Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 10501 - 10550 OF 15217 RESULTS

Signal peptide prediction based on analysis of experimentally verified cleavage sites
Protein Science, ISSN: 09618368
Zemin Zhang; William J. Henzel
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Phase I trial of irinotecan, infusional 5-fluorouracil, and leucovorin (FOLFIRI) with erlotinib (OSI-774): Early termination due to increased toxicities
Clinical Cancer Research, ISSN: 10780432
Wells A. Messersmith; Daniel A. Laheru; Neil N. Senzer; Ross C. Donehower; Paula Grouleff; Theresa Rogers; Kelley; David A. Ramies; Bert L. Lum; Manuel Hidalgo
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Suppressor of fused regulates Gli activity through a dual binding mechanism
Molecular and Cellular Biology, ISSN: 02707306
Mark Merchant; Vajdos; Ultsch; Henry R. Maun; K. Ulrich Wendt; Jennifer Cannon; William Desmarais; Lazarus; De Vos; Frederic J. De Sauvage
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A pH-sensitive function and phenotype: Evidence that EutH facilitates diffusion of uncharged ethanolamine in Salmonella enterica
Journal of Bacteriology, ISSN: 00219193
Joseph T. Penrod; Christopher C. Mace; John R. Roth
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Protein-protein interactions governing septin heteropentamer assembly and septin filament organization in Saccharomyces cerevisiae
Molecular Biology of the Cell, ISSN: 10591524
Matthias Versele; Björn Gullbrand; Shulewitz; Victor J. Cid; Shirin Bahmanyar; Raymond E. Chen; Patrick Barth; Tom Alber; Jeremy Thorner
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Capillary regression in vascular endothelial growth factor-deficient skeletal muscle
Physiological Genomics, ISSN: 15312267
Kechun Tang; Ellen C. Breen; Hans-Peter Gerber; Napoleone Ferrara; Peter D. Wagner
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Effect of long-term progestin treatment on endometrial vasculature in normal cycling mice
Contraception, ISSN: 00107824
Girling; Heryanto; Patel; Peter A.W. Rogers
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Quantification of cortical bone loss and repair for therapeutic evaluation in collagen-induced arthritis, by micro-computed tomography and automated image analysis
Arthritis and Rheumatism, ISSN: 00043591
Kai H. Barck; Wyne P. Lee; Laurie Diehl; Ross; Gribling; Yifan Zhang; Kathy Nguyen; Nicholas Van Bruggen; Stephen D. Hurst; Richard A. D. Carano
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Selective impairment of TLR-mediated innate immunity in human newborns: Neonatal blood plasma reduces monocyte TNF-α induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848
Journal of Immunology, ISSN: 00221767
Ofer Levy; Kol A. Zarember; Rene M. Roy; Colette Cywes; Godowski; Michael R. Wessels
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Real time quantitative PCR as a method to evaluate xenotropic murine leukemia virus removal during pharmaceutical protein purification
Biotechnology and Bioengineering, ISSN: 00063592
Shi; Qi Chen; Lenore A Norling; Allen S.L. Lau; Sherrie Krejci; Yuan Xu
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Structural and functional basis of the serine protease-like hepatocyte growth factor β-chain in met binding and signaling
Journal of Biological Chemistry, ISSN: 00219258
Daniel Kirchhofer; Xiaoyi Yao; Peek; Eigenbrot; Michael T. Lipari; Karen L Billeci; Henry R. Maun; Paul Moran; Santell; Wiesmann; Lazarus
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Bioinformatics and cancer target discovery
Drug Discovery Today, ISSN: 13596446
Brian Desany; Zemin Zhang
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The mouse frizzled 8 receptor is expressed in anterior organizer tissues
Gene Expression Patterns, ISSN: 1567133X
Lu; Elizabeth J. Robertson; Jane Brennan
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B-cell subsets in blood and lymphoid organs in Macaca fascicularis
Cytometry Part A, ISSN: 15524922
Yulia Vugmeyster; Howell; Anahid Bakshi; Flores; Hwang; Kathleen McKeever
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In vitro internalization, intracellular transport, and clearance of an anti-CD11a antibody (Raptiva) by human T-cells
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565
Greg P. Coffey; Stefanich; Susan Palmieri; Eckert; Josette Padilla-Eagar; Fielder; Susanne Pippig
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Receptor-mediated basic fibroblast growth factor signaling regulates cyclic pressure-induced human endothelial cell proliferation
Endothelium: Journal of Endothelial Cell Research, ISSN: 10623329
