Scientists / Publications

Publications

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DISPLAYING 3151 - 3200 OF 15217 RESULTS

A multitargeted probe-based strategy to identify signaling vulnerabilities in cancers
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Suman Rao; Guangyan Du; Marc Hafner; Kartik Subramanian; Peter K. Sorger; Nathanael S. Gray
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IRF2 transcriptionally induces GSDMD expression for pyroptosis
Science Signaling, ISSN: 19379145 19450877
Nobuhiko Kayagaki; Bettina L. Lee; Irma B. Stowe; Opher S. Kornfeld; Karen M. O'Rourke; Kathleen M. Mirrashidi; Benjamin Haley; Colin K. Watanabe; Merone Roose-Girma; Zora Modrusan; Sarah K. Kummerfeld; Rohit Reja; Yafei Zhang; Vicky Cho; Daniel Andrews; Lucy X. Morris; Christopher C. Goodnow; Edward M. Bertram; Vishva M. Dixit
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Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies
mAbs, ISSN: 19420870 19420862
Yi-Chun Hsiao; Yonglei Shang; Danielle DiCara; Angie Yee; Joyce Lai; Si Hyun Kim; Diego Ellerman; Corpuz; Yongmei Chen; Sharmila Rajan; Hao Cai; Yan Wu; Dhaya Seshasayee; Isidro Hötzel
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Method development of a novel PK assay for antibody-conjugated drug measurement of ADCs using peptide-linker drug analyte
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Suk-Joon Hyung; Dongwei Li; Neelima Koppada; Surinder Kaur; Ola M. Saad
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Manufacture of the PI3K β-Sparing Inhibitor Taselisib. Part 1: Early-Stage Development Routes to the Bromobenzoxazepine Core
Organic Process Research and Development, ISSN: 1520586X 10836160
Travis Remarchuk; Remy Angelaud; David Askin; Archana Kumar; Andrew S. Thompson; Hua Cheng; John F. Reichwein; Yanping Chen; Frederic St-Jean
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Quantitation of a Ketone Enolization and a Vinyl Sulfonate Stereoisomer Formation Using Inline IR Spectroscopy and Modeling
Organic Process Research and Development, ISSN: 1520586X 10836160
Kallakuri Suparna Rao; Frederic St-Jean; Archana Kumar
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Manufacture of the PI3K β-Sparing Inhibitor Taselisib. Part 2: Development of a Highly Efficient and Regioselective Late-Stage Process
Organic Process Research and Development, ISSN: 1520586X 10836160
Frederic St-Jean; Travis Remarchuk; Remy Angelaud; Diane Carrera; Danial Beaudry; Sushant Malhotra; Andrew McClory; Archana Kumar; Gerd Ohlenbusch; Andreas M. Schuster; Francis Gosselin
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Antibody-drug conjugates derived from cytotoxic seco-CBI-Dimer payloads are highly efficacious in xenograft models and form protein adducts in Vivo
Bioconjugate Chemistry, ISSN: 15204812 10431802
Dian Su; Jinhua Chen; Ely Cosino; Josefa Dela Cruz Chuh; Helen Davis; Geoffrey Del Rosario; Isabel Figueroa; Leanne Goon; Jintang He; Amrita Kamath; Surinder Kaur; Katherine R. Kozak; Jeffrey Lau; Donna W. Lee; M. Violet Lee; Douglas Leipold; Luna Liu; Peter S. Liu; Guo-Liang Lu; Nelson; Carl Ng; Thomas H. Pillow; Paul G. Polakis; Andrew G. Polson; Rebecca K. Rowntree; Ola M. Saad; Brian S. Safina; Nicola J. Stagg; Moana Tercel; Richard L. Vandlen; Breanna S. Vollmar; John Wai; Tao Wang; Binqing Wei; Keyang Xu; Juanjuan Xue; Zijin Xu; Gang Yan; Hui Yao; Shang-Fan Yu; Donglu Zhang; Fiona Zhong; Peter Dragovich
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Mouse venous thrombosis upon silencing of anticoagulants depends on tissue factor and platelets, not FXII or neutrophils
Blood, ISSN: 15280020 00064971
Marco Heestermans; Salam Salloum-Asfar; Tom Streef; El Houari Laghmani; Daniela Salvatori; Brenda M. Luken; Sacha S. Zeerleder; Henri M H Spronk; Suzanne J. Korporaal; Daniel Kirchhofer; Gerry T M Wagenaar; Henri H. Versteeg; Pieter H. Reitsma; Thomas Renné; Bart J M van Vlijmen
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Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse
