Genentech: Publications

May 13, 2020

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

OncoImmunology, ISSN: 21624011

Mathias Vormehr; Sophie M. Lehar; Lena M. Kranz; Siri Tahtinen; Yoko Oei; Vincent Javinal; Lélia Delamarre; Kerstin C. Walzer; Mustafa Diken; Sebastian Kreiter; Ira Mellman; Ugur Sahin; Jill Schartner; Özlem Türeci

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May 5, 2020

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Irene Tom; Victoria Pham; Kenneth J. Katschke Jr.; Wei Li; Wei-Ching Liang; Johnny Gutierrez; Andrew Ah Young; Isabel Figueroa; Shadi Toghi Eshghi; Ching Wei V. Lee; Jitendra Kanodia; Scott J. Snipas; Guy S. Salvesen; Phillip Lai; Lee Honigberg; Menno Van Lookeren Campagne; Daniel Kirchhofer; Amos Baruch; Jennie R. Lill

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May 5, 2020

High-throughput antibody screening from complex matrices using intact protein electrospray mass spectrometry

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

William S. Sawyer; Neha Srikumar; Joe Carver; Phillip Chu; Amy Shen; Ankai Xu; Ambrose Jon Williams; Christoph Spiess; Cong Wu; Yichin Liu; John C. Tran

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May 3, 2020

Cancer neoantigens and immunogenicity: mutation position matters

Molecular and Cellular Oncology, ISSN: 23723556

Aude-Hélène Capietto; Suchit Jhunjhunwala; Lélia Delamarre

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May 3, 2020

Beyond type 2 cytokines in asthma - new insights from old clinical trials

Expert Opinion on Therapeutic Targets, ISSN: 17447631 14728222

David F. Choy; Joseph R. Arron

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May 3, 2020

ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway

Autophagy, ISSN: 15548635 15548627

Zhiqiang Deng; Junghyun Lim; Qian Wang; Kerry Purtell; Shuai Wu; Gloria M. Palomo; Haiyan Tan; Giovanni Manfredi; Yanxiang Zhao; Junmin Peng; Bo Hu; Shi Chen; Zhenyu Yue

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May 1, 2020

Dose modification of subcutaneous tocilizumab in patients with rheumatoid arthritis

American Health and Drug Benefits, ISSN: 19422970 19422962

Jennie Best; Ibrahim Abbass; Lenore Tominna; William Reiss

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May 1, 2020

Reconstitution reveals two paths of force transmission through the kinetochore

eLife, ISSN: 2050084X

Grace Hamilton; Luke A. Helgeson; Cameron Noland; Charles L. Asbury; Yoana Dimitrova; Trisha N. Davis

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May 1, 2020

The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors

PLoS ONE, ISSN: 19326203

Jacob Rinaldi; Ethan S. Sokol; Ryan J. Hartmaier; Sally E. Trabucco; Garrett M Frampton; Michael E. Goldberg; Lee A. Albacker; Anneleen Daemen; Gerard Manning

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May 1, 2020

High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade

Nature Medicine, ISSN: 1546170X 10788956

Kobe Yuen; L-F Liu; Vinita Gupta; Shravan Madireddi; Shilpa Keerthivasan; Congfen Li; Deepali Rishipathak; P. Mickey Williams; Edward E. Kadel III; Koeppen; Ying-Jiun Chen; Zora Modrusan; Jane L. Grogan; Romain Banchereau; Ning Leng; AnnChristine Thåström; Xiaodong Shen; Kenji Hashimoto; Darren Tayama; Michiel S Van Der Heijden; Jonathan E. Rosenberg; David McDermott; Thomas Powles; Priti Hegde; Mahrukh Huseni; Sanjeev Mariathasan

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May 1, 2020

IMbrave 050: A Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation

Future Oncology, ISSN: 17448301 14796694

Stephen P. Hack; Spahn; Minshan Chen; Ann-Lii Cheng; Ahmed Kaseb; Masatoshi Kudo; Han Chu Lee; Adam Yopp; Pierce Chow; Shukui Qin

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May 1, 2020

Characterization of antineovascularization activity and ocular pharmacokinetics of phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor GNE-947

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Xingrong Liu; Xiaorong Liang; Jennifer Lecouter; Savita Ubhayakar; Jacob Z. Chen; Jay Cheng; Tom Lee; Joseph W. Lubach; Jim Nonomiya; Sheerin Shahidi-Latham; Cristine Quiason; Eric G. Solon; Matthew Wright; Cornelis E. Hop; Timothy P. Heffron

