Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 13851 - 13900 OF 15572 RESULTS

June 20, 1993

Crystals of human growth hormone-receptor complexes. Extracellular domains of the growth hormone and prolactin receptors and a hormone mutant designed to prevent receptor dimerization

Journal of Molecular Biology, ISSN: 00222836

Ultsch; De Vos

June 15, 1993

Selection of an anti-IGF-1 Fab from a Fab phage library created by mutagenesis of multiple CDR loops

Gene, ISSN: 03781119

Lisa J. Garrard; Henner

June 8, 1993

Glycosylphosphatidylinositol anchored proteins are preferentially targeted to the basolateral surface in Fischer rat thyroid epithelial cells

Journal of Cell Biology, ISSN: 00219525

Chiara Zurzolo; Michael P. Lisanti; Caras; Lucio Nitsch; Rodriguez-Boulan

June 1, 1993

Human macrophage inflammatory protein cr (MIP-1α) and MIP-1β chemoklnes attract distinct populations of lymphocytes

Journal of Experimental Medicine, ISSN: 15409538 00221007

Thomas J. Schall; Bacon; Camp; Kaspari; David V. Goeddel

June 1, 1993

O-linked fucose and other post-translational modifications unique to EGF modules

Glycobiology, ISSN: 09596658

Reed J. Harris; Spellman

June 1, 1993

Loss in expression of the retinoblastoma gene product in human gliomas is associated with advanced disease

Journal of Neuro-Oncology, ISSN: 0167594X 15737373

Wolfgang Hamel; Manfred Westphal; Shepard

June 1, 1993

Combinatorial mediators of inflammation?

Current Biology, ISSN: 09609822

Lasky

June 1, 1993

Prevention of metastasis by inhibition of the urokinase receptor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Crowley; Robert L. Cohen; Brian K. Lucas; Liu; Shuman; Levinson

May 20, 1993

Theoretical considerations for the design and development of a drug: Influence of pharmacokinetics and dosage regimen on receptor interactions

Pharmaceutical Research, ISSN: 07248741

Joyce Mordenti; Rescigno

April 23, 1993

Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor

Cell, ISSN: 00928674

Louis A. Tartaglia; Mike Rothe; Yan-Fen Hu; David V. Goeddel

April 16, 1993

Solid phase synthesis of peptide para -nitroanilides

Tetrahedron Letters, ISSN: 00404039

Burdick; Martin Struble; Burnier

April 1, 1993

Physical Properties of Recombinant Apolipoprotein(a) and Its Association with LDL to Form an Lp(a)-like Complex

Biochemistry, ISSN: 15204995 00062960

Martin L. Phillips; Audra V. Lembertas; Verne N. Schumaker; Lawn; Steven J. Shire; Zioncheck

March 26, 1993

Protein sorting by high-performance liquid chromatography. I. Biomimetic interaction chromatography of recombinant human deoxyribonuclease I on polyionic stationary phases

Journal of Chromatography A, ISSN: 00219673

Cacia; Quan; Vasser; Mary B. Sliwkowski; John Frenz

March 15, 1993

Proper glycosylation and phosphorylation of the type A natriuretic peptide receptor are required for hormone-stimulated guanylyl cyclase activity

Journal of Biological Chemistry, ISSN: 00219258

Koller; Michael T. Lipari; David V. Goeddel

March 1, 1993

Biochemical Characterization of the Extracellular Domain of the 75-Kilodalton Tumor Necrosis Factor Receptor

Biochemistry, ISSN: 15204995 00062960

Diane Pennica; Van Lam; Weber; William J. Kohr; Basa; Spellman; Avi Ashkenazi; Steven J. Shire; David V. Goeddel

March 1, 1993

Lack of impact of early catheterization and fibrin specificity on bleeding complications after thrombolytic therapy

Journal of the American College of Cardiology, ISSN: 07351097

Thomas C. Wall; Robert M. Califf; Stephen G. Ellis; Kristina Sigmon; Dean J. Kereiakes; Barry S. George; Joseph Samaha; David Sane; David Stump; Richard S. Stack; Eric Topol

March 1, 1993

A new yeast gene with a myosin-like heptad repeat structure

Molecular and General Genetics, ISSN: 00268925 16174623

Ralf Kölling; Nguyen; Ellson Y. Chen; David Botstein

February 28, 1993

An Alu sequence interupts a human 5-hydroxytryptamine1D receptor pseudogene

Gene, ISSN: 03781119

Tuan Nguyen; Adriano Marchese; James L. Kennedy; Arturas Petronis; Peroutka; Peter H. Wu; Brian F. O'Dowd

