Genentech: Publications

January 18, 2019

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp 3 -sp 2 Suzuki Coupling of a Benzyl Carbonate

Organic Process Research and Development, ISSN: 1520586X 10836160

Lauren E. Sirois; Matthew M. Zhao; Ngiap-Kie Lim; Mark S. Bednarz; Bryce A. Harrison; Wenxue Wu

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January 16, 2019

Development, Optimization, and Structural Characterization of an Efficient Peptide-Based Photoaffinity Cross-Linking Reaction for Generation of Homogeneous Conjugates from Wild-Type Antibodies

Bioconjugate Chemistry, ISSN: 15204812 10431802

Nicholas Vance; Neelie Zacharias; Ultsch; Guangmin Li; Aimee Fourie; Peter S. Liu; Julien Lafrance-Vanasse; James A. Ernst; Wendy N. Sandoval; Katherine R. Kozak; Gail L. Phillips; Weiru Wang; Jack D. Sadowsky

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January 14, 2019

Study of a Competing Hydrodefluorination Reaction during the Directed ortho-Lithiation/Borylation of 2-Fluorobenzaldehyde

Organometallics, ISSN: 15206041 02767333

Frederic St-Jean; Katarzyna A. Piechowicz; Lauren E. Sirois; Remy Angelaud; Francis Gosselin

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January 14, 2019

Directed Cp Rh III -Catalyzed Fluorosulfonylvinylation of Arenes

Organometallics, ISSN: 15206041 02767333

Gqwetha Ncube; Malcolm P. Huestis

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January 11, 2019

Fatty acid recognition in the Frizzled receptor family

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Aaron H Nile; Rami N. Hannoush

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January 9, 2019

Regio- and Enantioselective Iridium-Catalyzed Amination of Racemic Branched Alkyl-Substituted Allylic Acetates with Primary and Secondary Aromatic and Heteroaromatic Amines

Journal of the American Chemical Society, ISSN: 15205126 00027863

Seung Wook Kim; Leyah A. Schwartz; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische

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January 8, 2019

Why Computed Protein Folding Landscapes Are Sensitive to the Water Model

Journal of Chemical Theory and Computation, ISSN: 15499626 15499618

Ramu Anandakrishnan; Saeed Izadi; Alexey V. Onufriev

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January 8, 2019

Baseline characteristics associated with early visual acuity gains after ranibizumab treatment for retinal vein occlusion

BMC Ophthalmology, ISSN: 14712415

W. Lloyd Clark; Mimi Liu; John Kitchens; Pin-Wen Wang; Zdenka Haskova

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January 7, 2019

A phase I, randomized, observer-blinded, single and multiple ascending-dose study to investigate the safety, pharmacokinetics, and immunogenicity of BITS7201A, a bispecific antibody targeting IL-13 and IL-17, in healthy volunteers 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

BMC Pulmonary Medicine, ISSN: 14712466

Tracy Staton; Kun Peng; Ryan Owen; David F. Choy; Christopher R. Cabanski; Alice Fong; Flavia Brunstein; Kathila R. Alatsis; Hubert Chen

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January 7, 2019

In Situ Characterization of the Microstructural Evolution of Biopharmaceutical Solid-State Formulations with Implications for Protein Stability

Molecular Pharmaceutics, ISSN: 15438392 15438384

Stijn H.S. Koshari; Purnendu K. Nayak; Shalini Burra; Isidro E. Zarraga; Karthikan Rajagopal; Yun Liu; Norman J. Wagner; Abraham M. Lenhoff

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January 7, 2019

Trehalose Limits Fragment Antibody Aggregation and Influences Charge Variant Formation in Spray-Dried Formulations at Elevated Temperatures

Molecular Pharmaceutics, ISSN: 15438392 15438384

Karthikan Rajagopal; Debby P. Chang; Purnendu K. Nayak; Saeed Izadi; Thomas W. Patapoff; Jennifer Zhang; Robert F. Kelley; Alavattam Sreedhara

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January 7, 2019

In Vivo Stability Profiles of Anti-factor D Molecules Support Long-Acting Delivery Approaches

Molecular Pharmaceutics, ISSN: 15438392 15438384

Kelly M. Loyet; Hass; Wendy N. Sandoval; Ashley Morando; Peter S. Liu; Whitney Shatz; Leslie Dickmann; Margaret Kenrick; Jeremy Good; Teresa Davancaze; Alyssa M. Morimoto; Robert F. Kelley; Justin M. Scheer

