Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10251 - 10300 OF 15217 RESULTS

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
Journal of Biological Chemistry, ISSN: 00219258
Mark Larance; Georg Ramm; Jacqueline Stöckli; Ellen M. Van Dam; Stephanie Winata; Valerie Wasinger; Fiona Simpson; Michael Graham; Jagath R. Junutula; Michael Guilhaus; David E. James
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Concomitant administration of bevacizumab, irinotecan, 5-fluorouracil, and leucovorin: Nonclinical safety and pharmacokinetics
International Journal of Toxicology, ISSN: 10915818 1092874X
Jacques Gaudreault; Vanessa Shiu; Ann Bricarello; Brian J. Christian; Christina L. Zuch; Barbara Mounho
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Angiogenic inhibitors: A new therapeutic strategy in oncology
Nature Clinical Practice Oncology, ISSN: 17434254 17434262
Giampietro Gasparini; Raffaele Longo; Masakazu Toi; Napoleone Ferrara
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Aspirin sensitivity and severity of asthma: Evidence for irreversible airway obstruction in patients with severe or difficult-to-treat asthma
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Kimberly Mascia; Tmirah Haselkorn; Yamo Deniz; Dave P. Miller; Eugene R. Bleecker; Larry Borish
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The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C
Mutagenesis, ISSN: 02678357 14643804
Aaron M. Gruver; Kristi A. Miller; Changanamkandath Rajesh; Phillip G. Smiraldo; Saravanan Kaliyaperumal; Rachel Balder; Katie M. Stiles; Joanna S. Albala; Douglas L. Pittman
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A causal inference approach for constructing transcriptional regulatory networks
Bioinformatics, ISSN: 13674803 14602059
Biao Xing; Mark J. van der Laan
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Risk-based cleaning validation in biopharmaceutical API manufacturing
BioPharm International, ISSN: 1542166X
A. Hamid Mollah; Edward K. White
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VEGF as a therapeutic target in cancer
Oncology, ISSN: 00302414
Napoleone Ferrara
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Rapid on-membrane proteolytic cleavage for Edman sequencing and mass spectrometric identification of proteins
Electrophoresis, ISSN: 01730835
Victoria Pham; William J. Henzel; Jennie R. Lill
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IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
Immunity, ISSN: 10747613
Jochen Schmitz; Alexander M. Owyang; Elizabeth Oldham; Yaoli Song; Erin Murphy; Terrill McClanahan; Gerard Zurawski; Mehrdad Moshrefi; Jinzhong Qin; Xiaoxia Li; Daniel M. Gorman; J.Fernando Bazan; Robert A. Kastelein
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Cutting edge: TRAIL deficiency accelerates hematological malignancies
Journal of Immunology, ISSN: 00221767
Nadeen Zerafa; Jennifer A. Westwood; Erika Cretney; Sally Mitchell; Waring; Manuela Iezzi; Mark J. Smyth
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Severity assessment in asthma: An evolving concept
Journal of Allergy and Clinical Immunology, ISSN: 00916749
Mary K. Miller; Charles A. Johnson; Dave P. Miller; Yamo Deniz; Eugene R. Bleecker; Sally E. Wenzel
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Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers
Cancer Research, ISSN: 00085472
Daniel C. Gray; Adrian M. Jubb; Deborah A. Hogue; Patrick Dowd; Noelyn Kljavin; Sothy Yi; Wei Bai; Gretchen D. Frantz; Zemin Zhang; Koeppen; Frederic J. De Sauvage; David P. Davis
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Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes
Molecular Biology of the Cell, ISSN: 10591524
Alexander C. Theos; Danièle Tenza; José A. Martina; Ilse Hurbain; Andrew A. Peden; Elena V. Sviderskaya; Abigail Stewart; Margaret S. Robinson; Dorothy C. Bennett; Daniel F. Cutler; Juan S. Bonifacino; Michael S. Marks; Graça Raposo
