Scientists / Publications

Publications

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DISPLAYING 3501 - 3550 OF 15217 RESULTS

Safety and clinical activity of atezolizumab in head and neck cancer: Results from a phase I trial
Annals of Oncology, ISSN: 15698041 09237534
A. Dimitrios Colevas; Rastilav Bahleda; Fadi S. Braiteh; Ani Balmanoukian; Brana; Chau; Indrani Sarkar; Luciana L. Molinero; William Grossman; Fairooz F. Kabbinavar; Marcella Fassò; Carol O’Hear; John D. Powderly
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Multiproduct resin reuse for clinical and commercial manufacturing - Methodology and acceptance criteria
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Rizwan Sharnez; Steve Doares; Shane Manning; Krunal Mehta; Ekta Mahajan; Angela To; William Daniels; Judy Glynn; Sagar Dhamane; Xiaona Wen; Yunjuan Wang; Pankaj Gour; Constanze Guenther; Derek Foley; Ronan Hayes; Adam Mott; Sunil Prabhu; Dawn Tavalsky; Michael Hendershot; David Haas; Ashley Hesslein; Norbert Schuelke; Hendri Tjandra
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A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples
PLoS ONE, ISSN: 19326203
Sara Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo
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Assessment of OATP transporter-mediated drug–drug interaction using physiologically-based pharmacokinetic (PBPK) modeling – a case example
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Yuan Chen; Rui Zhu; Fang Ma; Jialin Mao; Eugene C. Chen; Edna F. Choo; Srikumar Sahasranaman; Lichuan Liu
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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease
PLoS Genetics, ISSN: 15537404 15537390
Nisha Rathore; Sree R. Ramani; Homer Pantua; Jian Payandeh; Tushar Bhangale; Arthur Wuster; Manav Kapoor; Yonglian Sun; Sharookh B. Kapadia; Lino C. Gonzalez Jr.; Ali A. Zarrin; Alison M. Goate; David V. Hansen; Timothy W. Behrens; Robert R. Graham
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Targeting the MAPK Pathway in RAS Mutant Cancers
Cold Spring Harbor Perspectives in Medicine, ISSN: 21571422
Sarah G. Hymowitz; Shiva Malek
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A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation
Journal of Experimental Medicine, ISSN: 15409538 00221007
Sonia Ventura; Florencia Cano; Yashaswini Kannan; Felix Breyer; Michael J. Pattison; Mark S. Wilson; Steven C. Ley
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Draft genome sequence of an erwinia tracheiphila isolate from an infected muskmelon (Cucumis melo)
Microbiology Resource Announcements, ISSN: 2576098X
Lori R. Shapiro; Andres Andrade; Erin D. Scully; Jorge Rocha; Joseph N. Paulson; Roberto Kolter
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Resolution of unexpected pregnancy-related findings in a rat embryofetal development and toxicokinetic study of monoclonal antibodies specific for hCMV
Birth Defects Research, ISSN: 24721727
Paula Katavolos; Prell; Doris Zane; Rong Deng; Wendy Halpern
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Disrupting Gram-negative bacterial outer membrane biosynthesis through inhibition of the lipopolysaccharide transporter MsbA
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Mary Kate Alexander; Anh Miu; Angela Oh; Mike Reichelt; Hoangdung Ho; Cecile Chalouni; Sharada Labadie; Lan Wang; Jun Liang; Nicholas N. Nickerson; Huiyong Hu; Lan Yu; Miaofen Du; Donghong Yan; Summer Park; Janice Kim; Min Xu; Benjamin D. Sellers; Hans E. Purkey; Nicholas J. Skelton; Michael F. T. Koehler; Jian Payandeh; Vishal A. Verma; Yiming Xu; Christopher M. Koth; Mireille Nishiyama
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FIR: Efficacy, Safety, and Biomarker Analysis of a Phase II Open-Label Study of Atezolizumab in PD-L1–Selected Patients With NSCLC
Journal of Thoracic Oncology, ISSN: 15561380 15560864
David Spigel; Jamie E. Chaft; Scott Gettinger; Bo H. Chao; Luc Dirix; Schmid; Laura Q.M. Chow; Rodney Hicks; Larry Leon; Jill Fredrickson; Marcin Kowanetz; Alan Sandler; Roel Funke; Naiyer A. Rizvi
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Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi-centre, non-interventional study
Haemophilia, ISSN: 13652516 13518216
