Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4601 - 4650 OF 15570 RESULTS

Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
Journal of Experimental Medicine, ISSN: 15409538 00221007
Victoria S. Pelly; Stephanie M. Coomes; Yashaswini Kannan; Manolis Gialitakis; Lewis J. Entwistle; Jimena Perez-Lloret; Stephanie Czieso; Isobel S. Okoye; Dominik Rückerl; Judith E. Allen; Frank Brombacher; Mark S. Wilson
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Time-to-event analysis of polatuzumab vedotin-induced peripheral neuropathy to assist in the comparison of clinical dosing regimens
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Dan Lu; Gillespie; Sandhya Girish; Priya Agarwal; Chunze Li; Jamie Hirata; Yu-Waye Chu; Kagedal; Leon; Maiya; Jin Y. Jin
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Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial
The Lancet Oncology, ISSN: 14745488 14702045
Diéras; David W. Miles; Sunil Verma; Pegram; Manfred Welslau; Baselga; Ian E. Krop; Kimberly Blackwell; Silke Hoersch; Xu; Marjorie Green; Luca Gianni
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Developments in therapy with monoclonal antibodies and related proteins
Clinical Medicine, Journal of the Royal College of Physicians of London, ISSN: 14734893 14702118
Shepard; Gail L. Phillips; Christopher D. Thanos; Marc Feldmann
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Rituximab treatment circumvents the prognostic impact of tumor-infiltrating T-cells in follicular lymphoma patients
Human Pathology, ISSN: 15328392 00468177
Luc Xerri; Sarah Huet; Jeffrey M. Venstrom; Edith Szafer-Glusman; Bettina Fabiani; Danielle Canioni; Catherine Chassagne-Clément; Peggy Dartigues-Cuilléres; Fréderic Charlotte; Camille Laurent; Benedicte Gelas-Dore; Christopher R. Bolen; Elizabeth A. Punnoose; Reda Bouabdallah; Pauline Brice; Morschhauser; Guillaume Cartron; Daniel Olive; Gilles Salles
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Cardiovascular Safety of Tocilizumab Versus Tumor Necrosis Factor Inhibitors in Patients With Rheumatoid Arthritis: A Multi-Database Cohort Study
Arthritis and Rheumatology, ISSN: 23265205 23265191
Seoyoung C. Kim; Daniel H. Solomon; James R. Rogers; Sara Gale; Micki Klearman; Khaled Sarsour; Sebastian Schneeweiss
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TREM2, Microglia, and Neurodegenerative Diseases
Trends in Molecular Medicine, ISSN: 1471499X 14714914
Felix L. Yeh; David V. Hansen; Morgan Sheng
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Applying stable isotope labeled amino acids in micropatterned hepatocyte coculture to directly determine the degradation rate constant for CYP3A4
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Sheerin Shahidi-Latham; Susan C. Wong; Jae H. Chang
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Characterizing neoantigens for personalized cancer immunotherapy
Current Opinion in Immunology, ISSN: 18790372 09527915
Aude-Hélène Capietto; Suchit Jhunjhunwala; Lélia Delamarre
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Responsiveness of the national eye institute visual function questionnaire-25 to visual acuity gains in patients with diabetic macular edema: Evidence from the RIDE and RISE Trials
Retina, ISSN: 15392864 0275004X
Ivan J. Suñer; Neil M. Bressler; Rohit Varma; Chantal M. Dolan; James Ward; Adam Turpcu
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BCL2 mutations do not confer adverse prognosis in follicular lymphoma patients treated with rituximab
American Journal of Hematology, ISSN: 10968652 03618609
Sarah Huet; Edith Szafer-Glusman; Bruno Tesson; Luc Xerri; Wayne J. Fairbrother; Kiran Mukhyala; Christopher R. Bolen; Elizabeth A. Punnoose; Laurie Tonon; Catherine Chassagne-Clément; Pierre Feugier; Alain Viari; Fabrice Jardin; Gilles Salles; Pierre Sujobert
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Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics
Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300
Christina de Zafra; Vito G. Sasseville; Steven Matsumoto; Christian Freichel; Milton; Timothy K. MacLachlan; Cindy A. Farman; Iona Raymond; Swati Gupta; Ronald Newton; Elke-Astrid Atzpodien; Evan A Thackaberry
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Serious adverse effects associated with glucocorticoid therapy in patients with giant cell arteritis (GCA): A nested case–control analysis
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Jessica C. Wilson; Khaled Sarsour; Neil Collinson; Katie Tuckwell; David Musselman; Micki Klearman; Pavel Napalkov; Susan S. Jick; John H. Stone; Christoph R. Meier
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Low immunogenicity of tocilizumab in patients with rheumatoid arthritis
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Gerd R. Burmester; Ernest Choy; Alan Kivitz; Atsushi Ogata; Bao; Akira Nomura; Stuart Lacey; Jinglan Pei; William Reiss; Attila Pethoe-Schramm; Navita L. Mallalieu; Thomas Wallace; Margaret Michalska; Herbert Birnboeck; Kay Stubenrauch; Mark C. Genovese
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Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis
Gut, ISSN: 14683288 00175749
Gail B. Gifford; Elise S. Demitrack; Theresa M. Keeley; Andrew Tam; Nilsa La Cunza; Priya H. Dedhia; Jason R. Spence; Diane M. Simeone; Ichiko Saotome; Angeliki Louvi; Christian W. Siebel; Linda C. Samuelson
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Concomitant Use of Statins in Tocilizumab-Treated Patients with Rheumatoid Arthritis: A Post Hoc Analysis
Rheumatology and Therapy, ISSN: 21986584 21986576
Martin Soubrier; Jinglan Pei; Frédérick Durand; Lars Gullestad; Ani John
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Stem cell plasticity enables hair regeneration following Lgr5 + cell loss
Nature Cell Biology, ISSN: 14764679 14657392
Joerg D. Hoeck; Brian Biehs; Antonina V. Kurtova; Noelyn Kljavin; Felipe de Sousa e Melo; Bruno Alicke; Koeppen; Zora Modrusan; Robert Piskol; Frederic J. De Sauvage
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Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Xiaojing Wang; Aleksandr Kolesnikov; Suzanne Tay; Grace Chan; Qi Chao; Steven Do; Jason H. Drummond; Allen Ebens; Ning Liu; Justin Ly; Eric Harstad; Huiyong Hu; John Moffat; Veerendra Munugalavadla; Jeremy Murray; Dionysos S. Slaga; Vickie Tsui; Matthew Volgraf; Heidi J. A. Wallweber; Jae H. Chang
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A survey of renal impairment pharmacokinetic studies for new oncology drug approvals in the USA from 2010 to early 2015: A focus on development strategies and future directions
Anti-Cancer Drugs, ISSN: 14735741 09594973
Jim J. Xiao; Jiyun S. Chen; Bert L. Lum; Richard A. Graham
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Mechanical ventilation in idiopathic pulmonary fibrosis: A nationwide analysis of ventilator use, outcomes, and resource burden
BMC Pulmonary Medicine, ISSN: 14712466
Joshua J. Mooney; Karina Raimundo; Eunice Chang; Michael S. Broder
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Glycation of antibodies: Modification, methods and potential effects on biological functions
mAbs, ISSN: 19420870 19420862
Bingchuan Wei; Kelsey Berning; Quan; Taylor Zhang
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A modular and adaptive mass spectrometry-based platform for support of bioprocess development toward optimal host cell protein clearance
mAbs, ISSN: 19420870 19420862
Donald Walker; Feng Yang; Joe Carver; Koman Joe; David A. Michels; X. Christopher Yu
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Mice deficient in NRROS show abnormal microglial development and neurological disorders
Nature Immunology, ISSN: 15292916 15292908
Kit Wong; Rajkumar Noubade; Paolo Manzanillo; Naruhisa Ota; Oded Foreman; Jason A. Hackney; Brad A. Friedman; Rajita Pappu; Kimberly Scearce-Levie; Wenjun Ouyang
