Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10451 - 10500 OF 15217 RESULTS

Toward Small–Molecule Agonists of Tnf Receptors
Nature Chemical Biology, ISSN: 15524469 15524450
Sarah G. Hymowitz; Avi Ashkenazi
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Industry-Based Medical Communications: Benchmarking Survey of Quality Assurance Practices
Therapeutic Innovation and Regulatory Science, ISSN: 21684790
S. Justin Hileman; Graham; Joyce Serrano Martin; Barry Grobman
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Recombinant DNA Technology and Cell Line Development
Cell Culture Technology for Pharmaceutical and Cell-Based Therapies,
Amy Y. Shen; Jana Van de Goor; Lisa Zheng; Arthur Reyes; Lynne Krummen
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Vascular bed-specific signaling and angiogenesis
Endothelial Cells in Health and Disease,
Napoleone Ferrara; Rui Lin; Jennifer Lecouter
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Applications of NMR spectroscopy in biopharmaceutical product development
Analytical Techniques for Biopharmaceutical Development,
Kao; Wong; Vanderlaan
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Activity-dependent internalization of smoothened mediated by β-Arrestin 2 and GRK2
Science, ISSN: 00368075
Wei Chen; Xiu-Rong Ren; Nelson; Larry S. Barak; James K. Chen; Philip A. Beachy; Frederic J. De Sauvage; Robert J. Lefkowitz
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Structural basis and therapeutic implication of the interaction of CCN proteins with glycoconjugates
Current Pharmaceutical Design, ISSN: 13816128
Luc Desnoyers
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IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice
Journal of Immunology, ISSN: 00221767
John E. Pearl; Shabaana A. Khader; Alejandra Solache; Leigh Gilmartin; Nico Ghilardi; Frederic J. De Sauvage; Andrea M. Cooper
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Integrin α4β1 function is required for cell survival in developing retina
Developmental Biology, ISSN: 00121606
Sergiu T. Leu; Susan A.L. Jacques; Kevin L. Wingerd; Sherry T. Hikita; Erin C. Tolhurst; Jan L. Pring; Derek Wiswell; Lisa Kinney; Nichol L. Goodman; Jackson; Dennis O. Clegg
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Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL
Cancer Research, ISSN: 00085472
Rajani Ravi; Ajay J. Jain; Richard D. Schulick; Vui Pham; Traci S. Prouser; Heather Allen; Elizabeth Garrett Mayer; Hua Yu; Drew M. Pardoll; Avi Ashkenazi; Atul Bedi
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Evaluation of a surrogate antibody for preclinical safety testing of an anti-CD11a monoclonal antibody
Regulatory Toxicology and Pharmacology, ISSN: 02732300
Janet Clarke; Will Leach; Susanne Pippig; Amita Joshi; Benjamin Wu; Robert House; Joseph Beyer
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Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in β3-integrin-deficient mice
Cancer Research, ISSN: 00085472
Andrew R. Reynolds; Louise E. Reynolds; Tobi Nagel; Julie C. Lively; Stephen D. Robinson; Daniel J. Hicklin; Bodary; Kairbaan M. Hodivala-Dilke
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Visualization tool for a terrain-based genetic algorithm
Proceedings - International Conference on Tools with Artificial Intelligence, ICTAI, ISSN: 10823409
V. Scott Gordon; James Thein
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Effect of anti-TGF-Β antibodies in syngeneic mouse models of metastasis
Journal of Musculoskeletal Neuronal Interactions, ISSN: 11087161
Richard A. D. Carano; Li; Bao; Li; Berry; Ross; Joe Kowalski; French; Dugger; Ralph H. Schwall; Wang; David T.W. Fei; Sarah L. Moseley; Ellen H. Filvaroff
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Transcriptional-based screens for pathway-specific, high-throughput target discovery in endothelial cells
Journal of Biomolecular Screening, ISSN: 10870571
Robert Yauch; Edward E. Kadel III; Cory Nicholas; Selwyna Tetangco; Douglas O. Clary
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Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression
Journal of Clinical Oncology, ISSN: 0732183X
Debasish Tripathy; Dennis J. Slamon; Melody A. Cobleigh; Andrew Arnold; Mansoor Saleh; Joanne E. Mortimer; Maureen Murphy; Stanford J. Stewart
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Development of a PCR method for mycoplasma testing of Chinese hamster ovary cell cultures used in the manufacture of recombinant therapeutic proteins
Biologicals, ISSN: 10451056
Joyce A. Eldering; Chantal Felten; Connie A. Veilleux; Barbara J. Potts
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The burden of illness associated with psoriasis: Cost of treatment with systemic therapy and phototherapy in the US