Hainsworth Y. Shin; Eric A. Schwartz; Rena Bizios; Mary E. Gerritsen
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Activation of caspases-8 and -10 by FLIPL
Biochemical Journal, ISSN: 02646021
Kelly M. Boatright; Cristina Deis; Jean-Bernard Denault; Daniel P. Sutherlin; Guy S. Salvesen
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Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells
Cancer Research, ISSN: 00085472
Ching Ching Leow; Maria Romero; Ross; Paul G. Polakis; Gao
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Caspase-8 serves both apoptotic and nonapoptotic roles
Journal of Immunology, ISSN: 00221767
Tae-Bong Kang; Tehila Ben-Moshe; Eugene Varfolomeev; Yael Pewzner-Jung; Nir Yogev; Anna Jurewicz; Ari Waisman; Ori Brenner; Rebecca Haffner; Erika Gustafsson; Parameswaran Ramakrishnan; Tsvee Lapidot; David Wallach
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Clinical benefits in patients with psoriasis after efalizumab therapy: Clinical trials versus practice
Cutis, ISSN: 00114162
Roberto R. Ricardo; Matthe Rhoa; Elaine K. Orenberg; Nicole F. Li; Amy Chen Rundle; Ivor Caro
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The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development
Molecular and Cellular Biology, ISSN: 02707306
Zhe Chen; Dennis J. Eastburn; Min Han
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Barriers to biologics
Cutis, ISSN: 00114162
Jeffrey M. Weinberg
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Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Frederic A. Fellouse; Wiesmann; Sachdev S. Sidhu
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Hybrid photoactive assemblies: Electron injection from host-guest complexes into semiconductor nanoparticles
Journal of the American Chemical Society, ISSN: 00027863
Cynthia Pagba; Giovanni Zordan; Elena Galoppini; Evgueni L. Piatnitski; Sarmimala Hore; Deshayes; Piotrowiak
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Activation and substrate specificity of caspase-14
Biochemistry, ISSN: 00062960
Jowita Mikolajczyk; Fiona L. Scott; Stan Krajewski; Daniel P. Sutherlin; Guy S. Salvesen
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Cuttin edge: Differential roles for phosphoinositide 3-kinases, p110γ and p110δ, lymphocyte chemotaxis and homing
Journal of Immunology, ISSN: 00221767
Karin Reif; Klaus Okkenhaug; Takehiko Sasaki; Josef Penninger; Bart Vanhaesebroeck; Jason G. Cyster
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Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway
Journal of Biological Chemistry, ISSN: 00219258
Klaus W. Wagner; Ingo H. Engels; Quinn L. Deveraux
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The therapeutic potential of hepatocyte growth factor for myocardial infarction and heart failure
Current Pharmaceutical Design, ISSN: 13816128
Hongkui Jin; Wyss; Renhui Yang; Ralph H. Schwall
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Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins
Journal of Biological Chemistry, ISSN: 00219258
Jagath R. Junutula; Eric Schonteich; Gayle M. Wilson; Andrew A. Peden; Richard H. Scheller; Rytis Prekeris
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Purification of antibody and antibody-fragment from E. coli homogenate using 6,9-diamino-2-ethoxyacridine lactate as precipitation agent
Biotechnology and Bioengineering, ISSN: 00063592
Josefine Persson; Philip M. Lester
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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Nature, ISSN: 00280836
Ingrid E. Wartz; Karen M. O'Rourke; Honglin Zhou; Mike Eby; Aravind; Somasekar Seshagiri; Ping Wu; Wiesmann; Rohan Baker; David L. Boone; Averil Ma; Eugene V. Koonin; Vishva M. Dixit
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A Substrate-phage approach for investigating caspase specificity
Protein Journal, ISSN: 15723887
Samantha Lien; Richard Pastor; Daniel P. Sutherlin; Henry B. Lowman
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Efficacy and safety of two unfractionated heparin dosing strategies with Tenecteplase in acute myocardial infarction (results from Assessment of the Safety and Efficacy of a New Thrombolytic Regimens 2 and 3)
American Journal of Cardiology, ISSN: 00029149
Jeptha P. Curtis; John H. Alexander; Yao Huang; Lars Wallentin; Verheugt; Paul W. Armstrong; Harlan M. Krumholz; Frans Van De Werf; Danays; Morris Cheeks; Christopher B. Granger
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Evolution and divergence of the genes for cytoplasmic, mitochondrial, and flagellar creatine kinases