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May 1, 2020

Absolute Bioavailability of Vemurafenib in Patients With BRAFV600 Mutation–Positive Malignancies

Clinical Pharmacology in Drug Development, ISSN: 21607648 2160763X

Weijiang Zhang; Dawn Colburn; Brian Simmons; Zsuzsanna Papai; Enric Bertran; Simone Schadt; Christophe Husser; Harper Forbes; Dieter Roethlisberger; Thomas Hartung

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May 1, 2020

A Potent Pan-TGFβ Neutralizing Monoclonal Antibody Elicits Cardiovascular Toxicity in Mice and Cynomolgus Monkeys

Toxicological Sciences, ISSN: 10960929 10966080

Mayur S. Mitra; Karla Lancaster; Adedeji; Gopinath S. Palanisamy; Rutwij A. Dave; Fiona Zhong; Matthew S. Holdren; Shannon J. Turley; Wei-Ching Liang; Yan Wu; Y. Gloria Meng; Jean-Michel Vernes; Melissa Schutten

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May 1, 2020

Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure

Journal of Clinical Investigation, ISSN: 15588238 00219738

Wei Zou; Nidhi Rohatgi; Jonathan R. Brestoff; John R. Moley; Yongjia Li; Jesse W. Williams; Yael Alippe; Hua Pan; Terri A. Pietka; Gabriel Mbalaviele; Elizabeth P. Newberry; Nicholas O. Davidson; Anwesha Dey; Kooresh I. Shoghi; Richard D. Head; Samuel A. Wickline; Gwendalyn J. Randolph; Nada A. Abumrad; Steven L. Teitelbaum

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May 1, 2020

Protein Stability and Photostability under In Vitro Vitreal Conditions – Implications for Long Acting Delivery of Protein Therapeutics for Ocular Disease

Pharmaceutical Research, ISSN: 1573904X 07248741

Neelima Mantha; Shalini Burra; Karthikan Rajagopal; Alavattam Sreedhara

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May 1, 2020

Safety and efficacy of satralizumab monotherapy in neuromyelitis optica spectrum disorder: a randomised, double-blind, multicentre, placebo-controlled phase 3 trial

Lancet Neurology, ISSN: 14744465 14744422

Traboulsee; Benjamin M Greenberg; Jeffrey L Bennett; Lech Szczechowski; Edward J Fox; Svitlana Shkrobot; Takashi Yamamura; Yusuke Terada; Yuichi Kawata; Padraig Wright; Athos Gianella-Borradori; Hideki Garren; Brian G Weinshenker

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May 1, 2020

Impact of delaying initiation of anaplastic lymphoma kinase inhibitor treatment on survival in patients with advanced non-small-cell lung cancer

Lung Cancer, ISSN: 18728332 01695002

Daniel Sheinson; Wong; Ning Wu; Mansfield

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May 1, 2020

Anti-vimentin antibodies: a unique antibody class associated with therapy-resistant lupus nephritis

Lupus, ISSN: 14770962 09612033

Andrew J Kinloch; Matthew Cascino; Jian Dai; Rene S Bermea; Kichul Ko; Margaret Vesselits; Leonard Dragone; Nirit Mor Vaknin; Maureen Legendre; David M Markovitz; Michael K. Okoreeh; Michael J. Townsend; Marcus R. Clark

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May 1, 2020

Pharmacokinetics of polatuzumab vedotin in combination with R/G-CHP in patients with B-cell non-Hodgkin lymphoma

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Colby S. Shemesh; Priya Agarwal; Tong Lu; Calvin Lee; Randall Dere; Xiaobin Li; Chunze Li; Jin Yan Jin; Sandhya Girish; Dale Miles; Dan Lu

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May 1, 2020

Paradise revealed III: why so many ways to die? Apoptosis, necroptosis, pyroptosis, and beyond

Cell Death and Differentiation, ISSN: 14765403 13509047

Marcelo Pires Amaral; Laura Migliari Branco; Andreas Strasser; Vishva M. Dixit; Karina R. Bortoluci

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May 1, 2020

Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors

Annals of Oncology, ISSN: 15698041 09237534

Isakoff; Tabernero; Molife; Jean-Charles Soria; Andrés Cervantes; Nicholas J. Vogelzang; Manish R. Patel; Hussain; Ari Baron; Guillem Argiles; Paul Conkling; Deepak Sampath; Daniel Maslyar; Premal Patel; Wai Y. Chan; Steven Gendreau; Luna Musib; Xu; Han Ma; Kui Lin; Bendell