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January 5, 2019

Seeking universal detectors for analytical characterizations

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Kelly Zhang; Kenji L. Kurita; Venkatramani; David J. Russell

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January 4, 2019

Macrolactamization Approaches to Arylomycin Antibiotics Core

Organic Letters, ISSN: 15237052 15237060

Ngiap-Kie Lim; Xin Linghu; Nicholas Wong; Haiming Zhang; C. Gregory Sowell; Francis Gosselin

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January 4, 2019

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

Science, ISSN: 10959203 00368075

Oliver J. Harrison; Jonathan L. Linehan; Han-Yu Shih; Nicolas Bouladoux; Seong-Ji Han; Margery Smelkinson; Shurjo K. Sen; Allyson L. Byrd; Michel Enamorado; Chen Yao; Samira Tamoutounour; Francois Van Laethem; Charlotte Hurabielle; Nicholas Collins; Andrea Paun; Rosalba Salcedo; John J. O'Shea; Yasmine Belkaid

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January 3, 2019

Cellular Plasticity in Intestinal Homeostasis and Disease

Cell Stem Cell, ISSN: 18759777 19345909

Felipe de Sousa e Melo; Frederic J. De Sauvage

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January 3, 2019

A telescoped Knochel-Hauser/Kumada-Corriu coupling strategy to functionalized aromatic heterocycles

Tetrahedron Letters, ISSN: 18733581 00404039

Kyle Clagg; Sara Hold; Archana Kumar; Stefan G. Koenig; Remy Angelaud

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January 2, 2019

Borrowing From Historical Control Data in Cancer Drug Development: A Cautionary Tale and Practical Guidelines

Statistics in Biopharmaceutical Research, ISSN: 19466315

Connor Jo Lewis; Somnath Sarkar; Jiawen Zhu; Bradley P. Carlin

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January 2, 2019

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer

Structure, ISSN: 18784186 09692126

Ping Wu; Chris J. Sneeringer; Keith Pitts; Eric S. Day; Bryan K. Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane L. Grogan; Timothy P. Heffron; Weiru Wang

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January 2, 2019

Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Chengfeng Ren; Aaron O. Bailey; Erica Vanderporten; Angela Oh; Wilson Phung; Melinda M. Mulvihill; Seth F. Harris; Yichin Liu; Guanghui Han; Wendy N. Sandoval

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January 2, 2019

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

mAbs, ISSN: 19420870 19420862

Robert G. Brinson; John P. Marino; Frank Delaglio; Luke W. Arbogast; Ryan M. Evans; Anthony Kearsley; Geneviève Gingras; Houman Ghasriani; Yves Aubin; Gregory K. Pierens; Xinying Jia; Mehdi Mobli; Hamish G. Grant; David W. Keizer; Kristian Schweimer; Jonas Ståhle; Göran Widmalm; Edward R. Zartler; Chad W. Lawrence; Patrick N. Reardon; John R. Cort; Ping Xu; Feng Ni; Saeko Yanaka; Koichi Kato; Stuart R. Parnham; Desiree Tsao; Andreas Blomgren; Torgny Rundlöf; Nils Trieloff; Peter Schmieder; Ross; Ken Skidmore; Kang Chen; David Keire; Darón I. Freedberg; Thea Suter-Stahel; Gerhard Wider; Gregor Ilc; Janez Plavec; Scott A. Bradley; Donna M. Baldisseri; Mauricio Luis Sforça; Ana Carolina de Mattos Zeri; Julie Yu Wei; Christina M. Szabo; Carlos A. Amezcua; John B. Jordan; Mats Wikström

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January 2, 2019

Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning

Analytical Chemistry, ISSN: 15206882 00032700

Jordan Baker; Dana McDaniel; David Cain; Paula Lee Tao; Charlene Li; Yuting Huang; Hongbin Liu; Judith Zhu-Shimoni; Milady Ninonuevo

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January 2, 2019

Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases

Expert Opinion on Drug Delivery, ISSN: 17447593 17425247

Whitney Shatz; Jeffrey Aaronson; Stefan T. Yohe; Robert F. Kelley; Yogeshvar N. Kalia

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January 2, 2019

High-resolution glycosylation site-engineering method identifies MICA epitope critical for shedding inhibition activity of anti-MICA antibodies

mAbs, ISSN: 19420870 19420862

T. Noelle Lombana; Marissa L. Matsumoto; Amy M. Berkley; Evangeline Toy; Ryan Cook; Yutian Gan; Du; Paul D. Schnier; Wendy N. Sandoval; Zhengmao Ye; Jill Schartner; Kim; Christoph Spiess

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January 1, 2019

Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?