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Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates
Bioconjugate Chemistry, ISSN: 15204812 10431802
Xiuxia Sun; Jose Ponte; Nicholas C. Yoder; Rassol Laleau; Jennifer A. Coccia; Leanne Lanieri; Qifeng Qiu; Rui Wu; E. Erica Hong; Megan Bogalhas; Lintao Wang; Ling Dong; Yulius Y. Setiady; Erin K. Maloney; Olga Ab; Xiaoyan Zhang; Jan Pinkas; Thomas A. Keating; Ravi Chari; Hans Erickson; John M. Lambert
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High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates
Analytical Chemistry, ISSN: 15206882 00032700
Jintang He; Dian Su; Carl Ng; Luna Liu; Shang-Fan Yu; Thomas H. Pillow; Geoffrey Del Rosario; Martine Darwish; Byoung-Chul Lee; Rachana Ohri; Hongxiang Zhou; Xueji Wang; Jiawei Lu; Surinder Kaur; Keyang Xu
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Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: Final update of the pivotal ERIVANCE BCC study
BMC Cancer, ISSN: 14712407
Aleksandar Sekulic; Michael R. Migden; Nicole Basset-Seguin; Claus Garbe; Anja Gesierich; Christopher D. Lao; Chris Miller; Laurent Mortier; Dedee F. Murrell; Omid Hamid; Jorge F. Quevedo; Jeannie Hou; Edward McKenna; Natalie Dimier; Sarah Williams; Dirk Schadendorf; Axel Hauschild
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Phase I study of GDC-0425, a checkpoint kinase 1 inhibitor, in combination with gemcitabine in patients with refractory solid tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Jeffery R. Infante; Antoine Hollebecque; Sophie Postel-Vinay; Todd M. Bauer; Elizabeth M. Blackwood; Marie Evangelista; Sami Mahrus; Franklin V. Peale Jr.; Xuyang Lu; Srikumar Sahasranaman; Rui Zhu; Yuan Chen; Xiao Ding; Elaine R. Murray; Jennifer L. Schutzman; Jennifer O. Lauchle; Jean-Charles Soria; Patricia M. LoRusso
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GUIDEseq: A bioconductor package to analyze GUIDE-Seq datasets for CRISPR-Cas nucleases
BMC Genomics, ISSN: 14712164
Lihua Julie Zhu; Michael Lawrence; Ankit Gupta; Hervé Pagès; Alper Kucukural; Manuel Garber; Scot A. Wolfe
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Effects of RG7652, a Monoclonal Antibody Against PCSK9, on LDL-C, LDL-C Subfractions, and Inflammatory Biomarkers in Patients at High Risk of or With Established Coronary Heart Disease (from the Phase 2 EQUATOR Study)
American Journal of Cardiology, ISSN: 18791913 00029149
Amos Baruch; Mosesova; John Davis; Nageshwar Budha; Alexandr Vilimovskij; Robert S. Kahn; Kun Peng; Kyra J. Cowan; Laura Pascasio Harris; Thomas R. Gelzleichter; Josh Lehrer; John C. Davis; Whittemore G. Tingley
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To the editor: Venetoclax and obinutuzumab in chronic lymphocytic leukemia
Blood, ISSN: 15280020 00064971
Kirsten Fischer; Othman Al-Sawaf; Anna-Maria Fink; Mark Dixon; Jasmin Bahlo; Simon Warburton; Thomas J. Kipps; Robert Weinkove; Sue Robinson; Till Seiler; Stephen Opat; Carolyn J. Owen; Javier López; Kathryn Humphrey; Rod A. Humerickhouse; Eugen Tausch; Lukas Frenzel; Barbara Eichhorst; Clemens M. Wendtner; Stephan Stilgenbauer; Anton W. Langerak; Jacque J.M. Van Dongen; Sebastian Böttcher; Matthias Ritgen; Valentin Goede; Mehrdad Mobasher; Michael Hallek
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Hospital cost and length of stay in idiopathic pulmonary fibrosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Joshua J. Mooney; Karina Raimundo; Eunice Chang; Michael S. Broder
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Employment and absenteeism in working-age persons with multiple sclerosis
Journal of Medical Economics, ISSN: 1941837X 13696998
Amber Salter; Nina Parikh Thomas; Tuula Tyry; Cutter; Ruth Ann Marrie
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Flexibility and Design: Conformational Heterogeneity along the Evolutionary Trajectory of a Redesigned Ubiquitin
