Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 51 - 100 OF 15390 RESULTS

Survey of Pharmaceutical Industry’s Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group
Drug Metabolism and Disposition, ISSN: 00909556
Helen E. Rollison; Pallabi Mitra; Hugues Chanteux; Zhizhou Fang; Xiaomin Liang; Seong Hee Park; Chester L. Costales; Imad Hanna; Nilay Thakkar; James Vergis; Daniel A.J. Bow; Kathleen M. Hillgren; Jochen Brumm; Xiaoyan Chu; Cornelis E. Hop; Yurong Lai; Cindy Yanfei Li; Kelly M. Mahar; Laurent Salphati; Rucha Sane; Shen; Kunal S. Taskar; Mitchell E. Taub; Kimio Tohyama; Christine Xu; Fenner
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Promoting diversity in clinical trials: insights from planning the ALUMNI AD study in historically underrepresented US populations with early symptomatic Alzheimer's disease
EClinicalMedicine,
Wise-Brown; Sharon A. Brangman; J. Neil Henderson; Monica Willis-Parker; Stephanie Monroe; Mintzer; Michael Grundman; Janice Smith; Rachelle S. Doody; Helen Lin; Beverly Assman; Gregory A. Rippon; Rozanno Gonzales; Sheila Seleri Assunção
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Generality of Enhancing the Dissolution Rates of Free Acid Amorphous Solid Dispersions by the Incorporation of Sodium Hydroxide
Molecular Pharmaceutics, ISSN: 15438384
Helen J. Zhang; Cheng W. Chiang; Tristan Maschmeyer-Tombs; Breanna Conklin; José G. Napolitano; Joseph W. Lubach; Karthik Nagapudi; Chen Mao; Yinshan Chen
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Toxigenic Clostridium perfringens Isolated from At-Risk Paediatric Inflammatory Bowel Disease Patients
Journal of Crohn's and Colitis, ISSN: 18739946
James Kuo; Jasmina Uzunovic; Amanda Jacobson; Michelle Dourado; Sarah Gierke; Manohary Rajendram; Daniela Keilberg; Jordan S. Mar; Emily Stekol; Joanna Curry; Sofia Verstraete; Jessica Lund; Yuxin Liang; Fiona B Tamburini; Natalie S. Omattage; Matthieu Masureel; Steven T. Rutherford; David Hackos; Man-Wah Tan; Allyson L. Byrd; Mary E. Keir; Elizabeth Skippington; Kelly M. Storek
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Author Correction: c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis (Nature Immunology, (2019), 20, 4, (471-481), 10.1038/s41590-019-0316-2)
Nature Immunology, ISSN: 15292908
Christian Neumann; Jonas Blume; Urmi Roy; Peggy P. Teh; Ajithkumar Vasanthakumar; Alexander Beller; Yang Liao; Frederik Heinrich; Teresita L. Arenzana; Jason A. Hackney; Celine Eidenschenk; Eric J. C. Gálvez; Christina Stehle; Gitta A. Heinz; Patrick Maschmeyer; Tom Sidwell; Yifang Hu; Derk Amsen; Chiara Romagnani; Hyun-Dong Chang; Andrey Kruglov; Mir-Farzin Mashreghi; Wei Shi; Till Strowig; Sascha Rutz; Axel Kallies; Alexander Scheffold
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Reconstitution of the alternative pathway of the complement system enables rapid delineation of the mechanism of action of novel inhibitors
Journal of Biological Chemistry, ISSN: 00219258
Andrew C. Goodrich; Norbert P. LeClair; Nita Shillova; William D. Morton; Arthur J. Wittwer; Kelly M. Loyet; Rami N. Hannoush
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Cost-effectiveness of large-panel next-generation sequencing in guiding first-line treatment decisions for patients with nonsquamous advanced non-small cell lung cancer
Journal of Managed Care and Specialty Pharmacy, ISSN: 23760540
