Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 9351 - 9400 OF 15491 RESULTS

MBX-102/JNJ39659100, a novel non-TZD selective partial PPAR-γ agonist lowers triglyceride independently of PPAR-α activation
PPAR Research, ISSN: 16874757 16874765
Francine M. Gregoire; Apurva Chandalia; Holly J. Clarke; L. Edward Clemens; Bindu Pandey; Vic Vicena; Paul Lee; Brian E. Lavan
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ATP-citrate lyase links cellular metabolism to histone acetylation
Science, ISSN: 00368075 10959203
Kathryn E. Wellen; Georgia Hatzivassiliou; Uma M. Sachdeva; Thi V. Bui; Justin R. Cross; Craig B. Thompson
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Development of a rapid sanitization solution for silica-based protein A affinity adsorbents
Journal of Chromatography A, ISSN: 00219673
Marc Rogers; Hiraoka-Sutow; Polly Mak; Fred Mann; Lebreton
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Effect of EDTA and methionine on preventing loss of viscosity of cellulose-based topical gel
AAPS PharmSciTech, ISSN: 15309932
Junyan A. Ji; Erika Ingham; John Wang
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Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation
Autophagy, ISSN: 15548635 15548627
Elsa N. N'Diaye; Jayanta Debnath; Eric J. Brown
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Ion exchange chromatography of monoclonal antibodies: Effect of resin ligand density on dynamic binding capacity
Journal of Chromatography A, ISSN: 00219673
Ann Marie Hardin; Chithkala Harinarayan; Gunnar Malmquist; Andreas Axén; Robert Van Reis
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Surface extenders and an optimal pore size promote high dynamic binding capacities of antibodies on cation exchange resins
Journal of Chromatography A, ISSN: 00219673
David S. Hart; Chithkala Harinarayan; Gunnar Malmquist; Andreas Axén; Mandakini Sharma; Robert Van Reis
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Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling
Cell, ISSN: 00928674
Zhaoyu Jin; Yun Li; Pitti; David Lawrence; Victoria Pham; Jennie R. Lill; Avi Ashkenazi
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Erratum: Erythropoietin dosing in children with chronic kidney disease: Based on body size or on hemoglobin deficit? (Pediatric Nephrology (2009) 10.1007/s00467-008-0955-2)
Pediatric Nephrology, ISSN: 0931041X
Ruediger E. Port; Otto Mehls
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Characterization of deamidated peptide variants by micro-preparative capillary electrophoresis and mass spectrometry
Journal of Chromatography A, ISSN: 00219673
Lynn Gennaro; Oscar Salas-Solano
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A therapeutic antibody and its antigen form different complexes in serum than in phosphate-buffered saline: A study by analytical ultracentrifugation
Analytical Biochemistry, ISSN: 10960309 00032697
Barthélemy Demeule; Steven J. Shire; Jun Liu
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A developmentally regulated Myb domain protein regulates expression of a subset of stage-specific genes in Entamoeba histolytica
Cellular Microbiology, ISSN: 14625814 14625822
Gretchen M. Ehrenkaufer; Jason A. Hackney; Upinder Singh
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A nanocube plasmonic sensor for molecular binding on membrane surfaces
Nano Letters, ISSN: 15306984
William J. Galush; Sarah A. Shelby; Martin J. Mulvihill; Andrea Tao; Peidong Yang; Jay T. Groves
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The effects of c-Abl mutation on developing B cell differentiation and survival
International Immunology, ISSN: 09538178 14602377
Hans D. Brightbill; Mark S. Schlissel
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Analytical methods for inferring functional effects of single base pair substitutions in human cancers
Human Genetics, ISSN: 03406717 14321203
William Lee; Peng Yue; Zemin Zhang
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Small-molecule inhibitors of store-operated calcium entry
ChemMedChem, ISSN: 18607179 18607187
Zachary K. Sweeney; Ana Minatti; Donald Button; Silvia Patrick
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Docking for fragment inhibitors of AmpC β-lactamase
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Denise G. Teotico; Kerim Babaoglu; Gabriel J. Rocklin; Rafaela S. Ferreira; Anthony M. Giannetti; Brian K. Shoichet
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Pharmacokinetic analysis of irinotecan plus bevacizumab in patients with advanced solid tumors
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Crystal S. Denlinger; Rebecca Blanchard; Lu Xu; Coen A. Bernaards; Samuel Litwin; Cynthia Spittle; Daniel J. Berg; Susan McLaughlin; Maryann Redlinger; Andrew Dorr; Julie Hambleton; Scott N. Holden; Anne Kearns; Sara Kenkare-Mitra; Bert L. Lum; Neal J. Meropol; Peter J. O'Dwyer
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Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941
Cancer Cell, ISSN: 15356108
Teemu T. Junttila; Robert W. Akita; Kathryn Parsons; Carter Fields; Gail L. Phillips; Lori S. Friedman; Deepak Sampath; Mark X. Sliwkowski
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The PRL -1149 G/T polymorphism and rheumatoid arthritis susceptibility
Arthritis and Rheumatism, ISSN: 00043591 15290131
Yvonne C. Lee; Soumya Raychaudhuri; Jing Cui; Immaculata De Vivo; Bo Ding; Lars Alfredsson; Leonid Padyukov; Karen H. Costenbader; Mark Seielstad; Robert R. Graham; Lars Klareskog; Peter K. Gregersen; Robert M. Plenge; Elizabeth W. Karlson
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How can we improve the translational landscape for a faster cure of type 1 diabetes?
