritis Research and Therapy, ISSN: 14786354 14786362
Aya Kawasaki; Ikue Ito; Koki Hikami; Jun Ohashi; Taichi Hayashi; Daisuke Goto; Isao Matsumoto; Satoshi Ito; Akito Tsutsumi; Minori Koga; Tadao Arinami; Robert R. Graham; Geoffrey Hom; Yoshinari Takasaki; Hiroshi Hashimoto; Timothy W. Behrens; Takayuki Sumida; Naoyuki Tsuchiya
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A paracrine requirement for hedgehog signalling in cancer
Nature, ISSN: 00280836 14764679
Robert Yauch; Stephen Gould; Suzie J. Scales; Tracy Tzu-Ling Tang; Hua Tian; Christina Ahn; Derek Marshall; Ling Fu; Thomas Januario; Dara Y. Kallop; Michelle Nannini; Karen Kotkow; James C. Marsters Jr.; Lee L. Rubin; Frederic J. De Sauvage
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Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer
Clinical Cancer Research, ISSN: 10780432
Sherry X. Yang; Seth M. Steinberg; Dat Nguyen; Thomas D Wu; Zora Modrusan; Sandra M. Swain
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c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Tatiana Goncharov; Anna V. Fedorova; Jasmin N. Dynek; Zobel; Deshayes; Wayne J. Fairbrother; Domagoj Vucic
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Hospitalized cardiovascular diseases in neovascular age-related macular degeneration
Archives of Ophthalmology, ISSN: 00039950 00039950
Bao-Anh Nguyen-Khoa; Earl L. Goehring; Winifred Werther; Emily W. Gower; Diana V. Do; Judith K. Jones
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Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis
Molecular Medicine, ISSN: 10761551
Chunyu Liu; Franak Batliwalla; Wentian Li; Annette T. Lee; Ronenn Roubenoff; Evan Beckman; Houman Khalili; Aarti Damle; Marlena Kern; Richard A. Furie; Najaf Amin; Robert M. Plenge; Marieke J.H. Coenen; Timothy W. Behrens; John P. Carulli; Peter K. Gregersen
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Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC)
Lung Cancer, ISSN: 01695002
Josh J. Carlson; Carolina Reyes; Nina Oestreicher; Deborah Lubeck; Scott D. Ramsey; David L. Veenstra
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Whole body physiologically-based pharmacokinetic models: Their use in clinical drug development
Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255
Andrea N. Edginton; Frank-Peter Theil; Walter Schmitt; Stefan Willmann
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The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase
Journal of Clinical Pharmacology, ISSN: 00912700 15524604
Reza Khosravan; Michael J. Kukulka; Jing-Tao Wu; Nancy Joseph-Ridge; Laurent Vernillet
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Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
Nature Genetics, ISSN: 10614036 15461718
Stacy L. Musone; Kimberly E. Taylor; Timothy T. Lu; Joanne Nititham; Ricardo C. Ferreira; Ward Ortmann; Nataliya Shifrin; Michelle Petri; M. Ilyas Kamboh; Manzi; Michael F. Seldin; Peter K. Gregersen; Timothy W. Behrens; Averil Ma; Pui-Yan Kwok; Lindsey A. Criswell
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Shifting patterns of inhaled antibiotic use in cystic fibrosis
Pediatric Pulmonology, ISSN: 87556863 10990496
Samuel M. Moskowitz; Stefanie J. Silva; Nicole Mayer-Hamblett; David J. Pasta; David R. Mink; Jenny A. Mabie; Michael W. Konstan; Wagener
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Growth hormone responsiveness: Peak stimulated growth hormone levels and other variables in idiopathic short stature (ISS): Data from the national cooperative growth study
Pediatric Endocrinology Reviews, ISSN: 15654753
Wayne V. Moore; Ken Dana; James W. Frane; Barbara M. Lippe
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T cell-independent development and induction of somatic hypermutation in human IgM+IgD+CD27+ B cells
Journal of Experimental Medicine, ISSN: 00221007 00221007
