Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 1301 - 1350 OF 15414 RESULTS

Kinetic, ESI-CID-MS, and Computational Studies of π-Allyliridium C,O-Benzoate-Catalyzed Allylic Amination: Understanding the Effect of Cesium Ion
ACS Catalysis, ISSN: 21555435
Woo-Ok Jung; Binh Khanh Mai; Minjin Yoo; Samuel W. J. Shields; Jason R. Zbieg; Craig E. Stivala; Peng Liu; Michael J. Krische
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Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet-Spengler Condensation
Organic Process Research and Development, ISSN: 1520586X 10836160
Jie Xu; Cheol K. Chung; Andrew McClory; Kyle A. Mack; Michael E. Dalziel; Alec Fettes; Kyle Clagg; Ngiap-Kie Lim; Georg Wuitschik; Christian Jenny; Laure Finet; Michael Kammerer; Haiming Zhang; Remy Angelaud; Francis Gosselin
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First-Generation Asymmetric Synthesis of the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) Featuring a Highly Efficient Pictet-Spengler Reaction and a C-N Coupling Reaction
Organic Process Research and Development, ISSN: 1520586X 10836160
Jie Xu; Kyle Clagg; Ngiap-Kie Lim; Georg Wuitschik; Cheol K. Chung; Haiming Zhang; Francis Gosselin
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The evolution, evolvability and engineering of gene regulatory DNA
Nature, ISSN: 14764687 00280836
Eeshit Dhaval Vaishnav; Carl G. de Boer; Jennifer Molinet; Moran Yassour; Lin Fan; Xian Adiconis; Dawn A. Thompson; Joshua Z. Levin; Francisco A. Cubillos; Aviv Regev
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Three-Component Coupling of Arenes, Ethylene, and Alkynes Catalyzed by a Cationic Bis(phosphine) Cobalt Complex: Intercepting Metallacyclopentenes for C-H Functionalization
Journal of the American Chemical Society, ISSN: 15205126 00027863
William G. Whitehurst; Junho Kim; Stefan G. Koenig; Paul J. Chirik
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Long-Term Safety and Efficacy of Tocilizumab in Early Systemic Sclerosis-Interstitial Lung Disease: Open-Label Extension of a Phase 3 Randomized Controlled Trial
American Journal of Respiratory and Critical Care Medicine,
Dinesh Khanna; Celia J.F. Lin; Daniel E. Furst; Bridget Wagner; Mauro Zucchetto; Ganesh Raghu; Fernando J. Martinez; Goldin; Jeffrey N. Siegel; Christopher P. Denton
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Long-Term Safety and Efficacy of Tocilizumab in Early Systemic Sclerosis–Interstitial Lung Disease :Open-Label Extension of a Phase 3 Randomized Controlled Trial
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Dinesh Khanna; Celia J.F. Lin; Daniel E. Furst; Bridget Wagner; Mauro Zucchetto; Ganesh Raghu; Fernando J. Martinez; Goldin; Jeffrey N. Siegel; Christopher P. Denton
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Long-Term Safety and Efficacy of Tocilizumab in Early Systemic Sclerosis-Interstitial Lung Disease: Open-Label Extension of a Phase 3 Randomized Controlled Trial
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970
Dinesh Khanna; Celia J.F. Lin; Daniel E. Furst; Bridget Wagner; Mauro Zucchetto; Ganesh Raghu; Fernando J. Martinez; Goldin; Jeffrey N. Siegel; Christopher P. Denton
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Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer
Cancer Cell, ISSN: 18783686 15356108
