Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 15151 - 15200 OF 15572 RESULTS

January 1, 1987

Industrial Scale Protein Purification: A Perspective

Bio/Technology, ISSN: 15206033 87567938

Nikos K. Harakas; Stuart E. Builder

January 1, 1987

Alternative Splicing Increases the Diversity of the Human Protein Kinase C Family

DNA, ISSN: 15577430 01980238

Lisa Coussens; Lucy M. Rhee; Parker; Axel Ullrich

January 1, 1987

Equilibrium and Kinetic Measurements of the Conformational Transition of Reduced Thioredoxin

Biochemistry, ISSN: 15204995 00062960

Robert F. Kelley; William Shalongc; Jagannadham; Earle Stellwagen

January 1, 1987

Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-α in rodents

Journal of Clinical Investigation, ISSN: 00219738

John R. Patton; Peters; McCabe; Crase; Hansen; Chen; Liggitt

January 1, 1987

Chicken Ovomucoid: Determination of Its Amino Acid Sequence, Determination of the Trypsin Reactive Site, and Preparation of All Three of Its Domains

Biochemistry, ISSN: 15204995 00062960

Ikunoshin Kato; James Schrode; William J. Kohr; Michael Laskowski Jr.

January 1, 1987

A national cooperative growth study on protropin

Acta Paediatrica Scandinavica, ISSN: 0001656X

Barry M. Sherman

January 1, 1987

Blocking of HIV-1 infectivity by a soluble, secreted form of the CD4 antigen

Science, ISSN: 00368075

Smith; Randal A. Byrn; Scot A. Marsters; Timothy Gregory; Jerome E. Groopman; Capon

January 1, 1987

Regulation of neutrophil migration and superoxide production by recombinant tumor necrosis factors-α and -β: Comparison to recombinant interferon-γ and interleukin-1α

Blood, ISSN: 00064971

Figari; Mori; Michael A. Palladino

January 1, 1987

Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene

Science, ISSN: 00368075

Dennis J. Slamon; Gary M. Clark; Steven Wong; Wendy J. Levin; Axel Ullrich; William L. McGuire

January 1, 1987

On the evolution of specificity and catalysis in subtilisin

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

James A. Wells; Cunningham; Graycar; David A. Estell; Paul J. Carter

January 1, 1987

Ovomucoid Third Domains from 100 Avian Species: Isolation, Sequences, and Hypervariability of Enzyme-Inhibitor Contact Residues

Biochemistry, ISSN: 15204995 00062960

Michael Laskowski Jr.; Ikunoshin Kato; Wojciech Ardelt; James Cook; Andrew Denton; Mark W. Emnie; William J. Kohr; Soon Jae Park; Kevin Parks; Barbara L. Schatzley; Oeyvind L. Schoenberger; Misao Tashiro; Gisela Vichot; Harry E. Whatley; Anna Wieczorek; Maciej Wieczorek

January 1, 1987

Gonadal Development and Gametogenesis in the Hypogonadal Mouse Are Restored by Gene Transfer

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Anthony J. Mason; Pitts; Nikolics; Szonyi; Josiah N. Wilcox; Peter H. Seeburg; Stewart

January 1, 1987

Identification of human uromodulin as the tamm-horsfall urinary glycoprotein

Science, ISSN: 00368075

Diane Pennica; William J. Kohr; Wun-Jing Kuang; Debbie Glaister; Aggarwal; Ellson Y. Chen; David V. Goeddel

January 1, 1987

Directing Ribosomes to a Single mRNA Species: A Method to Study Ribosomal Rna Mutations and Their Effects on Translation of a Single Messenger in Escherichia coli

Methods in Enzymology, ISSN: 15577988 00766879

Hui; Jhurani; Herman A. de Boer

January 1, 1987

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

Nature, ISSN: 00280836

S. Joseph Leibovich; Peter J. Polverini; Shepard; David M. Wiseman; Vera Shively; Nureddin Nuseir

January 1, 1987

Interaction of One-Chain and Two-Chain Tissue Plasminogen Activator with Intact and Plasmin-Degraded Fibrin