Multiple Sclerosis Journal - Experimental, Translational and Clinical,

Lisa Eunyoung Lee; Jillian K. Chan; Emilie Nevill; Adam Soares; Irene Vavasour; Erin L MacMillan; Hideki Garren; David Clayton; B. Mark Keegan; Roger Tam; Traboulsee; Shannon Kolind; Robert L. Carruthers

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January 1, 2019

Advanced imaging findings in progressive solitary sclerosis: a single lesion or a global disease?

Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173

Lisa Eunyoung Lee; Jillian K. Chan; Emilie Nevill; Adam Soares; Irene Vavasour; Erin L MacMillan; Hideki Garren; David Clayton; B. Mark Keegan; Roger Tam; Traboulsee; Shannon Kolind; Robert L. Carruthers

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January 1, 2019

Magnetic resonance spectroscopy evidence for declining gliosis in MS patients treated with ocrelizumab versus interferon beta-1a

Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173

Erin L MacMillan; Julia J Schubert; Irene Vavasour; Roger Tam; Alexander Rauscher; Carolyn Taylor; Rick White; Hideki Garren; David Clayton; Victoria Levesque; David K. B. Li; Shannon Kolind; Traboulsee

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January 1, 2019

HPLC and UHPLC for biopharmaceutical analysis

HPLC and UHPLC for Practicing Scientists,

Jennifer C. Rea; Taylor Zhang

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January 1, 2019

Process validation

Comprehensive Biotechnology,

David H. Reifsnyder; Nathan McKnight; Kelley

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January 1, 2019

Disposable bioreactors

Comprehensive Biotechnology,

Oosterhuis; Terry Hudson; Alberto D’Avino; Zijlstra; Ashraf Amanullah

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January 1, 2019

Homogeneity in the association of body mass index with type 2 diabetes across the UK Biobank: A Mendelian randomization study

Nature Methods, ISSN: 15491676 15491277

Michael Wainberg; Anubha Mahajan; Anshul Kundaje; Mark I. McCarthy; Erik Ingelsson; Nasa Sinnott-Armstrong; Manuel Rivas

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January 1, 2019

Cisplatin Ineligibility for Patients with Metastatic Urothelial Carcinoma: A Survey of Clinical Practice Perspectives among US Oncologists

Bladder Cancer, ISSN: 23523735 23523727

Matthew D. Galsky; Esprit Ma; Bijal Shah-Manek; Rosalina Mills; Long Ha; Craig Krebsbach; Eric Blouin; Darren Tayama; Sarika Ogale

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January 1, 2019

Healthcare costs of potential glucocorticoid-associated adverse events in patients with giant cell arteritis

ClinicoEconomics and Outcomes Research, ISSN: 11786981

Jennie Best; Amanda M. Kong; David Smith; Ibrahim Abbass; Margaret Michalska

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January 1, 2019

Phase i Study of DSTP3086S, an antibody-drug conjugate targeting six-transmembrane epithelial antigen of prostate 1, in metastatic castration-resistant prostate cancer

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Daniel C. Danila; Russell Z. Szmulewitz; Ulka Vaishampayan; Celestia S. Higano; Ari Baron; Houston N. Gilbert; Flavia Brunstein; Marija Milojic-Blair; Wang; Omar Kabbarah; Michael Mamounas; Bernard M. Fine; Daniel Maslyar; Alexander Ungewickell; Scher

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January 1, 2019

Immunoaffinity LC-MS/MS to quantify a PEGylated anti-Factor D Fab biotherapeutic in cynomolgus monkey serum

Bioanalysis, ISSN: 17576199 17576180

Luna Liu; Yanqiu Liu; Lu Dai; Cinzia Stella; Morse Faria; Junlong Shao; Jamie L Hicks; Diego F. Cortes; William R. Mylott; Eric Wakshull; Surinder Kaur; Keyang Xu

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January 1, 2019

2019 White Paper on Recent Issues in Bioanalysis: FDA BMV Guidance, ICH M10 BMV Guideline and Regulatory Inputs (Part 2-Recommendations on 2018 FDA BMV Guidance, 2019 ICH M10 BMV Draft Guideline and Regulatory Agencies' Input on Bioanalysis, Biomarkers and Immunogenicity)

