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Publications

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DISPLAYING 4201 - 4250 OF 15572 RESULTS

Effect of Brain Metastasis on Patient-Reported Outcomes in Advanced NSCLC Treated in Real-World Community Oncology Settings
Clinical Lung Cancer, ISSN: 19380690 15257304
Mark S. Walker; Wong; Arliene Ravelo; Paul J. E. Miller; Lee S. Schwartzberg
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Pharmacokinetic and Pharmacodynamic Modeling of Serum Etrolizumab and Circulating β7 Receptor Occupancy in Patients With Ulcerative Colitis
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Xiaohui Wei; Leonid Gibiansky; Yehong Wang; Franklin Fuh; Erickson; Sharon O'Byrne; Meina Tao Tang
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The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration
Ophthalmology, ISSN: 15494713 01616420
Monika Fleckenstein; Paul Mitchell; K. Bailey Freund; Srinivas Sadda; Frank G. Holz; Christopher Brittain; Erin C. Henry; Daniela Ferrara
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Pharmacokinetics of MHAA4549A, an Anti-Influenza A Monoclonal Antibody, in Healthy Subjects Challenged with Influenza A Virus in a Phase IIa Randomized Trial
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Rong Deng; Ai Ping Lee; Mauricio Maia; Jeremy Lim; Tracy Burgess; Priscilla Horn; Michael A. Derby; Elizabeth Newton; Jorge A. Tavel; William D. Hanley
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Next generation antibody drugs: Pursuit of the 'high-hanging fruit'
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Paul J. Carter; Greg A. Lazar
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Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody–Antibiotic Conjugate
Chemistry - A European Journal, ISSN: 15213765 09476539
Xin Linghu; Nathaniel Segraves; Ifat Abramovich; Nicholas Wong; Barbara Müller; Nadja Neubauer; Serena M. Fantasia; Sebastian Rieth; Stephan Bachmann; Michael Jansen; C. Gregory Sowell; David Askin; Stefan G. Koenig; Francis Gosselin
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Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial
The Lancet, ISSN: 1474547X 01406736
Thomas Powles; Ignacio Durán; Michiel S Van Der Heijden; Yohann Loriot; Nicholas J. Vogelzang; Ugo De Giorgi; Stephane Oudard; Margitta M. Retz; Daniel Castellano; Aristotelis Bamias; Aude Fléchon; Gwenaëlle Gravis; Syed Hussain; Toshimi Takano; Ning Leng; Edward E. Kadel III; Romain Banchereau; Priti Hegde; Sanjeev Mariathasan; Na Cui; Xiaodong Shen; Christina L. Derleth; Marjorie Green; Alain Ravaud
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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
Nature, ISSN: 14764687 00280836
Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Kobe Yuen; Wang; Edward E. Kadel III; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Romain Banchereau; Yagai Yang; Yinghui Guan; Cecile Chalouni; James Ziai; Yasin Senbabaoglu; Stephen Santoro; Daniel Sheinson; Jeffrey Hung; Jennifer M. Giltnane; Andrew A Pierce; Kathryn Mesh; Steve Lianoglou; Johannes Riegler; Richard A. D. Carano; Pontus Eriksson; Mattias Höglund; Loan Somarriba; Daniel L Halligan; Michiel S Van Der Heijden; Yohann Loriot; Jonathan E. Rosenberg; Lawrence Fong; Ira Mellman; Daniel S. Chen; Marjorie Green; Christina L. Derleth; Gregg D. Fine; Priti Hegde; Richard Bourgon; Thomas Powles
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Cluster Size and Quinary Structure Determine the Rheological Effects of Antibody Self-Association at High Concentrations
Journal of Physical Chemistry B, ISSN: 15205207 15206106
Wenhua Wang; Wayne G. Lilyestrom; Zhi Yu Hu; Thomas M. Scherer