February 20, 1993

X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling

Journal of Molecular Biology, ISSN: 00222836

Eigenbrot; Michael Randal; Presta; Paul J. Carter; Anthony A. Kossiakoff

February 12, 1993

Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

Cell, ISSN: 00928674

Kuldeep Neote; DiGregorio; John Mak; Richard Horuk; Thomas J. Schall

January 13, 1993

Extracellular matrix regulates expression of the TGF-β1 gene

Journal of Cell Biology, ISSN: 00219525

Charles H. Streuli; Christian Schmidhauser; Michael S. Kobrin; Mina J. Bissell; Rik Derynck

January 1, 1993

Homotypic leukocyte aggregation triggered by a monoclonal antibody specific for a novel epitope expressed by the integrin β1 subunit: Conversion of nonresponsive cells by transfecting human integrin α4 subunit cDNA

Journal of Cellular Biochemistry, ISSN: 10974644 07302312

John L. Bednarczyk; James N. Wygant; Margit C. Szabo; Laura Molinari‐Storey; Renz; Fong; Bradley W. McIntyre

January 1, 1993

Evidence supporting a role for cathepsin B in the generation of T cell antigenic epitopes of human growth hormone

Molecular Immunology, ISSN: 01615890

Gillian Bushell; Nelson; Chiu; Christopher Grimley; William J. Henzel; Burnier; Fong

January 1, 1993

Receptor/ligand interactions in the C-C chemokine family

Advances in Experimental Medicine and Biology, ISSN: 00652598

Thomas J. Schall; John Mak; DiGregorio; Kuldeep Neote

January 1, 1993

Production of Fusion Protein SpA:: EcoRI in Batch Culture in a 60‐L Airlift Tower Loop Reactor

Biotechnology Progress, ISSN: 15206033 87567938

Lutz Brandes; Xiaoan Wu; Hans E. Maschke; Heike Jürgens; Birgit Reinhardt; Karl Schügerl

January 1, 1993

Glycoprotein IIb IIIa Antagonists

Annual Reports in Medicinal Chemistry, ISSN: 00657743

Brent Blackburn; Thomas Gadek

January 1, 1993

Triply Convergent Synthesis of 15-(Phenoxymethyl) and 4,5-Allenyl Prostaglandins. Preparation of an Individual Isomer of Enprostil

Journal of Organic Chemistry, ISSN: 15206904 00223263

Owen W. Gooding; Colin C. Beard; Gary F. Cooper; Jackson

January 1, 1993

Thermodynamic Analysis of an Antibody Functional Epitope

Biochemistry, ISSN: 15204995 00062960

Robert F. Kelley; Mark P. O'Connell

January 1, 1993

Peptide Stability in Drug Development: In vitro Peptide Degradation in Plasma and Serum

Annual Reports in Medicinal Chemistry, ISSN: 00657743

Powell

January 1, 1993

Identification and Structural Analysis of the Tetrasaccharide NeuAcα(2→6)Galβ(1→4)GlcNAcβ(1→3)Fucαl→O-Linked to Serine 61 of Human Factor IX

Biochemistry, ISSN: 15204995 00062960

Reed J. Harris; Basa; Victor Ling; Spellman; Van Halbeek; John Glushka; Kenneth J. Smith

January 1, 1993

Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons

Journal of Neuroscience, ISSN: 02706474

Alun M. Davies; Antony Horton; Louis E. Burton; Charles H. Schmelzer; Richard L. Vandlen; Rosenthal

January 1, 1993

Overproduction of recombinant proteins by escherichia coli - employing the combinations of two and three different types of multicopy plasmids - in a 60-litre working volume airlift tower loop reactor

Process Biochemistry, ISSN: 13595113

Lutz Brandes; Xiaoan Wu; Hans E. Maschke; Karl Schügerl

January 1, 1993

The Human Erythrocyte Inflammatory Peptide (Chemokine) Receptor. Biochemical Characterization, Solubilization, and Development of a Binding Assay for the Soluble Receptor

