Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 12251 - 12300 OF 15217 RESULTS

December 12, 1997

Heregulins and the ErbB-2/3/4 receptors in gliomas

Journal of Neuro-Oncology, ISSN: 0167594X

Manfred Westphal; Leonie Meima; Szonyi; Julie A. Lofgren; Meissner; Wolfgang Hamel; Nikolics; Mark X. Sliwkowski

December 9, 1997

Inhibition of HIV type 1 infectivity by constrained α-helical peptides: Implications for the viral fusion mechanism

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

J. Kevin Judice; Jeffrey Tom; Wei Huang; Wrin; Vennari; Christos J. Petropoulos; Robert S. McDowell

December 9, 1997

A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

James Verna; Adriana Lodder; Kyunghee Lee; Alicia Vagts; Roymarie Ballester

December 1, 1997

Therapeutic monoclonal as the treatment of allergic disease

Proceedings of the Western Pharmacology Society, ISSN: 00838969

Paula Jardieu

December 1, 1997

Engineered receptor cytoplasmic domains with fixed signal output: Probing mechanism with design

FASEB Journal, ISSN: 08926638

Andrea G Cochran

December 1, 1997

Hemodynamic effects of scatter factor in conscious rats

FASEB Journal, ISSN: 08926638

Hongkui Jin; Renhui Yang; Annie Ko; Ralph H. Schwall; Bunting

December 1, 1997

ErbB3 is required for normal cerebellar and cardiac development: A comparison with ErbB2- and heregulin-deficient mice

Development (Cambridge), ISSN: 09501991

Sharon Erickson; Sue O'Shea; Nazli Ghaboosi; Linda Loverro; Gretchen D. Frantz; Michele Bauer; Lucy Lu; Mark Moore

December 1, 1997

Potent biflnctional anticoagulants: kunitz domain - tissue factor fusion proteins

FASEB Journal, ISSN: 08926638

Geoffrey F. Lee

December 1, 1997

How integrins are activated

Nature, ISSN: 00280836

Lasky

December 1, 1997

Intravenous infusion of vascular endothelial growth factor (VEGF) substantially attenuates its hemodynamic effects

FASEB Journal, ISSN: 08926638

Renhui Yang; Bunting; Annie Ko; Keyt; Napoleone Ferrara; Hongkui Jin

December 1, 1997

Inhibition of angiogenesis by blocking vegf action: mutational analysis of vegf:receptor binding and epitope mapping of neutralizing antibodies

Fibrinolysis and Proteolysis, ISSN: 13690191

Keyt

December 1, 1997

Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors

American Journal of Pathology, ISSN: 00029440

Alicia M. Viloria Petit; Janusz Rak; Mien-Chie Hung; Patricia Rockwell; Neil Goldstein; Brian M. Fendly; Robert S. Kerbel

December 1, 1997

Hemodynamic effects of scatter factor in conscious rats

Journal of Cardiovascular Pharmacology, ISSN: 01602446

Renhui Yang; Bunting; Annie Ko; Ralph H. Schwall; Hongkui Jin

December 1, 1997

RhDNase I is a well characterized protein

Pharmaceutical Sciences, ISSN: 13566881

Quan; Cacia; John Frenz; O'Connor

December 1, 1997

Engineering hyperactive human DNASE I with over 4000-fold higher activity in human serum

Protein Engineering, ISSN: 02692139

Pan; Tony H. Dodge; Baker; Sinicropi; Lazarus

December 1, 1997

Identification of components of the cell death pathway

Fibrinolysis and Proteolysis, ISSN: 13690191

Vishva M. Dixit

December 1, 1997

Native fluorescence detection of recombinant human growth hormone resolve from E. coli cell paste extract by capillary zone electrophoresls

FASEB Journal, ISSN: 08926638

McNerney; Robert L. Bridenbaugh

December 1, 1997

Metabolic labeling for monitoring sialylation of recombinant proteins in growing chinese hamster ovary cell cultures