Ibrahim Abbass; Daniel Sheinson; Anuj Shah; Adam Gondos; Sarika Ogale
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Outcomes of the EMDataResource cryo-EM Ligand Modeling Challenge
Nature Methods, ISSN: 15487091
Catherine L. Lawson; Andriy Kryshtafovych; Grigore Pintilie; Stephen K. Burley; Jiří Černý; Vincent B. Chen; Paul Emsley; Alberto Gobbi; Andrzej Joachimiak; Sigrid Noreng; Michael G. Prisant; Randy J. Read; Jane S. Richardson; Alexis Rohou; Bohdan Schneider; Benjamin D. Sellers; Chenghua Shao; Elizabeth Sourial; Chris I. Williams; Christopher J. Williams; Ying Yang; Venkat Abbaraju; Pavel V. Afonine; Matthew L. Baker; Paul S. Bond; Tom L. Blundell; Tom Burnley; Arthur Campbell; Renzhi Cao; Jianlin Cheng; Grzegorz Chojnowski; Cowtan; Frank DiMaio; Reza Esmaeeli; Nabin Giri; Helmut Grubmüller; Soon Wen Hoh; Jie Hou; Corey F. Hryc; Carola Hunte; Maxim Igaev; Agnel P. Joseph; Wei-Chun Kao; Daisuke Kihara; Dilip Kumar; Lijun Lang; Sean Lin; Sai R. Maddhuri Venkata Subramaniya; Sumit Mittal; Arup Mondal; Nigel W. Moriarty; Andrew Muenks; Garib Murshudov; Robert A. Nicholls; Mateusz Olek; Colin M. Palmer; Alberto Perez; Emmi Pohjolainen; Karunakar R. Pothula; Christopher N. Rowley; Daipayan Sarkar; Luisa U. Schäfer; Christopher J. Schlicksup; Gunnar F. Schröder; Mrinal Shekhar; Dong Si; Abhishek Singharoy; Oleg V. Sobolev; Genki Terashi; Andrea C. Vaiana; Sundeep C. Vedithi; Jacob Verburgt; Xiao Wang; Rangana Warshamanage; Martyn D. Winn; Simone Weyand; Keitaro Yamashita; Minglei Zhao; Michael F. Schmid; Helen Berman; Wah Chiu
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Matching-adjusted indirect comparison from the Lymphoma Epidemiology of Outcomes Consortium for Real World Evidence (LEO CReWE) study to a clinical trial of mosunetuzumab in relapsed or refractory follicular lymphoma
Haematologica, ISSN: 03906078
Matthew J. Maurer; Carla Casulo; Melissa C Larson; Thomas M. Habermann; Izidore S. Lossos; Yucai Wang; Loretta J. Nastoupil; Christopher Strouse; Dai Chihara; Peter Martin; Jonathon B Cohen; Wojciech Jurczak; W. Richard Burack; Jean L. Koff; Yong Mun; Anthony Masaquel; Mei Wu; Michael C. Wei; Ashwini Shewade; Jia Li; James R. Cerhan; Brian K. Link; Christopher R. Flowers
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The association of histopathologic features after neoadjuvant chemo-immunotherapy with clinical outcome: Sub-analyses from the randomized double-blinded, placebo-controlled, Phase III IMagyn050/GOG3015/ENGOT-ov39 study
Gynecologic Oncology, ISSN: 00908258
Paulette Mhawech-Fauceglia; Denis McCarthy; Akiko Tonooka; Giovanni Scambia; Yolanda Garcia; Pavel Dundr; Anne M. Mills; Kevin L. Moore; Sakiko Sanada; Leslie Bradford; Giulia Carlo Stella; Michael A. Bookman; Sudarshan K. Sharma; Frederic Selle; Luciana L. Molinero; Yvette He; Victor K. Khor; Charles N. Landen; Yvonne G. Lin
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Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
Cell Reports,
Kristel Dorighi; Anqi Zhu; Jean-Philippe Fortin; Jerry Hung-Hao Lo; Jawahar Sudhamsu; Timothy J. Wendorff; Durinck; Marinella G. Callow; Scott A. Foster; Benjamin Haley
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CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis
Cell Reports,
Kamakoti P. Bhat; Jinchu Vijay; Caroline K. Vilas; Jyoti Asundi; Jun Zou; Ted Lau; Xiaoyu Cai; Musaddeque Ahmed; Michal Kabza; Julie Weng; Jean-Philippe Fortin; Aaron T. L. Lun; Durinck; Marc Hafner; Michael Costa; Xin Ye