Biochemistry, ISSN: 15204995 00062960

Richard Horuk; Timothy J. Colby; Darbonne; Thomas J. Schall; Kuldeep Neote

January 1, 1993

Vascular endothelial growth factor

Trends in Cardiovascular Medicine, ISSN: 10501738

Napoleone Ferrara

January 1, 1993

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

Nature, ISSN: 00280836

K.Jin Kim; Bing Li; Jane Winer; Armanini; Nancy Gillett; Phillips; Napoleone Ferrara

January 1, 1993

Difficulties in Precise Quantitation of CD4+T Lymphocytes for Clinical Trials: A Review

Biologicals, ISSN: 10958320 10451056

David T.W. Fei; Paxton; Chen

January 1, 1993

5‐Hydroxytryptamine Receptors

Journal of Neurochemistry, ISSN: 14714159 00223042

Peroutka

January 1, 1993

The molecular basis for growth hormone-receptor interactions

Recent Progress in Hormone Research, ISSN: 00799963

James A. Wells; Cunningham; Fuh; Henry B. Lowman; Bass; Michael G. Mulkerrin; Ultsch; Abraham M. Devos

January 1, 1993

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: A model of glioblastoma multiforme pathophysiology

Molecular Biology of the Cell, ISSN: 10591524

Corey K. Goldman; Jin Kim; Wai Lee T. Wong; Vickie King; Tommy Brock; G. Yancey Gillespie

January 1, 1993

Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling

Journal of Immunology, ISSN: 00221767

Klaus Ley; Baker; Myron I. Cybulsky; Gimbrone Jr.; Francis W. Luscinskas

January 1, 1993

Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain

Journal of Biological Chemistry, ISSN: 00219258

Elisabeth T. Barfod; Yi Zheng; Wun-Jing Kuang; Matthew J. Hart; Tony Evans; Richard A. Cerione; Avi Ashkenazi

January 1, 1993

Engineering Fab' fragments for efficient F(ab)2 formation in Escherichia coli and for improved in vivo stability

Journal of Immunology, ISSN: 00221767

Maria L. Rodrigues; Snedecor; Christina Y. Chen; Wai Lee T. Wong; Shaily Garg; Gregory S. Blank; Daniel A. Maneval; Paul J. Carter

January 1, 1993

Structural and functional aspects of RGD-containing protein antagonists of glycoprotein IIb-IIIa

Current Opinion in Biotechnology, ISSN: 09581669

Lazarus; Robert S. McDowell

January 1, 1993

Synthetic chimeras of mouse growth factor‐associated glandular kallikreins. I. Kinetic properties

Protein Science, ISSN: 1469896X 09618368

Michael Blaber; Paul J. Isackson; Ralph A. Bradshaw; Burnier; James C. Marsters Jr.

January 1, 1993

Solution Structure of Human Type-α Transforming Growth Factor Determined by Heteronuclear NMR Spectroscopy and Refined by Energy Minimization with Restraints

Biochemistry, ISSN: 15204995 00062960

Franklin J. Moy; Yu-Chin Li; Peter Rauenbuehler; Winkler; Harold A. Scheraga; Gaetano T Montelione

January 1, 1993

Cysteine Pairing in the Glycoprotein IIbIIIa Antagonist Kistrin Using NMR, Chemical Analysis, and Structure Calculations

Biochemistry, ISSN: 15204995 00062960

Marc Adler; Paul J. Carter; Lazarus; Gerhard Wagner

January 1, 1993

Mapping of the Binding Interfaces of the Proteins of the Bacterial Phosphotransferase System, HPr and IIAglc

Biochemistry, ISSN: 15204995 00062960

Yuan Chen; Peter E. Wright; Jonathan Reizer; Milton H. Saier Jr.; Wayne J. Fairbrother

January 1, 1993

Assignment of 1H, 15N, and 13C Resonances, Identification of Elements of Secondary Structure and Determination of the Global Fold of the DNA-Binding Domain of GAL4

Biochemistry, ISSN: 15204995 00062960

Masahiro Shirakawa; Yasuharu Serikawa; Yoshimasa Kyogoku; Wayne J. Fairbrother; Peter E. Wright; Tadayasu Ohkubo

January 1, 1993

Expression, purification, and characterization of recombinant ornatin e, a potent glycoprotein iib-iiia antagonist

Protein Expression and Purification, ISSN: 10465928

Paul Mazur; Dennis; Jana L. Seymour; Lazarus

January 1, 1993

Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and Fc

Journal of Molecular Biology, ISSN: 00222836

Andrew H. Huber; Robert F. Kelley; Louis N. Gastinel; Pamela J. Bjorkman

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