Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4651 - 4700 OF 15570 RESULTS

Evaluation of heavy chain C-terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells
Biotechnology Progress, ISSN: 15206033 87567938
Zhilan Hu; Danming Tang; Shahram Misaghi; Guoying Jiang; X. Christopher Yu; Mandy Yim; David Shaw; Snedecor; Mike Laird; Amy Shen
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The Clinical Importance of Changes in Diabetic Retinopathy Severity Score
Ophthalmology, ISSN: 15494713 01616420
Michael S. Ip; Jiameng Zhang; Jason S. Ehrlich
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Seasonal variability of severe asthma exacerbations and clinical benefit from lebrikizumab
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Tracy Staton; Joseph R. Arron; Julie Olsson; Cécile T.J. Holweg; Matthews; David F. Choy
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Impact of physiologically based pharmacokinetic models on regulatory reviews and product labels: Frequent utilization in the field of oncology
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Yoshida; Nageshwar Budha; Jin Y. Jin
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Activity-based probes for the ubiquitin conjugation–deconjugation machinery: new chemistries, new tools, and new insights
FEBS Journal, ISSN: 17424658 1742464X
David S. Hewings; Flygare; Matthew Bogyo; Ingrid E. Wertz
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Melt extrusion vs. spray drying: The effect of processing methods on crystalline content of naproxen-povidone formulations
European Journal of Pharmaceutical Sciences, ISSN: 18790720 09280987
Abbe Haser; Tu Cao; Joseph W. Lubach; Tony Listro; Larry Acquarulo; Feng Zhang
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Reply
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Phillip Lieberman; Dale T. Umetsu; Gillis Carrigan; Abdelkader Rahmaoui
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Assessment of Correlation Between Early and Late Efficacy Endpoints to Identify Potential Surrogacy Relationships in Non-Hodgkin Lymphoma: a Literature-Based Meta-analysis of 108 Phase II and Phase III Studies
AAPS Journal, ISSN: 15507416
Rui Zhu; Dan Lu; Yu-Waye Chu; Akiko Chai; Michelle Green; Nancy Zhang; Jin Y. Jin
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Activity-based probes for the multicatalytic proteasome
FEBS Journal, ISSN: 17424658 1742464X
David S. Hewings; Flygare; Ingrid E. Wertz; Matthew Bogyo
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Longitudinal variation of serum periostin levels in adults with stable asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Ruth Semprini; Caswell-Smith; James Fingleton; Cécile T.J. Holweg; Matthews; Mark Weatherall; Beasley; Irene Braithwaite
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Cardiovascular and cerebrovascular events among patients receiving omalizumab: Pooled analysis of patient-level data from 25 randomized, double-blind, placebo-controlled clinical trials
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Carlos Iribarren; Kenneth J. Rothman; Mary S. Bradley; Gillis Carrigan; Mark D. Eisner; Hubert Chen
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Cardiovascular and cerebrovascular events among patients receiving omalizumab: Results from EXCELS, a prospective cohort study in moderate to severe asthma
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Carlos Iribarren; Abdelkader Rahmaoui; Aidan Long; Stanley J. Szefler; Mary S. Bradley; Gillis Carrigan; Mark D. Eisner; Hubert Chen; Theodore A. Omachi; Michael E. Farkouh; Kenneth J. Rothman
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Patient and physician preferences for anticancer drugs for the treatment of metastatic colorectal cancer: A discrete-choice experiment
Cancer Management and Research, ISSN: 11791322
Juan Marcos González; Sarika Ogale; Rob Morlock; Joshua Posner; A. Brett Hauber; Nicolas Sommer; Grothey
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NPTX2 and cognitive dysfunction in Alzheimer’s Disease
eLife, ISSN: 2050084X
Mei-Fang Xiao; Desheng Xu; Michael T Craig; Kenneth A Pelkey; Chun-Che Chien; Yang Shi; Juhong Zhang; Susan Resnick; Olga Pletnikova; David Salmon; James Brewer; Steven Edland; Jerzy Wegiel; Benjamin Tycko; Alena Savonenko; Roger H. Reeves; Juan C. Troncoso; Chris J. McBain; Douglas Galasko; Paul F Wegiel
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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult
eLife, ISSN: 2050084X
Martin Larhammar; Sarah Huntwork-Rodriguez; Zhiyu Jiang; Hilda Solanoy; Arundhati Sengupta Ghosh; Bei Wang; Joshua S. Kaminker; Kevin Huang; Jeffrey Eastham-Anderson; Michael Siu; Zora Modrusan; Madeline M. Farley; Marc Tessier-Lavigne; Joe Lewcock; Trent A. Watkins
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Highly Regioselective and Practical Synthesis of 5-Bromo-4-chloro-3-nitro-7-azaindole
Organic Process Research and Development, ISSN: 1520586X 10836160