Xenobiotica, ISSN: 13665928 00498254
Jae H. Chang; Xiaolin Zhang; Kirsten Messick; Yi-Chen Chen; Eugene C. Chen; Jonathan Cheong; Justin Ly
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Hydrogen-deuterium exchange mass spectrometry (HDX-MS) centroid data measured between 3.6 oC and 25.4 OC for the Fab fragment of NiStmab
Journal of Research of the National Institute of Standards and Technology, ISSN: 21657254
Jeffrey W. Hudgens; Elyssia S. Gallagher; Ioannis Karageorgos; Kyle W. Anderson; Richard Y.-C. Huang; Guodong Chen; George M. Bou-Assaf; Alfonso Espada; Michael J. Chalmers; Eduardo Harguindey; Hui-Min Zhang; Benjamin T. Walters; Jennifer Zhang; John Venable; Caitlin Steckler; Inhee Park; Ansgar Brock; Xiaojun Lu; Ratnesh Pandey; Arun Chandramohan; Ganesh Srinivasan Anand; Sasidhar N. Nirudodhi; Justin B. Sperry; Jason C. Rouse; James A. Carroll; Kasper D. Rand; Ulrike Leurs; David D. Weis; Mohammed A. Al-Naqshabandi; Tyler S. Hageman; Daniel Deredge; Patrick L. Wintrode; Malvina Papanastasiou; John D. Lambris; Sheng Li; Sarah Urata
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Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: Results from the CAVALLI phase 1b trial
Blood, ISSN: 15280020 00064971
Zelenetz; Gilles Salles; Kylie D. Mason; Carla Casulo; Le Gouill; Laurie H. Sehn; Herve Tilly; Guillaume Cartron; Martine E.D. Chamuleau; Andre Goy; Constantine S. Tam; Pieternella J. Lugtenburg; Adam M. Petrich; Arijit Sinha; Divya Samineni; Sylvia Herter; Ellen Ingalla; Edith Szafer-Glusman; Christian Klein; Deepak Sampath; Martin Kornacker; Mehrdad Mobasher; Morschhauser
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NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
eLife, ISSN: 2050084X
Ganapati V. Hegde; Cecile C. de la Cruz; Jennifer M. Giltnane; Lisa Crocker; Avinashnarayan Venkatanarayan Gabriele Schaefer; Debra Dunlap; Joerg D. Hoeck; Robert Piskol; Florian Gnad; Zora Modrusan; FredericJ. deSauvage; Christian W. Siebel; Erica L. Jackson
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Evidence-based study design for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia
Journal of Infectious Diseases, ISSN: 15376613 00221899
George H. Talbot; Anita Das; Stephanie Cush; Aaron Dane; Michele Wible; Roger Echols; Antoni Torres; Sue Cammarata; John H. Rex; John H. Powers; Thomas Fleming; Jeffrey Loutit; Steven Hoffmann; Jeff Alder; Mari Ariyasu; Helen Boucher; Carisa De Anda; Dennis Dixon; Mike Dudley; Janet Ehlert; Barry Eisenstein; Mark Eisner; Thomas File; Dean Follmann; David Friedland; Ian Friedland; Maria Arantxa Horga; Kellee Howard; Nicholas A. Kartsonis; Achim Kaufhold; Amy Kindrick; Lily Llorens; Paul McGovern; Philippe Prokocimer; Elyse Seltzer; Claire Sherman; Anthony Suffredini; Larry Tsai; Richard Wunderink; Joseph Toerner; Daniel Rubin
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Stability evaluation of hydrogen peroxide uptake samples from monoclonal antibody drug product aseptically filled in vapor phase hydrogen peroxide-sanitized barrier systems: A case study
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Devon Roshan Eisner; Ada Hui; Kirk Eppler; Vassia Tegoulia; Maa
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Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in nonsmall cell lung cancer
PLoS ONE, ISSN: 19326203
Willemijn S.M.E. Theelen; Thomas Kuilman; Katja Schulze; Wei Zou; Oscar Krijgsman; Dennis D.G.C. Peters; Sten Cornelissen; Kim Monkhorst; Pranamee Sarma; Teiko Sumiyoshi; Lukas Amler; Stefan M. Willems; Johannes L.G. Blaauwgeers; Carel Jm van Noesel; Daniel S. Peeper; Michel Van Den Heuvel; Marcin Kowanetz
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Determination of a no observable effect level for endotoxin following a single intravitreal administration to cynomolgus monkeys
Journal of Ocular Pharmacology and Therapeutics, ISSN: 15577732 10807683
Vlad Bantseev; Paul Miller; T. Michael Nork; Carol A. Rasmussen; Aija McKenzie; Brian J. Christian; Helen Booler; Evan A Thackaberry
