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Publications

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DISPLAYING 1001 - 1050 OF 15414 RESULTS

Pharmacokinetics, Pharmacodynamics, and Safety of Etrolizumab in Children With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease: Results from a Phase 1 Randomized Trial
Inflammatory Bowel Diseases,
Wenhui Zhang; Astrid Scalori; Franklin Fuh; Jacqueline McBride; Gaohong She; Jaroslaw Kierkus; Bartosz Korczowksi; Regan Li; Mariam Abouhossein; Alysha Kadva; Park; Meina Tao Tang
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Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib
Drug Metabolism and Disposition, ISSN: 1521009X
Louis Lin; Matthew Wright; Cornelis E. Hop; Harvey Wong
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Exacerbation Profile and Risk Factors in a Type-2-Low Enriched Severe Asthma Cohort: A Clinical Trial to Assess Asthma Exacerbation Phenotypes
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970
Pamela Jane McDowell; John Busby; Catherine E. Hanratty; Ratko Djukanovic; Ashley Woodcock; Samantha Walker; Tim Hardman; Joseph R. Arron; David F. Choy; Peter Bradding; Chris E. Brightling; Rekha Chaudhuri; Douglas Cowan; Adel Mansur; Stephen J. Fowler; Sarah Diver; Peter H. Howarth; James Lordan; Andrew Menzies-Gow; Timothy Harrison; Douglas S. Robinson; Cécile T.J. Holweg; Matthews; Ian D. Pavord; Liam G. Heaney
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Pharmacokinetics, Pharmacodynamics, and Safety of Etrolizumab in Children With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease: Results from a Phase 1 Randomized Trial
Inflammatory Bowel Diseases, ISSN: 15364844
Wenhui Zhang; Astrid Scalori; Franklin Fuh; Jacqueline McBride; Gaohong She; Jaroslaw Kierkus; Bartosz Korczowksi; Regan Li; Mariam Abouhossein; Alysha Kadva; Park; Meina Tao Tang
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Using a peptide-based mass spectrometry approach to quantitate proteolysis of an intact heterogeneous procollagen substrate by BMP1 for antagonistic antibody screening
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Cong Wu; Ryan Cook; Ping Wu; Neha Srikumar; Elin Chee; William S. Sawyer; Hua Wang; Meredith Hazen; Isidro Hötzel; Elsa-Noah N’Diaye; Ning Ding; Yichin Liu; John C. Tran; Zhengmao Ye
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New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Kathleen M. Giacomini; Sook Wah Yee; Megan L. Koleske; Ling Zou; Pär Matsson; Eugene C. Chen; Deanna L. Kroetz; Miles A. Miller; Elnaz Gozalpour; Xiaoyan Chu
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Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search
Rheumatology,
Nadia M T Roodenrijs; Paco M J Welsing; Joël van Roon; Jan L M Schoneveld; Marlies C. van der Goes; György Nagy; Michael J. Townsend; Jacob M. Van Laar
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Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search
Rheumatology, ISSN: 14620332
Nadia M T Roodenrijs; Paco M J Welsing; Joël van Roon; Jan L M Schoneveld; Marlies C. van der Goes; György Nagy; Michael J. Townsend; Jacob M. Van Laar
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Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab
Blood, ISSN: 00064971
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; D'Rozario; Carolyn J. Owen; Sarit E. Assouline; Nicole Lamanna; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Clemens H. Mellink; Brenda Chyla; Anesh Panchal; Tong Lu; Jenny Q. Wu; Yanwen Jiang; Marcus Lefebure; Michelle Boyer; Kater
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Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab
Blood, ISSN: 15280020 00064971
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; D'Rozario; Carolyn J. Owen; Sarit E. Assouline; Nicole Lamanna; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Clemens H. Mellink; Brenda Chyla; Anesh Panchal; Tong Lu; Jenny Q. Wu; Yanwen Jiang; Marcus Lefebure; Michelle Boyer; Kater
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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Alexander M. Taylor; Christopher Bailey; Lisa D. Belmont; Robert Campbell; Nico Cantone; Alexandre Côté; Terry Crawford; Richard T Cummings; Kevin Dement; Martin Duplessis; Megan Flynn; Andrew C. Good; Hon-Ren Huang; Shivangi Joshi; Yves Leblanc; Jeremy Murray; Christopher G. Nasveschuk; Adrianne Neiss; Florence Poy; F. Anthony Romero; Peter Sandy; Yong Tang; Vickie Tsui; Laura E. Zawadzke; Robert J. Sims; James E. Audia; Steve Bellon; Steven Magnuson; Brian K Albrecht; Andrea G Cochran
