Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10151 - 10200 OF 15217 RESULTS

February 3, 2006

New neurons follow the flow of cerebrospinal fluid in the adult brain

Science, ISSN: 00368075 10959203

Kazunobu Sawamoto; Hynek Wichterle; Oscar Gonzalez-Perez; Jeremy A. Cholfin; Masayuki Yamada; Nathalie Spassky; Noel S. Murcia; Jose Manuel Garcia-Verdugo; Oscar Marín; John L. R. Rubenstein; Marc Tessier-Lavigne; Hideyuki Okano; Arturo Alvarez-Buylla

February 1, 2006

Ocular versus extraocular neovascularization: Mirror images or vague resemblances

Investigative Ophthalmology and Visual Science, ISSN: 01460404

Peter A. Campochiaro; Rhoda Alani; Kari Alitalo; Peter Brooks; Ruth Caldwell; Peter Carmeliet; Pier Paolo Claudio; Robert D'Amato; Arup Das; Rainer De Martin; Michael Detmar; Napoleone Ferrara; Robert N. Frank; Marcus Fruttiger; Antonio Giordano; Maria Grant; Hans-Peter Hammes; Mats Hellstrom; David Hinton; Eli Keshet; Alisa Koch; Richard Lang; Donald M. McDonald; Jeremy Nathans; Dario Neri; Gera Neufeld; Jean Plouet; Gregg Semenza; Nader Sheibani; David T. Shima; Philip Thorpe; Rubin Tuder; Olga Volpert; Elizabeth Wagner; Bernhard Weber; Stanley Wiegand

February 1, 2006

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Developmental Biology, ISSN: 00121606

Xi-De Wang; Ching Ching Leow; Jiping Zha; Zhijun Tang; Zora Modrusan; Freddy Radtke; Michel Aguet; Frederic J. De Sauvage; Gao

February 1, 2006

Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the αl subunit of lymphocyte function-associated antigen-1

Protein Science, ISSN: 09618368 1469896X

Keating; Clark; Lisa D. Stefanich; Arellano; Caroline P. Edwards; Bodary; Steven A. Spencer; Thomas Gadek; James C. Marsters Jr.; Beresini

February 1, 2006

Identification and immunotherapeutic targeting of antigens induced by chemotherapy

Nature Biotechnology, ISSN: 10870156 15461696

Bonnee Rubinfeld; Archana Upadhyay; Suzanna Clark; Fong; Victoria Smith; Koeppen; Ross; Paul G. Polakis

February 1, 2006

Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma

Cancer, ISSN: 0008543X 10970142

Brian I. Rini; Vivian Weinberg; Sarah Dunlap; Alexandra Elchinoff; Nancy Yu; Robert Bok; Jeffery Simko; Small

January 20, 2006

In reply [2]

Journal of Clinical Oncology, ISSN: 0732183X

Fairooz F. Kabbinavar; Julie Hambleton; Robert Mass; Somnath Sarkar

January 15, 2006

Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice

Blood, ISSN: 00064971 00064971

Ajay K. Malik; Megan E. Baldwin; Franklin V. Peale Jr.; Fuh; Wei-Ching Liang; Henry B. Lowman; Meng; Napoleone Ferrara; Hans-Peter Gerber

January 15, 2006

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

Cancer Research, ISSN: 00085472

Klaus P. Hoeflich; Daniel C. Gray; Mike Eby; Janet Y. Tien; Leo Wong; Janeko Bower; Alvin Gogineni; Jiping Zha; Mary J. Cole; Howard M. Stern; Lesley J. Murray; David P. Davis; Somasekar Seshagiri

January 13, 2006

Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Wei-Ching Liang; Xiumin Wu; Franklin V. Peale Jr.; Chingwei V. Lee; Meng; Johnny Gutierrez; Ling Fu; Ajay K. Malik; Hans-Peter Gerber; Napoleone Ferrara; Fuh

