Genentech: Publications

November 1, 2008

Effect of therapeutic integrin (CD11a) blockade with efalizumab on immune responses to model antigens in humans: Results of a randomized, single blind study

Journal of Investigative Dermatology, ISSN: 0022202X 15231747

James G. Krueger; Hans D. Ochs; Piyush Patel; Ellen Gilkerson; Emma Guttman-Yassky; Wolfgang Dummer

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November 1, 2008

Increased plasma concentrations of cytoskeletal and Aa2+-binding proteins and their peptides in psoriasis patients

Clinical Chemistry, ISSN: 00099147

Tatiana Plavina; Marina Hincapie; Eric Wakshull; Subramanyam; William S. Hancock

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November 1, 2008

BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4

Genes and Development, ISSN: 08909369 15495477

Milena B. Furtado; Mark J. Solloway; Vanessa J. Jones; Mauro W. Costa; Christine Biben; Orit Wolstein; Jost I. Preis; Duncan B. Sparrow; Yumiko Saga; Sally Dunwoodie; Elizabeth J. Robertson; Patrick P. L. Tam; Richard P. Harvey

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November 1, 2008

Evidence for an asialoglycoprotein receptor on nonparenchymal cells for O-linked glycoproteins

Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103

Stefanich; Song Ren; Dimitry Danilenko; Lim; An Song; Suhasini Iyer; Fielder

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November 1, 2008

Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Deepak Dalvie; Weichao Chen; Chenghong Zhang; Alfin D. Vaz; Teresa Smolarek; Loretta M. Cox; Jian Lin; R. Scott Obach

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November 1, 2008

The environmental impact of disposable technologies

BioPharm International, ISSN: 1542166X

Andrew Sinclair; Lindsay Leveen; Miriam Monge; Janice Lim; Stacey Cox

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November 1, 2008

Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance

Metabolic Engineering, ISSN: 10967176 10967184

Ryan Sillers; Alison Chow; Bryan Tracy; Eleftherios T. Papoutsakis

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November 1, 2008

The response to combination therapy treatment regimens in severe/difficult-to-treat asthma

European Respiratory Journal, ISSN: 09031936 13993003

Campbell; Larry Borish; Tmirah Haselkorn; Lawrence Rasouliyan; June H. Lee; Sally E. Wenzel; Sean D. Sullivan

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November 1, 2008

Small RNAs with 5′-polyphosphate termini associate with a piwi-related protein and regulate gene expression in the single-celled eukaryote Entamoeba histolytica

PLoS Pathogens, ISSN: 15537366 15537374

Hanbang Zhang; Gretchen M. Ehrenkaufer; Justine M. Pompey; Jason A. Hackney; Upinder Singh

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October 28, 2008

Increased inflammatory gene expression in ABC transporter-deficient macrophages: Free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions

Circulation, ISSN: 00097322 15244539

Laurent Yvan-Charvet; Carrie Welch; Tamara A. Pagler; Mollie Ranalletta; Lamkanfi; Seongah Han; Minako Ishibashi; Rong Li; Nan Wang; Alan R. Tall

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October 28, 2008

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Yasuomi Urano; Hiroshi Watanabe; Stephanie R. Murphy; Yohei Shibuya; Yong Geng; Andrew A. Peden; Catherine C. Y. Chang; Ta Yuan Chang

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October 22, 2008

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake

Molecular Cancer Therapeutics, ISSN: 15357163

Yonglei Shang; Yifan Mao; Jennifer Batson; Suzie J. Scales; Gail L. Phillips; Lackner; Klara Totpal; Simon P. Williams; Yang; Zhijun Tang; Zora Modrusan; Christine Tan; Wei-Ching Liang; Ping Tsai Siao; Alexander N. Vanderbilt; Kenji Kozuka; Klaus P. Hoeflich; Janet Y. Tien; Ross; Congfen Li; Hoon Lee Sang; An Song; Yan Wu; Jean-Philippe Stephan; Avi Ashkenazi; Jiping Zha

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October 22, 2008

Kinetics of Wnt-driven β-catenin stabilization revealed by quantitative and temporal imaging

PLoS ONE, ISSN: 19326203

Rami N. Hannoush

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October 20, 2008

A PDZ-Binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells

Traffic, ISSN: 13989219 16000854

Sandra Maday; Eric Anderson; Henry C. Chang; James Shorter; Ayano Satoh; Jeff Sfakianos; Heike Fölsch; James M. Anderson; Zenta Walther; Ira Mellman