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Determination of BET Specific Surface Area of Hydrate-Anhydrate Systems Susceptible to Phase Transformation Using Inverse Gas Chromatography
AAPS PharmSciTech,
Minhthi Bui; Karthik Nagapudi; Paroma Chakravarty
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Disease-associated oligodendrocyte responses across neurodegenerative diseases
Cell Reports, ISSN: 22111247
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
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Disease-associated oligodendrocyte responses across neurodegenerative diseases
Cell Reports,
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
eLife, ISSN: 2050084X
Ariel Pribluda; Anneleen Daemen; Anthony Lima; Xi Wang; Marc Hafner; Chungkee Poon; Zora Modrusan; Anand K. Katakam; Oded Foreman; Jeffrey Eastham; Jeffrey Hung; Benjamin Haley; Julia T. Garcia; Erica L. Jackson; Melissa Junttila
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Development of Dual Practical Manufacturing Routes to Cognate Pyrrolobenzodiazepine-Based Linker-Drugs
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; Remy Angelaud; Christopher M. Crittenden; Kenji Kurita; David J. Russell; Jean-Francois Marcoux; Thomas Matt; Francis Gosselin
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Importance of Green and Sustainable Chemistry in the Chemical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Juan Colberg; King Kuok Hii; Stefan G. Koenig
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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
eLife,
Ariel Pribluda; Anneleen Daemen; Anthony Lima; Xi Wang; Marc Hafner; Chungkee Poon; Zora Modrusan; Anand K. Katakam; Oded Foreman; Jeffrey Eastham; Jeffrey Hung; Benjamin Haley; Julia T. Garcia; Erica L. Jackson; Melissa Junttila
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Single-cell analysis reveals clonally expanded tumor-associated CD57 +CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Michael Fehlings; Leesun Kim; Xiangnan Guan; Kobe Yuen; Alireza Tafazzol; Shomyseh Sanjabi; Oliver A. Zill; Deepali Rishipathak; Andrew Wallace; Alessandra Nardin; Siming Ma; Ana Milojkovic; Evan W. Newell; Sanjeev Mariathasan; Mahesh Yadav
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Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics
Journal of the American Chemical Society, ISSN: 15205126 00027863
Carmela Molinaro; Yukie Kawasaki; George Wanyoike; Taiki Nishioka; Tsuyoshi Yamamoto; Snedecor; Sarah J. Robinson; Francis Gosselin
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The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Journal of Chromatography A, ISSN: 18733778 00219673
Honorine Lardeux; Alexandre Goyon; Kelly Zhang; Jennifer M Nguyen; Matthew A Lauber; Davy Guillarme; Valentina D'Atri
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Analytical techniques for characterizing diastereomers of phosphorothioated oligonucleotides
Journal of Chromatography A, ISSN: 18733778 00219673
Tao Chen; Shijia Tang; Yige Fu; José G. Napolitano; Kelly Zhang
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The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Journal of Chromatography A, ISSN: 00219673
Honorine Lardeux; Alexandre Goyon; Kelly Zhang; Jennifer M Nguyen; Matthew A Lauber; Davy Guillarme; Valentina D'Atri
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Liquid chromatography coupled with photodiode array and a multivariate curve resolution – Alternating least square algorithm for identification and quantification of co-eluting impurities in pharmaceutical analysis
Journal of Chromatography A, ISSN: 18733778 00219673
Davide Vecchietti; Akira Nishio; Yuichiro Fujita; Takeshi Yoshida; Toshinobu Yanagisawa; Dawen Kou
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Liquid chromatography coupled with photodiode array and a multivariate curve resolution – Alternating least square algorithm for identification and quantification of co-eluting impurities in pharmaceutical analysis
Journal of Chromatography A, ISSN: 00219673
Davide Vecchietti; Akira Nishio; Yuichiro Fujita; Takeshi Yoshida; Toshinobu Yanagisawa; Dawen Kou