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May 1, 2020

Reproducible quantification of IgG uptake at endogenous and overexpressed FcRn levels at pH 7.4: Comparison of a wild type IgG and a stronger FcRn binding variant

Journal of Immunological Methods, ISSN: 18727905 00221759

Jianhuan Zhang; Jean-Michel Vernes; Xiaohui Wen; Ernest Oh; Suzie J. Scales; Y. Gloria Meng

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May 1, 2020

Patient-reported outcomes from the phase III IMpassion130 trial of atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer

Annals of Oncology, ISSN: 15698041 09237534

Sylvia Adams; Diéras; Carlos H. Barrios; Eric P. Winer; Andreas Schneeweiss; Iwata; Sherene Loi; Shilpen Patel; Henschel; Chui; Hope S. Rugo; Leisha A. Emens; Schmid

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May 1, 2020

Individual therapeutic DAS28-dcrit responses differentiate between effectiveness of rheumatoid arthritis therapies and reflect patient-reported outcomes: retrospective analysis of DAS28 responses in comparative tocilizumab studies

Rheumatology International, ISSN: 1437160X 01728172

Michaela Koehm; Matthew J. McIntosh; Michael W. Hofmann; Varghese Abraham; Cem Gabay; Ernest Choy; Arthur Kavanaugh; Harald Burkhardt; Frank Behrens

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May 1, 2020

Tissue scaffolds functionalized with therapeutic elastin-like biopolymer particles

Biotechnology and Bioengineering, ISSN: 10970290 00063592

Beyza Bulutoglu; Julie Devalliere; Sarah L. Deng; Aylin Acun; Sarah S. Kelangi; Basak E. Uygun; Martin L. Yarmush

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May 1, 2020

Endothelial intercellular cell adhesion molecule 1 contributes to cell aggregate formation in CHO cells cultured in serum-free media

Biotechnology Progress, ISSN: 15206033 87567938

Salina Louie; Amy Heidersbach; Noelia Blanco; Benjamin Haley; Christopher M. Rose; Peter S. Liu; Mandy Yim; Danming Tang; Cynthia Lam; Wendy N. Sandoval; David Shaw; Snedecor; Shahram Misaghi

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May 1, 2020

Applications and considerations for the use of genetically engineered mouse models in drug development

Cell and Tissue Research, ISSN: 14320878 0302766X

Webster; Sara F. Santagostino; Oded Foreman

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May 1, 2020

Patient-reported outcomes from the phase III IMpassion130 trial of atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer

Annals of Oncology, ISSN: 15698041 09237534

Sylvia Adams; Diéras; Carlos H. Barrios; Eric P. Winer; Andreas Schneeweiss; Iwata; Sherene Loi; Sheetal Patel; Henschel; Chui; Hope S. Rugo; Leisha A. Emens; Schmid

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May 1, 2020

Antitumor activity of ipatasertib combined with chemotherapy: results from a phase Ib study in solid tumors

Annals of Oncology, ISSN: 15698041 09237534

Isakoff; Tabernero; Molife; Jean-Charles Soria; Andrés Cervantes; Nicholas J. Vogelzang; Patel; Hussain; Ari Baron; Guillem Argiles; Paul Conkling; Deepak Sampath; Daniel Maslyar; Premal Patel; Wai Y. Chan; Steven Gendreau; Luna Musib; Xu; Han Ma; Kui Lin; Bendell

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April 30, 2020

Interleukin-17: A Social Cytokine

Cell, ISSN: 10974172 00928674

Casper C Hoogenraad; Lorena Riol-Blanco

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April 26, 2020

30 Years of Biotherapeutics Development-What Have We Learned?

Annual Review of Immunology, ISSN: 15453278 07320582

Nico Ghilardi; Rajita Pappu; Joseph R. Arron; Andrew A. Chan

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April 22, 2020

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

Science Translational Medicine, ISSN: 19466242 19466234

Marco A. S Baptista; Kalpan Merchant; Ted Barrett; Sakshi Bhargava; Dianne K. Bryce; Michael Ellis; Anthony A. Estrada; Matthew J. Fell; Brian K. Fiske; Reina N. Fuji; Paul Galatsis; Anastasia G. Henry; Sue Hill; Warren D. Hirst; Christopher Houle; Matthew E. Kennedy; Xingrong Liu; Matthew L. Maddess; Carrie Markgraf; Hong Mei; William A. Meier; Elie Needle; Stephen Ploch; Christopher Royer; Karin Rudolph; Alok K. Sharma; Antonia Stepan; Stefan J. Steyn; Craig Trost; Zhizhang Yin; Hongshi Yu; Xiang Wang; Todd Sherer