Biochemistry, ISSN: 15204995 00062960

Deborah L. Higgins; Gordon A. Vehar

January 1, 1987

Production of Recombinant Coagulation Proteins

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Gordon A. Vehar

January 1, 1987

A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression

Science, ISSN: 00368075

Suva; Genine Winslow; Wettenhall; R. Glenn Hammonds; Moseley; Diefenbach-Jagger; Rodda; Kemp; Rodriguez; Ellson Y. Chen; Hudson; Martin; William I. Wood

January 1, 1987

A repetitive sequence element 3′ of the human c‐Ha‐ras1 gene has enhancer activity

Journal of Cellular Physiology, ISSN: 10974652 00219541

Justus B. Cohen; Walter; Levinson

January 1, 1987

Structural basis of muscarinic acetylcholine receptor subtype diversity

Trends in Pharmacological Sciences, ISSN: 0165604X

Ernest G. Peralta; Winslow; Avi Ashkenazi; Smith; Ramachandran; Capon

January 1, 1987

Primary structure and mRNA localization of protein F1, a growth-related protein kinase C substrate associated with synaptic plasticity.

EMBO Journal, ISSN: 02614189

Rosenthal; Chan; William J. Henzel; Haskell; Wun-Jing Kuang; Ellson Y. Chen; Josiah N. Wilcox; Axel Ullrich; David V. Goeddel; Routtenberg

January 1, 1987

Growth hormone receptor and serum binding protein: Purification, cloning and expression

Nature, ISSN: 00280836

Leung; Steven A. Spencer; Cachianes; R. Glenn Hammonds; Collins; William J. Henzel; Ross Barnard; Michael J. Waters; William I. Wood

January 1, 1987

Monoclonal antibodies to human tumor necrosis factors alpha and beta: application for affinity purification, immunoassays, and as structural probes

Hybridoma, ISSN: 0272457X

Timothy S. Bringman; Aggarwal

January 1, 1987

Possible relationships between in vivo antitumour activity and toxicity of tumour necrosis factor-alpha.

CIBA Foundation Symposia, ISSN: 03005208

Michael A. Palladino; John R. Patton; Figari; Shalaby

January 1, 1987

Characterization of Recombinant Human a2-Antiplasmin and of Mutants Obtained by Site-Directed Mutagenesis of the Reactive Site

Biochemistry, ISSN: 15204995 00062960

William E. Holmes; Lijnen; Desire Collen

January 1, 1987

Corticotropin Receptors

Annals of the New York Academy of Sciences, ISSN: 17496632 00778923

Ramachandran; TSUBOKAWA; GOHIL

January 1, 1987

α2-antiplasmin enschede: Alanine insertion and abolition of plasmin inhibitory activity

Science, ISSN: 00368075

William E. Holmes; Lijnen; Nelles; Kluft; Nieuwenhuis; Rijken; Desire Collen

January 1, 1987

Effect of phorbol esters on down-regulation and redistribution of cell surface receptors for tumor necrosis factor-alpha.

Journal of Biological Chemistry, ISSN: 00219258

Aggarwal; Eessalu

January 1, 1987

Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.

EMBO Journal, ISSN: 02614189

Ernest G. Peralta; Avi Ashkenazi; Winslow; Smith; Ramachandran; Capon

December 19, 1986

Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the γ-aminobutyric acid type A receptor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Patrick W. Gray; Debbie Glaister; Peter H. Seeburg; Guidotti; Costa

December 19, 1986

The avian β-adrenergic receptor: Primary structure and membrane topology

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Yarden; Rodriguez; Wong; Brandt; May; Burnier; Harkins; Ellson Y. Chen; Ramachandran; Axel Ullrich

December 9, 1986

Human lecithin-cholesterol acyltransferase gene: Complete gene sequence and sites of expression

Nucleic Acids Research, ISSN: 03051048

McLean; Karen L. Wion; Drayna; Fielding; Lawn

December 1, 1986

Variable and conserved neutralization antigens of human immunodeficiency virus

Nature, ISSN: 00280836

Weiss; Clapham; Jonathan N. Weber; Angus G. Dalgleish; Lasky; Berman

December 1, 1986

A chimaeric receptor allows insulin to stimulate tyrosine kinase activity of epidermal growth factor receptor