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Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities
Trends in Cancer, ISSN: 24058033
Philamer C. Calses; James J. Crawford; Jennie R. Lill; Anwesha Dey
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A novel depurination methodology to assess DNA alkylation of chloro-bis-seco-cyclopropylbenzoindoles allowed for comparison of minor-groove reactivity S
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Shuai Wang; Buyun Chen; Peter Dragovich; Thomas H. Pillow; Leanna Staben; Jun Guo; Dian Su; Chenghong Zhang; Sudheer Bobba; Yong Ma; Jianshuang Wang; Dewakar Sangaraju; Binqing Wei; Gail L. Phillips; Cyrus Khojasteh; Donglu Zhang
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Health-related quality of life and health status in persons with haemophilia A with inhibitors: A prospective, multicentre, non-interventional study (NIS)
Haemophilia, ISSN: 13652516 13518216
Johnny N. Mahlangu; Johannes Oldenburg; Michael U. Callaghan; Midori Shima; Mancuso; Peter C. Trask; Michael Recht; Claudia Garcia; Renchi Yang; Michaela Lehle; Harrison Macharia; Elina Asikanius; Gallia Levy; Kruse-Jarres; Sylvia von Mackensen
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Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Martin Reck; Tony Mok; Makoto Nishio; Jotte; Federico Cappuzzo; Orlandi; Daniil Stroyakovskiy; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Lee; Coleman; Deng; Marcin Kowanetz; Geetha Shankar; Wei Lin; Mark A. Socinski
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Polatuzumab vedotin or pinatuzumab vedotin plus rituximab in patients with relapsed or refractory non-Hodgkin lymphoma: final results from a phase 2 randomised study (ROMULUS)
The Lancet Haematology, ISSN: 23523026
Morschhauser; Ian W. Flinn; Ranjana H. Advani; Laurie H. Sehn; Catherine S. Diefenbach; Kathryn S. Kolibaba; Oliver W. Press; Gilles Salles; Herve Tilly; Chen; Sarit E. Assouline; Bruce D. Cheson; Dreyling; Anton Hagenbeek; Pier Luigi Zinzani; Surai Jones; Ji Cheng; Dan Lu; Elicia M. Penuel; Jamie Hirata; Michael Wenger; Yu-Waye Chu; Jeff P. Sharman
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Opportunities and challenges using artificial intelligence in ADME/Tox
Nature Materials, ISSN: 14764660 14761122
Barun Bhhatarai; W. Patrick Walters; Cornelis E. Hop; Guido Lanza; Sean Ekins
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Synthetic Antigen Gels as Practical Controls for Standardized and Quantitative Immunohistochemistry
Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554
Kathy Hötzel; Charles Havnar; Hai Ngu; Sandra Rost; Scot D. Liu; Linda Rangell; Franklin V. Peale Jr.
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Microperimetry for geographic atrophy secondary to age-related macular degeneration
Survey of Ophthalmology, ISSN: 18793304 00396257
Karl G. Csaky; Praveen J. Patel; Yasir J. Sepah; David G. Birch; Diana V. Do; Michael S. Ip; Robyn H. Guymer; Chi D. Luu; Shamika Gune; Hugh Lin; Daniela Ferrara
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A novel method for determining antibody-dependent cellular phagocytosis
Journal of Immunological Methods, ISSN: 18727905 00221759
Lynn Kamen; Srividya Myneni; Chris Langsdorf; Elviza Kho; Benjamin A. Ordonia; Tara Thakurta; Kai Zheng; An Song; Shan Chung
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Interfacial Stress in the Development of Biologics: Fundamental Understanding, Current Practice, and Future Perspective
AAPS Journal, ISSN: 15507416
Jinjiang Li; Mary E. Krause; Xiaodong Chen; Yuan Cheng; Weiguo Dai; John J. Hill; Min Huang; Susan Jordan; Daniel P. LaCasse; Linda O. Narhi; Evgenyi Shalaev; Ian C. Shieh; Justin C. Thomas; Raymond Tu; Songyan Zheng; Lily Zhu
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Ocrelizumab efficacy in subgroups of patients with relapsing multiple sclerosis
Journal of Neurology, ISSN: 14321459 03405354
Benjamin Turner; Bruce A. C. Cree; Ludwig Kappos; Montalban; Caroline Papeix; Wolinsky; Regine Buffels; Damian Fiore; Hideki Garren; Jian Han; Stephen L. Hauser
