Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 13501 - 13550 OF 15572 RESULTS

The unexpected presence of hydroxylysine in non-collagenous proteins
Techniques in Protein Chemistry, ISSN: 10808914
Michael S. Molony; Wu; Lene K. Keyt; Reed J. Harris
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Exploring the Role of the Solvent in the Denaturation of a Protein: A Molecular Dynamics Study of the DNA Binding Domain of the 434 Repressor
Biochemistry, ISSN: 15204995 00062960
Celia A. Schiffer; Volker Dötsch; Kurt Wüthrich; Wilfred F. Van Gunsteren
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Structural and functional epitopes in the growth hormone receptor complex: Can information from large molecules lead to the design of small molecule mimetics?
Nature Biotechnology, ISSN: 0733222X
James A. Wells
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Cloning of the Murine Counterpart of the Tumor-Associated Antigen H-L6: Epitope Mapping of the Human and Murine L6 Antigens
Biochemistry, ISSN: 15204995 00062960
Caroline P. Edwards; Andrew G. Farr; John S. Marken; Andrew Nelson; Jürgen Bajorath; Karl Erik Hellstrom; Ingegerd Hellstrom; Alejandro Aruffo
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Anti-IgE therapy
Current Opinion in Immunology, ISSN: 09527915
Paula Jardieu
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Analysis of the Factor Vila Binding Site on Human Tissue Factor: Effects of Tissue Factor Mutations on the Kinetics and Thermodynamics of Binding
Biochemistry, ISSN: 15204995 00062960
Robert F. Kelley; Kimberly E. Costas; Mark P. O'Connell; Lazarus
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Structure-Based Design from Flexible Ligands
Annual Reports in Medicinal Chemistry, ISSN: 00657743
Robert S. McDowell; Dean R. Artis
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Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
EMBO Journal, ISSN: 02614189
Yi-Li Yang; Luiz F. L. Reis; Jovan Paylovic; Sano Aguzzi; Reinhold Schäfer; Aseem Kumar; Bryan R. G. Williams; Michel Aguet; Charles Weissmann
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Dissection of the Extracellular Human Interferon γ Receptor α-Chain into two Immunoglobulin-like Domains. Production in an Escherichia coli Thioredoxin Gene Fusion Expression System and Recognition by Neutralizing Antibodies
Biochemistry, ISSN: 15204995 00062960
Geoffrey Williams; Nicole Ruegg; Ashley Birch; Christoph Weber; Klaus Hofstädter; John A. Robinson; Michel Aguet; Gianni Garotta; Daniel Schlatter; Walter Huber
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X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp
Journal of Molecular Biology, ISSN: 00222836
Axel J. Scheidig; Sybille M. Franken; John E.T. Corrie; Gordon P. Reid; Alfred Wittinghofer; Emil F. Pai; Roger S. Goody
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Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families
American Journal of Human Genetics, ISSN: 00029297
Friedman; Szabo; Elizabeth A. Ostermeyer; Patrick Dowd; Lesley Butler; Tari Park; Ming K. Lee; Ellen L. Goode; Sarah E. Rowell; Mary-Claire King
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Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA
Science, ISSN: 00368075
Olivier Cases; Isabelle Seif; Joseph Grimsby; Patricia Gaspar; Kevin Chen; Sandrine Pournin; Ulrike Müller; Michel Aguet; Charles Babinet; Jean Chen Shih; Edward De Maeyer
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Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation
Neuron, ISSN: 08966273
Winslow; Paul Moran; Janet Valverde; Shih; Jean Q. Yuan; Suzy C. Wong; Siao Ping Tsai; Goddard; William J. Henzel; Franz Hefti; Klaus D. Beck; Caras
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The influence of heregulins on human Schwann cell proliferation
Journal of Neuroscience, ISSN: 02706474
Allan D. O. Levi; Richard P. Bunge; Julie A. Lofgren; Leonie Meima; Franz Hefti; Nikolics; Mark X. Sliwkowski
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Similar but nonidentical amino acid residues on vascular cell adhesion molecule-1 are involved in the interaction with α4β1 and α4β7 under different activity states
Journal of Immunology, ISSN: 00221767
Chiu; Crowe; Renz; Presta; Susan Jones; Irving L. Weissman; Sherman Fong
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Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
