Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 15251 - 15300 OF 15572 RESULTS

January 1, 1986

What is protein engineering?

Protein Engineering, Design and Selection, ISSN: 17410134 17410126

Wetzel

January 1, 1986

A Sensitive Radioimmunoprecipitation Assay for the Detection of Antibody to Recombinant Human Gamma-Interferon: Comparison to a Bioassay Neutralization Test

Journal of Interferon Research, ISSN: 15577465 01978357

Chen; Vincent R. Anicetti; Toni Klassen; Berthold; Gaby Zahn; Wert Jr.; Geier; Andrew J.S. Jones

January 1, 1986

Regulation of pro-opiomelanocortin gene transcription in individual cell nuclei

Science, ISSN: 00368075

Robert T. Fremeau Jr.; James R. Lundblad; Dolan B. Pritchett; Josiah N. Wilcox; James L. Roberts

January 1, 1986

Regulation of the chelatin promoter during the expression of human serum albumin or yeast phosphoglycerate kinase in yeast

Bio/Technology, ISSN: 0733222X

Etcheverry; Forrester; Ronald A. Hitzeman

January 1, 1986

Immunopharmacology of tumor necrosis factors α and β

Trends in Pharmacological Sciences, ISSN: 01656147

Michael A. Palladino; Bryan S Finkle

January 1, 1986

Tumor necrosis factors: Gene structure and biological activities

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

David V. Goeddel; Aggarwal; Patrick W. Gray; Leung; Nedwin; Michael A. Palladino; John R. Patton; Diane Pennica; Shepard; Sugarman

January 1, 1986

Sequences 3' of the human c-Ha-ras1 gene positively regulate its expression and transformation potential.

Gene amplification and analysis, ISSN: 02752778

Colby; Justus B. Cohen; Yu; Levinson

January 1, 1986

Proteolytic Processing of Human Factor VIII. Correlation of Specific Cleavages by Thrombin, Factor Xa, and Activated Protein C with Activation And Inactivation of Factor VIII Coagulant Activity

Biochemistry, ISSN: 15204995 00062960

Dan L. Eaton; Rodriguez; Gordon A. Vehar

January 1, 1986

Transforming growth factor‐α: Structure and biological activities

Journal of Cellular Biochemistry, ISSN: 10974644 07302312

Rik Derynck

January 1, 1986

Cloned factor VIII and the molecular genetics of hemophilia

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Lawn; William I. Wood; Jane Gitschier; Karen L. Wion; Eaton; Gordon A. Vehar; Tuddenham

January 1, 1986

Escherichia coli DnaK protein possesses a 5'-nucleotidase activity that is inhibited by appppA

Journal of Bacteriology, ISSN: 00219193

Bochner; Zylicz; Georgopoulos

January 1, 1986

Structural features of growth factor receptors with oncogenic potential

Biochemical Society Symposium, ISSN: 00678694

Ellson Y. Chen; Lisa Coussens; Yu-Cheng Liao

January 1, 1986

Unpaired Cysteine-54 Interferes with the Ability of an Engineered Disulfide To Stabilize T4 Lysozyme

Biochemistry, ISSN: 15204995 00062960

Perry; Wetzel

January 1, 1986

Purification and Characterization of Recombinant Single-Chain Urokinase Produced in Escherichia coli

Biochemistry, ISSN: 15204995 00062960

Winkler; Michael Blaber

January 1, 1986

D-Phe-Pro-Arg-chloromethylketone: Its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy

Thrombosis and Haemostasis, ISSN: 03406245

Mohler; Refino; Chen; Adair Hotchkiss

January 1, 1986

Human growth hormone: From clone to clinic

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Peter H. Seeburg

January 1, 1986

Molecular basis of a human purine nucleoside phosphorylase deficiency

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Steven R. Williams; R.Scott McIvor; Martin Jr.