Bioanalysis, ISSN: 17576199 17576180

Brian Booth; Lauren Stevenson; Renuka Pillutla; Michael H. Buonarati; Chris Beaver; Daniela Fraier; Fabio Garofolo; Sam Haidar; Rafiqul Islam; Christopher James; John Kadavil; Olga Kavetska; Li; Christina Satterwhite; Natasha Savoie; Sriram Subramaniam; Nilufer Tampal; Theingi Thway; Eric Woolf; Olivier Le Blaye; Matthew Andisik; Chad Briscoe; Stephanie Cape; Arindam Dasgupta; Saloumeh Kadkhodayan Fischer; Roger Hayes; John Kamerud; Gustavo Mendes Lima Santos; Corey Nehls; Catherine Soo; Stephen Vinter; Emma Whale; Keyang Xu; Seongeun Julia Cho; Anna Edmison; Sean Kassim; Thais Correa Rocha; Jan Welink; Shashi Amur; Abbas Bandukwala; Elana Cherry; Shirley Hopper; Akiko Ishii-Watabe; Susan Kirshner; Kevin Maher; Joao Pedras-Vasconcelos; Yoshiro Saito; Therese Solstad Saunders; Venke Skibeli; Verthelyi; Yow-Ming C. Wang; Haoheng Yan

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January 1, 2019

2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3-Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)

Bioanalysis, ISSN: 17576199 17576180

Steven Piccoli; Devangi Mehta; Alessandra Vitaliti; John Allinson; Shashi Amur; Steven Eck; Cherie Green; Michael Hedrick; Shirley Hopper; Allena Ji; Alison Joyce; Virginia Litwin; Kevin Maher; Joel Mathews; Kun Peng; Afshin Safavi; Yow-Ming C. Wang; Yan Zhang; Lakshmi Amaravadi; Nisha Palackal; Sai Thankamony; Chris Beaver; Eris Bame; Thomas Emrich; Grimaldi; Jonathan Haulenbeek; Vellalore Kakkanaiah; David Lanham; Andrew Mayer; Paul C Trampont; Laurent Vermet; Naveen Dakappagari; Catherine Aversa Fleener; Fabio Garofolo; Cynthia Rogers; Shabnam Tangri; Yuanxin Xu; Meina Liang; Manoj Rajadhyaksha; Susan Richards; Becky Schweighardt; Shobha Purushothama; Daniel Baltrukonis; Jochen Brumm; Elana Cherry; Jason Delcarpini; Carol Gleason; Susan Kirshner; Robert J Kubiak; Luying Pan; Michael A. Partridge; Joao Pedras-Vasconcelos; Qiang Qu; Venke Skibeli; Therese Solstad Saunders; Roland F Staack; Kay Stubenrauch; Albert Torri; Verthelyi; Haoheng Yan; Boris Gorovits; Rachel Palmer; Milton; Brian Long; Bart Corsaro; Vahid Farrokhi; Michele Fiscella; Neil Henderson; Vibha Jawa; Jim McNally; Rocio Murphy; Hanspeter Waldner; Tong-Yuan Yang

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January 1, 2019

2019 white paper on recent issues in bioanalysis: Chromatographic assays (part 1 - Innovation in small molecules and oligonucleotides & mass spectrometric method development strategies for large molecule bioanalysis)

Bioanalysis, ISSN: 17576199 17576180

Christine Fandozzi; Christopher Evans; Amanda Wilson; Dian Su; Melanie Anderson; Valerie Clausen; Lieve Dillen; Fabio Garofolo; Chris Holliman; Elliott Nickbarg; Timothy Olah; Ragu Ramanathan; Hui Zhang; Surinder Kaur; Renuka Pillutla; Hongbin Yu; Kevin Bateman; Lorella Di Donato; Shawna Hengel; Wenying Jian; Barry Jones; John Kellie; Anita Lee; Joe Palandra; Natasha Savoie; Petia Shipkova; Susan Spitz; Matthew Szapacs; Jian Wang; Katherine Wright; Jianing Zeng