FASEB Journal, ISSN: 08926638

Santeli; Ryll Twang; Jane Gunson; Warner

December 1, 1997

A novel receptor for Apo2L/TRAIL contains a truncated death domain

Current Biology, ISSN: 09609822

Scot A. Marsters; James P. Sheridan; Pitti; Arthur Huang; Skubatch; Daryl T. Baldwin; Jean Q. Yuan; Austin L. Gurney; Goddard; Godowski; Avi Ashkenazi

December 1, 1997

Evaluation of ABRF-96SEQ: A sequence assignment exercise

Techniques in Protein Chemistry, ISSN: 10808914

Joseph Fernandez; Arie Admon; Karen De Jongh; Greg Grant; William J. Henzel; William Lane; Kathryn Stone; Barbara Merrill

December 1, 1997

Pharmacokinetics and dynamics of longer half-life and pai-1 resistant tissue plasminogen activator mutants: slow clearing molecules are not rapidly inhibited

Fibrinolysis and Proteolysis, ISSN: 13690191

Bruce A. Kevtt; Lea Berleau; Hung V. Nguyen; Stephen Epplerf; Nishit Modif

December 1, 1997

Redesigning antibodies

FASEB Journal, ISSN: 08926638

Presta

December 1, 1997

Hepatic clearance and metabolism of tnk-tpa, a long half-life variant of rt-PA

Fibrinolysis and Proteolysis, ISSN: 13690191

Geralyn G. Deguzman; Richardson; Keyt; Zioncheck

December 1, 1997

TNK-tissue plasminogen activator compared with frontloaded tpa in acute myocardial infarction: clinical update

Fibrinolysis and Proteolysis, ISSN: 13690191

Bruce A. Kevt

December 1, 1997

Deep-lung delivery of therapeutic proteins

CHEMTECH, ISSN: 00092703

John R. Patton

December 1, 1997

Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6

Journal of Immunology, ISSN: 00221767

Richards; Christine Kerr; Minoru Tanaka; Takahiko Hara; Atsushi Miyajima; Diane Pennica; Fernando Botelho; Langdon

December 1, 1997

Downregulation of natriuretic peptide C-receptor protein in the hypertrophied ventricle of the aortovenocaval fistula rat

Cardiovascular Research, ISSN: 00086363

Lesley A. Brown; Richard A.D. Rutherford; Derek J.R. Nunez; John Wharton; David G Lowe; Martin R. Wilkins

December 1, 1997

Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis

Journal of Immunology, ISSN: 00221767

Encarnacion Montecino-Rodriguez; Ross Clark; Powell-Braxton; Kenneth Dorshkind

December 1, 1997

Minimization of a protein binding domain

FASEB Journal, ISSN: 08926638

Andrew Braisted

December 1, 1997

Mannose phosphorylat10n on secretory glycoproteins

FASEB Journal, ISSN: 08926638

Nase; Nishikawa; Walter Gregory; Akash Nanda; John Frenz; Stuart Kornfeld

December 1, 1997

High-dose aldesleukin in renal cell carcinoma: Long-term survival update

Cancer Journal from Scientific American, ISSN: 10814442

Richard I. Fisher; Steven A. Rosenberg; Mario Sznol; David R. Parkinson; Gwendolyn Fyfe

December 1, 1997

The resurgence of analytical ultracentrifugation: An old technique applied to a new technology

Proceedings of SPIE - The International Society for Optical Engineering, ISSN: 0277786X

Steven J. Shire; Jun Liu

December 1, 1997

Fourier-transform infrared spectroscopic analysis of the secondary structure of recombinant humanized immunoglobulin G

Pharmaceutical Sciences, ISSN: 13566881

Henry R. Costantino; Andya; Steven J. Shire; Chung C. Hsu

December 1, 1997

Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation

FASEB Journal, ISSN: 08926638

Yung-Hsiang Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner

December 1, 1997

Engineering hyperactive human dnase i with over 4000-fold higher activity in human serum by altering its functional mechan1sm