January 1, 1986

Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

Science, ISSN: 00368075

Lisa Coussens; Parker; Lucy M. Rhee; Yang-Feng; Ellson Y. Chen; Waterfield; Uta Francke; Axel Ullrich

January 1, 1986

Equilibrium and Kinetic Measurements of the Conformational Transition of Thioredoxin in Urea

Biochemistry, ISSN: 15204995 00062960

Jane Wilson; William Shalongo; David Lowery; Earle Stellwagen; Robert F. Kelley

January 1, 1986

The hypogonadal mouse: Reproductive functions restored by gene therapy

Science, ISSN: 00368075

Anthony J. Mason; Pitts; Nikolics; Szonyi; Josiah N. Wilcox; Peter H. Seeburg; Stewart

January 1, 1986

A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse

Science, ISSN: 00368075

Anthony J. Mason; Hayflick; Zoeller; Young III; Phillips; Nikolics; Peter H. Seeburg

January 1, 1986

The complete primary structure of protein kinase C - The major phorbol ester receptor

Science, ISSN: 00368075

Parker; Lisa Coussens; Nick Totty; Lucy M. Rhee; Susan Young; Ellson Y. Chen; Silvia Stabel; Waterfield; Axel Ullrich

January 1, 1986

Protein kinases in cellular signal transduction: Tyrosine kinase growth factor receptors and protein kinase C

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Axel Ullrich; Riedel; Yarden; Lisa Coussens; Gray; Dull; Schlessinger; Waterfield; Parker

January 1, 1986

Characterization studies of human tissue-type plasminogen activator produced by recombinant DNA technology

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Gordon A. Vehar; Spellman; Keyt; Ferguson; Rodney Keck; Chloupek; Reed J. Harris; William F. Bennett; Stuart E. Builder; William S. Hancock

January 1, 1986

Structure of the human insulin receptor precursor

Fernstrom Foundation Series, ISSN: 01677004

Axel Ullrich; Bell; Ellson Y. Chen

January 1, 1986

Sequence-Specific Cross-Linking of Deoxyoligonucleotides via Hybridization-Triggered Alkylation

Journal of the American Chemical Society, ISSN: 15205126 00027863

Thomas R. Webb; Matteucci

January 1, 1986

Endogeneous and heterologous expression of transforming growth factor-α in mammalian cells

Cold Spring Harbor Symposia on Quantitative Biology, ISSN: 00917451

Rik Derynck; Rosenthal; Patricia B. Lindquist

January 1, 1986

Transforming growth factor-α: A more potent angiogenic mediator than epidermal growth factor

Science, ISSN: 00368075

Alain B. Schreiber; Winkler; Rik Derynck

January 1, 1986

[60] Construction of Expression Vectors for Secretion of Human Interferons by Yeast

Methods in Enzymology, ISSN: 15577988 00766879

Ronald A. Hitzeman; Chung N. Chang; Matteucci; Jeanne Perry; William J. Kohr; Wulf; James R. Swartz; Christina Y. Chen; Arjun Singh

January 1, 1986

Cloning and expression of human lecithin-cholesterol acyltransferase cDNA

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

McLean; Fielding; Drayna; Dieplinger; Baer; William J. Kohr; William J. Henzel; Lawn

January 1, 1986

Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein

Science, ISSN: 00368075

Lasky; Jerome E. Groopman; Christopher Fennie; Patricia M. Benz; Capon; Dowbenko; Nakamura; Nunes; Renz; Berman

December 17, 1985

Urea treatment allows dithiothreitol to release the binding subunit of the insulin receptor from the cell membrane: Implications for the structural organization of the insulin receptor

Biochemical and Biophysical Research Communications, ISSN: 10902104 0006291X

Grunfeld; Judy Kwan Shigenaga; Ramachandran

December 1, 1985

A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone

Nature, ISSN: 00280836

Nikolics; Anthony J. Mason; Éva Sznyi; Ramachandran; Peter H. Seeburg

December 1, 1985

Genetic mapping and diagnosis of haemophilia A achieved through a BclI polymorphism in the factor VIII gene

