Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 11451 - 11500 OF 16125 RESULTS

Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteria
Antimicrobial Agents and Chemotherapy, ISSN: 00664804
Sharath S. Hegde; Noe Reyes; Tania Wiens; Nicole Vanasse; Robert Skinner; Julia McCullough; Koné Kaniga; John Pace; Roger Thomas; Jeng-Pyng Shaw; Glen Obedencio; J. Kevin Judice
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Human endocrine gland-derived vascular endothelial growth factor: Expression early in development and in Leydig cell tumors suggests roles in normal and pathological testis angiogenesis
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Michel Samson; Franklin V. Peale Jr.; Gretchen D. Frantz; Nathalie Rioux-Leclercq; Ewa Rajpert-De Meyts; Napoleone Ferrara
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High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold
Journal of Molecular Biology, ISSN: 00222836
Chingwei V. Lee; Wei-Ching Liang; Dennis; Eigenbrot; Sachdev S. Sidhu; Fuh
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VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis
EMBO Journal, ISSN: 02614189
Jianying Dong; Jeremy Grunstein; Max L. Tejada; Franklin V. Peale Jr.; Gretchen D. Frantz; Wei-Ching Liang; Wei Bai; Lanlan Yu; Joe Kowalski; Xiao Huan Liang; Fuh; Hans-Peter Gerber; Napoleone Ferrara
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A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response
Journal of Biological Chemistry, ISSN: 00219258
Dhaya Seshasayee; Hua Wang; Wyne P. Lee; Gribling; Ross; Nicholas Van Bruggen; Richard A. D. Carano; Iqbal S. Grewal
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Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand cooperates with chemotherapy to inhibit orthotopic lung tumor growth and improve survival
Cancer Research, ISSN: 00085472
Hongkui Jin; Renhui Yang; Fong; Klara Totpal; David Lawrence; Zhong Zheng; Ross; Koeppen; Ralph H. Schwall; Avi Ashkenazi
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Comprehensive mutational analysis of the M13 major coat protein: Improved scaffolds for C-terminal phage display
Journal of Molecular Biology, ISSN: 00222836
Heike A. Held; Sachdev S. Sidhu
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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Nature, ISSN: 00280836
Sanjeev Mariathasan; Kim Hewton; Denise M. Monack; Domagoj Vucic; French; Wyne P. Lee; Merone Roose-Girma; Sharon Erickson; Vishva M. Dixit
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Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system
Neuroscience, ISSN: 03064522
Gard; Gavin; Solodushko; Diane Pennica
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Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase
Science, ISSN: 00368075
Chieh Chang; Timothy W. Yu; Cornelia I. Bargmann; Marc Tessier-Lavigne
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Clinical targeting of VEGF and EGFR effective in non-small cell lung cancer
Cancer Biology and Therapy, ISSN: 15384047 15558576
Roy S. Herbst; Eric Mininberg; Ted Henderson; Edward S. Kim; George R. Blumenschein; J. Jack J. Lee; Mylene Truong; Waun Hong; David H. Johnson; David Carbone; Ben Garcia; Dong Xie; Kelley
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Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes
Cell Death and Differentiation, ISSN: 13509047
O'Reilly; Divisekera; Kim Newton; Scalzo; Kataoka; Puthalakath; Ito; David C.S. Huang; Andreas Strasser
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Convergent recognition of the IgE binding site on the high-affinity IgE receptor
Structure, ISSN: 09692126
Jennifer Stamos; Eigenbrot; Nakamura; Mark E. Reynolds; Jianping Yin; Henry B. Lowman; Wayne J. Fairbrother; Melissa A. Starovasnik
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Relation of age and race with hospital death after acute myocardial infarction
American Heart Journal, ISSN: 00028703
Ajay Manhapra; John G. Canto; Viola Vaccarino; Lori Parsons; Calarina I. Kiefe; Hal V. Barron; William J. Rogers; W.Douglas Weaver; Steven Borzak
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Decrease in tumor apparent permeability-surface area product to a MRI macromolecular contrast medium following angiogenesis inhibition with correlations to cytotoxic drug accumulation
Microcirculation, ISSN: 10739688
Heike E. Daldrup-Link; Yoshitaka Okuhata; Allan Wolfe; Sudesk Srivastav; Sven Øie; Napoleone Ferrara; Robert L. Cohen; David M. Shames; Robert C. Brasch
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The Risk Score Profile: A novel approach to characterising the risk of populations enrolled in clinical studies
European Heart Journal, ISSN: 0195668X
David A. Morrow; Elliott M. Antman; Sabina A. Murphy; Susan F. Assmann; Robert P. Giugliano; Christopher P. Cannon; C.Michael Gibson; Carolyn H. McCabe; Hal V. Barron; Frans Van De Werf; Eugene Braunwald