Structure, ISSN: 18784186 09692126
Justin T. Biel; Michael C. Thompson; Christian N. Cunningham; Jacob E. Corn; James S. Fraser
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αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis
Journal of Crohn's and Colitis, ISSN: 18764479
Christopher A. Lamb; John C Mansfield; Tew; Don L. Gibbons; Anna K. Long; Peter M. Irving; Laurie Diehl; Jeffrey Eastham-Anderson; Maria B. Price; Graeme O'Boyle; David E J Jones; Sharon O'Byrne; Adrian C. Hayday; Mary E. Keir; Jackson G. Egen; John A. Kirby
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Incidence, course, and management of toxicities associated with cobimetinib in combination with vemurafenib in the coBRIM study
Annals of Oncology, ISSN: 15698041
Brigitte Dréno; Antoni Ribas; James Larkin; Paolo A. Ascierto; Axel Hauschild; Luc Thomas; Jean-Jacques Grob; Daniel Koralek; Isabelle Rooney; Jessie Hsu; Edward McKenna; McArthur
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Vascular safety of ranibizumab in patients with diabetic macular edema: A pooled analysis of patient-level data from randomized clinical trials
JAMA Ophthalmology, ISSN: 21686165
Marco A. Zarbin; Cornelia Dunger-Baldauf; Zdenka Haskova; Prashil Koovejee; Marie-Catherine Mousseau; Philippe Margaron; Howard Snow; Paul E. Beaumont; Giovanni Staurenghi; Steve Francom
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Peptidoglycan association of murein lipoprotein is required for KpsD-dependent group 2 capsular polysaccharide expression and serum resistance in a uropathogenic escherichia coli isolate
mBio, ISSN: 21507511 21612129
Jingyu Diao; Catrien Bouwman; Donghong Yan; Jing Kang; Anand K. Katakam; Peter S. Liu; Homer Pantua; Abbas Alexander; Nicholas N. Nickerson; Cary D. Austin; Mike Reichelt; Wendy N. Sandoval; Min Xu; Chris Whitfield; Sharookh B. Kapadia
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Modulating therapeutic activity and toxicity of pyrrolobenzodiazepine antibody-drug conjugates with self-immolative disulfide linkers
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Thomas H. Pillow; Melissa Schutten; Shang-Fan Yu; Rachana Ohri; Jack D. Sadowsky; Kirsten Achilles Poon; Willy A. Solis; Fiona Zhong; Geoffrey Del Rosario; MaryAnn Go; Jeffrey Lau; Sharon Fong Yee; Jintang He; Luna Liu; Carl Ng; Keyang Xu; Douglas Leipold; Amrita Kamath; Donglu Zhang; Luke Masterson; Stephen J. Gregson; Philip W. Howard; Fan Fang; Jinhua Chen; Janet Gunzner; Katherine R. Kozak; Spencer; Paul G. Polakis; Andrew G. Polson; Flygare; Jagath R. Junutula
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Effect of fluorouracil, leucovorin, and oxaliplatin with or without onartuzumab in HER2-negative, MET-positive gastroesophageal adenocarcinoma: The METGastric randomized clinical trial
JAMA Oncology, ISSN: 23742445 23742437
Manish A. Shah; Bang; Florian Lordick; Maria Alsina; Meng Chen; Stephen P. Hack; Jean-Marie Bruey; Dustin Smith; Ian McCaffery; David S. Shames; See Phan; David Cunningham
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Processing impact on monoclonal antibody drug products: Protein subvisible particulate formation induced by grinding stress
PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440
Benson Gikanga; Devon Roshan Eisner; Robert Ovadia; Eric S. Day; Oliver B. Stauch; Maa
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Next-Generation Sequencing Reveals Novel Mutations in X-linked Intellectual Disability
OMICS A Journal of Integrative Biology, ISSN: 15578100 15362310
Babylakshmi Muthusamy; Lakshmi Dhevi N. Selvan; Thong T Nguyen; Jesna Manoj; Eric Stawiski; Bijay S. Jaiswal; Weiru Wang; Remya Raja; Vedam Laxmi Ramprasad; Ravi Gupta; Sakthivel Murugan; Jayarama S. Kadandale; Keshava Prasad; Kavita Reddy; Andrew S. Peterson; Akhilesh Pandey; Somasekar Seshagiri; Satish Chandra Girimaji; Harsha Gowda