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High-Throughput Cysteine Scanning to Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers
Bioconjugate Chemistry, ISSN: 15204812 10431802
Rachana Ohri; Sunil Bhakta; Aimee Fourie-O'Donohue; Josefa Dela Cruz Chuh; Siao Ping Tsai; Ryan Cook; Binqing Wei; Carl Ng; Athena W. Wong; Aaron B. Bos; Farzam Farahi; Jiten Bhakta; Thomas H. Pillow; Helga Raab; Richard L. Vandlen; Paul G. Polakis; Yichin Liu; Hans Erickson; Jagath R. Junutula; Katherine R. Kozak
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Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads
Bioconjugate Chemistry, ISSN: 15204812 10431802
Donglu Zhang; Hoa Le; Josefa Dela Cruz-Chuh; Sudheer Bobba; Jun Guo; Leanna Staben; Chenghong Zhang; Yong Ma; Katherine R. Kozak; Gail L. Phillips; Breanna S. Vollmar; Jack D. Sadowsky; Richard L. Vandlen; Binqing Wei; Dian Su; Peter W. Fan; Peter Dragovich; S. Cyrus Khojasteh; Cornelis E. Hop; Thomas H. Pillow
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Targeted therapy for advanced solid tumors on the basis of molecular profiles: Results from mypathway, an open-label, phase IIA multiple basket study
Journal of Clinical Oncology, ISSN: 15277755 0732183X
John Hainsworth; Funda Meric-Bernstam; Charles Swanton; Herbert Hurwitz; David Spigel; Christopher J. Sweeney; Howard A. Burris; Ron Bose; Bongin Yoo; Alisha Stein; Beattie; Razelle Kurzrock
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Challenges of developing small-molecule kinase inhibitors for brain tumors and the need for emphasis on free drug levels
Neuro-Oncology, ISSN: 15235866 15228517
Timothy P. Heffron
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Synthesis of a selective estrogen receptor degrader via a stereospecific elimination approach
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Theresa Cravillion; Scott Savage; Andrew McClory; Chong Han; Haiming Zhang; Antonio G. DiPasquale; Francis Gosselin
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Two-Step Synthesis of 3,4-Dihydropyrrolopyrazinones from Ketones and Piperazin-2-ones
Organic Letters, ISSN: 15237052 15237060
Cosme Sandoval; Ngiap-Kie Lim; Haiming Zhang
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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Molecular Cell, ISSN: 10974164 10972765
Tatiana Goncharov; Stefanie Hedayati; Melinda M. Mulvihill; Anita Izrael-Tomasevic; Zobel; Surinc Er Jeet; Anna V. Fedorova; Celine Eidenschenk; Jason Devoss; Kebing Yu; Andrey S. Shaw; Donald S. Kirkpatrick; Wayne J. Fairbrother; Deshayes; Domagoj Vucic
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How many human proteoforms are there?
Nature Chemical Biology, ISSN: 15524469 15524450
Ruedi Aebersold; Jeffrey N Agar; I Jonathan Amster; Mark S Baker; Carolyn Bertozzi; Emily S Boja; Catherine E Costello; Benjamin F Cravatt; Catherine Fenselau; Benjamin A. Garcia; Ying Ge; Jeremy Gunawardena; Ronald C Hendrickson; Paul J Hergenrother; Christian G Huber; Alexander R Ivanov; Ole N Jensen; Michael C Jewett; Neil L Kelleher; Laura Kiessling; Nevan J. Krogan; Martin R Larsen; Joseph A Loo; Rachel R Ogorzalek Loo; Emma Lundberg; Michael J Maccoss; Parag Mallick; Vamsi K Mootha; Milan Mrksich; Tom W Muir; Steven M Patrie; James J Pesavento; Sharon J Pitteri; Henry Rodriguez; Alan Saghatelian; Wendy N. Sandoval; Hartmut Schlüter; Salvatore Sechi; Sarah A Slavoff; Lloyd M Smith; Michael Snyder; Paul M Thomas; Mathias Uhlén; Jennifer E Van Eyk; Marc Vidal; David R Walt; Forest M White; Evan R Williams; Therese Wohlschlager; Vicki H Wysocki; Nathan A Yates; Nicolas L Young; Bing Zhang
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How many human proteoforms are there?
