Genentech: Publications

April 1, 2008

PTEN in brain tumors

Expert Review of Neurotherapeutics, ISSN: 14737175 17448360

Daphne A. Haas-Kogan; David Stokoe

April 1, 2008

TLR7 agonist 852A inhibition of tumor cell proliferation is dependent on plasmacytoid dendritic cells and type I IFN

Journal of Interferon and Cytokine Research, ISSN: 10799907

Jon R. Inglefield; Calin Dumitru; Sefik S. Alkan; Sheila J. Gibson; Kenneth E. Lipson; Mark A. Tomai; Chris J. Larson; John P. Vasilakos

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April 1, 2008

STAT3-mediated Up-regulation of BLIMP1 is coordinated with BCL6 down-regulation to control human plasma cell differentiation

Journal of Immunology, ISSN: 15506606 00221767

Sean A. Diehl; Heike Schmidlin; Maho Nagasawa; Simon D. Van Haren; Mark J. Kwakkenbos; Etsuko Yasuda; Tim Beaumont; Ferenc A. Scheeren; Hergen Spits

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April 1, 2008

Developing and promoting an intranet site for a drug information service

American Journal of Health-System Pharmacy, ISSN: 10792082

Emily C. Costerison; Graham

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March 20, 2008

Rapid identification of reactive cysteine residues for site-specific labeling of antibody-Fabs

Journal of Immunological Methods, ISSN: 00221759

Jagath R. Junutula; Sunil Bhakta; Helga Raab; Karen E. Ervin; Eigenbrot; Richard L. Vandlen; Richard H. Scheller; Henry B. Lowman

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March 19, 2008

Identification of direct target genes using joint sequence and expression likelihood with application to DAF-16

PLoS ONE, ISSN: 19326203

Ron X. Yu; Jie Liu; Nick True; Wei Wang

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March 15, 2008

Intestinal epithelial cell up-regulation of LY6 molecules during colitis results in enhanced chemokine secretion

Journal of Immunology, ISSN: 15506606 00221767

Ken Flanagan; Zora Modrusan; Jennine Cornelius; Arvind Chavali; Ian Kasman; László Kömüves; Lian Mo; Laurie Diehl

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March 13, 2008

Immunoglobulin dynamics, conformational fluctuations, and nonlinear elasticity and their effects on stability

Journal of Physical Chemistry B, ISSN: 15206106

Tim J. Kamerzell; Joshua D. Ramsey; C. Russell Middaugh

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March 13, 2008

VEGF inhibition and renal thrombotic microangiopathy

New England Journal of Medicine, ISSN: 15334406 00284793

Vera Eremina; J. Ashley Jefferson; Jolanta Kowalewska; Hochster; Mark Haas; Joseph Weisstuch; Catherine Richardson; Jeffrey B. Kopp; M. Golam Kabir; Peter H. Backx; Hans-Peter Gerber; Napoleone Ferrara; Laura Barisoni; Charles E. Alpers; Susan E. Quaggin

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March 11, 2008

A Trigger Squeezed

Structure, ISSN: 09692126

Eigenbrot

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March 7, 2008

Regulation of a Late Phase of T Cell Polarity and Effector Functions by Crtam

Cell, ISSN: 00928674

Jung-Hua Yeh; Sachdev S. Sidhu; Andrew A. Chan

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March 1, 2008

Conservation of inner domain modules in the surface envelope glycoproteins of an ancient rabbit lentivirus and extant lentiviruses and betaretroviruses

Virology, ISSN: 00426822 10960341

Isidro Hötzel

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March 1, 2008

Multi-step variance minimization in sequential tests

Statistics and Computing, ISSN: 09603174

Zheng Su; Jiaqiao Hu; Wei Zhu

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March 1, 2008

Subcutaneous efalizumab is not effective in the treatment of alopecia areata

Journal of the American Academy of Dermatology, ISSN: 01909622

Vera H. Price; Maria K. Hordinsky; Elise A. Olsen; Janet L. Roberts; Elaine C. Siegfried; Elyse S. Rafal; Neil J. Korman; Basel Altrabulsi; Hoi M. Leung; Marvin Garovoy; Ivor Caro; David A. Whiting

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March 1, 2008

Targeting IAP (inhibitor of apoptosis) proteins for therapeutic intervention in tumors

Current Cancer Drug Targets, ISSN: 15680096

Domagoj Vucic

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March 1, 2008

Egfl7 knockdown causes defects in the extension and junctional arrangements of endothelial cells during Zebrafish vasculogenesis

Developmental Dynamics, ISSN: 10588388 10970177

Ann De Mazière; Leon Parker; Suzanne Van Dijk; Weilan Ye; Judith Klumperman

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March 1, 2008

The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis

Molecular Biology of the Cell, ISSN: 10591524

Elsa N. N'Diaye; Aylin C. Hanyaloglu; Kimberly K. Kajihara; Manojkumar A. Puthenveedu; Ping Wu; Mark Von Zastrow; Eric J. Brown