January 13, 2006

When proteomes collide

Science, ISSN: 00368075 10959203

Joel S. Bader; John Chant

January 10, 2006

Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer

Journal of Clinical Oncology, ISSN: 0732183X

Adrian M. Jubb; Herbert Hurwitz; Wei Bai; Holmgren; Tobin; A. Steven Guerrero; Fairooz F. Kabbinavar; Scott N. Holden; Novotny; Gretchen D. Frantz; Kenneth J. Hillan; Koeppen

January 3, 2006

Hospital improvement in time to reperfusion in patients with acute myocardial infarction, 1999 to 2002

Journal of the American College of Cardiology, ISSN: 07351097

Robert L. McNamara; Jeph Herrin; Elizabeth H. Bradley; Edward L. Portnay; Jeptha P. Curtis; Yongfei Wang; David J. Magid; Martha Blaney; Harlan M. Krumholz

January 1, 2006

Nontraditional roles for certified pharmacy technicians in a pharmaceutical company

Journal of the American Pharmacists Association, ISSN: 15443450 15443191

Stacey M. Fung; Christine Gilmour; David McCracken; Korban Shane; Gary Matsuura

January 1, 2006

Synthetic therapeutic antibodies

Nature Chemical Biology, ISSN: 15524469 15524450

Sachdev S. Sidhu; Frederic A. Fellouse

January 1, 2006

Clinical and psychosocial characteristics of men with erectile dysfunction: Baseline data from ExCEED™

Journal of Sexual Medicine, ISSN: 17436109 17436095

David M. Latini; David F. Penson; Katrine L. Wallace; Deborah Lubeck; Tom F. Lue

January 1, 2006

Longitudinal differences in psychological outcomes for Men with erectile dysfunction: Results from ExCEED™

Journal of Sexual Medicine, ISSN: 17436109 17436095

David M. Latini; David F. Penson; Katrine L. Wallace; Deborah Lubeck; Tom F. Lue

January 1, 2006

Paracrine VEGF/VE-cadherin action on ovarian cancer permeability

Experimental Biology and Medicine, ISSN: 15353699 15353702

Limin Hu; Napoleone Ferrara; Robert B. Jaffe

January 1, 2006

Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Aditya A. Wakankar; Ronald T. Borchardt

January 1, 2006

Targeted therapies in solid tumors: Monoclonal antibodies and small molecules

Human Antibodies, ISSN: 10932607

Louis M. Weiner; Hossein Borghaei

January 1, 2006

Regulation of ERK3/MAPK6 expression by BRAF

International Journal of Oncology, ISSN: 17912423 10196439

Klaus P. Hoeflich; Mike Eby; William F. Forrest; Daniel C. Gray; Janet Y. Tien; Howard M. Stern; Lesley J. Murray; David P. Davis; Zora Modrusan; Somasekar Seshagiri

January 1, 2006

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

ACS Chemical Biology, ISSN: 15548937

Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O. Elliott; Heidi J. A. Wallweber; David C Okawa; Flygare; Domagoj Vucic; Wayne J. Fairbrother; Deshayes

January 1, 2006

Is tobacco use a problem among deaf college students?

American Annals of the Deaf, ISSN: 0002726X

Barbara A. Berman; Coen A. Bernaards; Elizabeth A. Eckhardt; Heidi B. Kleiger; Lauren Maucere; Leanne Streja; Glenn Wong; Shari Barkin; Roshan Bastani

January 1, 2006

Evaluation of erlotinib in advanced non-small cell lung cancer: Impact on the budget of a U.S. health insurance plan

Journal of Managed Care Pharmacy, ISSN: 10834087

Scott D. Ramsey; Lauren Clarke; Tripthi V. Kamath; Deborah Lubeck

January 1, 2006

The application of mechanism-based PK/PD modeling in pharmacodynamic-based dose selection of muM17, a surrogate monoclonal antibody for efalizumab

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Benjamin Wu; Amita Joshi; Song Ren; Chee Ng

January 1, 2006

Apples and oranges: Comparing computer systems audits

Drug Information Journal, ISSN: 00928615

Jacques Mourrain

January 1, 2006

Ranibizumab for Treatment of Neovascular Age-Related Macular Degeneration. A Phase I/II Multicenter, Controlled, Multidose Study