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Development of a First-Generation Stereocontrolled Manufacturing Process of TRPA1 Inhibitor GDC-6599
Organic Process Research and Development, ISSN: 10836160
Allen Y. Hong; Katarzyna A. Piechowicz; Jacob C. Timmerman; Haiming Zhang; Carmela Molinaro; Francis Gosselin
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Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding
ACS Medicinal Chemistry Letters,
Jun Liang; Michael J. Lambrecht; Teresita L. Arenzana; Samuel Aubert-Nicol; Linda Bao; Broccatelli; Jianping Cai; Celine Eidenschenk; Christine Everett; Thomas Garner; Felix Gruber; Pouyan Haghshenas; Malcolm P. Huestis; Peter L. Hsu; Ponien Kou; Araz Jakalian; Larouche-Gauthier; Jean-Philippe Leclerc; Dennis H. Leung; Aaron Martin; Jeremy Murray; Madeleine S. Prangley; Sascha Rutz; Satoko Kakiuchi-Kiyota; Alexander Lee Satz; Nicholas J. Skelton; Micah Steffek; Daniel Stoffler; Jawahar Sudhamsu; Sophia Tan; Jian Wang; Shouliang Wang; Qiuyue Wang; Timothy J. Wendorff; Moreno Wichert; Arun Yadav; Christine Yu; Xiaojing Wang
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Publisher Correction: Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells(Nature, 10.1038/s41586-024-07121-9)
Nature, ISSN: 00280836
Xiangnan Guan; Ruozhen Hu; Yoonha Choi; Shyam Srivats; Barzin Y. Nabet; John Silva; Lisa M McGinnis; Robert Hendricks; Katherine Nutsch; Karl L. Banta; Ellen Duong; Alexis D. Dunkle; Patrick Chang; Chia-Jung Han; Stephanie Mittman; Nandini Molden; Pallavi Daggumati; Wendy Connolly; Melissa L. Johnson; Rodriguez-Abreu; Byoung Chul Cho; Antoine Italiano; Ignacio Gil-Bazo; Enriqueta Felip; Ira Mellman; Sanjeev Mariathasan; David S. Shames; Raymond D. Meng; Eugene Y. Chiang; Robert J. Johnston; Namrata S. Patil
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Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability
Journal of Medicinal Chemistry, ISSN: 00222623
Hao Wu; Jeremy Murray; Noriko Ishisoko; Alexandra Frommlet; Gauri Deshmukh; Antonio G. DiPasquale; Melinda M. Mulvihill; Donglu Zhang; John Quinn; Robert A. Blake; Wayne J. Fairbrother; Jakob Fuhrmann
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Context-Specific Stress Causes Compartmentalized SARM1 Activation and Local Degeneration in Cortical Neurons
Journal of Neuroscience, ISSN: 02706474
Flora I. Hinz; Carmela Louise M. Villegas; Jasmine Roberts; Heming Yao; Shreya Gaddam; Anton Delwig; Samantha A. Green; Craig Fredrickson; Max Adrian; Raymond Asuncion; Tommy K. Cheung; Margaret Hayne; David Hackos; Christopher M. Rose; David Richmond; Casper C Hoogenraad
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Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3H-spiro[benzofuran-2,4′-piperidine] Building Block
Journal of Organic Chemistry, ISSN: 00223263
Matthew M. Pompeo; Sean M. Kelly; Frederic St-Jean; Thomas M. Bass; Derek M. Dalton; Daniel Zell; Chong Han; Lauren E. Sirois; Francis Gosselin
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The Exonuclease TREX1 Constitutes an Innate Immune Checkpoint Limiting cGAS/STING-Mediated Antitumor Immunity
Cancer immunology research, ISSN: 23266066
Junghyun Lim; Ryan Rodriguez; Katherine Williams; John Silva; Alan G. Gutierrez; Paul Tyler; Faezzah Baharom; Tao Sun; Eva Lin; Scott E. Martin; Brandon D. Kayser; Robert J. Johnston; Ira Mellman; Lélia Delamarre; Nathaniel West; Sören Müller; Yan Qu; Klaus D. Heger