Nature, ISSN: 00280836

Riedel; Dull; Schlessinger; Axel Ullrich

December 1, 1986

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

Nature, ISSN: 00280836

Yarden; Escobedo; Wun-Jing Kuang; Yang-Feng; Daniel; Tremble; Ellson Y. Chen; Ando; Harkins; Uta Francke; Fried; Axel Ullrich; Williams

December 1, 1986

Two interleukin 1 genes in the mouse: Cloning and expression of the cDNA for murine interleukin 1β

Journal of Immunology, ISSN: 00221767

Patrick W. Gray; Debbie Glaister; Ellson Y. Chen; David V. Goeddel; Diane Pennica

December 1, 1986

Cloning of cDNA for a stylar glycoprotein associated with expression of self-incompatibility in Nicotiana alata

Nature, ISSN: 00280836

Anderson; Cornish; Mau; Williams; Hoggart; Atkinson; Bonig; Grego; Simpson; Roche; Haley; Penschow; Hugh D. Niall; Geoffrey W. Tregear; Coghlan; Crawford; Clarke

December 1, 1986

Cloning and expression of human apolipoprotein D cDNA

Journal of Biological Chemistry, ISSN: 00219258

Drayna; Fielding; McLean; Baer; Castro; Ellson Y. Chen; Comstock; William J. Henzel; William J. Kohr; Lucy M. Rhee

December 1, 1986

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors

Nature, ISSN: 00280836

Donald R. Bertolini; Nedwin; Timothy S. Bringman; Donna D. Smith; Gregory R. Mundy

December 1, 1986

In vivo formation and stability of engineered disulfide bonds in subtilisin

Journal of Biological Chemistry, ISSN: 00219258

James A. Wells; Powers

December 1, 1986

Modulation of receptors and cytotoxic response of tumor necrosis factor-α by various lectins

Journal of Biological Chemistry, ISSN: 00219258

Aggarwal; Traquina; Eessalu

December 1, 1986

Production of native, correctly folded bovine pancreatic trypsin inhibitor by Escherichia coli

Journal of Biological Chemistry, ISSN: 00219258

Cara Berman Marks; Vasser; Ng; William J. Henzel; Anderson

December 1, 1986

Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

John R. Patton; Shepard; Wilking; Gail D. Lewis; Aggarwal; Eessalu; Gavin; Grunfeld

December 1, 1986

Effects of interferon-γ and tumor necrosis factor-α on the expression of an Ia antigen on a murine macrophage cell line

Journal of Immunology, ISSN: 00221767

Chang; Lee

December 1, 1986

The murine transforming growth factor-β precursor

Journal of Biological Chemistry, ISSN: 00219258

Rik Derynck; Jarrett; Ellson Y. Chen; David V. Goeddel

December 1, 1986

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

Nature, ISSN: 00280836

Grace H.W. Wong; David V. Goeddel

December 1, 1986

The purification of fully active recombinant transforming growth factor α produced in Escherichia coli

Journal of Biological Chemistry, ISSN: 00219258

Winkler; Timothy S. Bringman; Marks

December 1, 1986

Construction and Characterization of an Active Factor VIII Variant Lacking the Central One-Third of the Molecule

Biochemistry, ISSN: 15204995 00062960

Dan L. Eaton; William I. Wood; Eaton; Hass; Hollingshead; Karen L. Wion; Mather; Lawn; Gordon A. Vehar; Cornelia M. Gorman

December 1, 1986

Natural killer-sensitive targets stimulate production of TNF-α but not TNF-β (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes

Journal of Immunology, ISSN: 00221767

Peters; Ortaldo; Shalaby; eta l.

December 1, 1986

Comparison of TNF-α and TNF-β cytolytic biological activities in a serum-free bioassay

Lymphokine Research, ISSN: 02776766

Susan M. Kramer; Monique E. Carver; Apperson

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