Ophthalmology, ISSN: 01616420

Jeffrey S. Heier; Andrew N. Antoszyk; Peter Reed Pavan; Steven R. Leff; Philip J. Rosenfeld; Thomas A. Ciulla; Richard F. Dreyer; Ronald C. Gentile; Judy P. Sy; Gary Hantsbarger; Naveed Shams

January 1, 2006

Tolerability and Efficacy of Multiple Escalating Doses of Ranibizumab (Lucentis) for Neovascular Age-Related Macular Degeneration

Ophthalmology, ISSN: 01616420

Philip J. Rosenfeld; Jeffrey S. Heier; Gary Hantsbarger; Naveed Shams

January 1, 2006

Potential inhibitors of chemokine function: Analysis of noncovalent complexes of CC chemokine and small polyanionic molecules by ESI FT-ICR mass spectrometry

Journal of the American Society for Mass Spectrometry, ISSN: 10440305

Yonghao Yu; Matthew D. Sweeney; Ola M. Saad; Julie A. Leary

January 1, 2006

Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-1

Annals of Oncology, ISSN: 15698041 09237534

Brid M. Ryan; Gottfried E. Konecny; Kahlert; Wang; Untch; Meng; Pegram; Podratz; John Crown; Dennis J. Slamon; Duffy

January 1, 2006

Asthma in older adults: Observations from the Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) study

Annals of Allergy, Asthma and Immunology, ISSN: 10811206

Raymond G. Slavin; Tmirah Haselkorn; June H. Lee; Zheng; Yamo Deniz; Sally E. Wenzel

January 1, 2006

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

Cancer Cell, ISSN: 15356108

Phillips; Samir Kharbanda; Ruihuan Chen; William F. Forrest; Robert Soriano; Thomas D Wu; Anjan Misra; Janice M. Nigro; Howard Colman; Liliana Soroceanu; P. Mickey Williams; Zora Modrusan; Burt G. Feuerstein; Kenneth D. Aldape

January 1, 2006

A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys

American Journal of Pathology, ISSN: 00029440

Yulia Vugmeyster; Dhaya Seshasayee; Wesley S. Chang; Anahid Storn; Howell; Susan Sa; Tenea Nelson; Flavius Martin; Iqbal S. Grewal; Ellen Gilkerson; Ben Wu; Jeffrey S. Thompson; Barbara N. Ehrenfels; Song Ren; An Song; Thomas R. Gelzleichter; Dimitry Danilenko

January 1, 2006

Effect of intravitreal injection of ranibizumab in combination with verteporfin PDT on normal primate retina and choroid

Investigative Ophthalmology and Visual Science, ISSN: 01460404

Ivana K. Kim; Deeba Husain; Norman Michaud; Edward Connolly; Anne Marie Lane; Khayyam Durrani; Ali Hafezi-Moghadam; Evangelos S. Gragoudas; Charles A. O'Neill; Joseph Beyer; Joan W. Miller

January 1, 2006

An overview of the pharmacokinetics and pharmacodynamics of efalizumab: A monoclonal antibody approved for use in psoriasis

Journal of Clinical Pharmacology, ISSN: 00912700 15524604

Amita Joshi; Bauer; Peter Kuebler; Mark White; Cecilia Leddy; Peter Compton; Marvin Garovoy; Paul Kwon; Patricia Walicke; Russell L Dedrick

January 1, 2006

Self-association of therapeutic proteins: Implications for product development

Misbehaving Proteins: Protein (Mis)Folding, Aggregation, and Stability,

Cromwell; Chantal Felten; Heather Flores; Jun Liu; Steven J. Shire

January 1, 2006

Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma

Neuro-Oncology, ISSN: 15228517

Michael D. Prados; Kathleen R. Lamborn; Susan Chang; Eric Burton; Nicholas Butowski; Mary Malec; Ami Kapadia; Jane Rabbit; Margaretta S. Page; Ann Fedoroff; Dong Xie; Kelley