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Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Mark Collinge; Haley Neff-LaFord; Surekha Akella; Birgit Fogal; Kathryn Fraser; Jacob Jabbour; Kirsty Harper; Curtis Maier; Laurent Malherbe; Nikki Marshall; Gautham K. Rao; Kavita Raman; Hollie Skaggs; Felix Weber; Claudette L. Fuller
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Accelerated Predictive Stability Study of a Pediatric Drug Product for a Supplemental New Drug Application
AAPS PharmSciTech,
Viktoria Rakers; Jin Wang; Dawen Kou
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Clinical Value of Timely Targeted Therapy for Patients With Advanced Non–Small Cell Lung Cancer With Actionable Driver Oncogenes
Oncologist, ISSN: 10837159
Thomas Stricker; Neha Jain; Esprit Ma; Elaine B. Yu; Rongrong Wang; Robert Schuldt; Richard Price; Szado; Jesse Sussell; Sarika Ogale; Victor Lin; Arrowsmith; Slater; Daniel Vaena; Harry Staszewski; Bruno Fang; Lasika Seneviratne; Davey B Daniel
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A randomized, double-blind study of zinpentraxin alfa in patients with myelofibrosis who were previously treated with or ineligible for ruxolitinib: stage 2 of a phase II trial
Haematologica, ISSN: 03906078
Srdan Verstovsek; Moshe Talpaz; Martha Wadleigh; Alessandro Isidori; Peter te Boekhorst; Michael Savona; Prithviraj Bose; Olga Pozdnyakova; Ruben Mesa; Tarec C. El-Galaly; Jennifer O’Sullivan; Katia Gamel; Higgins; Sudhakar Katakam; Boyan Todorov; Kerstin Trunzer; Claire N. Harrison
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Impact of P-gp inhibition on systemic exposure of pralsetinib and dosing considerations
Clinical and Translational Science, ISSN: 17528054
Julia Suchomel; Priya Agarwal; Doreen Anders; Kevin Hughes; Yang Tang; Rucha Sane; Astrid Scalori; Sunil Sharma; Sravanthi Cheeti
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Optimizing Messenger RNA Analysis Using Ultra-Wide Pore Size Exclusion Chromatography Columns
International Journal of Molecular Sciences, ISSN: 16616596
Valentina D'Atri; Honorine Lardeux; Alexandre Goyon; Mateusz Imiołek; Szabolcs Fekete; Matthew A Lauber; Kelly Zhang; Davy Guillarme
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HER2 Gene Expression Levels Are Predictive and Prognostic in Patients with Metastatic Colorectal Cancer Enrolled in CALGB/SWOG 80405
Journal of Clinical Oncology, ISSN: 0732183X
Francesca Battaglin; Fang-Shu Ou; Xueping Qu; Hochster; Donna Niedzwiecki; Richard M. Goldberg; Robert J. Mayer; Karam Ashouri; Tyler J. Zemla; Charles D. Blanke; Alan P. Venook; Omar Kabbarah; Heinz-Josef Lenz; Federico Innocenti
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Quantitative analysis of bone marrow fibrosis highlights heterogeneity in myelofibrosis and augments histological assessment: An Insight from a phase II clinical study of zinpentraxin alfa
HemaSphere,
Hosuk Ryou; Korsuk Sirinukunwattana; Ruby Wood; Alan Aberdeen; Jens Rittscher; Olga Weinberg; Robert P. Hasserjian; Olga Pozdnyakova; Franklin V. Peale Jr.; Higgins; Pontus Lundberg; Kerstin Trunzer; Claire N. Harrison; Daniel Royston
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Population pharmacokinetics and CD20 binding dynamics for mosunetuzumab in relapsed/refractory B-cell non-Hodgkin lymphoma