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Development of a kinetic antibody-dependent cellular cytotoxicity assay
Journal of Immunological Methods, ISSN: 18727905 00221759
Lynn Kamen; Tara Thakurta; Srividya Myneni; Kai Zheng; Shan Chung
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Ocrelizumab infusion experience in patients with relapsing and primary progressive multiple sclerosis: Results from the phase 3 randomized OPERA I, OPERA II, and ORATORIO studies
Multiple Sclerosis and Related Disorders, ISSN: 22110356 22110348
Lori Mayer; Ludwig Kappos; Michael K. Racke; Rammohan; Traboulsee; Stephen L. Hauser; Laura Julian; Harold Köndgen; Carrie Li; Julie Napieralski; Hanzhe Zheng; Wolinsky
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A prospective observational safety study of patients with BRAF V 600 -mutated unresectable or metastatic melanoma treated with vemurafenib (Zelboraf Safety Study)
British Journal of Dermatology, ISSN: 13652133 00070963
Pippa G. Corrie; Terheyden; ten Tije; Herbst; Jansen; Marples; Debus; Marconcini; Blasinska-Morawiec; Freivogel; Munson; Grant R. Goodman; Jessie Hsu; Natalia Sadetsky; Dawn Colburn; Piotr Rutkowski
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Quantitative X-Ray Microcomputed Tomography Assessment of Internal Tablet Defects
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Edward Yost; Pascal Chalus; Shawn Zhang; Stefanie Peter; Ajit S. Narang
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Durability of Diabetic Retinopathy Improvement with As-Needed Ranibizumab: Open-Label Extension of RIDE and RISE Studies
Ophthalmology, ISSN: 15494713 01616420
Jennifer K. Sun; Pin-Wen Wang; Sarah Taylor; Zdenka Haskova
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Quantitative neuroimaging measures of myelin in the healthy brain and in multiple sclerosis
Human Brain Mapping, ISSN: 10970193 10659471
Jonathan O'Muircheartaigh; Irene Vavasour; Emil Ljungberg; David K. B. Li; Alexander Rauscher; Victoria Levesque; Hideki Garren; David Clayton; Roger Tam; Traboulsee; Shannon Kolind
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Development of a Subcutaneous Fixed-Dose Combination of Pertuzumab and Trastuzumab: Results From the Phase Ib Dose-Finding Study
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Whitney P. Kirschbrown; Chris J. Wynne; Kagedal; Russell D. Wada; Hanbin Li; Wang; Ihsan Nijem; Tanja Badovinac-Crnjevic; Helena Gasser; Sarah Heeson; Jennifer Eng-Wong; Amit Garg
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Safety and efficacy of vismodegib in relapsed/refractory acute myeloid leukaemia: results of a phase Ib trial
British Journal of Haematology, ISSN: 13652141 00071048
Dale Bixby; Richard Noppeney; Tara L. Lin; Jorge E. Cortes; Jürgen Krauter; Karen Yee; Bruno C. Medeiros; Alwin Krämer; Sarit E. Assouline; Walter Fiedler; Natalie Dimier; Brian Simmons; Todd Riehl; Dawn Colburn
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Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Steven J. McKerrall; Nguyen; Kwong Wah Lai; Philippe Bergeron; Lunbin Deng; Antonio G. DiPasquale; Jae H. Chang; Jun Chen; Tania Chernov-Rogan; David Hackos; Jonathan M. Maher; Daniel F. Ortwine; Jodie Pang; Jian Payandeh; William R. Proctor; Shannon D. Shields; Jennifer Vogt; Pengfei Ji; Wenfeng Liu; Elisa Ballini; Lilia Schumann; Glauco Tarozzo; Girish Bankar; Sultan Chowdhury; Abid Hasan; Johnson; Kuldip Khakh; Sophia Lin; Charles J. Cohen; Christoph Dehnhardt; Brian S. Safina; Daniel P. Sutherlin
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A prognostic model of persistent bacteremia and mortality in complicated staphylococcus aureus bloodstream infection
Clinical Infectious Diseases, ISSN: 15376591 10584838
Alessander O. Guimaraes; Yi Cao; Kyu Hong; Oleg Mayba; Melicent Peck; Johnny Gutierrez; Felicia Ruffin; Montserrat Carrasco-Triguero; Jason Dinoso; Angelo Clemenzi-Allen; Catherine A. Koss; Stacey A. Maskarinec; Chambers; Vance G. Fowler; Amos Baruch; Carrie M. Rosenberger