Chong Han; Keena L. Green; Eugen Pfeifer; Francis Gosselin
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Highly Regioselective and Practical Synthesis of 5-Bromo-4-chloro-3-nitro-7-azaindole
Organic Process Research and Development, ISSN: 10836160
Chong Han; Keena L. Green; Eugen Pfeifer; Francis Gosselin
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A Novel Cascade Benzyne Nucleophilic Addition/Fries Rearrangement for Entry into 2,3-Disubstituted Phenols
Synlett, ISSN: 14372096 09365214
Sarah M. Bronner; Daniel Lee; Vlad Bacauanu; Patrick Cyr
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The Janus Kinase (JAK) FERM and SH2 domains: Bringing specificity to JAK-receptor interactions
Frontiers in Endocrinology, ISSN: 16642392
Ryan Ferrao; Patrick J. Lupardus
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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19379145 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason A. Hackney; Cesar A. Corzo; Jenna L. Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; A F. Setiadi; Ross Francis; Andres Paler Martinez; Youngsu C. Kwon; Vladimir Ramirez-Carrozzi; Yonglian Sun; Patricia W. Grigg; Merone Roose-Girma; Surinc Er Jeet; Kai H. Barck; Anna Pham; Naruhisa Ota; Connie Ha; Stinson; Joseph Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent Mckenzie; Michael J. Townsend; Richard A. D. Carano; Søren Warming; Domagoj Vucic; Jason De Voss; Wyne P. Lee; Jennie R. Lill; Ali A. Zarrin
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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason A. Hackney; Cesar A. Corzo; Jenna L. Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; A F. Setiadi; Ross Francis; Andres Paler Martinez; Youngsu C. Kwon; Vladimir Ramirez-Carrozzi; Yonglian Sun; Patricia W. Grigg; Merone Roose-Girma; Surinc Er Jeet; Kai H. Barck; Anna Pham; Ota; Connie Ha; Stinson; Joseph Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent S. McKenzie; Michael J. Townsend; Richard A. D. Carano; Søren Warming; Domagoj Vucic; Jason De Voss; Wyne P. Lee; Jennie R. Lill; Ali A. Zarrin
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Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Aaron H Nile; Susmith Mukund; Karen Stanger; Weiru Wang; Rami N. Hannoush
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The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19379145 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason A. Hackney; Cesar A. Corzo; Jenna L. Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzadeh; Patrick Caplazi; Ivan Peng; A F. Setiadi; Ross Francis; Andres Paler Martinez; Youngsu C. Kwon; Vladimir Ramirez-Carrozzi; Yonglian Sun; Patricia W. Grigg; Merone Roose-Girma; Surinc Er Jeet; Kai H. Barck; Anna Pham; Naruhisa Ota; Connie Ha; Stinson; Joseph Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent Mckenzie; Michael J. Townsend; Richard A. D. Carano; Søren Warming; Domagoj Vucic; Jason De Voss; Wyne P. Lee; Jennie R. Lill; Ali A. Zarrin
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A CEACAM6-high airway neutrophil phenotype and CEACAM6-high epithelial cells are features of severe asthma
Journal of Immunology, ISSN: 15506606 00221767
Aarti Shikotra; David F. Choy; Salman Siddiqui; Greer Arthur; Deepti R. Nagarkar; Guiquan Jia; Adam K. A. Wright; Chandra M. Ohri; Emma Doran; Claire A. Butler; Beverley Hargadon; Abbas Alexander; Janet Jackman; Lawren C. Wu; Liam G. Heaney; Joseph R. Arron; Peter Bradding
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Compatibility study of a parenteral microdose polyethylene glycol formulation in medical devices and identification of degradation impurity by 2D-LC/MS
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Lulu Dai; Geoffrey K. Yeh; Yingqing Ran; Peter M. Yehl; Kelly Zhang
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Transcription factor Etv5 is essential for the maintenance of alveolar type II cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Zhen Zhang; Kim Newton; Sarah K. Kummerfeld; Webster; Donald S. Kirkpatrick; Lilian Phu; Jeffrey Eastham-Anderson; Jinfeng Liu; Wyne P. Lee; Jiansheng Wu; Hong Li; Melissa Junttila; Vishva M. Dixit
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Genomics and evolution of protein phosphatases
Science Signaling, ISSN: 19379145 19450877
Mark J. Chen; Jack E. Dixon; Gerard Manning
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Validation of a two-dimensional liquid chromatography method for quality control testing of pharmaceutical materials
Journal of Chromatography A, ISSN: 18733778 00219673
Samuel H. Yang; Jennifer Wang; Kelly Zhang
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Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell–associated damage in IFNα-driven lupus nephritis
JCI insight, ISSN: 23793708