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The future of asthma research and development: A roadmap from the European Asthma Research and Innovation Partnership (EARIP)
European Respiratory Journal, ISSN: 13993003 09031936
Sarah Masefield; Jessica Edwards; Kjeld Hansen; Dominique Hamerlijnck; Karin Lisspers; Marc Van Der Schee; Liliana Silva; Matthews; Mina Gaga; Ian Adcock; Stephen Holgate; Samantha Walker; Pippa Powell
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Cost and health care utilization in patients with asthma and high oral corticosteroid use
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
Michael S. Broder; Karina Raimundo; Ka Ming Ngai; Eunice Chang; Noelle M. Griffin; Liam G. Heaney
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Omalizumab in children with uncontrolled allergic asthma: Review of clinical trial and real-world experience
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Bradley E. Chipps; Bob Lanier; Henry Milgrom; Antoine Deschildre; Gunilla Hedlin; Stanley J. Szefler; Meyer Kattan; Farid Kianifard; Benjamin Ortiz; Tmirah Haselkorn; Ahmar Iqbal; Karin Rosén; Benjamin L. Trzaskoma; William W. Busse
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Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions
Molecular Pharmaceutics, ISSN: 15438392 15438384
Justin Ly; Kirsten Messick; Ann R. Qin; Ryan Takahashi; Edna F. Choo
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Routine Assessment of Patient Index Data 3 and the American College of Rheumatology/European League Against Rheumatism Provisional Remission Definitions as Predictors of Radiographic Outcome in a Rheumatoid Arthritis Clinical Trial With Tocilizumab
Arthritis Care and Research, ISSN: 21514658 2151464X
Muznay N. Khawaja; Martin J. Bergman; Jeffrey Yourish; Jinglan Pei; William Reiss; Edward Keystone
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Mapping the Binding Interface of VEGF and a Monoclonal Antibody Fab-1 Fragment with Fast Photochemical Oxidation of Proteins (FPOP) and Mass Spectrometry
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Ying Zhang; Aaron T. Wecksler; Patricia Molina; Galahad Deperalta; Michael L. Gross
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Erlotinib and bevacizumab in patients with advanced non-small-cell lung cancer and activating EGFR mutations (BELIEF): an international, multicentre, single-arm, phase 2 trial
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Rafael Rosell; Urania Dafni; Enriqueta Felip; Alessandra Curioni-Fontecedro; Oliver Gautschi; Solange Peters; Bartomeu Massutí; Ramon Palmero; Santiago Ponce Aix; Enric Carcereny; Martin Früh; Miklos Pless; Sanjay Popat; Athanasios Kotsakis; Sinead Cuffe; Paolo Bidoli; Adolfo Favaretto; Patrizia Froesch; Noemí Reguart; Javier Puente; Linda Coate; Fabrice Barlesi; Daniel Rauch; Michael Thomas; Carlos Camps; Jose Gómez-Codina; Margarita Majem; Rut Porta; Riyaz Shah; Emer Hanrahan; Roswitha Kammler; Barbara Ruepp; Manuela Rabaglio; Marie Kassapian; Niki Karachaliou; Rachel Tam; David S. Shames; Molina; Rolf A Stahel
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Trastuzumab emtansine versus taxane use for previously treated HER2-positive locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma (GATSBY): an international randomised, open-label, adaptive, phase 2/3 study
The Lancet Oncology, ISSN: 14745488 14702045
Peter C Thuss-Patience; Manish A. Shah; Atsushi Ohtsu; Eric Van Cutsem; Jaffer A. Ajani; Hugo Castro; Wasat Mansoor; Hyun Cheol Chung; Gyorgy Bodoky; Kohei Shitara; Gail L. Phillips; Tina van der Horst; Marie-Laurence Harle-Yge; Betsy Althaus; Yoon-Koo Kang
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Novel mechanism of decyanation of GDC-0425 by cytochrome P450
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Jason S Halladay; Michael Siu; Yuan Chen; Cornelis E. Hop; S. Cyrus Khojasteh; Shuguang Ma
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