Journal of Clinical Investigation, ISSN: 00219738
Robert S. Warren; Hui Yuan; Mary R. Matli; Nancy Gillett; Napoleone Ferrara
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Structuraldeterminants of calcium signaling by RGD peptidesin rat osteoclasts: Integrin-dependent and -independent actions
Experimental Cell Research, ISSN: 00144827
Shankar; Thomas Gadek; Burdick; Ian Davison; Mason; Horton
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NGF receptor expression in sensory neurons develops normally in embryos lacking NGF
Developmental Biology, ISSN: 00121606
Alun M. Davies; Sean Wyatt; Merry Nishimura; Phillips
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Neutrophilia in mice that lack the murine IL-8 receptor homolog
Science, ISSN: 00368075
Shuster; Marcus E. Kehrli Jr.; Mark R. Ackermann; Mark Moore; Cacalano; William I. Wood; Edward Bailish
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Aequorea green fluorescent protein analysis by flow cytometry
Communications in Clinical Cytometry, ISSN: 10970320 01964763
J. Dezz Ropp; Christopher J. Donahue; David Wolfgang-Kimball; Jeff Hooley; James Y. W. Chin; Robert A. Hoffman; R. Andrew Cuthbertson; Kenneth D. Bauer
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Buffer exchange using size exclusion chromatography, countercurrent dialysis, and tangential flow filtration: Models, development, and industrial application
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Ronald T. Kurnik; Audrey W. Yu; Gregory S. Blank; Arlene R. Burton; David Smith; Atul M. Athalye; Robert Van Reis
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Kidney as a major clearance organ for recombinant human interleukin‐1 receptor antagonist
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Dong‐Chool Kim; Barbara Reitz; David F. Carmichael; Duane C. Bloedow
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Truncated and Catalytic Isoforms of trkB are Co‐expressed in Neurons of Rat and Mouse CNS
European Journal of Neuroscience, ISSN: 14609568 0953816X
Armanini; McMahon; Sutherland; David L. Shelton; Phillips
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Adverse event data collection and reporting: A discussion of two grey areas
Therapeutic Innovation and Regulatory Science, ISSN: 21684804 21684790
Nickas
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Regional changes of ciliary neurotrophic factor and nerve growth factor levels in post mortem spinal cord and cerebral cortex from patients with motor disease
Nature Medicine, ISSN: 1546170X 10788956
Anand; Parrett; Martin; Zeman; Foley; Swash; Leigh; Jesse M. Cedarbaum; Lindsay; Williams-Chestnut; Sinicropi
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The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trka-igg fusion molecule
Nature Medicine, ISSN: 1546170X 10788956
McMahon; David L. H. Bennett; John V. Priestley; David L. Shelton
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Online education program helps teachers teach science
Bio/Technology, ISSN: 0733222X
Geoff Teeter
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Removal of sialic acid from a glycoprotein in CHO cell culture supernatant by action of an extracellular cho cell sialidase
Bio/Technology, ISSN: 0733222X
Michael J. Gramer; Charles F. Goochee; Valerie Y. Chock; Dave Brousseau; Mary B. Sliwkowski
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CD40 ligand has potent antiviral activity
Nature Medicine, ISSN: 1546170X 10788956
Janet Ruby; Horst Bluethmann; Michel Aguet; Ian A. Ramshaw
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A hot spot of binding energy in a hormone-receptor interface
Science, ISSN: 00368075
Clackson; James A. Wells
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Ligand-induced autoregulation of IFN-γ receptor β chain expression in T helper cell subsets
Science, ISSN: 00368075
Bach; Susanne J. Szabo; Anand S. Dighe; Avi Ashkenazi; Michel Aguet; Kenneth M. Murphy; Schreiber
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Myocardial infarction and the nondiagnostic ECG: Strategies to meet the challenges
Journal of Emergency Nursing, ISSN: 15272966 00991767
Katherine A. Littrell; Donna Walker; Cindy Worthy
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A simulation study of estimators for rates of change in longitudinal studies with attrition
Statistics in Medicine, ISSN: 10970258 02776715
Wang-Clow; Mary Lange; Laird; Ware