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March 1, 2008

Combination intravitreal triamcinolone injection and cryotherapy for exudative retinal detachments in severe coats disease

Retina, ISSN: 0275004X

Chris S. Bergstrom; G. Baker Hubbard III

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March 1, 2008

Effect of food or antacid on pharmacokinetics and pharmacodynamics of febuxostat in healthy subjects

British Journal of Clinical Pharmacology, ISSN: 03065251 13652125

Reza Khosravan; Brian Grabowski; Jing-Tao Wu; Nancy Joseph-Ridge; Laurent Vernillet

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March 1, 2008

Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: Support for a crucial role of intron 1 polymorphisms

Arthritis and Rheumatism, ISSN: 00043591

Aya Kawasaki; Chieko Kyogoku; Jun Ohashi; Risa Miyashita; Koki Hikami; Makio Kusaoi; Katsushi Tokunaga; Yoshinari Takasaki; Hiroshi Hashimoto; Timothy W. Behrens; Naoyuki Tsuchiya

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March 1, 2008

Preclinical absorption, distribution, metabolism and excretion (ADME) characterization of ICAM1988, an LFA-1/ICAM antagonist, and its prodrug

Xenobiotica, ISSN: 00498254 13665928

S. Cyrus Khojasteh; Douglas Leipold; Lai; Hank La; Matthew Baumgardner; Desino; Gudmundsson; Duane C. Bloedow; Bodary; Mark E. Reynolds; Thomas Gadek; Sara Kenkare-Mitra

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March 1, 2008

Tumor necrosis factor: Renaissance as a cancer therapeutic?

Current Cancer Drug Targets, ISSN: 15680096

Dylan Daniel; Nicholas S. Wilson

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March 1, 2008

Gene signatures reflect the marked heterogeneity of tissue-resident macrophages

Immunology and Cell Biology, ISSN: 08189641 14401711

Nick N. Gorgani; Yan Ma; Hilary F. Clark

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March 1, 2008

A new ELISA for use in a 3-ELISA system to assess concentrations of VEGF splice variants and VEGF110 in ovarian cancer tumors

Clinical Chemistry, ISSN: 00099147

Johnny Gutierrez; Gottfried E. Konecny; Kyu Hong; Alexander Burges; Timothy D. Henry; Pier D. Lambiase; Lee Wong Wai; Meng

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March 1, 2008

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells

Journal of Immunology, ISSN: 15506606 00221767

Marcel Batten; Noelyn Kljavin; Ji Li; Michael J. Walter; Frederic J. De Sauvage; Nico Ghilardi

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March 1, 2008

The mitochondrial serine protease HtrA2/Omi: An overview

Cell Death and Differentiation, ISSN: 13509047 14765403

Vande Walle; Lamkanfi; Vandenabeele

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March 1, 2008

Reducing bias in parameter estimates from stepwise regression in proportional hazards regression with right-censored data

Lifetime Data Analysis, ISSN: 13807870

Chang-Heok Soh; David P. Harrington; Alan M. Zaslavsky

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March 1, 2008

Rituximab in relapsing-remitting multiple sclerosis: A 72-week, open-label, phase I trial

Annals of Neurology, ISSN: 03645134

Amit Bar-Or; Peter A Calabresi; Douglas Arnlod; Clyde Markowitz; Stuart Shafer; Lloyd H. Kasper; Waubant; Suzanne Gazda; Robert J. Fox; Michael Panzara; Neena Sarkar; Sunil Agarwal; Craig H. Smith

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March 1, 2008

Global regulatory expectations for process changes, versions and multiple manufacturing sites

American Pharmaceutical Outsourcing, ISSN: 15296318

Shelley Suggett

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March 1, 2008

Current Cancer Drug Targets: Editorial

Current Cancer Drug Targets, ISSN: 15680096

Domagoj Vucic

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March 1, 2008

Effects of an Anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: Optimizing methods to quantify vascular changes

Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783

Claudio Campa; Ian Kasman; Weilan Ye; Wyne P. Lee; Fuh; Napoleone Ferrara

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March 1, 2008

Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets

Genome Research, ISSN: 10889051 15495469

David S. Johnson; Wei Li; D. Benjamin Gordon; Arindam Bhattacharjee; Bo Curry; Jayati Ghosh; Leonardo Brizuela; Jason S. Carroll; Myles Brown; Paul Flicek; Christoph M. Koch; Ian Dunham; Mark Bieda; Xiaoqin Xu; Farnham; Philipp Kapranov; David A. Nix; Thomas R. Gingeras; Xinmin Zhang; Heather Holster; Nan Jiang; Roland D. Green; Jun S. Song; Scott A. McCuine; Elizabeth Anton; Loan Nguyen; Nathan D. Trinklein; Zhen Ye; Keith Ching; David Hawkins; Bing Ren; Peter C. Scacheri; Joel Rozowsky; Alexander Karpikov; Ghia Euskirchen; Sherman Weissman; Mark Gerstein; Michael Snyder; Annie Yang; Zarmik Moqtaderi; Heather Hirsch; Hennady P. Shulha; Yutao Fu; Zhi-Ping Weng; Kevin Struhl; Richard M. Myers; Jason D. Lieb; X. Shirley Liu