Current Medical Research and Opinion, ISSN: 03007995
William H. Crown; Bresnahan; Lucinda S. Orsini; Sean Kennedy; Craig Leonardi
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The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton
Molecular Biology of the Cell, ISSN: 10591524
Melanie L. Styers; Gloria Salazar; Rachal Love; Andrew A. Peden; Andrew P. Kowalczyk; Victor Faundez
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Endocytosis and sorting of ErbB2 and the site of action of cancer therapeutics trastuzumab and geldanamycin
Molecular Biology of the Cell, ISSN: 10591524
Cary D. Austin; Ann De Mazière; Paul Pisacane; Suzanne Van Dijk; Eigenbrot; Mark X. Sliwkowski; Judith Klumperman; Richard H. Scheller
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Competency-based benchmarking: Revolutionizing biopharmaceutical product launches
Benchmarking, ISSN: 14635771
Mark J. Ahn; Daniel Dornbusch
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Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro
Angiogenesis, ISSN: 09696970
Yaning Wang; David T.W. Fei; Vanderlaan; An Song
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Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
Journal of Clinical Oncology, ISSN: 0732183X
David H. Johnson; Louis Fehrenbacher; Novotny; Roy S. Herbst; John J. Nemunaitis; David M. Jablons; Corey Langer; Russell F. DeVore III; Jacques Gaudreault; Lisa A. Damico; Holmgren; Fairooz F. Kabbinavar
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Roles of active site tryptophans in substrate binding and catalysis by α-1,3 galactosyltransferase
Glycobiology, ISSN: 09596658
Yingnan Zhang; Ashlesha Deshpande; Zhihong Xie; Ramanathan Natesh; K. Ravi Acharya; Keith Brew
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Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Jennifer Lecouter; Constance Zlot; Max L. Tejada; Franklin V. Peale Jr.; Napoleone Ferrara
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Impurity effects on the crystallization kinetics of ampicillin
Industrial and Engineering Chemistry Research, ISSN: 08885885
Ottens; Lebreton; Zomerdijk; Rijkers; Bruinsma; Van Der Wielen
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Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival
Journal of Biological Chemistry, ISSN: 00219258
Beatrix Schäfer; Beatrice Marg; Andreas Gschwind; Axel Ullrich
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The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Nature, ISSN: 00280836
Xiaowel Lu; Ferdinand Le Noble; Li Yuan; Quingjan Jiang; Benjamin De Lafarge; Daisuke Sugiyama; Christiane Bréant; Filip Claes; Frederik De Smet; Jean-Léon Thomas; Monica Autiero; Peter Carmeliet; Marc Tessier-Lavigne; Anne Eichmann
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Vascular endothelial growth factor-induced nitric oxide-and PGI 2-dependent relaxation in human internal mammary arteries: A comparative study with KDR and Flt-1 selective mutants
Journal of Cardiovascular Pharmacology, ISSN: 01602446
Wei Wei; Hongkui Jin; Zhi-Wu Chen; Zioncheck; Anthony P. C. Yim; Guo-Wei He
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Tissue distribution, stability, and pharmacokinetics of APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in human colon carcinoma COLO205 tumor-bearing nude mice
Drug Metabolism and Disposition, ISSN: 00909556
Hong Xiang; Cindy B. Nguyen; Kelley; Noel Dybdal; Escandon
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Detection and in vitro and in vivo characterization of porcine circovirus DNA from a porcine-derived commercial pepsin product
Journal of General Virology, ISSN: 00221317
Fenaux; Opriessnig; Halbur; Yuan Xu; Barbara J. Potts; Meng
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The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
Critical Care Medicine, ISSN: 00903493
Derek C. Angus; Pierre-Francois Laterre; Jeffrey D. Helterbrand; E. Wesley Ely; Daniel E. Ball; Rekha Garg; Lisa A. Weissfeld; Gordon R. Bernard
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Novel biologic agents for multiple sclerosis and their impact on managed care
Formulary, ISSN: 1082801X
Schumarry H. Chao; Craig H. Smith
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A new suite of automated bioreactors at Genentech: A case study employing standards, guidelines, and software: From requirements to validation
Pharmaceutical Engineering, ISSN: 02738139
Ronald E. Menéndez
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Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53
Molecular and Cellular Biology, ISSN: 02707306
David Dornan; Mirjam Eckert; Maura Wallace; Harumi Shimizu; Eleanor Ramsay; Ted R. Hupp; Kathryn L. Ball