FASEB Journal, ISSN: 08926638

Clark Q. Pan; Tony H. Dodge; Baker; Sinicropi; Lazarus

December 1, 1997

Rapid analytical tryptic mapping of a recominant chimeric monoclonal antibody and method validation challenges

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kannan; Michael G. Mulkerrin; Zhang; Gray; Steinharter; Sewerin; Baffi; Reed J. Harris; Karunatilake

December 1, 1997

Data handling issues in a gmp environment

FASEB Journal, ISSN: 08926638

Nolan

December 1, 1997

Solution structure of the EGF-1 domain from blood coagulation factor VII by NMR spectroscopy: The effect of O-fucosylation

FASEB Journal, ISSN: 08926638

Kao; Geoffrey F. Lee; Yang Wanga; Robert F. Kelley; Spellman; Laura Lerner

December 1, 1997

Validation of an HPLC method for the analysis of the charge heterogeneity of the recombinant monoclonal antibody IDEC-C2B8 after papain digestion

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Kathy Moorhouse; Wassim Nashabeh; James Deveney; Nancy Bjork; Michael G. Mulkerrin; Thomas C. Ryskamp

November 28, 1997

Crystal structure at 1.7 Å resolution f VEGF in complex with domain 2 of the Fit-1 receptor

Cell, ISSN: 00928674

Wiesmann; Fuh; Hans W. Christinger; Eigenbrot; James A. Wells; De Vos

November 28, 1997

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL- 1 signaling

Science, ISSN: 00368075

Marta Muzio; Jian Ni; Ping Feng; Vishva M. Dixit

November 20, 1997

Interaction of human IgE with soluble forms of IgE high affinity receptors

Pharmaceutical Research, ISSN: 07248741

Jun Liu; Jane Ruppel; Steven J. Shire

November 14, 1997

Caspases: Intracellular signaling by proteolysis

Cell, ISSN: 00928674

Guy S. Salvesen; Vishva M. Dixit

November 13, 1997

A link between axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand Ephrin-A5/AL-1

Cell and Tissue Research, ISSN: 0302766X

Caras

November 13, 1997

Hepatocyte-derived cell lines express a functional receptor for cardiotrophin-1

European Cytokine Network, ISSN: 11485493

Olivier Robledo; Catherine Guillet; Sylvie Chevalier; Maryvonne Fourcin; Josy Froger; Annick Pouplard-Barthelaix; Diane Pennica; Hugues Gascan

November 7, 1997

Structural plasticity in a remodeled protein-protein interface

Science, ISSN: 00368075

Shane Atwell; Ultsch; De Vos; James A. Wells

November 1, 1997

The effect of inhaling a dry powder of sodium chloride on the airways of asthmatic subjects

European Respiratory Journal, ISSN: 09031936

Anderson; Spring; Moore; Rodwell; Spalding; Gonda; Chan; Andrew J. Walsh; Clark

November 1, 1997

Capillary electrophoresis based immunoassays: A critical review

Electrophoresis, ISSN: 01730835

Dieter Schmalzing; Wassim Nashabeh

November 1, 1997

The use of sequential high-performance liquid chromatography and capillary zone electrophoresis to separate the glycosylated peptides from recombinant tissue plasminogen activator to a detailed level of microheterogeneity

Analytical Biochemistry, ISSN: 00032697

Shiaw-Lin Wu

October 25, 1997

Potent α4β1 peptide antagonists as potential anti-inflammatory agents

Journal of Medicinal Chemistry, ISSN: 00222623

Jackson; Quan; Dean R. Artis; Thomas E. Rawson; Brent Blackburn; Martin Struble; Geraldine Fitzgerald; Kathryn S. Chan; Sheldon Mullins; Burnier; Wayne J. Fairbrother; Clark; Maureen Berisini; Henry Chui; Renz; Susan Jones; Sherman Fong

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