Nature Chemical Biology, ISSN: 15524469 15524450
Ruedi Aebersold; Jeffrey N Agar; I Jonathan Amster; Mark S Baker; Carolyn Bertozzi; Emily S Boja; Catherine E Costello; Benjamin F Cravatt; Catherine Fenselau; Benjamin A. Garcia; Ying Ge; Jeremy Gunawardena; Ronald C Hendrickson; Paul J Hergenrother; Christian G Huber; Alexander R Ivanov; Ole N Jensen; Michael C Jewett; Neil L Kelleher; Laura Kiessling; Nevan J. Krogan; Martin R Larsen; Joseph A Loo; Rachel R Ogorzalek Loo; Emma Lundberg; Michael J Maccoss; Parag Mallick; Vamsi K Mootha; Milan Mrksich; Tom W Muir; Steven M Patrie; James J Pesavento; Sharon J Pitteri; Henry Rodriguez; Alan Saghatelian; Wendy N. Sandoval; Hartmut Schlüter; Salvatore Sechi; Sarah A Slavoff; Lloyd M Smith; Michael Snyder; Paul M Thomas; Mathias Uhlén; Jennifer E Van Eyk; Marc Vidal; David R Walt; Forest M. White; Evan R Williams; Therese Wohlschlager; Vicki H Wysocki; Nathan A Yates; Nicolas L Young; Bing Zhang
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Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India
BMC Medical Genetics, ISSN: 14712350
Viswanathan Mohan; Venkatesan Radha; Thong T Nguyen; Eric Stawiski; Kanika Bajaj Pahuja; Leonard D. Goldstein; Jennifer A. Tom; Ranjit Mohan Anjana; Monica Kong-Beltran; Tushar Bhangale; Suresh Jahnavi; Radhakrishnan Chandni; Vijay Gayathri; Paul George; Na Zhang; Sakthivel Murugan; Sameer Phalke; Subhra Chaudhuri; Ravi Gupta; Jingli A. Zhang; Sam Santhosh; Stinson; Zora Modrusan; Vedam Laxmi Ramprasad; Somasekar Seshagiri; Andrew S. Peterson
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Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Binqing Wei; Janet Gunzner; Hui Yao; Tao Wang; Jing Wang; Zijin Xu; Jinhua Chen; John Wai; Jim Nonomiya; Siao Ping Tsai; Josefa Chuh; Katherine R. Kozak; Yichin Liu; Shang-Fan Yu; Jeffrey Lau; Guangmin Li; Gail L. Phillips; Douglas Leipold; Amrita Kamath; Dian Su; Keyang Xu; Eigenbrot; Stefan Steinbacher; Rachana Ohri; Helga Raab; Leanna Staben; Guiling Zhao; Flygare; Thomas H. Pillow; Vishal A. Verma; Luke Masterson; Philip W. Howard; Brian S. Safina
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Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance
eLife, ISSN: 2050084X
Daniel J. Fazakerley; Rima Chaudhuri; Pengyi Yang; Ghassan J. Maghzal; Kristen C. Thomas; James R. Krycer; Sean J. Humphrey; Benjamin L. Parker; Kelsey H. Fisher-Wellman; Christopher C. Meoli; Nolan J. Hoffman; Ciana Diskin; James G. Burchfield; Mark J. Cowley; Warren Kaplan; Zora Modrusan; Ganesh Kolumam; Yang; Daniel L. Chen; Samocha-Bonet; Greenfield; Kyle L. Hoehn; Roland Stocker; David E. James
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Ocrelizumab: A New Therapeutic Paradigm for Multiple Sclerosis
Biochemistry, ISSN: 15204995 00062960
Peter Chin; Andrew A. Chan
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Grking the smoothened signal
Science Signaling, ISSN: 19379145 19450877
Hayley J. Sharpe; Frederic J. De Sauvage
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Peak purity in liquid chromatography, part 1: Basic concepts, commercial software, and limitations
LC-GC Europe, ISSN: 14716577
Sarah C. Rutan; Venkatramani; Dwight R. Stoll
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IFN-stimulated gene expression, type 2 inflammation, and endoplasmic reticulum stress in asthma
American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X
Nirav R. Bhakta; Stephanie Christenson; Srilaxmi Nerella; Owen D. Solberg; Christine Nguyen; David F. Choy; Kyle L. Jung; Suresh Garudadri; Luke R. Bonser; Joshua L. Pollack; Lorna T. Zlock; David J. Erle; Charles Langelier; Joseph L. Derisi; Joseph R. Arron; John V. Fahy; Prescott G. Woodruff
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Engineered cysteine antibodies: An improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability
Protein Engineering, Design and Selection, ISSN: 17410134 17410126
Sussman; Westendorf; Meyer; Leiske; Anderson; Okeley; Stephen C. Alley; Lyon; Sanderson; Paul J. Carter; Benjamin
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Polarized trafficking: the palmitoylation cycle distributes cytoplasmic proteins to distinct neuronal compartments
Current Opinion in Cell Biology, ISSN: 18790410 09550674
Elena Tortosa; Casper C Hoogenraad
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Racial and Ethnic Composition of Cancer Clinical Drug Trials: How Diverse Are We?