Clinical and Translational Science, ISSN: 17528054
Brendan C. Bender; Chi-Chung Li; Mathilde Marchand; Turner; Feifei Li; Shweta Vadhavkar; Wang; Rong Deng; James Lu; Jin Jin; Chunze Li; Shen Yin; Michael C. Wei; Pascal Chanu
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Aqueous humour interleukin-6 and vision outcomes with anti-vascular endothelial growth factor therapy
Eye,
Yasir J. Sepah; Diana V. Do; Marina Mesquida; Bann-Mo Day; Steven Blotner; Rubbia Afridi; Muhammad Sohail Halim; Kyu Hong; Eric Wakshull; Sascha Fauser; Ivaylo Stoilov; Quan Dong Nguyen
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Implementation of a Three-Way Comparability Assessment for a Bioanalytical Anti-Drug Antibody Method
AAPS Journal,
Rosanna S. Kwok; Ihsan Nijem; Ann Brady; Robert Hendricks
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Adaptive and Innate Immunity Are Key Drivers of Age at Onset of Multiple Sclerosis
Neurology: Genetics,
Elina Misicka; Yunfeng Huang; Stephanie J. Loomis; Nilanjana Sadhu; Fisher; Arie R. Gafson; Heiko Runz; Ellen Tsai; Xiaoming Jia; Ann E. Herman; Paola G. Bronson; Tushar Bhangale; Farren B. Briggs
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Molecular underpinnings of dedifferentiation and aggressiveness in chromophobe renal cell carcinoma
JCI insight,
Payal Kapur; Hua Zhong; Daniel Le; Ratna Mukhopadhyay; Jeffrey Miyata; Deyssy Carrillo; Dinesh Rakheja; Satwik Rajaram; Durinck; Zora Modrusan; James Brugarolas
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The inactivation of tolC sensitizes Escherichia coli to perturbations in lipopolysaccharide transport
iScience,
Shawna Zhu; Mary Kate Alexander; Telmo O. Paiva; Kenneth Rachwalski; Anh Miu; Yiming Xu; Vishal A. Verma; Mike Reichelt; Yves F. Dufrêne; Eric D. Brown; Georgina Cox
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Using the Dynamic Well-Stirred Model to Extrapolate Hepatic Clearance of Organic Anion-Transporting Polypeptide Transporter Substrates without Assuming Albumin-Mediated Hepatic Drug Uptake
Drug Metabolism and Disposition,
Zhengyin Yan; Li Ma; Nicky Hwang; Julie Huang; Jane R. Kenny; Cornelis E. Hop
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N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
Immunity, ISSN: 10747613
Alexander D. Gitlin; Maltzman; Yuzuka Kanno; Klaus D. Heger; Rohit Reja; Alexander F Schubert; Linsey J. Wierciszewski; Homer Pantua; Sharookh B. Kapadia; Seth F. Harris; Webster; Kim Newton; Vishva M. Dixit
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Human Pharmacokinetic and CYP3A DDI Prediction of GDC-2394 using PBPK Modeling and Biomarker Assessment
Drug Metabolism and Disposition, ISSN: 00909556
Jesse Yu; Fei Tang; Fang Ma; Susan C. Wong; Jing Wang; Justin Ly; Liuxi Chen; Jialin Mao
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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule
Pharmaceutics,
Iraj Hosseini; Brett Fleisher; Jennifer A. Getz; Jérémie Decalf; Mandy Kwong; Meric A. Ovacik; Travis W. Bainbridge; Christine Moussion; Gautham K. Rao; Kapil Gadkar; Amrita Kamath; Ramanujan
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Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe Chronic Obstructive Pulmonary Disease
American Journal of Respiratory Cell and Molecular Biology,