Journal of Molecular Evolution, ISSN: 00222844
Tomohiko Suzuki; Chisa Mizuta; Kouji Uda; Keiko Ishida; Kanae Mizuta; Sona Sona; Deanne M. Compaan; W. Ross Ellington
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Vascular endothelial growth factor: Basic science and clinical progress
Endocrine Reviews, ISSN: 0163769X
Napoleone Ferrara
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Allosteric inhibition of protein tyrosine phosphatase 1B
Nature Structural and Molecular Biology, ISSN: 15459993
Wiesmann; Kenneth J. Barr; Jenny Kung; Jiang Zhu; Daniel A. Erlanson; Wang Shen; Bruce J. Fahr; Min Zhong; Lisa Taylor; Mike Randall; Robert S. McDowell; Stig K. Hansen
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Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer
Clinical Cancer Research, ISSN: 10780432
Yiping Zeng; Kenneth Opeskin; Megan E. Baldwin; Lisa G. Horvath; Marc G. Achen; Steven A. Stacker; Robert L. Sutherland; Elizabeth D. Williams
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Comparing total health care costs and treatment patterns of HIV patients in a managed care setting
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, ISSN: 09540121
Purdum; Johnson; Globe
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BMP signaling initiates a neural crest differentiation program in embryonic rat CNS stem cells
Experimental Neurology, ISSN: 00144886
Shyam Gajavelli; Patrick M. Wood; Diane Pennica; Scott R. Whittemore; Tsoulfas
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The RCP-Rab11 complex regulates endocytic protein sorting
Molecular Biology of the Cell, ISSN: 10591524
Andrew A. Peden; Eric Schonteich; John Chun; Jagath R. Junutula; Richard H. Scheller; Rytis Prekeris
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Rituximab-mediated depletion of cynomolgus monkey B cells in vitro in different matrices: Possible inhibitory effect of IgG
International Immunopharmacology, ISSN: 15675769
Yulia Vugmeyster; Howell
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Human IgE response to the Schistosoma haematobium 22.6 kDa antigen
Parasite Immunology, ISSN: 01419838
Fitzsimmons; Stewart; Karl F. Hoffmann; Jane L. Grogan; Maria Yazdanbakhsh; David W. Dunne
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Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteria
Antimicrobial Agents and Chemotherapy, ISSN: 00664804
Sharath S. Hegde; Noe Reyes; Tania Wiens; Nicole Vanasse; Robert Skinner; Julia McCullough; Koné Kaniga; John Pace; Roger Thomas; Jeng-Pyng Shaw; Glen Obedencio; J. Kevin Judice
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Human endocrine gland-derived vascular endothelial growth factor: Expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Michel Samson; Franklin V. Peale Jr.; Gretchen D. Frantz; Nathalie Rioux-Leclercq; Ewa Rajpert-De Meyts; Napoleone Ferrara
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High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold
Journal of Molecular Biology, ISSN: 00222836
Chingwei V. Lee; Wei-Ching Liang; Dennis; Eigenbrot; Sachdev S. Sidhu; Fuh
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VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis
EMBO Journal, ISSN: 02614189
Jianying Dong; Jeremy Grunstein; Max L. Tejada; Franklin V. Peale Jr.; Gretchen D. Frantz; Wei-Ching Liang; Wei Bai; Lanlan Yu; Joe Kowalski; Xiao Huan Liang; Fuh; Hans-Peter Gerber; Napoleone Ferrara
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A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response
Journal of Biological Chemistry, ISSN: 00219258
Dhaya Seshasayee; Hua Wang; Wyne P. Lee; Gribling; Ross; Nicholas Van Bruggen; Richard A. D. Carano; Iqbal S. Grewal
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Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand cooperates with chemotherapy to inhibit orthotopic lung tumor growth and improve survival
Cancer Research, ISSN: 00085472
Hongkui Jin; Renhui Yang; Fong; Klara Totpal; David Lawrence; Zhong Zheng; Ross; Koeppen; Ralph H. Schwall; Avi Ashkenazi
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Comprehensive mutational analysis of the M13 major coat protein: Improved scaffolds for C-terminal phage display
Journal of Molecular Biology, ISSN: 00222836
Heike A. Held; Sachdev S. Sidhu
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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Nature, ISSN: 00280836
Sanjeev Mariathasan; Kim Hewton; Denise M. Monack; Domagoj Vucic; French; Wyne P. Lee; Merone Roose-Girma; Sharon Erickson; Vishva M. Dixit
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