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October 15, 2008

Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen

Cancer Research, ISSN: 00085472

Rinke Bos; Suzanne Van Duikeren; Hans Morreau; Kees Franken; Ton N. M. Schumacher; John B. Haanen; Sjoerd H. van der Burg; Cornelis J. M. Melief; Rienk Offringa

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October 8, 2008

Cross-species differential plasma protein binding of MBX-102/JNJ39659100: A novel PPAR-γ agonist

PPAR Research, ISSN: 16874757 16874765

Holly J. Clarke; Francine M. Gregoire; Fang Ma; Robert Martin; Spring Zhao; Brian E. Lavan

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October 6, 2008

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Journal of Cell Biology, ISSN: 00219525 00219525

Michael Degtyarev; Ann De Mazière; Christine Orr; Jie Lin; Brian Lee; Janet Y. Tien; Wei Wei Prior; Suzanne Van Dijk; Hong Wu; Daniel C. Gray; David P. Davis; Howard M. Stern; Lesley J. Murray; Klaus P. Hoeflich; Judith Klumperman; Lori S. Friedman; Kui Lin

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October 6, 2008

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Journal of Cell Biology, ISSN: 00219525 00219525

Michael Degtyarev; Ann De Mazière; Christine Orr; Jie Lin; Brian B. Lee; Janet Y. Tien; Wei Wei Prior; Suzanne Van Dijk; Hong Wu; Daniel C. Gray; David P. Davis; Howard M. Stern; Lesley J. Murray; Klaus P. Hoeflich; Judith Klumperman; Lori S. Friedman; Kui Lin

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October 1, 2008

γ-Glutamyltranspeptidase-mediated degradation of diclofenac-s-acyl- glutathione in vitro and in vivo in rat

Chemical Research in Toxicology, ISSN: 0893228X

Mark P. Grillo; Fengmei Hua; Kristi L. March; Leslie Z. Benet; Charles G. Knutson; Joseph A. Ware

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October 1, 2008

In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: Inhibition of cytosolic phospholipase A2α overcomes the asthma-associated response

Clinical and Experimental Allergy, ISSN: 09547894 13652222

Whalen; Legault; Hang; Hill; Kasaian; Donaldson; Bensch; Bensch; Baker; Reddy; Wood; Ramarao; Ellis; Csimma; McKee; Clark; Ryan; Dorner; O'Toole

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October 1, 2008

Clinical pharmacokinetics of bevacizumab in patients with solid tumors

Cancer Chemotherapy and Pharmacology, ISSN: 03445704

Jian-Feng Lu; Rene Bruno; Stephen M. Eppler; Novotny; Bert L. Lum; Jacques Gaudreault

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October 1, 2008

Magnetic resonance imaging and spectroscopy for monitoring liver steatosis

Journal of Magnetic Resonance Imaging, ISSN: 10531807 15222586

Gary J. Cowin; Julie R. Jonsson; Judith D. Bauer; Susan Ash; Azmat Ali; Emma J. Osland; David M. Purdie; Andrew D. Clouston; Elizabeth E. Powell; Graham J. Galloway

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October 1, 2008

From the authors

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Derek C. Angus; Walter T. Linde-Zwirble; Amber E. Barnato; Sherri L. Alexander

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October 1, 2008

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition

Biochemical Journal, ISSN: 02646021

Neil E. Torbett; Antonio Luna-Moran; Zachary A. Knight; Andrew Houk; Mark Moasser; William Weiss; Kevan Shokat; David Stokoe

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October 1, 2008

Fluorescence in situ hybridization subgroup analysis of TRIBUTE, a phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer

Clinical Cancer Research, ISSN: 10780432

Fred R. Hirsch; Marileila Varella-Garcia; Rafal Dziadziuszko; Yun Xiao; Sujatha Gajapathy; Margaret Skokan; Ming Lin; Vincent O'Neill; Paul A. Bunn Jr.