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Involvement of α4 integrins in maintenance of cardiac sympathetic axons
Autonomic Neuroscience: Basic and Clinical, ISSN: 15660702
Kevin L. Wingerd; William C. Wayne; Jackson; Dennis O. Clegg
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Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
New England Journal of Medicine, ISSN: 00284793 15334406
Edward H. Romond; Edith A. Perez; John Bryant; Vera J. Suman; Charles E. Geyer Jr.; Nancy E. Davidson; Elizabeth Tan-Chiu; Silvana Martino; Soonmyung Paik; Peter A. Kaufman; Sandra M. Swain; Thomas M. Pisansky; Louis Fehrenbacher; Leila A. Kutteh; Victor G. Vogel; Daniel W. Visscher; Greg Yothers; Robert B. Jenkins; Ann M. Brown; Shaker R. Dakhil; Eleftherios P. Mamounas; Wilma L. Lingle; Pam Klein; James N. Ingle; Norman Wolmark
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Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis
Journal of Experimental Medicine, ISSN: 00221007 00221007
Sanjeev Mariathasan; David S. Weiss; Vishva M. Dixit; Denise M. Monack
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Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin
Journal of Biological Chemistry, ISSN: 00219258
Bin Fan; Thomas D Wu; Wei Li; Daniel Kirchhofer
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Neuroscience: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans
Science, ISSN: 00368075 10959203
Vuk Koprivica; Kin-Sang Cho; Jong Bae Park; Glenn Yiu; Jasvinder K. Atwal; Bryan B. Gore; Jieun A. Kim; Estelle Lin; Marc Tessier-Lavigne; Dong Feng Chen; Zhigang He
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Achieving door-to-balloon times that meet quality guidelines: How do successful hospitals do it?
Journal of the American College of Cardiology, ISSN: 07351097
Elizabeth H. Bradley; Sarah A. Roumanis; Martha J. Radford; Tashonna R. Webster; Robert L. McNamara; Jennifer A. Mattera; Barbara A. Barton; David N. Berg; Edward L. Portnay; Harry Moscovitz; Janet Parkosewich; Eric S. Holmboe; Martha Blaney; Harlan M. Krumholz
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TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice
Immunology and Cell Biology, ISSN: 08189641
Erika Cretney; Jonathan L. McQualter; Nobuhiko Kayagaki; Hideo Yagita; Claude C.A. Bernard; Iqbal S. Grewal; Avi Ashkenazi; Mark J. Smyth
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The external RNA controls consortium: A progress report
Nature Methods, ISSN: 15487091 15491676
Shawn C. Baker; Steven R. Bauer; Richard P. Beyer; James D. Brenton; Bud Bromley; John Burrill; Helen Causton; Michael P. Conley; Rosalie Elespuru; Michael Fero; Carole Foy; James Fuscoe; Xiaolian Gao; David Lee Gerhold; Patrick Gilles; Federico Goodsaid; Xu Guo; Joe Hackett; Richard D. Hockett; Pranvera Ikonomi; Rafael A. Irizarry; Ernest S. Kawasaki; Tamma Kaysser-Kranich; Kathleen Kerr; Gretchen Kiser; Walter H. Koch; Kathy Y. Lee; Chunmei Liu; Z. Lewis Liu; Anne Lucas; Chitra F. Manohar; Garry Miyada; Zora Modrusan; Helen Parkes; Raj K. Puri; Laura Reid; Thomas B. Ryder; Marc Salit; Raymond R. Samaha; Uwe Scherf; Timothy J. Sendera; Robert A. Setterquist; Leming Shi; Richard Shippy; Jesus V. Soriano; Elizabeth A. Wagar; Janet A. Warrington; Mickey Williams; Frederike Wilmer; Mike Wilson; Paul K. Wolber; Xiaoning Wu; Renata Zadro
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The septin-binding protein anillin is overexpressed in diverse human tumors
Clinical Cancer Research, ISSN: 10780432
Peter A. Hall; Christopher B. Todd; Paula L. Hyland; Simon S. McDade; Grabsch; Mit Dattani; Kenneth J. Hillan; S. E. Hilary Russell
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Population pharmacokinetics of trastuzumab in patients with HER2+ metastatic breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Rene Bruno; Carla Washington; Jian-Feng Lu; Lieberman; Ludger Banken; Pam Klein
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Pathogen recognition: TLRs throw us a curve
Immunity, ISSN: 10747613