Oncologist, ISSN: 1549490X 10837159
Leslie Dickmann; Jennifer L. Schutzman
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Safety and efficacy of subcutaneous tocilizumab in systemic sclerosis: Results from the open-label period of a phase II randomised controlled trial (faSScinate)
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Dinesh Khanna; Christopher P. Denton; Celia J.F. Lin; Jacob M. Van Laar; Tracy M. Frech; Marina E. Anderson; Murray Baron; Lorinda Chung; Gerhard Fierlbeck; Santhanam Lakshminarayanan; Yannick Allanore; Janet E. Pope; Gabriela Riemekasten; Virginia D. Steen; Ulf Müller-Ladner; Helen Spotswood; Laura Burke; Jeffrey N. Siegel; Angelika Jahreis; Daniel E. Furst
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Microglia in Alzheimer's disease
Journal of Cell Biology, ISSN: 15408140 00219525
David V. Hansen; Jesse E. Hanson; Morgan Sheng
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SUV420H2 is an epigenetic regulator of epithelial/ mesenchymal states in pancreatic cancer
Journal of Cell Biology, ISSN: 15408140 00219525
Manuel Viotti; Catherine Wilson; Mark L. McCleland; Koeppen; Benjamin Haley; Suchit Jhunjhunwala; Christiaan N. Klijn; Zora Modrusan; David Arnott; Marie Classon; Jean-Philippe Stephan; Ira Mellman
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Effect of Microenvironmental pH Modulation on the Dissolution Rate and Oral Absorption of the Salt of a Weak Acid – Case Study of GDC-0810
Pharmaceutical Research, ISSN: 1573904X 07248741
Hao Helen Hou; Wei Jia; Lichuan Liu; Sravanthi Cheeti; Jane Li; Ewa Nauka; Karthik Nagapudi
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Transporter expression in noncancerous and cancerous liver tissue from donors with hepatocellular carcinoma and chronic hepatitis C infection quantified by LC-MS/MS proteomics
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Sarah Billington; Adrian S. Ray; Laurent Salphati; Guangqing Xiao; Xiaoyan Chu; W. Griffith Humphreys; Mingxiang Liao; Caroline A. Lee; Anita Mathias; Cornelis E. Hop; Christopher Rowbottom; Raymond Evers; Yurong Lai; Edward J. Kelly; Bhagwat Prasad; Jashvant D. Unadkat
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Dual Effect of Histidine on Polysorbate 20 Stability: Mechanistic Studies
Pharmaceutical Research, ISSN: 1573904X 07248741
Lin Zhang; Sandeep Yadav; John Wang; Olivier Mozziconacci; Christian Schöneich
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Pharmacokinetics and exposure-response analysis of RG7667, a combination of two anticytomegalovirus monoclonal antibodies, in a phase 2a randomized trial to prevent cytomegalovirus infection in high-risk kidney transplant recipients
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Rong Deng; Yehong Wang; Mauricio Maia; Tracy Burgess; Jacqueline McBride; X. Charlene Liao; Jorge A. Tavel; William D. Hanley
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Leveraging Humanized Animal Models to Understand Human Drug Disposition: Opportunities, Challenges, and Future Directions
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Edna F. Choo; Laurent Salphati
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Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Jinze Li; Eric Morinello; Thomas Larsen; Denzil Frost; Ivor Caro; Stephen Gould; Lisa Wong; Angela Hendricks; Noel Dybdal; Donna M. Dambach; Melissa Schutten
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A short field guide to fibroblast function in immunity
Seminars in Immunology, ISSN: 10963618 10445323
Matthew B. Buechler; Shannon J. Turley
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Correction to: Population pharmacokinetics of trastuzumab emtansine in previously treated patients with HER2-positive advanced gastric cancer (AGC) (Cancer Chemotherapy and Pharmacology, (2017), 80, 6, (1147-1159), 10.1007/s00280-017-3443-1)