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Efficacy of PUVA phototherapy compared with biologics
Cosmetic Dermatology, ISSN: 10413766
John Y. Koo; Rachel Wenner
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Simple quantitative live cell and anti-idiotypic antibody based ELISA for humanized antibody directed to cell surface protein CD20
Journal of Immunological Methods, ISSN: 00221759
Kyu Hong; Presta; Yanmei Lu; Ashley Penn; Adams; Anan Chuntharapai; Yang; Wai Lee T. Wong; Meng
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Pharmacokinetics of novel dipeptide ester prodrugs of acyclovir after oral administration: Intestinal absorption and liver metabolism
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565
Banmeet S. Anand; Suresh Katragadda; Ashim K. Mitra
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Current immunomodulatory therapies for multiple sclerosis
Formulary, ISSN: 1082801X
Craig H. Smith
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The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity
Journal of Immunology, ISSN: 00221767
David Artis; Alejandro V. Villarino; Michael Silverman; Weimian He; Elizabeth M. Thornton; Sharon Mu; Shamin Summer; Todd M. Covey; Elaine Huang; Hiroki Yoshida; Gary Koretzky; Michael Goldschmidt; Gary D. Wu; Frederic J. De Sauvage; Hugh R. P. Miller; Christiaan J. M. Saris; Phillip Scott; Christopher A. Hunter
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Early withdrawal of statin therapy in patients with non-ST-segment elevation myocardial infarction: National registry of myocardial infarction
Archives of Internal Medicine, ISSN: 00039926
Frederick A. Spencer; Gregg C. Fonarow; Paul D. Frederick; R. Scott Wright; Nathan R. Every; Robert J. Goldberg; Joel M. Gore; Wei Dong; Richard C. Becker; William J. French
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Angiogenesis-dependent and independent phases of intimal hyperplasia
Circulation, ISSN: 00097322
Rohit Khurana; Zhenwu Zhuang; Shalini Bhardwaj; Masahiro Murakami; Ebo De Muinck; Seppo Yla-Herttuala; Napoleone Ferrara; John F. Martin; Ian Zachary; Michael Simons
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The crystal structure of A proliferation-inducing ligand, APRIL
Journal of Molecular Biology, ISSN: 00222836
Heidi J. A. Wallweber; Deanne M. Compaan; Melissa A. Starovasnik; Sarah G. Hymowitz
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COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas
Cancer Research, ISSN: 00085472
David Dornan; Sheila Bheddah; Kim Newton; William Inice; Gretchen D. Frantz; Patrick Dowd; Koeppen; Vishva M. Dixit; French
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Bevacizumab in colorectal cancer [2] (multiple letters)
New England Journal of Medicine, ISSN: 00284793
Guru Sonpavde; Waseem Sharieff; Herbert Hurwitz; Novotny; Fairooz F. Kabbinavar
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Differential requirements for semaphorin 3F and slit-1 in axonal targeting, fasciculation, and segregation of olfactory sensory neuron projections
Journal of Neuroscience, ISSN: 02706474
Jean-François Cloutier; Amar Sahay; Ernie C. Chang; Marc Tessier-Lavigne; Catherine Dulac; Alex L. Kolodkin; David D. Ginty
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GEPIS - Quantitative gene expression profiling in normal and cancer tissues
Bioinformatics, ISSN: 13674803
Yan Zhang; Eberhard; Gretchen D. Frantz; Patrick Dowd; Thomas D Wu; Yan Zhou; Colin K. Watanabe; Shiuh-Ming Luoh; Paul G. Polakis; Kenneth J. Hillan; William I. Wood; Zemin Zhang
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Racial and ethnic differences in time to acute reperfusion therapy for patients hospitalized with myocardial infarction
JAMA - Journal of the American Medical Association, ISSN: 00987484
Elizabeth H. Bradley; Jeph Herrin; Yongfei Wang; Robert L. McNamara; Tashonna R. Webster; David J. Magid; Martha Blaney; Eric D. Peterson; John G. Canto; Charles V. Pollack Jr.; Harlan M. Krumholz
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Efalizumab (anti-CD11a)-induced increase in peripheral blood leukocytes in psoriasis patients is preferentially mediated by altered trafficking of memory CD8+ T cells into lesional skin
Clinical Immunology, ISSN: 15216616
Yulia Vugmeyster; Toyoko Kikuchi; Michelle A. Lowes; Francesca Chamian; Mark Kagen; Patricia Gilleaudeau; Edmund Lee; Howell; Bodary; Wolfgang Dummer; James G. Krueger
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Production technologies for monoclonal antibodies and their fragments
Current Opinion in Biotechnology, ISSN: 09581669
Dana C. Andersen; Dorothea Reilly
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