Nature, ISSN: 00280836

Jane Gitschier; Drayna; Tuddenham; Ray L. White; Lawn

December 1, 1985

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

Nature, ISSN: 00280836

Axel Ullrich; Bell; Ellson Y. Chen; Herrera; Petruzzelli; Dull; Gray; Lisa Coussens; Yu-Cheng Liao; TSUBOKAWA; Anthony J. Mason; Peter H. Seeburg; Grunfeld; Rosen; Ramachandran

December 1, 1985

Effect of interleukin 2, interferon-γ, and mitogens on the production of tumor necrosis factors α and β

Journal of Immunology, ISSN: 00221767

Nedwin; Svedersky; Timothy S. Bringman; Michael A. Palladino; David V. Goeddel

December 1, 1985

Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-β

Nature, ISSN: 00280836

Anthony J. Mason; Hayflick; Nicholas Ling; Esch; Naoto Ueno; Shao-Yao Ying; Roger Guillemin; Hugh D. Niall; Peter H. Seeburg

December 1, 1985

HEAT MANAGEMENT IN FERMENTATION PROCESSES.

Princ of Biotechnol, Eng Consid,

Swartz

December 1, 1985

Bacterial expression of the acquired immunodeficiency syndrome retrovirus p24 gag protein and its use as a diagnostic reagent

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Dowbenko; Bell; Charles V. Benton; Jerome E. Groopman; Nguyen; David Vetterlein; Capon; Lasky

December 1, 1985

Human transforming growth factor-α causes precocious eyelid opening in newborn mice

Nature, ISSN: 00280836

Joseph M. Smith; Michael B. Sporn; Anita B. Roberts; Rik Derynck; Winkler; Harry Gregory

December 1, 1985

Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon

Nature, ISSN: 00280836

Aggarwal; Eessalu; Hass

December 1, 1985

Characterization of specific high affinity receptors for human tumor necrosis factor on mouse fibroblasts

Journal of Biological Chemistry, ISSN: 00219258

Hass; Adair Hotchkiss; Mohler; Aggarwal

December 1, 1985

Distribution of factor VIII MRNA and antigen in human liver and other tissues

Nature, ISSN: 00280836

Karen L. Wion; Deirdre Kelly; Summerfield; Tuddenham; Lawn

December 1, 1985

Immunocytochemical localization in rat brain of a prolactin release-inhibiting sequence of gonadotropin-releasing hormone prohormone

Nature, ISSN: 00280836

Phillips; Nikolics; Dale Branton; Peter H. Seeburg

December 1, 1985

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

Nature, ISSN: 00280836

Towia A. Libermann; Harris R. Nusbaum; Nissim Razon; Richard Kris; Lax; Hermona Soreq; Nigel Whittle; Waterfield; Axel Ullrich; Schlessinger

December 1, 1985

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Diane Pennica; Hayflick; Timothy S. Bringman; Michael A. Palladino; David V. Goeddel

December 1, 1985

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

Nature, ISSN: 00280836

Rik Derynck; Jarrett; Ellson Y. Chen; Eaton; Bell; Richard K. Assoian; Anita B. Roberts; Michael B. Sporn; David V. Goeddel

December 1, 1985

Topology of signal recognition particle receptor in endoplasmic reticulum membrane

Nature, ISSN: 00280836

Leander Lauffer; Pablo D. Garcia; Harkins; Lisa Coussens; Axel Ullrich; Peter Walter

December 1, 1985

Activation of human polymorphonuclear neutrophil functions by interferon-γ and tumor necrosis factors

Journal of Immunology, ISSN: 00221767

Shalaby; Aggarwal; Rinderknecht; Svedersky; Bryan S Finkle; Michael A. Palladino

December 1, 1985

A phase I trial of recombinant gamma interferon in patients with cancer

Cancer Immunology, Immunotherapy, ISSN: 03407004 14320851

Kenneth A. Foon; Stephen A. Sherwin; Paul G. Abrams; Henry C. Stevenson; Pamela Holmes; Annette E. Maluish; Robert K. Oldham; Ronald B. Herberman

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