Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10201 - 10250 OF 15217 RESULTS

Discovery of thrombin activatable fibrinolysis inhibitor (TAFI)
Journal of Thrombosis and Haemostasis, ISSN: 15387836 15387933
Bertina; Van Tilburg; Haverkate; Bouma; Von Dem Borne; Meijers; William Campbell; Dan L. Eaton; Dirk F. Hendriks; Willemse
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Interleukin-27R (WSX-1/T-cell cytokine receptor) gene-deficient mice display enhanced resistance to Leishmania donovani infection but develop severe liver immunopathology
American Journal of Pathology, ISSN: 00029440
Lucia E. Rosas; Anjali A. Satoskar; Kimberly M. Roth; Tracy L. Keiser; Joseph Barbi; Christopher A. Hunter; Frederic J. De Sauvage; Abhay R. Satoskar
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Large-scale trends in the evolution of gene structures within 11 animal genomes
PLoS Computational Biology, ISSN: 15537358 1553734X
Mark Yandell; Chris J. Mungall; Chris Smith; Simon Prochnik; Joshua S. Kaminker; George Hartzell; Suzanna E. Lewis; Gerald M. Rubin
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TGF-β regulates the mechanical properties and composition of bone matrix
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Guive Balooch; Mehdi Balooch; Ravi K. Nalla; Stephen Schilling; Ellen H. Filvaroff; Grayson W. Marshall; Sally J. Marshall; Robert O. Ritchie; Rik Derynck; Tamara Alliston
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Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Michelle A. Lowes; Francesca Chamian; Maria V. Abello; Judilyn Fuentes-Duculan; Shao-Lee Lin; Rachel Nussbaum; Inna Novitskaya; Henrietta Carbonaro; Irma Cardinale; Toyoko Kikuchi; Patricia Gilleaudeau; Mary Sullivan-Whalen; Knut Wittkowski; Kim Papp; Marvin Garovoy; Wolfgang Dummer; Ralph M. Steinman; James G. Krueger
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Identification of the minimal protein domain required for priming activity of munc13-1
Current Biology, ISSN: 09609822
David R. Stevens; Zheng-Xing Wu; Ulf Matti; Harald Junge; Claudia Schirra; Ute Becherer; Sonja M. Wojcik; Nils Brose; Jens Rettig
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Angiogenesis as a therapeutic target
Nature, ISSN: 00280836 14764679
Napoleone Ferrara; Robert S. Kerbel
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Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients
Clinical Cancer Research, ISSN: 10780432
Robert Yauch; Thomas Januario; Eberhard; Guy Cavet; Wenjing Zhu; Ling Fu; Thinh Q. Pham; Robert Soriano; Stinson; Somasekar Seshagiri; Zora Modrusan; Chin-Yu Lin; Vincent O'Neill; Lukas Amler
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MORT1/FADD is involved in liver regeneration
World Journal of Gastroenterology, ISSN: 10079327
Marcus Schuchmann; Felix Rückert; Jose F. Garcia-Lazaro; Andrea Karg; Jürgen Burg; Natalia Knorr; Jürgen Siebler; Eugene Varfolomeev; David Wallach; Wolfgang Schreiber; Ansgar W. Lohse; Peter R. Galle
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Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Cary D. Austin; Xiaohui Wen; Lewis Gazzard; Nelson; Richard H. Scheller; Suzie J. Scales
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Interspecies exchange mutagenesis of the first epidermal growth factor-like domain of human factor VII
Journal of Thrombosis and Haemostasis, ISSN: 15387933 15387836
Williamson; Pyke; Sampath Sridhara; Robert F. Kelley; Morris A. Blajchman; Bryan J. Clarke
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Molecular determinants of kinase pathway activation by Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Eugene Varfolomeev; Heather Maecker; Darcie Sharp; David Lawrence; Renz; Domagoj Vucic; Avi Ashkenazi
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P63 is an essential proapoptotic protein during neural development
Neuron, ISSN: 08966273
W. Bradley Jacobs; Gregory Govoni; Daniel Ho; Jasvinder K. Atwal; Fanie Barnabe-Heider; William M. Keyes; Alea A. Mills; Freda D. Miller; David R. Kaplan
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A smooth operator for LPS responses
Nature Immunology, ISSN: 15292908 15292916
Godowski
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TWEAK attenuates the transition from innate to adaptive immunity
Cell, ISSN: 00928674
Heather Maecker; Eugene Varfolomeev; Frank C. Kischkel; David Lawrence; Heidi LeBlanc; Wyne P. Lee; Stephen D. Hurst; Dimitry Danilenko; Jun Li; Ellen H. Filvaroff; Becky Yang; Dylan Daniel; Avi Ashkenazi
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Salutary effects of combining early very low-dose systemic estradiol with growth hormone therapy in girls with Turner syndrome