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January 1, 2019

Microglia in Brain Development, Homeostasis, and Neurodegeneration

Annual Review of Genetics, ISSN: 15452948 00664197

Christopher J. Bohlen; Brad A. Friedman; Borislav Dejanovic; Morgan Sheng

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January 1, 2019

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer

Oncotarget, ISSN: 19492553

C. Andrew Boswell; Daniela Bumbaca Yadav; Eduardo E. Mundo; Shang-Fan Yu; Jennifer A. Lacap; Aimee Fourie-O’Donohue; Katherine R. Kozak; Gregory Z. Ferl; Crystal Zhang; Jason Ho; Sheila Ulufatu; Leslie A. Khawli; Kedan Lin

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January 1, 2019

Streamlined Characterization of an Antibody-Drug Conjugate by Two-Dimensional and Four-Dimensional Liquid Chromatography/Mass Spectrometry

Analytical Chemistry, ISSN: 15206882 00032700

Alexandre Goyon; Michael Kim; Lu Dai; Christopher Cornell; Fred Jacobson; Davy Guillarme; Cinzia Stella

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January 1, 2019

Immunogenicity of antibody-drug conjugates: Observations across 8 molecules in 11 clinical trials

Bioanalysis, ISSN: 17576199 17576180

Montserrat Carrasco-Triguero; Randall Dere; Marija Milojic-Blair; Ola M. Saad; Denise Nazzal; Kyu Hong; Surinder Kaur

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January 1, 2019

Evaluation of in-study cut points to enable appropriate interpretation of clinical immunogenicity results

Bioanalysis, ISSN: 17576199 17576180

Jochen Brumm; Kun Peng

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January 1, 2019

Cis -Selective synthesis of 1,3-disubstituted tetrahydro-β-carbolines from N -sulfonyl N, S -acetals

Organic and Biomolecular Chemistry, ISSN: 14770520

Shao-Xiong Luo; Yanzhou Liu; Michael J. Lambrecht; Daniel F. Ortwine; Antonio G. DiPasquale; Jun Liang; Xiaojing Wang; Jason R. Zbieg; Jun Li

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January 1, 2019

Imaging patients with metastatic castration-resistant prostate cancer using 89Zr-DFO-MSTP2109A anti-STEAP1 antibody

Journal of Nuclear Medicine, ISSN: 2159662X 01615505

Jorge A. Carrasquillo; Bernard M. Fine; Neeta Pandit-Taskar; Steven M. Larson; Stephen E. Fleming; Josef J. Fox; Sarah M. Cheal; Joseph A. O’Donoghue; Shutian Ruan; Govind Ragupathi; Serge K. Lyashchenko; John L. Humm; Scher; Mithat Gonen; Simon P. Williams; Daniel C. Danila; Michael J. Morris

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January 1, 2019

A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155

Molecular and Cellular Proteomics, ISSN: 15359484 15359476

Bushra Husain; Sree R. Ramani; Eugene Y. Chiang; Isabelle Lehoux; Sairupa Paduchuri; Tia A. Arena; Patel; Blair Wilson; Pamela Chan; Yvonne Franke; Athena W. Wong; Jennie R. Lill; Shannon J. Turley; Lino C. Gonzalez Jr.; Jane L. Grogan; Nadia Martinez-Martin

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January 1, 2019

Comparative effectiveness of first-line nab-paclitaxel versus paclitaxel monotherapy in triple-negative breast cancer

Journal of Comparative Effectiveness Research, ISSN: 20426313 20426305

Patricia Luhn; Chui; Angela Hsieh; Jingbo Yi; Almut Mecke; Preeti S. Bajaj; Waseem Hasnain; Adeline Falgas; Thanh G.N. Ton; Allison W. Kurian

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January 1, 2019

From Discovery to Market Readiness: The Research and Development of the β-Sparing Phosphatidylinositol 3-Kinase Inhibitor Taselisib

ACS Symposium Series, ISSN: 19475918 00976156

Remy Angelaud; Steven T. Staben; Timothy P. Heffron; Andreas M. Schuster; Frederic St-Jean

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January 1, 2019

Discovery and Development of the First Antibody-Antibiotic Conjugate Linker-Drug

ACS Symposium Series, ISSN: 19475918 00976156

Stefan G. Koenig; Thomas H. Pillow

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January 1, 2019

The Discovery of the Nav1.7 Inhibitor GDC-0276 and Development of an Efficient Large-Scale Synthesis

ACS Symposium Series, ISSN: 19475918 00976156

Andreas Stumpf; Daniel P. Sutherlin; Christoph Dehnhardt; Remy Angelaud

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