Peter Kirk; J.Fernando Bazan
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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
Cell, ISSN: 00928674
Sophie Pattingre; Amina Tassa; Xueping Qu; Rita Garuti; Huan Liang Xiao; Noboru Mizushima; Milton Packer; Michael D. Schneider; Beth Levine
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Inhibitory effects of interferon-γ on myocardial hypertrophy
Cytokine, ISSN: 10434666
Hongkui Jin; Wei Li; Renhui Yang; Annie Ogasawara; Hsienwie Lu; Nicholas F. Paoni
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Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
Journal of Experimental Medicine, ISSN: 00221007
Kyle I. Happel; Patricia J. Dubin; Mingquan Zheng; Nico Ghilardi; Christie Lockhart; Lee J. Quinton; Anthony R. Odden; Judd E. Shellito; Gregory J. Bagby; Steve Nelson; Jay K. Kolls
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A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging
Biochemical Journal, ISSN: 02646021
Stanley W. Botchway; Ignasi Barba; Randolf Jordan; Rebecca Harmston; Peter M. Haggie; Simon P. Williams; Alexandra M. Fulton; Anthony W. Parker; Kevin M. Brindle
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Novel method of generating prostate-specific Cre-loxP gene switching via intraductal delivery of adenovirus
Prostate, ISSN: 02704137
Ching Ching Leow; Xi-De Wang; Gao
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Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40
Cancer Research, ISSN: 00085472
Che-Leung Law; Kristine A. Gordon; John Collier; Kerry Klussman; Julie A. McEarchern; Charles G. Cerveny; Bruce J. Mixan; Wyne P. Lee; Zhonghau Lin; Patricia A. Valdez; Alan Wahl; Iqbal S. Grewal
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Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Roland H. Friedel; Andrew Plump; Lu; Kerri Spilker; Christine Jolicoeur; Karen G. Wong; Tadmiri R. Venkatesh; Avraham Yaron; Mary Hynes; Bin Chen; Ami Okada; Susan K. McConnell; Helen Rayburn; Marc Tessier-Lavigne
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Bioanalytical method validation for macromolecules in support of pharmacokinetic studies
Pharmaceutical Research, ISSN: 07248741 1573904X
JoMarie Smolec; Binodh DeSilva; Wendell Smith; Russell Weiner; Marian Kelly; Ben Lee; Masood Khan; Richard Tacey; Howard Hill; Abbie Celniker; Vinod Shah; Ronald Bowsher; Mire-Sluis; John W. A. Findlay; Mary Saltarelli; Quarmby; David Lansky; Robert Dillard; Martin Ullmann; Steve Keller; H. Thomas Karnes
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Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab
Journal of Surgical Oncology, ISSN: 00224790
Frank A. Scappaticci; Louis Fehrenbacher; Cartwright; John Hainsworth; William Heim; Jordan Berlin; Fairooz F. Kabbinavar; Novotny; Somnath Sarkar; Herbert Hurwitz
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Protein-interaction mapping in search of effective drug targets
BioEssays, ISSN: 02659247
Amitabha Chaudhuri; John Chant
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Determination of HER2 gene amplification by fluorescence in situ hybridization and concordance with the clinical trials immunohistochemical assay in women with metastatic breast cancer evaluated for treatment with trastuzumab
Breast Cancer Research and Treatment, ISSN: 01676806
Noel Dybdal; Grazyna Leiberman; Steven M. Anderson; Bryan McCune; Alex Bajamonde; Robert L. Cohen; Robert Mass; Corsee Sanders; Michael F. Press
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Portfolio management by late-phase design
Good Clinical Practice Journal, ISSN: 13500961
Susan Morris; Elizabeth Tschosik
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Recombinant tissue plasminogen activator for minor strokes: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study experience
Annals of Emergency Medicine, ISSN: 01960644