Johnny N. Mahlangu; Johannes Oldenburg; Michael U. Callaghan; Midori Shima; Elena Santagostino; Maggie Moore; Michael Recht; Claudia Garcia; Renchi Yang; Michaela Lehle; Harrison Macharia; Elina Asikanius; Gallia Levy; Kruse-Jarres
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Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology
AAPS Journal, ISSN: 15507416
Danielle Mandikian; Isabel Figueroa; Amy Oldendorp; Hanine Rafidi; Sheila Ulufatu; Michelle G. Schweiger; Jessica A. Couch; Noel Dybdal; Sean B. Joseph; Saileta Prabhu; Gregory Z. Ferl; C. Andrew Boswell
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Development and clinical validation of the Genedrive point-of-care test for qualitative detection of hepatitis C virus
Gut, ISSN: 14683288 00175749
Alba Llibre; Yusuke Shimakawa; Estelle Mottez; Shaun Ainsworth; Tan-Phuc Buivan; Rick Firth; Elliott Harrison; Arielle R Rosenberg; Jean-François Meritet; Arnaud Fontanet; Pablo Castan; Antonio Madejón; Mark Laverick; Allison Glass; Raquel Viana; Stanislas Pol; C Patrick McClure; William Lucien Irving; Gino Miele; Matthew L. Albert; Darragh Duffy
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Achieving greater efficiency and higher confidence in single-cell cloning by combining cell printing and plate imaging technologies
Biotechnology Progress, ISSN: 15206033 87567938
Mandy Yim; David Shaw
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Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine
Pharmaceutical Research, ISSN: 1573904X 07248741
Michelle Z. Dion; Danielle L. Leiske; Vikas K. Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury
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Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4
Clinical and Experimental Immunology, ISSN: 13652249 00099104
Armanda Casrouge; Sauer; Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert
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NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis
Nature Immunology, ISSN: 15292916 15292908
Zuliang Jie; Jin-Young Yang; Meidi Gu; Hui Wang; Xiaoping Xie; Yanchuan Li; Ting Liu; Lele Zhu; Jianhong Shi; Lingyun Zhang; Xiaofei Zhou; Donghyun Joo; Hans D. Brightbill; Yingzi Cong; Daniel Lin; Xuhong Cheng; Shao-Cong Sun
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Crystal anisotropy explains structure-mechanics impact on tableting performance of flufenamic acid polymorphs
European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411
Abhay Jain; Harsh S. Shah; Paul R. Johnson; Ajit S. Narang; Ken R. Morris; Rahul V. Haware
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Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development
Clinical and Translational Science, ISSN: 17528062 17528054
Meric A. Ovacik; Kedan Lin
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Development of a label-free FcRn-mediated transcytosis assay for in vitro characterization of FcRn interactions with therapeutic antibodies and Fc-fusion proteins
Journal of Immunological Methods, ISSN: 18727905 00221759
Shan Chung; Yuwen L. Lin; Van Nguyen; Lynn Kamen; Kai Zheng; Bianca Vora; An Song
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Effect of OATP1B1/1B3 Inhibitor GDC-0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Lichuan Liu; Sravanthi Cheeti; Yoshida; Edna F. Choo; Eugene C. Chen; Buyun Chen; Mary Gates; Stina M. Singel; Roland Morley; Joseph A. Ware; Srikumar Sahasranaman
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Type 2 Biomarkers and Prediction of Future Exacerbations and Lung Function Decline in Adult Asthma
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Ruth Semprini; Mathew Williams; Alex Semprini; Alice McDouall; James Fingleton; Cécile T.J. Holweg; Mark Weatherall; Beasley; Irene Braithwaite
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A pharmacology guided approach for setting limits on product-related impurities for bispecific antibody manufacturing
Journal of Pharmacological and Toxicological Methods, ISSN: 1873488X 10568719
Sharmila Rajan; Junichiro Sonoda; Timothy Tully; Ambrose Jon Williams; Feng Yang; Frank D. Macchi; Terry Hudson; Mark Chen; Shannon Liu; Nicole R. Valle; Kyra J. Cowan; Thomas R. Gelzleichter