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April 21, 2020

Characterization of Antisense Oligonucleotide Impurities by Ion-Pairing Reversed-Phase and Anion Exchange Chromatography Coupled to Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry Using a Versatile Two-Dimensional Liquid Chromatography Setup

Analytical Chemistry, ISSN: 15206882 00032700

Alexandre Goyon; Kelly Zhang

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April 20, 2020

Bioinformatics driven high-quality genome assembly and annotation of venomous animals for effective anti-venom development

Toxicon, ISSN: 18793150

Kushal Suryamohan

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April 17, 2020

Process Development Overcomes a Challenging Pd-Catalyzed C-N Coupling for the Synthesis of RORc Inhibitor GDC-0022

Organic Process Research and Development, ISSN: 1520586X 10836160

Lauren E. Sirois; David Lao; Jie Xu; Remy Angelaud; Jerry Tso; Brandon Scott; Paroma Chakravarty; Sushant Malhotra; Francis Gosselin

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April 16, 2020

A reference map of the human binary protein interactome

Nature, ISSN: 14764687 00280836

Katja Luck; Dae-Kyum Kim; Luke Lambourne; Kerstin Spirohn; Bridget E. Begg; Wenting Bian; Ruth Brignall; Tiziana Cafarelli; Francisco J. Campos-Laborie; Benoit Charloteaux; Dongsic Choi; Atina G. Coté; Meaghan Daley; Steven Deimling; Alice Desbuleux; Amélie Dricot; Marinella Gebbia; Madeleine F. Hardy; Nishka Kishore; Jennifer J. Knapp; István A. Kovács; Irma Lemmens; Miles W. Mee; Joseph C. Mellor; Carl Pollis; Carles Pons; Aaron D. Richardson; Sadie Schlabach; Bridget Teeking; Anupama Yadav; Mariana Babor; Dawit Balcha; Omer Basha; Christian Bowman-Colin; Suet-Feung Chin; Soon Gang Choi; Claudia Colabella; Georges Coppin; Cassandra D’Amata; David De Ridder; Steffi De Rouck; Miquel Duran-Frigola; Hanane Ennajdaoui; Florian Goebels; Liana Goehring; Anjali Gopal; Ghazal Haddad; Elodie Hatchi; Mohamed Helmy; Yves Jacob; Yoseph Kassa; Serena Landini; Roujia Li; Natascha van Lieshout; Andrew MacWilliams; Dylan Markey; Joseph N. Paulson; Sudharshan Rangarajan; John Rasla; Ashyad Rayhan; Thomas Rolland; Adriana San-Miguel; Yun Shen; Dayag Sheykhkarimli; Gloria M. Sheynkman; Eyal Simonovsky; Murat Taşan; Alexander Tejeda; Vincent Tropepe; Jean-Claude Twizere; Yang Wang; Robert J. Weatheritt; Jochen Weile; Yu Xia; Xinping Yang; Esti Yeger-Lotem; Quan Zhong; Patrick Aloy; Gary D. Bader; Javier De Las Rivas; Suzanne Gaudet; Tong Hao; Janusz Rak; Jan Tavernier; David E. Hill; Marc Vidal; Frederick P. Roth; Michael A. Calderwood

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April 15, 2020

First-in-human phase i study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma

Clinical Cancer Research, ISSN: 15573265 10780432

Patrick Y. Wen; Timothy F. Cloughesy; Alan G. Olivero; Kari M. Morrissey; Wilson; Xuyang Lu; Lars Mueller; Alexandre Coimbra; Benjamin M. Ellingson; Elizabeth Gerstner; Eudocia Q. Lee; Jordi Rodon

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April 15, 2020

The tumor suppressor BAP1 regulates the hippo pathway in pancreatic ductal adenocarcinoma

Cancer Research, ISSN: 15387445 00085472

Ho-June Lee; Trang Pham; Matthew T. Chang; Dwight Barnes; Allen G. Cai; Rajkumar Noubade; Klara Totpal; Xu Chen; Christopher Tran; Thijs Hagenbeek; Xiumin Wu; Jeffrey Eastham-Anderson; Janet Tao; Wyne P. Lee; Boris C. Bastian; Carbone; Webster; Anwesha Dey

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April 15, 2020

Automated middle-up approach for the characterization of biotherapeutic products by combining on-line hinge-specific digestion with RPLC-HRMS analysis

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Julien Camperi; Davy Guillarme; Ming Lei; Cinzia Stella