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Tae Won Kim; Howard A. Burris; Maria J. de Miguel Luken; Pishvaian; Bang; Michael S. Gordon; Ahmad Awada; D. Ross Camidge; F. Stephen Hodi; Grant A. McArthur; Miller; Andrés Cervantes; Laura Q.M. Chow; Alexander M. Lesokhin; Annemie Rutten; Mario Sznol; Deepali Rishipathak; Shang-Chiung Chen; Stefanich; Tony Pourmohamad; Maria Anderson; Jeong Kim; Mahrukh Huseni; Ina Rhee; Siu
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Monitoring multiple quality attributes of a complex Fc-fusion protein during cell culture production processes by mD-LC-MS peptide mapping
Talanta, ISSN: 00399140
Julien Camperi; Sanket Dahotre; Davy Guillarme; Cinzia Stella
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clinical Cancer Research, ISSN: 10780432
Tae Won Kim; Howard A. Burris; Maria J. de Miguel Luken; Pishvaian; Bang; Michael S. Gordon; Ahmad Awada; D. Ross Camidge; F. Stephen Hodi; Grant A. McArthur; Miller; Andrés Cervantes; Laura Q.M. Chow; Alexander M. Lesokhin; Annemie Rutten; Mario Sznol; Deepali Rishipathak; Shang-Chiung Chen; Stefanich; Tony Pourmohamad; Maria Anderson; Jeong Kim; Mahrukh Huseni; Ina Rhee; Siu
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Attached Nitrogen Test by 13C-14N Solid-State NMR Spectroscopy for the Structure Determination of Heterocyclic Isomers
Organic Letters, ISSN: 15237052 15237060
Rick W. Dorn; Brendan J. Wall; Sarah B. Ference; Sean R. Norris; Joseph W. Lubach; Aaron J. Rossini; Brett VanVeller
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Immune microenvironment characteristics in multiple myeloma progression from transcriptome profiling
Frontiers in Oncology, ISSN: 2234943X
Jin Wang; Yi Hu; Habib Hamidi; Cedric Dos Santos; Jingyu Zhang; Elizabeth A. Punnoose; Wenjin Li
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The “η-sweet-spot” (ηmax) in liquid-assisted mechanochemistry: polymorph control and the role of a liquid additive as either a catalyst or an inhibitor in resonant acoustic mixing (RAM)
Faraday Discussions, ISSN: 13645498 13596640
Lori Gonnet; Tristan H. Borchers; Cameron B. Lennox; Jogirdas Vainauskas; Yong Teoh; Hatem M. Titi; Christopher J. Barrett; Stefan G. Koenig; Karthik Nagapudi; Tomislav Friščić
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mRNA Display and Its Growing Potential in the Discovery of de Novo Therapeutic Peptide Candidates
ACS Symposium Series, ISSN: 19475918 00976156
Christina Helmling; Christian N. Cunningham
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mRNA Display and Its Growing Potential in the Discovery of de Novo Therapeutic Peptide Candidates
ACS Symposium Series, ISSN: 00976156
Christina Helmling; Christian N. Cunningham
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Preface
ACS Symposium Series, ISSN: 19475918 00976156
Swapnil V. Ghodge; Kaustav Biswas; Andrei A. Golosov
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NMR Spectroscopy for Studying Peptide Conformations and Cell Permeability
ACS Symposium Series, ISSN: 00976156
Kaustav Biswas; Andrei A. Golosov; Emel Adaligil; Wayne J. Fairbrother
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NMR Spectroscopy for Studying Peptide Conformations and Cell Permeability
ACS Symposium Series, ISSN: 19475918 00976156
Kaustav Biswas; Andrei A. Golosov; Emel Adaligil; Wayne J. Fairbrother
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Chiral Amines via Enantioselective π-Allyliridium-C,O-Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration
Accounts of Chemical Research,
Craig E. Stivala; Jason R. Zbieg; Peng Liu; Michael J. Krische
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VERONICA: Randomized Phase II Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors - Efficacy, Safety, and Biomarker Results
Clinical Cancer Research,
Geoffrey J. Lindeman; Tharu M. Fernando; Rebecca Bowen; Katarzyna J. Jerzak; Xinni Song; Thomas Decker; Frances Boyle; Steven McCune; Anne Armstrong; Catherine Shannon; Gianfilippo Bertelli; Ching-Wei Chang; Rupal Desai; Kushagra Gupta; Wilson; Aulde Flechais; Aditya Bardia
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Chiral Amines via Enantioselective π-Allyliridium-C,O-Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration
Accounts of Chemical Research, ISSN: 15204898
Craig E. Stivala; Jason R. Zbieg; Peng Liu; Michael J. Krische
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Chiral Amines via Enantioselective π-Allyliridium- C, O-Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration
Accounts of Chemical Research, ISSN: 15204898 00014842