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Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Salman Siddiqui; Aarti Shikotra; Matthew Richardson; Emma Doran; David F. Choy; Alex Bell; Cary D. Austin; Jeffrey Eastham-Anderson; Beverley Hargadon; Joseph R. Arron; Andrew J. Wardlaw; Chris E. Brightling; Liam G. Heaney; Peter Bradding
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CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts
Alzheimer's and Dementia, ISSN: 15525279 15525260
Oskar Hansson; John P. Seibyl; Erik Stomrud; Henrik Zetterberg; John Q. Trojanowski; Tobias Bittner; Valeria Lifke; Veronika Corradini; Udo Eichenlaub; Richard Batrla; Katharina Buck; Katharina Zink; Christina Rabe; Kaj Blennow; Leslie Shaw
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Mitigation of Oxidation in Therapeutic Antibody Formulations: a Biochemical Efficacy and Safety Evaluation of N-Acetyl-Tryptophan and L-Methionine
Pharmaceutical Research, ISSN: 1573904X 07248741
Michelle Z. Dion; Danielle L. Leiske; Vikas Sharma; Christina L. Zuch de Zafra; Cleo M. Salisbury
View on Scopus
Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4
Clinical and Experimental Immunology, ISSN: 13652249 00099104
Armanda Casrouge; Sauer; Rosa Barreira da Silva; Tejera-Alhambra; Sánchez-Ramón; Cancrini; Molly A. Ingersoll; Aiuti; Matthew L. Albert
View on Scopus
A method for manual and automated multiplex RNAscope in situ hybridization and immunocytochemistry on cytospin samples
PLoS ONE, ISSN: 19326203
Sara M. Chan; Audrey Filézac de L’Etang; Linda Rangell; Patrick Caplazi; John Lowe; Valentina Romeo
View on Scopus
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kim Newton; Dugger; Arundhati Sengupta Ghosh; Ron Ferrando; Felix Chu; Janet Tao; Wendy Lam; Susan Haller; Sara M. Chan; Susan Sa; Debra Dunlap; Jeffrey Eastham-Anderson; Hai Ngu; Jeffrey Hung; French; Webster; Brad Bolon; Jinfeng Liu; Rohit Reja; Sarah K. Kummerfeld; Ying-Jiun Chen; Zora Modrusan; Joe Lewcock; Vishva M. Dixit
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Kinase Inhibitors for the Treatment of Immunological Disorders: Recent Advances
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Marian C. Bryan; Naomi S. Rajapaksa
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GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shumei Wang; Vickie Tsui; Terry Crawford; James E. Audia; Burdick; Beresini; Alexandre Côté; Richard T Cummings; Martin Duplessis; E. Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; F. Anthony Romero; Yong Tang; Alexander M. Taylor; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea G Cochran
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Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti-PD-L1)
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Marcin Kowanetz; Wei Zou; Scott Gettinger; Koeppen; Mark Kockx; Schmid; Edward E. Kadel III; Ignacio I. Wistuba; Jamie E. Chaft; Naiyer A. Rizvi; David Spigel; Alexander Spira; Fred R. Hirsch; Victor Cohen; Dustin Smith; Zachary Boyd; Natasha Miley; Susan Flynn; Vincent Leveque; David S. Shames; Ballinger; Mocci; Geetha Shankar; Roel Funke; Garret M. Hampton; Alan Sandler; Lukas Amler; Ira Mellman; Daniel S. Chen; Priti Hegde
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Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; David Leahy; Andrew S. Wells
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A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition
Nature, ISSN: 14764687 00280836
Brian Biehs; Gerrit J. P. Dijkgraaf; Robert Piskol; Bruno Alicke; Soufiane Boumahdi; Franklin V. Peale Jr.; Stephen Gould; Frederic J. De Sauvage
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Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3
Science Translational Medicine, ISSN: 19466242 19466234
Dionysos S. Slaga; Diego Ellerman; T. Noelle Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer A. Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy Lo; James T. Koerber; Klara Totpal; Prell; Genee Y. Lee; Christoph Spiess; Teemu T. Junttila
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Chemotherapy combines effectively with Anti-PD-L1 treatment and can augment antitumor responses
Journal of Immunology, ISSN: 15506606 00221767
Rafael Cubas; Marina Moskalenko; Jeanne Cheung; Michelle Yang; Erin McNamara; Huizhong Xiong; Sabine Hoves; Carola H. Ries; Kim; Stephen Gould