Ferenc A. Scheeren; Maho Nagasawa; Kees Weijer; Tom Cupedo; Jörg Kirberg; Nicolas Legrand; Hergen Spits
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Ocrelizumab, a humanized anti-CD20 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I/II randomized, blinded, placebo-controlled, dose-ranging study
Arthritis and Rheumatism, ISSN: 00043591
Mark C. Genovese; Jeffrey Kaine; Mitchell B. Lowenstein; José Del Giudice; Andrew Baldassare; Joy Schechtman; Edward Fudman; Michael Kohen; Gujrathi; Robert G. Trapp; Nadera J. Sweiss; Spaniolo; Wolfgang Dummer
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Health-related quality of life impact of bevacizumab when combined with irinotecan, 5-fluorouracil, and leucovorin or 5-fluorouracil and leucovorin for metastatic colorectal cancer
Oncologist, ISSN: 10837159 1549490X
Fairooz F. Kabbinavar; Joel F. Wallace; Holmgren; Jing Yi; Cella; Yost; Herbert Hurwitz
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Effect of Rhesus D incompatibility on schizophrenia depends on offspring sex
Schizophrenia Research, ISSN: 09209964
Christina G.S. Palmer; Erin Mallery; Joni A. Turunen; Hsin-Ju Hsieh; Leena Peltonen; Jouko Lonnqvist; J. Arthur Woodward; Janet S. Sinsheimer
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Argatroban anticoagulation in intensive care patients: Effects of heart failure and multiple organ system failure
Journal of Intensive Care Medicine, ISSN: 08850666 15251489
Susan M. Begelman; Sarkis B. Baghdasarian; Inder M. Singh; Michael A. Militello; Marcie J. Hursting; John R. Bartholomew
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Reduced insulin secretion and content in VEGF-A deficient mouse pancreatic islets
Experimental and Clinical Endocrinology and Diabetes, ISSN: 09477349
Normund Jabs; Franklin; Brenner; Gromada; Napoleone Ferrara; Wollheim; Eckhard Lammert
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A specificity map for the PDZ domain family
PLoS Biology, ISSN: 15449173 15457885
Raffi Tonikian; Yingnan Zhang; Stephen L. Sazinsky; Bridget Currell; Jung-Hua Yeh; Boris Reva; Heike A. Held; Brent A. Appleton; Marie Evangelista; Yan Wu; Xiaofeng Xin; Andrew A. Chan; Somasekar Seshagiri; Lasky; Chris Sander; Charles Boone; Gary D. Bader; Sachdev S. Sidhu
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A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein-Protein Interfaces
Journal of Molecular Biology, ISSN: 00222836
Ryan N. Gilbreth; Kaori Esaki; Akiko Koide; Sachdev S. Sidhu; Shohei Koide
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IL-22 in mucosal immunity
Mucosal Immunology, ISSN: 19330219
Wenjun Ouyang; Patricia A. Valdez
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On the edge of validation - Cancer protease fibroblast activation protein
Mini-Reviews in Medicinal Chemistry, ISSN: 13895575
Beni B. Wolf; Quan; Thuy Tran; Wiesmann; Daniel P. Sutherlin
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TGFβ induces SIK to negatively regulate type I receptor kinase signaling
Journal of Cell Biology, ISSN: 00219525 00219525
Marcin Kowanetz; Peter Lönn; Michael Vanlandewijck; Katarzyna Kowanetz; Carl-Henrik Heldin; Aristidis Moustakas
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Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies
Cell, ISSN: 00928674
Kim Newton; Marissa L. Matsumoto; Ingrid E. Wertz; Donald S. Kirkpatrick; Jennie R. Lill; Jenille Tan; Dugger; Nathaniel C. Gordon; Sachdev S. Sidhu; Frederic A. Fellouse; László Kömüves; French; Ron Ferrando; Cynthia Lam; Deanne M. Compaan; Christine Yu; Ivan Bosanac; Sarah G. Hymowitz; Robert F. Kelley; Vishva M. Dixit
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The Unique N Terminus of the UbcH10 E2 Enzyme Controls the Threshold for APC Activation and Enhances Checkpoint Regulation of the APC
Molecular Cell, ISSN: 10972765