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Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines
Journal of Organic Chemistry, ISSN: 15206904 00223263
Haiming Zhang; Beryl X. Li; Brian Wong; Andreas Stumpf; C. Gregory Sowell; Francis Gosselin
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Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: Final update of the pivotal ERIVANCE BCC study (BMC Cancer. (2017) 17 (332) DOI: 10.1186/s12885-017-3286-5)
BMC Cancer, ISSN: 14712407
Aleksandar Sekulic; Michael R. Migden; Nicole Basset-Seguin; Claus Garbe; Anja Gesierich; Christopher D. Lao; Chris Miller; Laurent Mortier; Dedee F. Murrell; Omid Hamid; Jorge F. Quevedo; Jeannie Hou; Edward McKenna; Natalie Dimier; Sarah Williams; Dirk Schadendorf; Axel Hauschild
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BcGST-an interactive bias-correction method to identify over-represented gene-sets in boutique arrays
Bioinformatics, ISSN: 14602059 13674803
Kevin Y.X. Wang; Alexander M. Menzies; Ines Pires da Silva; James S. Wilmott; Yibing Yan; Matthew Wongchenko; Richard F. Kefford; Richard A. Scolyer; Georgina V. Long; Garth Tarr; Samuel Mueller; Yang
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Central nervous system metastasis in patients with HER2-positive metastatic breast cancer: Patient characteristics, treatment, and survival from systhers
Clinical Cancer Research, ISSN: 15573265 10780432
Sara A. Hurvitz; O'Shaughnessy; Ginny Mason; Denise A. Yardley; Mohammad Jahanzeb; Adam Brufsky; Hope S. Rugo; Sandra M. Swain; Peter A. Kaufman; Debasish Tripathy; Laura Chu; Haocheng Li; Vincent Antao; Melody A. Cobleigh
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Human growth hormone
Pharmaceutical Biotechnology: Fundamentals and Applications,
Dao; Barbara M. Lippe; Mike Laird; Ingrid Beierle
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Recombinant human deoxyribonuclease I
Pharmaceutical Biotechnology: Fundamentals and Applications,
Lazarus; Wagener
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Monoclonal antibodies: From structure to therapeutic application
Pharmaceutical Biotechnology: Fundamentals and Applications,
Rong Deng; C. Andrew Boswell; Wendy Putnam; Meina Tao Tang; Amit Garg; Chunze Li; Shan Chung; Sandhya Girish
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General Purpose Water Model Can Improve Atomistic Simulations of Intrinsically Disordered Proteins
Journal of Chemical Theory and Computation, ISSN: 15499626 15499618
Parviz Seifpanahi Shabane; Saeed Izadi; Alexey V. Onufriev
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Autophagy Regulation of Metabolism Is Required for CD8 + T Cell Anti-tumor Immunity
Cell Reports, ISSN: 22111247
Devorkin; Nils Pavey; Gillian Carleton; Alexandra Comber; Cally Ho; Junghyun Lim; Erin McNamara; Haochu Huang; Kim; Lauren G. Zacharias; Noboru Mizushima; Tatsuya Saitoh; Shizuo Akira; Wayne Beckham; Alireza Lorzadeh; Michelle Moksa; Qi Cao; Aditya Murthy; Martin Hirst; DeBerardinis; Julian J. Lum
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RALying Regeneration through Wnt Internalization in Stem Cells
Cell Stem Cell, ISSN: 18759777 19345909
Helen Tauc; Heinrich Jasper
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Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation
Cell Reports, ISSN: 22111247
Denise De Almeida Nagata; Eugene Y. Chiang; Suchit Jhunjhunwala; Patrick Caplazi; Vidhyalakshmi Arumugam; Zora Modrusan; Emily Chan; Mark Merchant; Lingyan Jin; David Arnott; F. Anthony Romero; Steven Magnuson; Karen Gascoigne; Jane L. Grogan
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Single-institution retrospective review of patients with recurrent glioblastoma treated with bevacizumab in clinical practice
Health Science Reports, ISSN: 23988835
Annick Desjardins; James E. Herndon; Frances McSherry; Arliene Ravelo; Eric S. Lipp; Patrick Healy; Katherine B. Peters; John H. Sampson; Dina Randazzo; Nicolas Sommer; Allan H. Friedman; Henry S. Friedman
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