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Rosenfield; Nancy Devine; Joanne Julius Hunold; Nelly Mauras; Thomas Moshang Jr.; Allen W. Root
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Analysis of protein therapeutics by capillary electrophoresis: Applications and challenges
Developments in Biologicals, ISSN: 14246074
Stacey Ma
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Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance- associated protein 2 (rMrp2)
European Journal of Pharmaceutical Sciences, ISSN: 09280987
Chee Ng; Yun-De Xiao; Bert L. Lum; Yong-Hae Han
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Expression of HIF-1α in human tumours [5]
Journal of Clinical Pathology, ISSN: 00219746
Adrian M. Jubb; Kenneth J. Hillan
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Rituximab in combination with fludarabine chemotherapy in low-grade or follicular lymphoma
Journal of Clinical Oncology, ISSN: 0732183X
Myron S. Czuczman; Koryzna; Mohr; Stewart; Donohue; Blumenson; Bernstein; McCarthy; Alam; Hernandez-Ilizaliturri; Skipper; Brown; Chanan-Khan; Klippenstein; Loud; Mike K Rock; Benyunes; Grillo-Lopez; Bernstein
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Development and the boundaries of the firm: A knowledge-based examination in drug development
Academy of Management 2005 Annual Meeting: A New Vision of Management in the 21st Century, AOM 2005,
Jeffrey T. Macher; Christopher S. Boerner
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Targeted therapy: Wave of the future
Journal of Clinical Oncology, ISSN: 0732183X
Pegram; Pietras; Alex Bajamonde; Pam Klein; Gwendolyn Fyfe
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Requirement for the SnoN oncoprotein in transforming growth factor β-induced oncogenic transformation of fibroblast cells
Molecular and Cellular Biology, ISSN: 02707306
Qingwei Zhu; Sonia Pearson-White; Kunxin Luo
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Class I FIPs, Rab11-binding proteins that regulate endocytic sorting and recycling
Methods in Enzymology, ISSN: 00766879
Elizabeth Tarbutton; Andrew A. Peden; Jagath R. Junutula; Rytis Prekeris
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Agreement in histologic assessments of the pituitary pars intermedia in aged horses
American Journal of Veterinary Research, ISSN: 00029645
Dianne McFarlane; Lisa M. Miller; Linden E. Craig; Noel Dybdal; Perry L. Habecker; Margaret A. Miller; Jon S. Patterson; Alastair E. Cribb
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Heterogeneity of recombinant antibodies: Linking structure to function
Developments in Biologicals, ISSN: 14246074
Reed J. Harris
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Isolation and culture of hair cell progenitors from postnatal rat cochleae
Journal of Neurobiology, ISSN: 00223034
Suo-qiang Zhai; Li Shi; Bu-Er Wang; Gui-liang Zheng; Wei Song; Yin-yan Hu; Gao
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Proteomics
Methods in Enzymology, ISSN: 00766879
Stults; David Arnott
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Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Andrew R. Hoffman; Beverly M. K. Biller; David Cook; Joyce Baptista; Bernard L. Silverman; Dao; Kenneth M. Attie; Fielder; Thomas J. Maneatis; Barbara M. Lippe
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Impaired skin barrier function in dermatologic disease and repair with moisturization
Cutis, ISSN: 00114162
Mark Lebwohl; Lisa G. Herrmann
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Strategies for developing a successful electronic submission
American Pharmaceutical Review, ISSN: 10998012
Pawson
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Clinical efficacy of efalizumab in patients with chronic plaque psoriasis: Results from three randomized placebo-controlled phase III trials: Part I
Journal of Cutaneous Medicine and Surgery, ISSN: 12034754
David M. Pariser; Kenneth B. Gordon; Kim Papp; Craig Leonardi; Paul Kwon; Peter Compton; Amy Chen Rundle; Patricia Walicke; Mark Lebwohl
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Safety of efalizumab in patients with moderate to severe chronic plaque psoriasis: Review of clinical data. Part II
Journal of Cutaneous Medicine and Surgery, ISSN: 12034754
Kim Papp; Charles Camisa; Stephen P. Stone; Ivor Caro; Xiaolin Wang; Peter Compton; Patricia Walicke; Alice Gottlieb
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Symptom control and improved functioning: The effect of omalizumab on Asthma-Related Quality of Life (ARQL)
Journal of Asthma, ISSN: 02770903 15324303
Allan T. Luskin; Mark Kosinski; Bresnahan; Ashby; Dennis A. Wong
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Minimally important differences were estimated for the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) instrument using a combination of distribution- and anchor-based approaches