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April 15, 2020

Characterization of therapeutic oligonucleotides by liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Alexandre Goyon; Peter M. Yehl; Kelly Zhang

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April 15, 2020

First-in-human phase i study to evaluate the brain-penetrant PI3K/mTOR inhibitor GDC-0084 in patients with progressive or recurrent high-grade glioma

Clinical Cancer Research, ISSN: 15573265 10780432

Patrick Y. Wen; Timothy Cloughesy; Alan G. Olivero; Kari M. Morrissey; Wilson; Xuyang Lu; Lars Mueller; Alexandre Coimbra; Benjamin M. Ellingson; Elizabeth Gerstner; Eudocia Q. Lee; Jordi Rodon

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April 14, 2020

Neutrophils Follow Stromal Omens to Limit Peritoneal Inflammation

Immunity, ISSN: 10974180 10747613

Matthew B. Buechler; Shannon J. Turley

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April 9, 2020

Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody

JCI insight, ISSN: 23793708

Karin Staflin; Christina L. Zuch de Zafra; Leah Schutt; Vanessa Clark; Fiona Zhong; Maria Hristopoulos; Robyn Clark; Ji Li; Mary Mathieu; Xiaocheng Chen; Jennifer A. Johnston; Justin Low; Ryan Ybarra; Dionysos S. Slaga; Yang; Meric A. Ovacik; Noel Dybdal; Klara Totpal; Melissa Junttila; Diego Ellerman; Genee Y. Lee; Dennis; Prell; Teemu T. Junttila

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April 9, 2020

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors

ACS Medicinal Chemistry Letters, ISSN: 19485875

Brendan T. Parr; Richard Pastor; Benjamin D. Sellers; Zhonghua Pei; Firoz A. Jaipuri; Georgette M. Castanedo; Lewis Gazzard; Sanjeev Kumar; Xiaokai Li; Wen Liu; Rohan Mendonca; Roheeth K. Pavana; Hima Potturi; Cheng Shao; Venkata Velvadapu; Jesse P. Waldo; Guosheng Wu; Po-Wai Yuen; Zuhui Zhang; Yamin Zhang; Seth F. Harris; Angela Oh; Antonio G. DiPasquale; Kevin Dement; Hank La; Leanne Goon; Amy Gustafson; Erica Vanderporten; Mario R. Mautino; Yichin Liu

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April 9, 2020

Complete genome sequences of the human pathogen paenibacillus thiaminolyticus mbale and type Strain P. Thiaminolyticus NRRL B-4156

Microbiology Resource Announcements, ISSN: 2576098X

Christine Hehnly; Lijun Zhang; Joseph N. Paulson; Mathieu Almeida; Benjamin von Bredow; Dona S.S. Wijetunge; Michael Y. Galperin; Kathryn Sheldon; Steven J. Schiff; James R. Broacha

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April 6, 2020

Mutation position is an important determinant for predicting cancer neoantigens

Journal of Experimental Medicine, ISSN: 15409538 00221007

Aude-Hélène Capietto; Suchit Jhunjhunwala; Samuel B. Pollock; Patrick J. Lupardus; Jim Wong; Lena Hänsch; James Cevallos; Yajun Chestnut; Ajay Fernandez; Nicolas Lounsbury; Tamaki Nozawa; Manmeet Singh; Zhiyuan Fan; Cecile C. de la Cruz; Qui Phung; Lucia Taraborrelli; Benjamin Haley; Jennie R. Lill; Ira Mellman; Richard Bourgon; Lélia Delamarre

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April 3, 2020

Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance

Journal of Proteome Research, ISSN: 15353907 15353893

Victoria Pham; Pitti; Charles Tindell; Tommy K. Cheung; Alexandre Masselot; Jean-Philippe Stephan; Gulfem D. Guler; Catherine Wilson; Jennie R. Lill; David Arnott; Marie Classon

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April 2, 2020

Entering the era of computationally driven drug development

Drug Metabolism Reviews, ISSN: 10979883 03602532

Neha Maharao; Victor Antontsev; Matthew Wright; Jyotika Varshney

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April 1, 2020

ALK Mutation Status Before and After Alectinib Treatment in Locally Advanced or Metastatic ALK-Positive NSCLC: Pooled Analysis of Two Prospective Trials

Journal of Thoracic Oncology, ISSN: 15561380 15560864

Johannes Noé; Alex Lovejoy; Sai-Hong Ignatius Ou; Stephanie J. Yaung; Walter Bordogna; Daniel M. Klass; Craig A. Cummings; Alice T. Shaw

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