Craig E. Stivala; Jason R. Zbieg; Peng Liu; Michael J. Krische
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Untreated bleeds in people with hemophilia A in a noninterventional study and intrapatient comparison after initiating emicizumab in HAVEN 1–3
Research and Practice in Thrombosis and Haemostasis, ISSN: 24750379
Michael U. Callaghan; Elina Asikanius; Michaela Lehle; Johannes Oldenburg; Johnny N. Mahlangu; Marianne Uguen; Sammy Chebon; Kruse-Jarres; Jiménez-Yuste; Midori Shima; Peter C. Trask; Kempton; Craig Kessler; Gallia Levy; Flora Peyvandi
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VERONICA: Randomized Phase II Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors - Efficacy, Safety, and Biomarker Results
Clinical Cancer Research, ISSN: 15573265 10780432
Geoffrey J. Lindeman; Tharu M. Fernando; Rebecca Bowen; Katarzyna J. Jerzak; Xinni Song; Thomas Decker; Frances Boyle; Steven McCune; Anne Armstrong; Catherine Shannon; Gianfilippo Bertelli; Ching-Wei Chang; Rupal Desai; Kushagra Gupta; Wilson; Aulde Flechais; Aditya Bardia
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Pharmacokinetics and Exposure-Response Analysis of Venetoclax + Obinutuzumab in Chronic Lymphocytic Leukemia: Phase 1b Study and Phase 3 CLL14 Trial
Advances in Therapy, ISSN: 18658652 0741238X
Divya Samineni; Leonid Gibiansky; Wang; Shweta Vadhavkar; Richa Rajwanshi; Tandon; Arijit Sinha; Othman Al-Sawaf; Kirsten Fischer; Michael Hallek; Ahmed Hamed Salem; Chunze Li; Dale Miles
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Omalizumab treatment reduces asthma exacerbations regardless of airway bronchodilator reversibility
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Samuel DeLeon; Franco Barsanti; Cécile T.J. Holweg; Bongin Yoo; Blaine Creasy; Michael E. Wechsler
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Pharmacokinetics and Exposure-Response Analysis of Venetoclax + Obinutuzumab in Chronic Lymphocytic Leukemia: Phase 1b Study and Phase 3 CLL14 Trial
Advances in Therapy, ISSN: 18658652 0741238X
Divya Samineni; Leonid Gibiansky; Bei Wang; Shweta Vadhavkar; Richa Rajwanshi; Tandon; Arijit Sinha; Othman Al-Sawaf; Kirsten Fischer; Michael Hallek; Ahmed Hamed Salem; Chunze Li; Dale Miles
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Erratum to Gene Set Enrichment Analyses Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy. Am J Ophthalmol 2022;233:111-123 (American Journal of Ophthalmology (2022) 233 (111–123), (S0002939421003366), (10.1016/j.ajo.2021.06.014))
American Journal of Ophthalmology, ISSN: 18791891 00029394
Lucia Sobrin; Gayatri Susarla; Lynn K. Stanwyck; John M. Rouhana; Ashley Li; Samuela Pollack; Robert P. Igo; Richard A. Jensen; Xiaohui Li; Maggie C.Y. Ng; Albert V Smith; Jane Z. Kuo; Kent D. Taylor; Barry I. Freedman; Donald W. Bowden; Alan Penman; Ching J. Chen; Jamie E. Craig; Sharon G. Adler; Emily Y. Chew; Mary Frances Cotch; Brian L. Yaspan; Paul Mitchell; Jie Jin Wang; Barbara E.K. Klein; Tien Y. Wong; Jerome I. Rotter; Kathryn Burdon; Sudha K. Iyengar; Ayellet V. Segrè
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Applications of Model-Based Meta-Analysis in Drug Development
Pharmaceutical Research, ISSN: 1573904X 07248741
Phyllis Chan; Kirill Peskov; Xuyang Song
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Comment on A Implication of baseline levels and early changes of C-reactive protein for subsequent clinical outcomes of patients with rheumatoid arthritis treated with tocilizumab'
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Attila Pethoe-Schramm; Jenny Devenport; William Reiss
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Application of Empirical Scalars to Enable Early Prediction of Human Hepatic Clearance Using in Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Robert Jones; Christian Leung; Jae H. Chang; Suzanne Brown; Ning Liu; Zhengyin Yan; Jane R. Kenny; Broccatelli
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Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study
The Lancet Oncology, ISSN: 14702045
Lihua E. Budde; Laurie H. Sehn; Matthew Matasar; Stephen J. Schuster; Sarit E. Assouline; Pratyush Giri; Kuruvilla; Miguel Canales; Sascha Dietrich; Keith Fay; Matthew Ku; Loretta J. Nastoupil; Chan Yoon Cheah; Michael C. Wei; Shen Yin; Chi-Chung Li; Huang Huang; Antonia Kwan; Elicia M. Penuel; Nancy L. Bartlett
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