Journal of Clinical Epidemiology, ISSN: 08954356
Yost; Cella; Chawla; Holmgren; Eton; Ayanian; West
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Predicting clinical benefit in non-small-cell lung cancer patients treated with epidermal growth factor tyrosine kinase inhibitors
Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451
Lukas Amler; Goddard; Kenneth J. Hillan
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Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycin
Annals of the Rheumatic Diseases, ISSN: 00034967
Sandorfi; Louneva; Hitraya; Hajnoczky; Saitta; Sergio A. Jimenez
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Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
Journal of Clinical Oncology, ISSN: 0732183X
Agus; Michael S. Gordon; Charles Taylor; Ronald B. Natale; Beth Karlan; David Mendelson; Michael F. Press; David E. Allison; Mark X. Sliwkowski; Grade Lieberman; Stephen Kelsey; Gwendolyn Fyfe
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UV microscopy at 280 nm is effective in screening for the growth of protein microcrystals
Journal of Applied Crystallography, ISSN: 00218898 16005767
Christopher S. Lunde; Shahab Rouhani; Jonathan P. Remis; Steven E. Ruzin; James A. Ernst; Robert M. Glaeser
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Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
Journal of Clinical Oncology, ISSN: 0732183X
Eberhard; Bruce E. Johnson; Lukas Amler; Goddard; Sherry Heldens; Roy S. Herbst; William L. Ince; Pasi A. Jänne; Thomas Januario; David H. Johnson; Pam Klein; Vincent A. Miller; Michael Ostland; David A. Ramies; Dragan Sebisanovic; Stinson; Zhang; Somasekar Seshagiri; Kenneth J. Hillan
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Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
Journal of Clinical Oncology, ISSN: 0732183X
Fairooz F. Kabbinavar; Joseph Schulz; Michael McCleod; Taral Patel; John T. Hamm; Joel Randolph Hecht; Robert Mass; Brent Perrou; Betty Nelson; Novotny
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Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
Journal of Clinical Oncology, ISSN: 0732183X
David B. Agus; Michael S. Gordon; Charles Taylor; Ronald B. Natale; Beth Karlan; David Mendelson; Michael F. Press; David E. Allison; Mark X. Sliwkowski; Grade Lieberman; Stephen Kelsey; Gwendolyn Fyfe
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Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
Journal of Clinical Oncology, ISSN: 0732183X
Fairooz F. Kabbinavar; Julie Hambleton; Robert Mass; Herbert Hurwitz; Emily Bergsland; Somnath Sarkar
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Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
Journal of Clinical Oncology, ISSN: 0732183X
Kathy Miller; Linnea I. Chap; Frankie Ann Holmes; Melody A. Cobleigh; P. Kelly Marcom; Louis Fehrenbacher; Maura N. Dickler; Beth A. Overmoyer; Reimann; Amy Sing; Virginia K. Langmuir; Hope S. Rugo
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Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
Journal of Clinical Oncology, ISSN: 0732183X
Eberhard; Bruce E. Johnson; Lukas Amler; Goddard; Sherry Heldens; Roy S. Herbst; William Ince; Pasi A. Jänne; Thomas Januario; David H. Johnson; Pam Klein; Vincent A. Miller; Michael Ostland; David A. Ramies; Dragan Sebisanovic; Stinson; Zhang; Somasekar Seshagiri; Kenneth J. Hillan
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Attenuating lymphocyte activity: The crystal structure of the BTLA-HVEM complex
Journal of Biological Chemistry, ISSN: 00219258
Deanne M. Compaan; Lino C. Gonzalez Jr.; Irene Tom; Kelly M. Loyet; Dan L. Eaton; Sarah G. Hymowitz
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Isolation and characterization of the B-cell marker CD20
Biochemistry, ISSN: 00062960
James A. Ernst; Hong Li; Hok Seon Kim; Nakamura; Yansura; Richard L. Vandlen
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Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation
Journal of Experimental Medicine, ISSN: 00221007 00221007
Honglin Zhou; Denise M. Monack; Nobuhiko Kayagaki; Ingrid E. Wertz; Jianping Yin; Beni B. Wolf; Vishva M. Dixit
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Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
Developmental Biology, ISSN: 00121606
Scott R. May; Amir M. Ashique; Mattias Karlen; Baolin Wang; Yiguo Shen; Konstantinos Zarbalis; Jeremy Reiter; Johan Ericson; Andrew S. Peterson
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Immune thrombocytopenia associated with efalizumab therapy for psoriasis [7]
Annals of Internal Medicine, ISSN: 00034819
Theodore E. Warkentin; Paul Kwon
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