Namrata S. Patil; Barzin Y. Nabet; Sören Müller; Koeppen; Wei Zou; Jennifer M. Giltnane; Amelia Au-Yeung; Shyam Srivats; Jason H. Cheng; Chikara Takahashi; Patricia De Almeida; Avantika S. Chitre; Jane L. Grogan; Linda Rangell; Sangeeta Jayakar; Maureen Peterson; Allison W. Hsia; William E. O'Gorman; Ballinger; Romain Banchereau; David S. Shames
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Impact of Immune Checkpoint Inhibitors on COVID-19 Severity in Patients with Cancer
Oncologist, ISSN: 1549490X
Ruoding Tan; Cindy Yun; Seetasith; Daniel Sheinson; Robert Walls; Innocent Ngwa; Josina C. Reddy; Qing Zhang; Matthew H Secrest; Peter Lambert; Khaled Sarsour
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Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Vishal A. Verma; Lan Wang; Sharada Labadie; Jun Liang; Benjamin D. Sellers; Jian Wang; Liting Dong; Qiuyue Wang; Shuang Zhang; Zhongya Xu; Yexia Zhang; Yanan Niu; Xinxin Wang; John Wai; Michael F. T. Koehler; Huiyong Hu; Mary Kate Alexander; Mireille Nishiyama; Anh Miu; Yiming Xu; Jodie Pang; Anand K. Katakam; Mike Reichelt; Cary D. Austin; Hoangdung Ho; Jian Payandeh; Christopher M. Koth
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Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
Immunity, ISSN: 10974180 10747613
Karl L. Banta; Xiaozheng Xu; Avantika S. Chitre; Amelia Au-Yeung; Chikara Takahashi; William E. O'Gorman; Thomas D Wu; Stephanie Mittman; Rafael Cubas; Laetitia Comps-Agrar; Amit Fulzele; Eric J. Bennett; Jane L. Grogan; Enfu Hui; Eugene Y. Chiang; Ira Mellman
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Effect of magnesium stearate surface coating method on the aerosol performance and permeability of micronized fluticasone propionate
International Journal of Pharmaceutics, ISSN: 18733476 03785173
Vineet Kumar; Bharti Sethi; Evelyn Yanez; Dennis H. Leung; Yashwardhan Y. Ghanwatkar; Jonathan Cheong; Jerry Tso; Ajit S. Narang; Karthik Nagapudi; Ram I. Mahato
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A multi-dimensional integrative scoring framework for predicting functional variants in the human genome
American Journal of Human Genetics, ISSN: 15376605 00029297
Xihao Li; Godwin Yung; Hufeng Zhou; Ryan Sun; Zilin Li; Kangcheng Hou; Martin Jinye Zhang; Yaowu Liu; Theodore Arapoglou; Chen Wang; Iuliana Ionita-Laza; Xihong Lin
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Structural architecture of the human NALCN channelosome
Nature, ISSN: 14764687 00280836
Marc Kschonsak; Han Chow Chua; Claudia Weidling; Nourdine Chakouri; Cameron Noland; Katharina Schott; Timothy Chang; Christine Tam; Nidhi Patel; Christopher P. Arthur; Alexander Leitner; Manu Ben-Johny; Claudio Ciferri; Stephan Alexander Pless; Jian Payandeh
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Development of Software Workflow for the Rapid Detection of Cross-Linked Dipeptides
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Aaron T. Wecksler; Lawrie Veale; Maria Basanta-Sanchez; Marshall Bern
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Assessment of the Cost-Effectiveness of HER2-Targeted Treatment Pathways in the Neoadjuvant Treatment of High-Risk HER2-Positive Early-Stage Breast Cancer
Advances in Therapy, ISSN: 18658652 0741238X
Jesse A. Sussell; Joshua A. Roth; Craig S. Meyer; Fung; Svenn A. Hansen
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Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance)
Journal of Clinical Oncology, ISSN: 15277755 0732183X