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Shang-Chiung Chen; Kagedal; Yuying Gao; Wang; Marie-Laurence Harle-Yge; Sandhya Girish; Jin Y. Jin; Chunze Li
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The Use of a 2,2'-Azobis (2-Amidinopropane) Dihydrochloride Stress Model as an Indicator of Oxidation Susceptibility for Monoclonal Antibodies
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Michelle Z. Dion; Y. John Wang; Daniel Bregante; Wayman Chan; Nisana Andersen; Amy Hilderbrand; Danielle L. Leiske; Cleo M. Salisbury
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Comparison of platform host cell protein ELISA to process-specific host cell protein ELISA
Biotechnology and Bioengineering, ISSN: 10970290 00063592
Feny Gunawan; Julie C. Nishihara; Peter S. Liu; Wendy N. Sandoval; Vanderlaan; Heidi Zhang; Denise C. Krawitz
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Does site-of-care for oncology infusion therapy influence treatment patterns, cost, and quality in the United States?
Journal of Medical Economics, ISSN: 1941837X 13696998
Sari Hopson; Adrianne Casebeer; Stephen Stemkowski; Dana Drzayich Antol; Zhuliang Tao; Andrew Howe; Jeffrey Patton; Art Small; Anthony Masaquel
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Response to omalizumab using patient enrichment criteria from trials of novel biologics in asthma
Allergy: European Journal of Allergy and Clinical Immunology, ISSN: 13989995 01054538
Thomas B. Casale; Bradley E. Chipps; Karin Rosén; Benjamin L. Trzaskoma; Tmirah Haselkorn; Theodore A. Omachi; Greenberg; Nicola A. Hanania
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Curvature of designed armadillo repeat proteins allows modular peptide binding
Journal of Structural Biology, ISSN: 10958657 10478477
Simon Hansen; Patrick Ernst; Sebastian L.B. König; Christian Reichen; Christina Ewald; Daniel Nettels; Peer R. E. Mittl; Benjamin Schuler; Pluckthun
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Effectiveness of biologic and non-biologic antirheumatic drugs on anaemia markers in 153,788 patients with rheumatoid arthritis: New evidence from real-world data
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Sanjoy Ketan Paul; Olga Montvida; Jennie Best; Sara Gale; Attila Pethoe-Schramm; Khaled Sarsour
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Clinicopathologic Correlation of Anti–Vascular Endothelial Growth Factor–Treated Type 3 Neovascularization in Age-Related Macular Degeneration
Ophthalmology, ISSN: 15494713 01616420
Miaoling Li; Rosa Dolz-Marco; Jeffrey D. Messinger; Lan Wang; Richard M. Feist; Christopher A. Girkin; Sarra Gattoussi; Daniela Ferrara; Christine A. Curcio; K. Bailey Freund
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Amphiphilic π-Allyliridium C,O-Benzoates Enable Regio- and Enantioselective Amination of Branched Allylic Acetates Bearing Linear Alkyl Groups
Journal of the American Chemical Society, ISSN: 15205126 00027863
Arismel Tena Meza; Thomas Wurm; Lewis Smith; Seung Wook Kim; Jason R. Zbieg; Craig E. Stivala; Michael J. Krische
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HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors
Breast Cancer Research, ISSN: 1465542X 14655411
Anneleen Daemen; Gerard Manning
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Trace level determination of chloroacetyl chloride and degradation products by derivatization gas chromatography
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Marie-France Morissette; Larry Wigman; Jerry Tso
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DEM based computational model to predict moisture induced cohesion in pharmaceutical powders
International Journal of Pharmaceutics, ISSN: 18733476 03785173
Raj Mukherjee; Chen Mao; Sayantan Chattoraj; Bodhisattwa Chaudhuri
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