Dmitry Khalenkow; Brandsma; Timens; David F. Choy; Michele A. Grimbaldeston; Carrie M. Rosenberger; Dirk-Jan Slebos; Kerstjens; Alen Faiz; Gerard H. Koppelman; Nawijn; van den Berge; Victor Guryev
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Deep Learning Approaches for Detecting of Nascent Geographic Atrophy in Age-Related Macular Degeneration
Ophthalmology Science,
Heming Yao; Zhichao Wu; Simon S. Gao; Robyn H. Guymer; Verena Steffen; Hao Chen; Mohsen Hejrati; Miao Zhang
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Graph-pMHC: graph neural network approach to MHC class II peptide presentation and antibody immunogenicity
Briefings in bioinformatics, ISSN: 14675463
William John Thrift; Jason Perera; Sivan Cohen; Nicolas Lounsbury; Hem R. Gurung; Christopher M. Rose; Jieming Chen; Suchit Jhunjhunwala; Kai Liu
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Six-year follow-up and subgroup analyses of a phase 2 trial of venetoclax for del(17p) chronic lymphocytic leukemia
Blood advances, ISSN: 24739529
Stephan Stilgenbauer; Eugen Tausch; Andrew W. Roberts; Matthew S. Davids; Barbara Eichhorst; Michael Hallek; Hillmen; Christof Schneider; Johannes Schetelig; Sebastian Böttcher; Kater; Yanwen Jiang; Michelle Boyer; Relja Popovic; Majd T. Ghanim; Michael Moran; Wendy J. Sinai; Xifeng Wang; Nabanita Mukherjee; Brenda Chyla; William G. Wierda; John F. Seymour
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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
Molecular Cell, ISSN: 10974164 10972765
Jerry Li; Nicholas Purser; Joanna Liwocha; Daniel C. Scott; Holly A. Byers; Barbara Steigenberger; Spencer Hill; Ishita Tripathi-Giesgen; Trent Hinkle; Fynn M. Hansen; J. Rajan Prabu; Senthil K. Radhakrishnan; Donald S. Kirkpatrick; Kurt M. Reichermeier; Brenda A. Schulman; Gary Kleiger
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Genome-wide characterization of circulating metabolic biomarkers
Nature, ISSN: 14764687 00280836
Minna Karjalainen; Savita Karthikeyan; Clare Oliver-Williams; Eeva Sliz; Elias Allara; Wing Tung Fung; Praveen Surendran; Weihua Zhang; Pekka Jousilahti; Kati Kristiansson; Veikko Salomaa; Matt Goodwin; David A. Hughes; Mike Boehnke; Lilian Fernandes Silva; Xianyong Yin; Anubha Mahajan; Matt J. Neville; Natalie van Zuydam; Renée de Mutsert; Ruifang Li-Gao; Dennis Mook-Kanamori; Ayse Demirkan; Jun Liu; Raymond Noordam; Stella Trompet; Zhengming Chen; Christiana Kartsonaki; Liming Li; Kuang Lin; Fiona A. Hagenbeek; Jouke-Jan Hottenga; René Pool; M Arfan Ikram; Joyce B.J. Van Meurs; Toomas Haller; Yuri Milaneschi; Mika Kähönen; Pashupati P. Mishra; Peter K Joshi; Erin Macdonald-Dunlop; Massimo Mangino; Jonas Zierer; Ilhan E. Acar; Carel Hoyng; Yara T. E. Lechanteur; Lude Franke; Alexander Kurilshikov; Alexandra Zhernakova; Marian Beekman; Erik van den Akker; Ivana Kolcic; Ozren Polasek; Igor Rudan; Christian Gieger; Melanie Waldenberger; Folkert W Asselbergs; Caroline Hayward; Jingyuan Fu; Anneke I. den Hollander; Cristina Menni; Tim D. Spector; James F. Wilson; Terho Lehtimäki; Olli T. Raitakari; Brenda Penninx; Tõnu Esko; Robin G. Walters; J Wouter Jukema; Naveed Sattar; Mohsen Ghanbari; Ko Willems van Dijk; Fredrik Karpe; Mark I. McCarthy; Markku Laakso; Marjo-Riitta Jarvelin; Nicholas J. Timpson; Markus Perola; Jaspal S Kooner; John C Chambers; Cornelia M. van Duijn; P. Eline Slagboom; Dorret I. Boomsma; John Danesh; Mika Ala-Korpela; Adam S. Butterworth; Johannes Kettunen