En Cheng; Fang-Shu Ou; Chao Ma; Donna Spiegelman; Sui Zhang; Xin Zhou; Tiffany M. Bainter; Leonard Saltz; Donna Niedzwiecki; Robert J. Mayer; Renaud Whittom; Alexander Hantel; Al B. Benson; Daniel Atienza; Michael Messino; Hedy L. Kindler; Edward L. Giovannucci; Erin L. Van Blarigan; Justin C. Brown; Kimmie Ng; Cary P. Gross; Jeffrey A. Meyerhardt; Charles Fuchs
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Atezolizumab Treatment of Tumors with High Tumor Mutational Burden from MyPathway, a Multicenter, Open-Label, Phase IIa Multiple Basket Study
Cancer Discovery, ISSN: 21598290 21598274
Claire F Friedman; John Hainsworth; Razelle Kurzrock; David Spigel; Howard A. Burris; Christopher J. Sweeney; Funda Meric-Bernstam; Yong Wang; Jonathan Levy; Jessica Grindheim; David S. Shames; Katja Schulze; Arisha Patel; Charles Swanton
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Structural basis for HCMV Pentamer receptor recognition and antibody neutralization
Science Advances, ISSN: 23752548
Marc Kschonsak; Matthew C. Johnson; Rachel Schelling; Evan M. Green; Lionel Rouge; Hoangdung Ho; Nidhi Patel; Cem Kilic; Edward Kraft; Christopher P. Arthur; Alexis Rohou; Laetitia Comps-Agrar; Nadia Martinez-Martin; Laurent Perez; Jian Payandeh; Claudio Ciferri
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Atezolizumab Treatment of Tumors with High Tumor Mutational Burden from MyPathway, a Multicenter, Open-Label, Phase IIa Multiple Basket Study
Cancer Discovery, ISSN: 21598290
Claire F Friedman; John Hainsworth; Razelle Kurzrock; David Spigel; Howard A. Burris; Christopher J. Sweeney; Funda Meric-Bernstam; Yong Wang; Jonathan Levy; Jessica Grindheim; David S. Shames; Katja Schulze; Arisha Patel; Swanton
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In Vivo Modeling of Tumor Heterogeneity for Immuno-Oncology Studies: Failures, Improvements, and Hopes
Current Protocols, ISSN: 26911299
Ashley V. DiMarco; Danilo Maddalo
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Survival in Young-Onset Metastatic Colorectal Cancer: Findings from Cancer and Leukemia Group B (Alliance)/SWOG 80405
Journal of the National Cancer Institute, ISSN: 14602105 00278874
Marla Lipsyc-Sharf; Sui Zhang; Fang-Shu Ou; Chao Ma; Nadine Jackson McCleary; Donna Niedzwiecki; I-Wen Chang; Heinz-Josef Lenz; Charles D. Blanke; Sorbarikor Piawah; Katherine Van Loon; Tiffany M. Bainter; Alan P. Venook; Robert J. Mayer; Charles Fuchs; Federico Innocenti; Andrew B. Nixon; Richard M. Goldberg; O'Reilly; Jeffrey A. Meyerhardt; Kimmie Ng
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Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
Aging Cell, ISSN: 14749726 14749718
Dafni Chondronasiou; Diljeet Gill; Lluc Mosteiro; Rocío G. Urdinguio; Antonio Berenguer-Llergo; Mònica Aguilera; Sylvere Durand; Fanny Aprahamian; Nitharsshini Nirmalathasan; María Abad; Daniel E. Martin-Herranz; Camille Stephan-Otto Attolini; Neus Prats; Guido Kroemer; Mario F. Fraga; Wolf Reik; Manuel Serrano
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Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer
Clinical Cancer Research, ISSN: 15573265 10780432
Shi; Julia Wulfkuhle; Malgorzata Nowicka; Rosa I. Gallagher; Saura; Nuciforo; Calvo; Andersen; Passos-Coelho; Gil Gil; Bermejo; Debra A. Pratt; Eva Ciruelos; Patricia Villagrasa; Matthew Wongchenko; Emanuel Petricoin; Oliveira; Isakoff