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October 1, 2008

A coordinated approach to cutaneous wound healing: Vibrational microscopy and molecular biology

Journal of Cellular and Molecular Medicine, ISSN: 15821838

K. L. Andrew Chan; Guojin Zhang; Marjana Tomic-Canic; Olivera Stojadinovic; Brian Lee; Carol R. Flach; Richard Mendelsohn

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October 1, 2008

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization

RNA, ISSN: 13558382 14699001

Martin Jinek; Ana Eulalio; Andreas Lingel; Sigrun Helms; Elena Conti; Elisa Izaurralde

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October 1, 2008

Validation of Treatment Benefit Scale for Assessing Subjective Outcomes in Treatment of Overactive Bladder

Urology, ISSN: 00904295 15279995

Shoshana Colman; Chapple; Nitti; Haag-Molkenteller; Hastedt; Massow

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October 1, 2008

Reactive hyperemia and BOLD MRI demonstrate that VEGF inhibition, age, and atherosclerosis adversely affect functional recovery in a murine model of peripheral artery disease

Journal of Magnetic Resonance Imaging, ISSN: 10531807 15222586

Joan M. Greve; Simon P. Williams; Lisa J. Bernstein; Hope Goldman; Franklin V. Peale Jr.; Bunting; Nicholas Van Bruggen

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October 1, 2008

Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis

Gut, ISSN: 00175749

Colin L. Noble; Abbas Alexander; Jennine Cornelius; Charles W. Lees; Gwo-Tzer Ho; Toy; Zora Modrusan; Pal; Zhong; Sreedevi Chalasani; Hilary F. Clark; Ian D. Arnott; Ian D. Penman; Jack Satsangi; Laurie Diehl

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October 1, 2008

Regional variation in gene expression in the healthy colon is dysregulated in ulcerative colitis

Gut, ISSN: 00175749

Colin L. Noble; Abbas Alexander; Jennine Cornelius; Charles W. Lees; Gwo-Tzer Ho; Toy; Zora Modrusan; Pal; Fiona Zhong; Sreedevi Chalasani; Hilary F. Clark; Ian D. Arnott; Ian D. Penman; Jack Satsangi; Laurie Diehl

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September 30, 2008

Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Nancy Dumont; Matthew B. Wilson; Yongping Crawford; Paul A. Reynolds; Mahvash Sigaroudinia; Thea D. Tlsty

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September 30, 2008

Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

Science Signaling, ISSN: 19450877 19379145

Marie Evangelista; Tze Yang Lim; James Lee; Leon Parker; Amir M. Ashique; Andrew S. Peterson; Weilan Ye; David P. Davis; Frederic J. De Sauvage

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September 26, 2008

Robustness of virus removal by protein A chromatography is independent of media lifetime

Journal of Chromatography A, ISSN: 00219673

Scott Lute; Lenore A Norling; Michael Hanson; Rachel Emery; Denise Stinson; Kevin Padua; Gregory S. Blank; Qi Chen; Kurt Brorson

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September 25, 2008

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Journal of Medicinal Chemistry, ISSN: 00222623

Adrian J. Folkes; Khatereh Ahmadi; Wendy K. Alderton; Sonia Alix; Stewart Baker; Gary Box; Irina Chuckowree; Paul A. Clarke; Paul Depledge; Suzanne A. Eccles; Lori S. Friedman; Angela Hayes; Timothy Hancox; Arumugam Kugendradas; Letitia Lensun; Pauline Moore; Alan G. Olivero; Jodie Pang; Sonal Patel; Giles H. Pergl-Wilson; Florence I. Raynaud; Anthony Robson; Nahid Saghir; Laurent Salphati; Sukhjit Sohal; Ultsch; Melanie Valenti; Heidi J. A. Wallweber; Chi Wan Nan; Wiesmann; Paul Workman; Alexander Zhyvoloup; Marketa J. Zvelebil; Stephen Shuttleworth

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September 24, 2008

Inducible BRAF Suppression Models for Melanoma Tumorigenesis

Methods in Enzymology, ISSN: 00766879

Klaus P. Hoeflich; Bijay S. Jaiswal; David P. Davis; Somasekar Seshagiri

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September 20, 2008

Two-stage randomization designs in drug development

Statistics in Medicine, ISSN: 02776715 10970258

Marcel Wolbers; Jeffrey D. Helterbrand

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September 19, 2008

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: A case-control association study of the STAT1-STAT4 region