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Pharmacokinetic and pharmacodynamic characteristics of a long-acting Growth Hormone (GH) preparation (nutropin depot) in GH-deficient children
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Stephen F. Kemp; Fielder; Kenneth M. Attie; Sandra L. Blethen; Edward O. Reiter; Kathleen M. Ford; Marian; Dao; Lee; Saenger
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PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates
Nature, ISSN: 00280836
Lu; Annete G. M. Borchers; Christine Jolicoeur; Helen Rayburn; Julie C. Baker; Marc Tessier-Lavigne
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Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma
Cancer, ISSN: 0008543X
Kimberly Blackwell; Herbert Hurwitz; Lieberman; Novotny; Stacey Snyder; Mark Dewhirst; Charles Greenberg
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Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells
Blood, ISSN: 00064971
Boris A. Hesser; Xiao Huan Liang; Camenisch; Suya Yang; Lewin; Richard Scheller; Napoleone Ferrara; Hans-Peter Gerber
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Targeting interferon-α: A promising approach for systemic lupus erythematosus therapy
Lupus, ISSN: 09612033
Kerstin N. Schmidt; Wenjun Ouyang
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Circulating humoral factors and endothelial progenitor cells in patients with differing coronary collateral support
Circulation, ISSN: 00097322
Pier D. Lambiase; Richard J. Edwards; Prodromos Anthopoulos; Salman Rahman; Meng; Clifford A. Bucknall; Simon R. Redwood; Jeremy D. Pearson; Marber
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Vascular endothelial growth factor as a target for anticancer therapy
Oncologist, ISSN: 10837159
Napoleone Ferrara
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T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva™): Mechanisms of action
Dermatology, ISSN: 10188665
Jullien; Prinz; Richard G. B. Langley; Ivor Caro; Wolfgang Dummer; Amita Joshi; Russell L Dedrick; Natta
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Crystal structure of the HGF β-chain in complex with the Sema domain of the Met receptor
EMBO Journal, ISSN: 02614189
Jennifer Stamos; Lazarus; Xiaoyi Yao; Daniel Kirchhofer; Wiesmann
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Flex test: A fluorescent dextran test for UF membrane characterization
Journal of Membrane Science, ISSN: 03767388
Poonam Mulherkar; Robert Van Reis
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Gene expression profiling for prognosis using Cox regression
Statistics in Medicine, ISSN: 02776715
Yudi Pawitan; Bjöhle; Wedren; Humphreys; Skoog; Huang; Lukas Amler; Shaw; Hall; Bergh
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Cost-effectiveness of testing for hypercoagulability and effects on treatment strategies in patients with deep vein thrombosis
American Journal of Medicine, ISSN: 00029343
Andrew D. Auerbach; Gillian D. Sanders; Julie Hambleton
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An industry survey on current practices in the design and analysis of active control studies
Journal of Biopharmaceutical Statistics, ISSN: 10543406
Christy Chuang-Stein; Corsee Sanders; Steve Snapinn
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AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells
Journal of Biological Chemistry, ISSN: 00219258
Gloria Salazar; Rachal Love; Melanie L. Styers; Erica Werner; Andrew A. Peden; Sandra Rodriguez; Marla Gearing; Bruce H. Wainer; Victor Faundez
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Notch1-expressing cells are indispensable for prostatic branching morphogenesis during development and re-growth following castration and androgen replacement
Journal of Biological Chemistry, ISSN: 00219258
Xi-De Wang; Shou; Peter Wong; French; Gao
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Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
New England Journal of Medicine, ISSN: 00284793
Herbert Hurwitz; Louis Fehrenbacher; Novotny; Thomas Cartwright; John Hainsworth; William Heim; Jordan Berlin; Ari Baron; Susan Griffing; Holmgren; Napoleone Ferrara; Gwendolyn Fyfe; Rogers; Robert Ross; Fairooz F. Kabbinavar
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Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes
Endocrinology, ISSN: 00137227
Ling Fu; Linu M. John; Adams; Yu; Elizabeth Tomlinson; Renz; P. Mickey Williams; Robert Soriano; Corpuz; Moffat; Richard L. Vandlen; Laura C. Simmons; Foster; Jean-Philippe Stephan; Siao Ping Tsai; Stewart
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A public gene trap resource for mouse functional genomics [1]
Nature Genetics, ISSN: 10614036
William C. Skarnes; Harald Von Melchner; Wolfgang Wurst; Geoff Hicks; Alex S. Nord; Tony Cox; Stephen G. Young; Patricia Ruiz; Phil Soriano; Marc Tessier-Lavigne; Bruce R. Conklin; William L. Stanford; Janet Rossant