Steven R. Levine; Joseph P. Broderick; Thomas Brott; Thomas DeGraba; Susan C. Fagan; Michael R. Frankel; James C. Grotta; E. Clarke Haley Jr.; Scott Hamilton; Thomas Kwiatkowski; Christopher A. Lewandowski; Yan Lin; Richard Libman; Mei Lu; Patrick Lyden; John R. Marler; Lewis Morgenstern; Suresh Patel; Corsee Sanders; Barbara C. Tilley
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Effect of statin use within the first 24 hours of admission for acute myocardial infarction on early morbidity and mortality
American Journal of Cardiology, ISSN: 00029149
Gregg C. Fonarow; R. Scott Wright; Frederick A. Spencer; Paul D. Fredrick; Wei Dong; Nathan R. Every; William J. French
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Technical report # 39: Cold chain guidance for medicinal products: Maintaining the quality of temperature-sensitive medicinal products through the transportation environment
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Rafik H. Bishara; Jim Antonopoulos; Mari Bakken; Daniel Colton; Laura Fontan; Derrick Gallagher; Paul Harber; Kelly Klien; Chris Landauer; Teresa Lucas; Sarvang Mishra; Kevin O'Donnell; Oumer Salim; Jeff Seeley; Bob Seevers; Edward G. Smith; Douglas Staruk; Donald Wilson
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Partial remission of psoriasis following rituximab therapy for non-hodgkin lymphoma
Cutis, ISSN: 00114162
Fiza Singh; Jeffrey M. Weinberg
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Alcohol as a risk factor for plaque-type psoriasis
Cutis, ISSN: 00114162
Shahrad M. Behnam; Shahdad E. Behnam; John Y. Koo
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Separation of genomic DNA from plasmid DNA by selective renaturation with immobilized metal affinity capture
Biotechnology Progress, ISSN: 87567938
Tony Cano; Jason C. Murphy; George E. Fox; Richard C. Willson
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Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis
Protein Science, ISSN: 09618368 1469896X
Gábor Pál; Shun-Yin Fong; Anthony A. Kossiakoff; Sachdev S. Sidhu
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NMR methods for studying the structure and dynamics of RNA
ChemBioChem, ISSN: 14394227
Michael P. Latham; Darin J. Brown; Scott A. McCallum; Arthur Pardi
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Mutations increasing exposure of a receptor binding site epitope in the soluble and oligomeric forms of the caprine arthritis-encephalitis lentivirus envelope glycoprotein
Virology, ISSN: 00426822
Isidro Hötzel; William P. Cheevers
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Sex and racial differences in the management of acute myocardial infarction, 1994 through 2002
New England Journal of Medicine, ISSN: 00284793
Viola Vaccarino; Saif S. Rathore; Nanette K. Wenger; Paul D. Frederick; Jerome L. Abramson; Hal V. Barron; Ajay Manhapra; Susmita Mallik; Harlan M. Krumholz
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ERM is required for transcriptional control of the spermatogonial stem cell niche
Nature, ISSN: 00280836
Chen Chen; Wenjun Ouyang; Vadim Grigura; Qing Zhou; Kay Carnes; Hyunjung J. Lim; Guang-Quan Zhao; Silvia Arber; Natasza Kurpios; Theresa L. Murphy; Alec M. Cheng; John A. Hassell; Varadaraj Chandrashekar; Marie-Claude Hofmann; Rex A. Hess; Kenneth M. Murphy
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Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 00987484
David J. Magid; Yongfei Wang; Jeph Herrin; Robert L. McNamara; Elizabeth H. Bradley; Jeptha P. Curtis; Charles V. Pollack Jr.; William J. French; Martha Blaney; Harlan M. Krumholz
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Relationship between time of day, day of week, timeliness of reperfusion, and in-hospital mortality for patients with acute ST-segment elevation myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 15383598 00987484
David J. Magid; Yongfei Wang; Jeph Herrin; Robert L. McNamara; Elizabeth H. Bradley; Jeptha P. Curtis; Charles V. Pollack Jr.; William J. French; Martha Blaney; Harlan M. Krumholz
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