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Expression of the genes encoding the rat renal Insulin-Like growth factor-I system
Journal of the American Society of Nephrology, ISSN: 10466673
Ralph Rabkin; Michael Brody; Lucy Lu; Curtis Chan; Allison M. Shaheen; Nancy Gillett
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Novel inherited mutations and variable expressivity of BRCA1 alleles, including the founder mutation 185delAG in Ashkenazi Jewish families
American Journal of Human Genetics, ISSN: 00029297
Lori S. Friedman; Szabo; Elizabeth A. Ostermeyer; Patrick Dowd; Lesley Butler; Tari Park; Ming K. Lee; Ellen L. Goode; Sarah E. Rowell; Mary-Claire King
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Subtiligase: A tool for semisynthesis of proteins
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Thomas K. Chang; Jackson; Burnier; James A. Wells
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Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Tory M. Hagen; Shaonan Huang; John T. Curnutte; Patricia Fowler; Violeta Martinez; Carol M. Wehr; Bruce N. Ames; Francis V. Chisari
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The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin
EMBO Journal, ISSN: 02614189
Urfer; Tsoulfas; Soppet; Escandon; Parada; Presta
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Monoclonal antibodies detect different distribution patterns of IL-8 receptor A and IL-8 receptor B on human peripheral blood leukocytes
Journal of Immunology, ISSN: 00221767
Anan Chuntharapai; James Lee; Hébert; K.Jin Kim
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Guanylyl cyclase receptors
Journal of Biological Chemistry, ISSN: 00219258
Garbers; David G Lowe
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Application of capillary high-performance liquid chromatography to biotechnology, with reference to the analysis of recombinant DNA-derived human growth hormone
Journal of Chromatography B: Biomedical Sciences and Applications, ISSN: 03784347
John E. Battersby; Andrew W. Guzzetta; William S. Hancock
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Entry of naive CD4 T cells into peripheral lymph nodes requires I-selectin
Journal of Experimental Medicine, ISSN: 15409538 00221007
Linda M. Bradley; Susan R. Watson; Susan L. Swain
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Phase I studies with biologicals
European Journal of Clinical Research, ISSN: 09613692
Froehlich
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Temperature as a variable in reversed-phase high-performance liquid chromatographic separations of peptide and protein samples. II. Selectivity effects observed in the separation of several peptide and protein mixtures
Journal of Chromatography A, ISSN: 00219673
Chloupek; William S. Hancock; Brian A. Marchylo; Kirkland; Barry E. Boyes; Lloyd R. Snyder
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Temperature as a variable in reversed-phase high-performance liquid chromatographic separations of peptide and protein samples. I. Optimizing the separation of a growth hormone tryptic digest
Journal of Chromatography A, ISSN: 00219673
William S. Hancock; Chloupek; Kirkland; Lloyd R. Snyder
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Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins
Neuroscience Letters, ISSN: 03043940
Alun M. Davies; Rosenthal
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HIV-1(MN) recombinant gp120 vaccine serum, which fails to neutralize primary isolates of HIV-1, does not antagonize neutralization by antibodies from infected individuals [2]
AIDS, ISSN: 02699370
Wrin; Nunberg
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Biologic activities of the murine β-chemokine TCA3
Journal of Immunology, ISSN: 00221767
Yi Luo; Joseph Laning; Shamala Devi; John Mak; Thomas J. Schall; Martin E. Dorf
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Rupture of the mitochondrial outer membrane impairs porin assembly
Journal of Biological Chemistry, ISSN: 00219258
Mitchell Smith; Shawn Hicks; Kevin Baker; Roy McCauley
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Mutagenesis identifies amino-terminal residues of nerve growth factor necessary for Trk receptor binding and biological activity
Journal of Biological Chemistry, ISSN: 00219258
Shih; Laramee; Charles H. Schmelzer; Louis E. Burton; Winslow
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