Matthew K. Summers; Borlan Pan; Kiran Mukhyala; Peter K Jackson
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Advances in Technology and Process Development for Industrial-Scale Monoclonal Antibody Purification
Process Scale Purification of Antibodies,
Nuno Fontes; Robert Van Reis
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Downstream Processing of Monoclonal Antibodies: Current Practices and Future Opportunities
Process Scale Purification of Antibodies,
Kelley; Gregory S. Blank; Ann L. Lee
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Bootstrap quantile estimation via importance resampling
Computational Statistics and Data Analysis, ISSN: 01679473
Jiaqiao Hu; Zheng Su
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Potent and selective pyrazole-based inhibitors of B-Raf kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Joshua D. Hansen; Jonas Grina; Bradley J. Newhouse; Michael Welch; George Topalov; Nicole Littman; Michele Callejo; Susan L. Gloor; Matthew Martinson; Ellen R. Laird; Barbara J. Brandhuber; Guy Vigers; Tony Morales; Richard D. Woessner; Nikole Randolph; Joseph P. Lyssikatos; Alan G. Olivero
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Antibody Purification: Drivers of Change
Process Scale Purification of Antibodies,
Narahari Pujar; Duncan Low; O'Leary
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Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
Blood, ISSN: 15280020 00064971
David D. Kim; Takashi Miwa; Yuko Kimura; Retoa Schwendener; Menno Van Lookeren Campagne; Wen-Chao Song
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A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability
Journal of Medicinal Chemistry, ISSN: 00222623
Thomas E. Rawson; Matthias Rüth; Elizabeth M. Blackwood; Burdick; Laura B. Corson; Jennafer Dotson; Jason H. Drummond; Carter Fields; Guy J. Georges; Bernhard Goller; Jason S Halladay; Thomas Hunsaker; Tracy L. Kleinheinz; Hans-Willi Krell; Jun Li; Jun Liang; Anja Limberg; Angela McNutt; John Moffat; Gail L. Phillips; Yingqing Ran; Brian S. Safina; Ultsch; Leslie Walker; Wiesmann; Birong Zhang; Aihe Zhou; Bing-Yan Zhu; Petra Rüger; Andrea G Cochran
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Liposomal packaging generates Wnt protein with in vivo biological activity
PLoS ONE, ISSN: 19326203
Nathan T. Morrell; Philipp Leucht; Ludan Zhao; Jae-Beom Kim; Derk ten Berge; Karthik Ponnusamy; A. Lyonel Carre; Henryk Dudek; Marie Zachlederova; Michael McElhaney; Shirley A. Brunton; Janet Gunzner; Marinella G. Callow; Paul G. Polakis; Michael Costa; Xiaoyan M. Zhang; Jill A. Helms; Roel Nusse
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FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development
Neural Development, ISSN: 17498104
Ugo Borello; Inma Cobos; Jason E. Long; Cornelis Murre; John L. R. Rubenstein
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Wolman disease/cholesteryl ester storage disease: Efficacy of plant-produced human lysosomal acid lipase in mice
Journal of Lipid Research, ISSN: 00222275 15397262
Hong Du; Terri L. Cameron; Stephen J. Garger; Gregory P. Pogue; Lee A. Hamm; Earl White; Kathleen M. Hanley; Gregory A. Grabowski
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Application of high-performance tangential flow filtration (HPTFF) to the purification of a human pharmaceutical antibody fragment expressed in Escherichia coli
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Lebreton; Arick Brown; Robert Van Reis
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Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition
Molecular Biology of the Cell, ISSN: 10591524
Wanli Tang; Judy Qiju Wu; Yanxiang Guo; David V. Hansen; Jennifer A. Perry; Christopher D. Freel; Leta Nutt; Peter K Jackson; Sally Kornbluth
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