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Prognostic and Predictive Biomarkers in Patients with Coronavirus Disease 2019 Treated with Tocilizumab in a Randomized Controlled Trial∗
Critical Care Medicine, ISSN: 15300293 00903493
Jennifer A. Tom; Min Bao; Larry Tsai; Aditi Qamra; David Summers; Montserrat Carrasco-Triguero; Jacqueline McBride; Carrie M. Rosenberger; Celia J.F. Lin; William Stubbings; Kevin G. Blyth; Jordi Carratalà; Bruno François; Thomas Benfield; Derrick Haslem; Paolo Bonfanti; Cor H. van der Leest; Nidhi Rohatgi; Lothar Wiese; Charles Edouard Luyt; Farrah Kheradmand; Ivan O. Rosas; Fang Cai
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Joint MRI T1 Unenhancing and Contrast-enhancing Multiple Sclerosis Lesion Segmentation with Deep Learning in OPERA Trials
Radiology, ISSN: 15271315 00338419
Anitha Priya Krishnan; Zhuang Song; David Clayton; Laura Gaetano; Xiaoming Jia; De Crespigny; Thomas Bengtsson; Richard A. D. Carano
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Diet- and Lifestyle-Based Prediction Models to Estimate Cancer Recurrence and Death in Patients With Stage III Colon Cancer (CALGB 89803/Alliance)
Journal of Clinical Oncology, ISSN: 15277755 0732183X
En Cheng; Fang-Shu Ou; Chao Ma; Donna Spiegelman; Sui Zhang; Xin Zhou; Tiffany M. Bainter; Leonard Saltz; Donna Niedzwiecki; Robert J. Mayer; Renaud Whittom; Alexander Hantel; Al Benson; Daniel Atienza; Michael Messino; Hedy L. Kindler; Edward L. Giovannucci; Erin L. Van Blarigan; Justin C. Brown; Kimmie Ng; Cary P. Gross; Jeffrey A. Meyerhardt; Charles Fuchs
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Corrigendum to “A novel method to produce synthetic murine CXCL10 for efficient screening of functional variants” [Bioorg. Chem. 116 (2021) 105376] (Bioorganic Chemistry (2021) 116, (S0045206821007537), (10.1016/j.bioorg.2021.105376))
Bioorganic Chemistry, ISSN: 10902120 00452068
Jérémie Decalf; Jeffrey Tom; Elaine Mai; Hilda Hernandez-Barry; Cameron Noland; Breanna S. Vollmar; Alice Li; Hong Li; Daniel Xie; Lunchao Zhu; Jian Payandeh; Kelly M. Loyet; Cong Wu; Laetitia Comps-Agrar; Christine Moussion; Matthew L. Albert; Aimin Song
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Engineering interferons and interleukins for cancer immunotherapy
Advanced Drug Delivery Reviews, ISSN: 18728294 0169409X
Patrick Holder; Shion A. Lim; Christine S. Huang; Preeti Sharma; Yavuz S. Dagdas; Beyza Bulutoglu; Jonathan T. Sockolosky
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NTRK gene fusions are detected in both secretory and non-secretory breast cancers
Pathology International, ISSN: 14401827 13205463
Sophia L. Maund; Ethan S. Sokol; Armande Ang Houle; Jeffrey S. Ross; Wilson
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Update to improve reproducibility and interpretability: A response to “Machine Learning for Tumor Growth Inhibition”
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Phyllis Chan; James Lu; Rene Bruno; Jin Yan Jin
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Assessment of the Cost-Effectiveness of HER2-Targeted Treatment Pathways in the Neoadjuvant Treatment of High-Risk HER2-Positive Early-Stage Breast Cancer
Advances in Therapy, ISSN: 18658652 0741238X
Jesse Sussell; Joshua A. Roth; Craig S. Meyer; Fung; Svenn A. Hansen