January 1, 2006

Concordance between central and local laboratory HER2 testing from a community-based clinical study

Clinical Breast Cancer, ISSN: 15268209

Josina C. Reddy; Reimann; Steven M. Anderson; Pam Klein

January 1, 2006

Somatic mutations lead to an oncogenic deletion of Met in lung cancer

Cancer Research, ISSN: 00085472

Monica Kong-Beltran; Somasekar Seshagiri; Jiping Zha; Wenjing Zhu; Kaumudi Bhawe; Nerissa Mendoza; Thomas Holcomb; Kanan Pujara; Stinson; Ling Fu; Christophe Severin; Linda Rangell; Ralph H. Schwall; Lukas Amier; Dineli Wickramasinghe; Robert Yauch

January 1, 2006

Erratum: Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution (Journal of Pharmaceutical Sciences [2005] 94 [1928-1940] DOI: 10.1002/jps.20347)

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Jun Liu; Mary D. H. Nguyen; Andya; Steven J. Shire

January 1, 2006

Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma

Mayo Clinic Proceedings, ISSN: 00256196

Martha Lacy; Angela Dispenzieri; Morie A. Gertz; Philip R. Greipp; Kimberly L. Gollbach; Suzanne R. Hayman; Shaji Kumar; John A. Lust; S. Vincent Rajkumar; Stephen J. Russell; Witzig; Steven R. Zeldenrust; David Dingli; P. Lief Bergsagel; Rafael Fonseca; Craig B. Reeder; A. Keith Stewart; Vivek Roy; Robert J. Dalton; Alan B. Carr; Deepak Kademani; Eugene E. Keller; Christopher F. Viozzi; Robert A. Kyle

January 1, 2006

Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Thomas B. Casale; William W. Busse; Joel N. Kline; Zuhair K. Ballas; Mark H. Moss; Robert G. Townley; Masoud Mokhtarani; Vicki Seyfert-Margolis; Adam Asare; Kirk Bateman; Yamo Deniz

January 1, 2006

Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers

Pharmaceutical Research, ISSN: 07248741

Chee Ng; Stefanich; Banmeet S. Anand; Fielder; Louis Vaickus

January 1, 2006

Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei

International Journal of Infectious Diseases, ISSN: 12019712

Steven P. LaRosa; Steven M. Opal; Barbara Utterback; Sau Chi Betty Yan; Jeffrey D. Helterbrand; Andrew J.H. Simpson; Wipada Chaowagul; Nicholas J. White; Charles J. Fisher Jr.

January 1, 2006

Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma

AIDS Research and Human Retroviruses, ISSN: 08892229

Seth Rakoff-Nahoum; Peter Kuebler; Jonas J. Heymann; Megan E. Sheehy; Gabriel M. Ortiz; Graham S. Ogg; Jason D. Barbour; Jack Lenz; Alan D. Steinfeld; Douglas F. Nixon

January 1, 2006

Proteomic studies support the use of multi-product immunoassays to monitor host cell protein impurities

Proteomics, ISSN: 16159853 16159861

Denise C. Krawitz; William F. Forrest; G. Tony Moreno; Joshua Kittleson; Kathleen M. Champion

January 1, 2006

The crystal structure of murine coronin-1: A regulator of actin cytoskeletal dynamics in lymphocytes

Structure, ISSN: 09692126

Brent A. Appleton; Ping Wu; Wiesmann

January 1, 2006

Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer.

Cancer treatment and research, ISSN: 09273042

Arndt J Schottelius; Harald Dinter

January 1, 2006

IL-27 limits IL-2 production during Th1 differentiation

Journal of Immunology, ISSN: 00221767

Alejandro V. Villarino; Jason S. Stumhofer; Christiaan J. M. Saris; Robert A. Kastelein; Frederic J. De Sauvage; Christopher A. Hunter

January 1, 2006

Counterpoint: Why biogenerics are a strawman

Nature Biotechnology, ISSN: 15461696 10870156

Robert L. Garnick

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