Journal of Clinical Investigation, ISSN: 00219738 15588238
Matthias von Herrath; Andrew A. Chan
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Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE
Genes and Immunity, ISSN: 14664879 14765470
David L. Morris; Robert R. Graham; Erwig; Patrick M. Gaffney; Kathy L. Moser; Timothy W. Behrens; Timothy J. Vyse; Deborah S. Cunninghame Graham
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Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Maura N. Dickler; Melody A. Cobleigh; Kathy Miller; Pam Klein; Eric P. Winer
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Predictive biomarkers in the development of oncology drugs: A therapeutic industry perspective
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Bernard M. Fine; Lukas Amler
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Microtubule amplification in the assembly of mitotic spindle and the maturation of kinetochore fibers
Communicative and Integrative Biology, ISSN: 19420889
Hui Zhu; Kayleen Fang; Guowei Fang
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Some notable properties of the standard oncology phase i design
Journal of Biopharmaceutical Statistics, ISSN: 10543406 15205711
Gregory J. Hather; Howard M. Mackey
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High-throughput generation of tagged stable cell lines for proteomic analysis
Proteomics, ISSN: 16159853 16159861
Jorge Z. Torres; Julie J. Miller; Peter K Jackson
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Atg5-independent sequestration of ubiquitinated mycobacteria
PLoS Pathogens, ISSN: 15537366 15537374
Cathleen A. Collins; Ann De Mazière; Suzanne Van Dijk; Fredric Carlsson; Judith Klumperman; Eric J. Brown
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Plk1 and aurora A regulate the depolymerase activity and the cellular localization of Kif2a
Journal of Cell Science, ISSN: 00219533
Chang-Young Jang; Judith A. Coppinger; Akiko Seki; John R. Yates; Guowei Fang
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Estimating glomerular filtration rate: Cockcroft-gault and modification of diet in renal disease formulas compared to renal inulin clearance
Clinical Journal of the American Society of Nephrology, ISSN: 15559041 1555905X
Rossini Botev; Jean-Pierre Mallié; Cecilé Couchoud; Otto Schück; Jean-Pierre Fauvel; Jack F. M. Wetzels; Nelson Lee; Natale G. De Santo; Massimo Cirillo
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Second International Conference on Accelerating Biopharmaceutical Development: March 9-12, 2009, Coronado, CA USA
mAbs, ISSN: 19420862
Janice M. Reichert; Nitya M. Jacob; Ashraf Amanullah
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Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice
Journal of Clinical Investigation, ISSN: 00219738 15588238
Jing Qing; Xiangnan Du; Yongmei Chen; Pamela Chan; Hao Li; Ping Wu; Scot A. Marsters; Scott Stawicki; Janet Y. Tien; Klara Totpal; Ross; Susanna Y. Stinson; David Dornan; French; Qian-Rena Wang; Jean-Philippe Stephan; Yan Wu; Wiesmann; Avi Ashkenazi
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Regulating laboratory-developed tests
Nature Biotechnology, ISSN: 10870156 15461696
Hal V. Barron
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Molecular mechanisms of mTOR-mediated translational control
Nature Reviews Molecular Cell Biology, ISSN: 14710072 14710080
Xiaoju Max Ma; John Blenis
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How can we improve the translational landscape for a faster cure of type 1 diabetes?