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Conventional wastewater treatment and reuse site practices modify bacterial community structure but do not eliminate some opportunistic pathogens in reclaimed water
Science of the Total Environment, ISSN: 18791026 00489697
Prachi Kulkarni; Nathan D. Olson; Joseph N. Paulson; Mihai Pop; Cynthia Maddox; Emma Claye; Rachel E. Rosenberg Goldstein; Manan Sharma; Shawn G. Gibbs; Emmanuel F. Mongodin; Amy R. Sapkota
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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors
Cancer Cell, ISSN: 18783686 15356108
Ivana Yen; Frances Shanahan; Mark Merchant; Christine Orr; Thomas Hunsaker; Matthew Durk; Hank La; Xiaolin Zhang; Scott E. Martin; Eva Lin; John Chan; Yihong Yu; Dhara Amin; Richard M. Neve; Amy Gustafson; Avinashnarayan Venkatanarayan; Scott A. Foster; Joachim Rudolph; Christiaan N. Klijn; Shiva Malek
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Quality assessment and interference detection in targeted mass spectrometry data using machine learning 03 Chemical Sciences 0301 Analytical Chemistry
Clinical Proteomics, ISSN: 15590275 15426416
Shadi Toghi Eshghi; Paul Auger; W Rodney Mathews
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Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin
Journal of Organic Chemistry, ISSN: 15206904 00223263
Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin
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High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants
mAbs, ISSN: 19420870 19420862
Danielle DiCara; Nisana Andersen; Ruby Chan; James A. Ernst; Gai Ayalon; Greg A. Lazar; Nick Agard; Amy Hilderbrand; Isidro Hötzel
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Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid
mAbs, ISSN: 19420870 19420862
Rina Fong; Kimberly K. Kajihara; Matthew Chen; Isidro Hötzel; Sanjeev Mariathasan; Wouter L. W. Hazenbos; Patrick J. Lupardus
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Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model
mAbs, ISSN: 19420870 19420862
Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng
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Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry
mAbs, ISSN: 19420870 19420862
Jintang He; Shang-Fan Yu; Sharon Fong Yee; Surinder Kaur; Keyang Xu
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Cost-effectiveness of obinutuzumab plus bendamustine followed by obinutuzumab monotherapy for the treatment of follicular lymphoma patients who relapse after or are refractory to a rituximab-containing regimen in the US
Journal of Medical Economics, ISSN: 1941837X 13696998
Gregory F. Guzauskas; Anthony Masaquel; Carolina Reyes; Coen A. Bernaards; Tania Krivasi; David L. Veenstra
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Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole
Xenobiotica, ISSN: 13665928 00498254
Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang
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The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function
Cell Reports, ISSN: 22111247
Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Merone Roose-Girma; Robert J. Newman; Søren Warming; Michelle Nannini; Deepak Sampath; Kim; Jane L. Grogan; Ira Mellman
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Long-term safety of pirfenidone: Results of the prospective, observational PASSPORT study
ERJ Open Research, ISSN: 23120541
Vincent Cottin; Dirk Koschel; Andreas Günther; Carlo Albera; Arata Azuma; C Magnus Sköld; Sara Tomassetti; Philip Hormel; John L. Stauffer; Indiana Strombom; Klaus-Uwe Kirchgaessler; Toby M. Maher
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Primary efficacy results from B-F1RST, a prospective phase II trial evaluating blood-based tumour mutational burden (bTMB) as a predictive biomarker for atezolizumab (atezo) in 1L non-small cell lung cancer (NSCLC)
Annals of Oncology, ISSN: 15698041
Edward S. Kim; Velcheti; Tarek Mekhail; Leal; Dowell; Tsai; Dakhil; Stella; Shen; Hu; Sarah M. Paul; David S. Shames; Erica Schleifman; David Fabrizio; Yun; Phan; Mark A. Socinski
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