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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Binqing Wei; Kirk D. Robarge; Sharada Labadie; Jinhua Chen; Laura B. Corson; Antonio G. DiPasquale; Peter Dragovich; Eigenbrot; Marie Evangelista; Benjamin P. Fauber; Anna Hitz; Rebecca Hong; Kwong Wah Lai; Wenfeng Liu; Shuguang Ma; Shiva Malek; Thomas O'Brien; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Ultsch; Zijin Xu; Ivana Yen; Dong Yu; Qin Yue; Aihe Zhou; Hans E. Purkey
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Adherence to and Persistence with Disease-Modifying Therapies for Multiple Sclerosis Over 24 Months: A Retrospective Claims Analysis
Neurology and Therapy, ISSN: 21936536 21938253
Gabriel Pardo; Elmor D. Pineda; Carmen D. Ng; Komal Bawa; Daniel Sheinson; Nicole G. Bonine
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Gaussian process modeling for dissolution curve comparisons
Journal of the Royal Statistical Society. Series C: Applied Statistics, ISSN: 14679876 00359254
Tony Pourmohamad; Cristian Oliva-Aviles; Robert Richardson
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An Interlaboratory Comparison on the Characterization of a Sub-micrometer Polydisperse Particle Dispersion
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Kurt D. Benkstein; Gurusamy Balakrishnan; Ashwinkumar Bhirde; Pascal Chalus; Tapan K. Das; Ngoc Do; David L. Duewer; Nazar Filonov; Fook Chiong Cheong; Patrick Garidel; Nicole S. Gill; Adam D. Grabarek; David G. Grier; Judith Hadley; Andrew D. Hollingsworth; Wesley W. Howard; Maciej Jarzębski; Wim Jiskoot; Sambit Kar; Vikram Kestens; Harshit Khasa; Yoen Joo Kim; Atanas Koulov; Anja Matter; Laura A. Philips; Christine Probst; Yannic Ramaye; Theodore W. Randolph; Dean C. Ripple; Stefan Romeijn; Miguel Saggu; Franziska Schleinzer; Jared R. Snell; Jan “Kuba” Tatarkiewicz; Heather Anne Wright; Dennis T. Yang
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Archway Randomized Phase 3 Trial of the Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration
Ophthalmology, ISSN: 15494713 01616420
Nancy M. Holekamp; Peter A. Campochiaro; Margaret A. Chang; Daniel M. Miller; Dante Joseph Pieramici; Anthony P. Adamis; Christopher Brittain; Erica Evans; Derrick Kaufman; Katie F. Maass; Shienal Patel; Shrirang Ranade; Natasha Singh; Giulio Barteselli; Carl D. Regillo
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Long-term efficacy and safety of omalizumab for nasal polyposis in an open-label extension study
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Philippe Gevaert; Rebecca Saenz; Jonathan Corren; Joseph Han; Joaquim Mullol; Stella E. Lee; Randall A. Ow; Rui Zhao; Monet Howard; Kit Wong; Lutaf Islam; Monica Ligueros-Saylan; Theodore A. Omachi; Claus Bachert
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Disease-modifying effects of ranibizumab for central retinal vein occlusion
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN: 1435702X 0721832X
Jason M. Huang; Rahul N. Khurana; Avanti Ghanekar; Pin-Wen Wang; Bann-Mo Day; Barbara Blodi; Amitha Domalpally; Carlos Quezada-Ruiz; Michael S. Ip
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YOSEMITE and RHINE: Phase 3 Randomized Clinical Trials of Faricimab for Diabetic Macular Edema: Study Design and Rationale
Ophthalmology Science, ISSN: 26669145
Nicole Eter; Rishi Singh; Francis Abreu; Kemal Asik; Karen Basu; Caroline R. Baumal; Andrew Chang; Karl G. Csaky; Zdenka Haskova; Hugh Lin; Carlos Quezada Ruiz; Paisan Ruamviboonsuk; David Silverman; Charles C. Wykoff; Jeffrey R. Willis
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Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison
International Journal of Toxicology, ISSN: 1092874X 10915818
Mylène Pouliot; Bussiere; Aldo Coppi; Kristen Holbrook; Amy Shelton; Samantha Sparapani; Jonathan M. Maher; Tanja S. Zabka; Emmanuel Boulay; Simon Authier
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Comparison of logP and logD correction models trained with public and proprietary data sets
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Ignacio Aliagas; Alberto Gobbi; Man-Ling Lee; Benjamin D. Sellers
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Risk profiling of patients with relapsed/refractory diffuse large B-cell lymphoma by measuring circulating tumor DNA
Blood advances, ISSN: 24739537 24739529
Alex F. Herrera; Samuel Tracy; Brandon Croft; Stephen Opat; Jill M. Ray; Alex Lovejoy; Lisa Musick; Joseph N. Paulson; Laurie H. Sehn; Yanwen Jiang
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Atezolizumab Treatment of Tumors with High Tumor Mutational Burden from MyPathway, a Multicenter, Open-Label, Phase IIa Multiple Basket Study
Cancer Discovery, ISSN: 21598290 21598274
Claire F Friedman; John Hainsworth; Razelle Kurzrock; David Spigel; Howard A. Burris; Christopher J. Sweeney; Funda Meric-Bernstam; Yong Wang; Jonathan Levy; Jessica Grindheim; David S. Shames; Katja Schulze; Arisha Patel; Swanton
View on Scopus
Prognostic and Predictive Biomarkers in Patients with Coronavirus Disease 2019 Treated with Tocilizumab in a Randomized Controlled Trial∗
Critical Care Medicine, ISSN: 15300293 00903493
Jennifer A. Tom; Bao; Larry Tsai; Aditi Qamra; David Summers; Montserrat Carrasco-Triguero; Jacqueline McBride; Carrie M. Rosenberger; Celia J.F. Lin; William Stubbings; Kevin G. Blyth; Jordi Carratalà; Bruno François; Thomas Benfield; Derrick Haslem; Paolo Bonfanti; Cor H. van der Leest; Nidhi Rohatgi; Lothar Wiese; Charles Edouard Luyt; Farrah Kheradmand; Ivan O. Rosas; Fang Cai
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Bax and Bak knockout apoptosis-resistant Chinese hamster ovary cell lines significantly improve culture viability and titer in intensified fed-batch culture process
Biotechnology Progress, ISSN: 15206033 87567938
Danming Tang; Cynthia Lam; Niels Bauer; Simon Auslaender; Snedecor; Mike Laird; Shahram Misaghi
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Spatial components of molecular tissue biology
Nature Biotechnology, ISSN: 15461696 10870156
Giovanni Palla; David S. Fischer; Aviv Regev; Fabian J. Theis
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MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging
Nature Methods, ISSN: 15487105 15487091
Denis Schapiro; Artem Sokolov; Clarence Yapp; Yu-An Chen; Jeremy L. Muhlich; Joshua Hess; Allison L. Creason; Ajit J. Nirmal; Gregory J. Baker; Maulik K. Nariya; Jia-Ren Lin; Zoltan Maliga; Connor A. Jacobson; Matthew W. Hodgman; Juha Ruokonen; Samouil L. Farhi; Domenic Abbondanza; Eliot T. McKinley; Daniel Persson; Courtney Betts; Shamilene Sivagnanam; Aviv Regev; Jeremy Goecks; Robert J. Coffey; Lisa Coussens; Sandro Santagata; Peter K. Sorger
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Single-cell profiling of proteins and chromatin accessibility using PHAGE-ATAC
Nature Biotechnology, ISSN: 15461696 10870156
Evgenij Fiskin; Caleb A. Lareau; Leif S. Ludwig; Gökcen Eraslan; Feimei Liu; Aaron M. Ring; Ramnik J. Xavier; Aviv Regev
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