Arthritis Research and Therapy, ISSN: 14786354 14786362

Aya Kawasaki; Ikue Ito; Koki Hikami; Jun Ohashi; Taichi Hayashi; Daisuke Goto; Isao Matsumoto; Satoshi Ito; Akito Tsutsumi; Minori Koga; Tadao Arinami; Robert R. Graham; Geoffrey Hom; Yoshinari Takasaki; Hiroshi Hashimoto; Timothy W. Behrens; Takayuki Sumida; Naoyuki Tsuchiya

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September 18, 2008

A paracrine requirement for hedgehog signalling in cancer

Nature, ISSN: 00280836 14764679

Robert Yauch; Stephen Gould; Suzie J. Scales; Tracy Tzu-Ling Tang; Hua Tian; Christina Ahn; Derek Marshall; Ling Fu; Thomas Januario; Dara Y. Kallop; Michelle Nannini; Karen Kotkow; James C. Marsters Jr.; Lee L. Rubin; Frederic J. De Sauvage

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September 15, 2008

Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer

Clinical Cancer Research, ISSN: 10780432

Sherry X. Yang; Seth M. Steinberg; Dat Nguyen; Thomas D Wu; Zora Modrusan; Sandra M. Swain

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September 5, 2008

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Tatiana Goncharov; Anna V. Fedorova; Jasmin N. Dynek; Zobel; Deshayes; Wayne J. Fairbrother; Domagoj Vucic

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September 1, 2008

Hospitalized cardiovascular diseases in neovascular age-related macular degeneration

Archives of Ophthalmology, ISSN: 00039950 00039950

Bao-Anh Nguyen-Khoa; Earl L. Goehring; Winifred Werther; Emily W. Gower; Diana V. Do; Judith K. Jones

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September 1, 2008

Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis

Molecular Medicine, ISSN: 10761551

Chunyu Liu; Franak Batliwalla; Wentian Li; Annette T. Lee; Ronenn Roubenoff; Evan Beckman; Houman Khalili; Aarti Damle; Marlena Kern; Richard A. Furie; Najaf Amin; Robert M. Plenge; Marieke J.H. Coenen; Timothy W. Behrens; John P. Carulli; Peter K. Gregersen

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September 1, 2008

Comparative clinical and economic outcomes of treatments for refractory non-small cell lung cancer (NSCLC)

Lung Cancer, ISSN: 01695002

Josh J. Carlson; Carolina Reyes; Nina Oestreicher; Deborah Lubeck; Scott D. Ramsey; David L. Veenstra

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September 1, 2008

Whole body physiologically-based pharmacokinetic models: Their use in clinical drug development

Expert Opinion on Drug Metabolism and Toxicology, ISSN: 17425255

Andrea N. Edginton; Frank-Peter Theil; Walter Schmitt; Stefan Willmann

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September 1, 2008

The effect of age and gender on pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase

Journal of Clinical Pharmacology, ISSN: 00912700 15524604

Reza Khosravan; Michael J. Kukulka; Jing-Tao Wu; Nancy Joseph-Ridge; Laurent Vernillet

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September 1, 2008

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

Nature Genetics, ISSN: 10614036 15461718

Stacy L. Musone; Kimberly E. Taylor; Timothy T. Lu; Joanne Nititham; Ricardo C. Ferreira; Ward Ortmann; Nataliya Shifrin; Michelle Petri; M. Ilyas Kamboh; Manzi; Michael F. Seldin; Peter K. Gregersen; Timothy W. Behrens; Averil Ma; Pui-Yan Kwok; Lindsey A. Criswell

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September 1, 2008

Shifting patterns of inhaled antibiotic use in cystic fibrosis

Pediatric Pulmonology, ISSN: 87556863 10990496

Samuel M. Moskowitz; Stefanie J. Silva; Nicole Mayer-Hamblett; David J. Pasta; David R. Mink; Jenny A. Mabie; Michael W. Konstan; Wagener

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September 1, 2008

Growth hormone responsiveness: Peak stimulated growth hormone levels and other variables in idiopathic short stature (ISS): Data from the national cooperative growth study

Pediatric Endocrinology Reviews, ISSN: 15654753

Wayne V. Moore; Ken Dana; James W. Frane; Barbara M. Lippe

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September 1, 2008

T cell-independent development and induction of somatic hypermutation in human IgM+IgD+CD27+ B cells

Journal of Experimental Medicine, ISSN: 00221007 00221007

Ferenc A. Scheeren; Maho Nagasawa; Kees Weijer; Tom Cupedo; Jörg Kirberg; Nicolas Legrand; Hergen Spits

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