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Acute metabolic acidosis: Characterization and diagnosis of the disorder and the plasma potassium response
Journal of the American Society of Nephrology, ISSN: 10466673
Jean-Martin Wiederseiner; Juergen Muser; Thomas Lutz; Henry N. Hulter; Reto Krapf
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Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor
Molecular and Cellular Biology, ISSN: 02707306
Oliver M. Fischer; Stefan Hart; Andreas Gschwind; Norbert Prenzel; Axel Ullrich
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Creation and characterization of a mouse model of mandibular distraction osteogenesis
Bone, ISSN: 87563282
Tony D. Fang; Randall P. Nacamuli; Hanjoon M. Song; Kenton D. Fong; Stephen M. Warren; Ali Salim; Richard A. D. Carano; Ellen H. Filvaroff; Michael T. Longaker
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Novel role for netrins in regulating epithelial behavior during lung branching morphogenesis
Current Biology, ISSN: 09609822
Yuru Liu; Elke Stein; Timothy Oliver; Yong Li; William J. Brunken; Manuel Koch; Marc Tessier-Lavigne; Brigid L.M. Hogan
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Pharmacy benefits and the use of drugs by the chronically ill
JAMA - Journal of the American Medical Association, ISSN: 00987484
Dana P. Goldman; Geoffrey F. Joyce; Jose J. Escarce; Jennifer E. Pace; Matthew D. Solomon; Marianne Laouri; Pamela B. Landsman; Steven M. Teutsch
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Identification of Wnt responsive genes using a murine mammary epithelial cell line model system
BMC Developmental Biology, ISSN: 1471213X
Lisa A. Taneyhill; Diane Pennica
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Thyrotropin-Releasing Hormone Is Induced in the Left Ventricle of Rats with Heart Failure and Can Provide Inotropic Support to the Failing Heart
Circulation, ISSN: 00097322
Hongkui Jin; Grazyna Fedorowicz; Renhui Yang; Annie Ogasawara; Franklin V. Peale Jr.; Thinh Q. Pham; Nicholas F. Paoni
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The Dorsolateral Corticospinal Tract in Mice: An Alternative Route for Corticospinal Input to Caudal Segments following Dorsal Column Lesions
Journal of Comparative Neurology, ISSN: 00219967
Oswald Steward; Binhai Zheng; Carole Ho; Kim Anderson; Marc Tessier-Lavigne
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The ubiquitin ligase COP1 is a critical negative regulator of p53
Nature, ISSN: 00280836
David Dornan; Ingrid E. Wertz; Harumi Shimizu; David Arnott; Gretchen D. Frantz; Patrick Dowd; Karen M. O'Rourke; Koeppen; Vishva M. Dixit
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Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Brent Segelke; Mark Knapp; Saloumeh Kadkhodayan; Rod Balhorn; Bernhard Rupp
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N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: Structure-activity relationship of the benzoyl moiety
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Burdick; James C. Marsters Jr.; Ignacio Aliagas; Mark S. Stanley; Beresini; Clark; Robert S. McDowell; Thomas Gadek
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Expression of Toll-Like Receptor 2 on CD16+ Blood Monocytes and Synovial Tissue Macrophages in Rheumatoid Arthritis
Arthritis and Rheumatism, ISSN: 00043591
Mitsuhiro Iwahashi; Masahiro Yamamura; Tetsushi Aita; Akira Okamoto; Akiko Ueno; Norio Ogawa; Sachiko Akashi; Kensuke Miyake; Godowski; Hirofumi Makino
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Phage-display as a tool for quantifying protein stability determinants
European Journal of Biochemistry, ISSN: 00142956
Joanne D. Kotz; Christopher J. Bond; Andrea G Cochran
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Growth Hormone (GH) Replacement Therapy in Adult-Onset GH Deficiency: Effects on Body Composition in Men and Women in a Double-Blind, Randomized, Placebo-Controlled Trial
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Andrew R. Hoffman; Joyce Kuntze; Joyce Baptista; Howard B. A. Baum; Gerhard Baumann; Beverly M. K. Biller; Richard V. Clark; David Cook; Silvio E. Inzucchi; David Kleinberg; Anne Klibanski; Lawrence S. Phillips; E. Chester Ridgway; Richard J. Robbins; Janet Schlechte; Meeta Sharma; Michael O. Thorner; Mary Lee Vance
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Rab14 Is Involved in Membrane Trafficking between the Golgi Complex and Endosomes
Molecular Biology of the Cell, ISSN: 10591524
Jagath R. Junutula; Ann De Mazière; Andrew A. Peden; Karen E. Ervin; Raj J. Advani; Suzanne Van Dijk; Judith Klumperman; Richard H. Scheller
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Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques
International Journal of Toxicology, ISSN: 10915818 1092874X
Sandhya Ramanathan-Girish; Paul Catz; Moire R. Creek; Benjamin Wu; David Thomas; Donald J. Krogstad; Dibyendu De; Jon C. Mirsalis; Carol E. Green
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