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Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings
Advanced Drug Delivery Reviews, ISSN: 0169409X
Michael Z. Liao; Dan Lu; Tong Lu; Leonid Gibiansky; Rong Deng; Divya Samineni; Randall Dere; Andy Lin; Jamie Hirata; Shen; Donglu Zhang; Dongwei Li; Chunze Li; Dale Miles
View on Scopus
Platinum ineligibility and survival outcomes in patients with advanced urothelial carcinoma receiving first-line treatment
Journal of the National Cancer Institute, ISSN: 00278874
Shilpa Gupta; Alexander Andreev-Drakhlin; Otto Fajardo; Marcella Fassò; Jorge A. Garcia; Christopher Wee; Carsten Schröder
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Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis
Journal of Clinical Investigation, ISSN: 00219738
Gopinath Prakasam; Akhilesh Mishra; Alana Christie; Jeffrey Miyata; Deyssy Carrillo; Vanina Toffessi Tcheuyap; Hui Ye; Quyen N. Do; Yunguan Wang; Oscar Reig Torras; Ramesh Butti; Hua Zhong; Jeffrey Gagan; Kevin B. Jones; Thomas J. Carroll; Zora Modrusan; Durinck; Mai-Carmen Requena-Komuro; Noelle S. Williams; Ivan Pedrosa; Tao Wang; Dinesh Rakheja; Payal Kapur; James Brugarolas
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2023 White Paper on Recent Issues in Bioanalysis: ISR for ADA Assays, the Rise of dPCR vs qPCR, International Reference Standards for Vaccine Assays, Anti-AAV TAb Post-Dose Assessment, NanoString Validation, ELISpot as Gold Standard (Part 3 - Recommendations on Gene Therapy, Cell Therapy, Vaccines Immunogenicity & Technologies; Biotherapeutics Immunogenicity & Risk Assessment; ADA/NAb Assay/Reporting Harmonization)
Bioanalysis,
Johanna Mora; Rachel Palmer; Leslie Wagner; Bonnie Wu; Michael A. Partridge; Meena; Ivo Sonderegger; John Smeraglia; Nicoletta Bivi; Naveen Dakappagari; Sandra Diebold; Fabio Garofolo; Grimaldi; Warren Kalina; John Kamerud; Sumit Kar; Jean-Claude Marshall; Christian Mayer; Andrew Melton; Keith D. Merdek; Katrina Nolan; Serge Picard; Weiping Shao; Jessica Seitzer; Yoichi Tanaka; Omar Tounekti; Adam Vigil; Karl Walravens; Joshua Xu; Weifeng Xu; Yuanxin Xu; Lin Yang; Liang Zhu; Verthelyi; Robert J Kubiak; Kelly Coble; Swati Gupta; Mohsen Rajabi Abhari; Susan Richards; Yuan Song; Martin Ullmann; Boris Calderon; Isabelle Cludts; George R. Gunn; Shalini Gupta; Akiko Ishii-Watabe; Mohanraj Manangeeswaran; Kimberly Maxfield; Fred McCush; Christine O'Day; Kate Peng; Johann Poetzl; Michele Rasamoelisolo; Ola M. Saad; Kara Scheibner; Sophie Shubow; Sam Song; Seth Thacker
View on Scopus
Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice
EBioMedicine,
Yi Lu; Longyu Mu; Justin Elstrott; Chaoying Fu; Cailu Sun; Tonghui Su; Xiaofan Ma; Jia Yan; Hong Jiang; Jesse E. Hanson; Yang Geng; Yelin Chen
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AviTrap: A novel solution to achieve complete biotinylation
PLoS ONE,
Cheng Lu; Jack Bevers; Tulika Tyagi; Hao To; May Lin; Shu Ti; Gerry Nakamura; WeiYu Lin; Yongmei Chen; Yan Wu; Hong Li; Jiansheng Wu; Feng Wang
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Exploring the Impact of Hepatic Impairment on Pralsetinib Pharmacokinetics
Pharmaceutics,
Kit Wun Kathy Cheung; Yang Tang; Doreen Anders; Barata; Astrid Scalori; Priya Agarwal; Rucha Sane; Sravanthi Cheeti
View on Scopus
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