Journal of Clinical Investigation, ISSN: 00219738 15588238
Matthias von Herrath; Andrew Chan
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Increasing IgG concentration modulates the conformational heterogeneity and bonding network that influence solution properties
Journal of Physical Chemistry B, ISSN: 15206106
Tim J. Kamerzell; Sonoko Kanai; Jun Liu; Steven J. Shire; Y. John Wang
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Co-amplified genes at 8p12 and 11q13 in breast tumors cooperate with two major pathways in oncogenesis
Oncogene, ISSN: 09509232 14765594
Kwek; Roy; Zhou; Climent; Martinez-Climent; Jane Fridlyand; Albertson
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Crystal structure of full-length KcsA in its closed conformation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Serdar Uysal; Valeria Vásquez; Valentina Tereshko; Kaori Esaki; Frederic A. Fellouse; Sachdev S. Sidhu; Shohei Koide; Eduardo Perozo; Anthony A. Kossiakoff
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High-throughput, high-accuracy array-based resequencing
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jianbiao Zheng; Martin Moorhead; Li Weng; Farooq Siddiqui; Victoria E. H. Carlton; James S. Ireland; Liana Lee; Joseph Peterson; Jennifer Wilkins; Sean Lin; Zhengyan Kan; Somasekar Seshagiri; Ronald W. Davis; Malek Faham
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G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Farbod Shojaei; Xiumin Wu; Xueping Qu; Marcin Kowanetz; Lanlan Yu; Martha Tan; Meng; Napoleone Ferrara
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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
Immunity, ISSN: 10747613
Paul G. Thomas; Pradyot Dash; Jerry R. Aldridge Jr.; Ali H. Ellebedy; Cory Reynolds; Amy J. Funk; William J. Martin; Lamkanfi; Richard Webby; Kelli L. Boyd; Peter C. Doherty; Thirumala-Devi Kanneganti
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Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Kenneth J. Katschke Jr.; Scott Stawicki; Micah Steffek; Jianping Yin; Hongkang Xi; Lizette Sturgeon; Hass; Kelly M. Loyet; Laura DeForge; Yan Wu; Menno Van Lookeren Campagne; Wiesmann
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Hepatobiliary disposition of thyroid hormone in Mrp2-deficient TR- rats: Reduced biliary excretion of thyroxine glucuronide does not prevent xenobiotic-induced hypothyroidism
Toxicological Sciences, ISSN: 10966080 10960929
Lloyd Lecureux; Matthew Z. Dieter; David M. Nelson; Linda Watson; Harvey Wong; Brian Gemzik; Curtis D. Klaassen; Lois D. Lehman-McKeeman
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Efficient error determination in sequential clinical trial design
Journal of Computational and Graphical Statistics, ISSN: 10618600
Jiaqiao Hu; Zheng Su
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Small molecule clearance in ultrafiltration/diafiltration in relation to protein interactions: Study of citrate binding to a fab
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Chithkala Harinarayan; Ken Skidmore; Kao; Andrew Zydney; Robert Van Reis
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Comment on "Reassessment of the role of mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching"
Journal of Immunology, ISSN: 00221767 15506606
Hideharu Sekine; Ricardo C. Ferreira; Qiang Pan-Hammarström; Lennart Hammarström; Gary S. Gilkeson; Timothy W. Behrens
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The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf
Development (Cambridge), ISSN: 09501991 14779129
Idit Eshkar-Oren; Sergey V. Viukov; Sharbel Salameh; Sharon Krief; Chun-Do Oh; Haruhiko Akiyama; Hans-Peter Gerber; Napoleone Ferrara; Elazar Zelzer
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Characterization and regulation of Bv8 in human blood cells
Clinical Cancer Research, ISSN: 10780432
Cuiling Zhong; Xueping Qu; Martha Tan; Meng; Napoleone Ferrara
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VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Fan Zhang; Zhongshu Tang; Xu Hou; Johan Lennartsson; Yang Li; Alexander W. Koch; Pierre Scotney; Chunsik Lee; Pachiappan Arjunan; Lijin Dong; Anil Kumar; Tuomas T. Rissanen; Bin Wang; Nobuo Nagai; Pierre Fons; Robert Fariss; Yongqing Zhang; Eric Wawrousek; Ginger Tansey; James Raber; Guo-Hua Fong; Hao Ding; David A. Greenberg; Kevin G. Becker; Jean-Marc Herbert; Andrew Nash; Seppo Yla-Herttuala; Yihai Cao; Ryan J. Watts; Xuri Lia
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Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nature Chemical Biology, ISSN: 15524469 15524450
Yingnan Zhang; Brent A. Appleton; Wiesmann; Ted Lau; Michael Costa; Rami N. Hannoush; Sachdev S. Sidhu
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