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March 1, 2008

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Nature Medicine, ISSN: 10788956 1546170X

Yan Zheng; Patricia A. Valdez; Dimitry Danilenko; Yan Hu; Susan Sa; Qian Gong; Abbas Alexander; Zora Modrusan; Nico Ghilardi; Frederic J. De Sauvage; Wenjun Ouyang

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March 1, 2008

Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): A potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL

Cancer Chemotherapy and Pharmacology, ISSN: 03445704

Amrita Kamath; Jian Wang; Francis Y. F. Lee; Punit H. Marathe

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February 28, 2008

Stem Cell Factor Functions as an Outgrowth-Promoting Factor to Enable Axon Exit from the Midline Intermediate Target

Neuron, ISSN: 08966273

Bryan B. Gore; Karen G. Wong; Marc Tessier-Lavigne

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February 28, 2008

Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

New England Journal of Medicine, ISSN: 15334406 00284793

Geoffrey Hom; Robert R. Graham; Barmak Modrek; Kimberly E. Taylor; Ward Ortmann; Sophie Garnier; Annette T. Lee; Sharon A. Chung; Ricardo C. Ferreira; P. V. Krishna Pant; Dennis G. Ballinger; Kosoy; F. Yesim Demirci; M. Ilyas Kamboh; Amy H. Kao; Tian; Iva Gunnarsson; Anders A. Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Manzi; Michael F. Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A. Criswell; Peter K. Gregersen; Timothy W. Behrens

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February 20, 2008

Vesicle priming and recruitment by ubMunc13-2 are differentially regulated by calcium and calmodulin

Journal of Neuroscience, ISSN: 02706474 02706474

Dragoslav Zikich; Aviv Mezer; Frederique Varoqueaux; Anton Sheinin; Harald Junge; Esther Nachliel; Rely Melamed; Nils Brose; Menachem Gutman; Uri Ashery

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February 20, 2008

Are Phase 2 screening trials in Oncology obsolete?

Statistics in Medicine, ISSN: 02776715 10970258

Holmgren

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February 19, 2008

Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Farbod Shojaei; Mallika Singh; Jennifer D. Thompson; Napoleone Ferrara

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February 15, 2008

A study in glycation of a therapeutic recombinant humanized monoclonal antibody: Where it is, how it got there, and how it affects charge-based behavior

Analytical Biochemistry, ISSN: 10960309 00032697

Quan; Emily W. Alcala; Irena Petkovska; Domenic Matthews; Eleanor Canova-Davis; Ron Taticek; Stacey Ma

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February 14, 2008

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

New England Journal of Medicine, ISSN: 15334406 00284793

Stephen L. Hauser; Waubant; Douglas L. Arnold; Timothy Vollmer; Jack Antel; Robert J. Fox; Amit Bar-Or; Michael Panzara; Neena Sarkar; Sunil Agarwal; Annette Langer-Gould; Craig H. Smith

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February 8, 2008

Comprehensive analysis of the factors contributing to the stability and solubility of autonomous human VH domains

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Pierre A. Barthelemy; Helga Raab; Brent A. Appleton; Christopher J. Bond; Ping Wu; Wiesmann; Sachdev S. Sidhu

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February 5, 2008

pH dependent effect of glycosylation on protein stability

European Journal of Pharmaceutical Sciences, ISSN: 09280987

Wei Wang; Kris Antonsen; Y. John Wang; Wang

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February 5, 2008

Engineering and Overproduction of Polyketide Natural Products

Modern Biopharmaceuticals: Design, Development and Optimization,

Martha Lovato Tse; Chaitan Khosla

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February 1, 2008

Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling

Immunology and Cell Biology, ISSN: 08189641 14401711

Nicholas S. Wilson; Louise J. Young; Fiona Kupresanin; Shalin H. Naik; David Vremec; William R. Heath; Shizuo Akira; Ken Shortman; Jeff Boyle; Eugene Maraskovsky; Gabrielle T Belz; Jose A. Villadangos

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February 1, 2008

Effect of food on the pharmacokinetics of erlotinib, an orally active epidermal growth factor receptor tyrosine-kinase inhibitor, in healthy individuals

Anti-Cancer Drugs, ISSN: 09594973

Jie Ling; Scott Fettner; Bert L. Lum; Myriam Riek; Ashok Rakhit

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February 1, 2008

Interaction between bevacizumab and murine VEGF-A: A reassessment

Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783

Lanlan Yu; Xiumin Wu; Zhiyong Cheng; Chingwei V. Lee; Jennifer Lecouter; Claudio Campa; Fuh; Henry B. Lowman; Napoleone Ferrara

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February 1, 2008