Arna Katewa; Yugang Wang; Jason A. Hackney; Tao Huang; Eric Suto; Nandhini Ramamoorthi; Cary D. Austin; Meire C. Bremer; Jacob Z. Chen; James J. Crawford; Kevin S. Currie; Peter Blomgren; Jason Devoss; Julie Dipaolo; Jonathan Hau; Adam R. Johnson; Justin Lesch; Laura DeForge; Zhonghua Lin; Marya Liimatta; Joseph W. Lubach; Sami McVay; Zora Modrusan; Allen Nguyen; Chungkee Poon; Jianyong Wang; Lichuan Liu; Wyne P. Lee; Harvey Wong; Wendy B. Young; Michael J. Townsend; Karin Reif
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Computationally Discovered Potentiating Role of Glycans on NMDA Receptors
Scientific Reports, ISSN: 20452322
Anton V. Sinitskiy; Nathaniel H. Stanley; David Hackos; Jesse E. Hanson; Benjamin D. Sellers; Vijay S. Pande
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Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands
Journal of Clinical Investigation, ISSN: 15588238 00219738
Jooho Chung; Christen Ebens; Eric Perkey; Vedran Radojcic; Ute Koch; Leonardo Scarpellino; Alexander Tong; Frederick Allen; Sherri Wood; Jiane Feng; Ann Friedman; David Granadier; Ivy T. Tran; Qian Chai; Lucas Onder; Minhong Yan; Pavan Reddy; Bruce R. Blazar; Alex Y. Huang; Todd V. Brennan; D. Keith Bishop; Burkhard Ludewig; Christian W. Siebel; Freddy Radtke; Sanjiv A. Luther; Ivan Maillard
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bisFabs: Tools for rapidly screening hybridoma IgGs for their activities as bispecific antibodies
mAbs, ISSN: 19420870 19420862
Sanket Patke; Ji Li; Peiyin Wang; Dionysos S. Slaga; Jennifer A. Johnston; Sunil Bhakta; Siler Panowski; Liping L. Sun; Teemu T. Junttila; Justin M. Scheer; Diego Ellerman
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[18F] Positron emission tomography response after rituximab-containing induction therapy in follicular lymphoma is an independent predictor of survival after adjustment for FLIPI in academic and community-based practice
Leukemia and Lymphoma, ISSN: 10292403 10428194
Ida Wong-Sefidan; Michelle Byrtek; Zhou; Jonathan W. Friedberg; Christopher R. Flowers; Zelenetz; Keith Dawson; Erin G. Reid
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Staphylococcus aureus type I signal peptidase: Essential or not essential, that’s the question
Microbial Cell, ISSN: 23112638
Wouter L. W. Hazenbos; Elizabeth Skippington; Man-Wah Tan
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Preference for subcutaneous or intravenous administration of rituximab among patients with untreated CD20+ diffuse large B-cell lymphoma or follicular lymphoma: Results from a prospective, randomized, open-label, crossover study (PrefMab)
Annals of Oncology, ISSN: 15698041 09237534
Rummel; Kim; Aversa; Wolfram Brugger; Capochiani; Plenteda; Re; Peter C. Trask; Osborne; Smith; Grigg
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Incidence and management of diarrhea in patients with HER2-positive breast cancer treated with pertuzumab
Annals of Oncology, ISSN: 15698041 09237534
Sandra M. Swain; Andreas Schneeweiss; Luca Gianni; Gao; Alisha Stein; Waldron-Lynch; Sarah Heeson; Beattie; Bongin Yoo; Javier Cortés; Baselga
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Response to "quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is It Worth?"
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Ian E. Templeton; Yuan Chen; Jialin Mao; Jian Lin; Hongbin Yu; Peters; Shebley; Varma
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Response to "quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites by Physiologically Based Pharmacokinetic Models: Is It Worth?"
CPT: Pharmacometrics and Systems Pharmacology,
Ian E. Templeton; Yuan Chen; Jialin Mao; Lin; Hongbin Yu; Peters; Shebley; Varma
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Importance of angioedema-free days in patients with chronic idiopathic or spontaneous urticaria
Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206
James L. Zazzali; Allen P. Kaplan; Marcus Maurer; Karina Raimundo; Benjamin L. Trzaskoma; Evgeniya Antonova; Karin Rosén
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Ras-MEK signaling mediates a critical Chk1-dependent DNA damage response in cancer cells
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Ho-June Lee; Yi Cao; Victoria Pham; Elizabeth M. Blackwood; Catherine Wilson; Marie Evangelista; Christiaan N. Klijn; David Stokoe; Jeffrey Settleman
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Tools for communication: Novel infrastructure to address patient-perceived gaps in oncology care
Clinical journal of oncology nursing, ISSN: 1538067X 10921095
Suzanne McMullen; Shelagh Szabo; Ronald J. Halbert; Catherine Lai; Aparna R. Parikh; Mikele M. Bunce; Raya Khoury; Anthony Masaquel
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Dying cells actively regulate adaptive immune responses
Nature Reviews Immunology, ISSN: 14741741 14741733
Nader Yatim; Sean P. Cullen; Matthew L. Albert
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Effect of Omalizumab on Blood Basophil Counts in Patients with Chronic Idiopathic/Spontaneous Urticaria
Journal of Investigative Dermatology, ISSN: 15231747 0022202X
Sarbjit S. Saini; Theodore A. Omachi; Benjamin L. Trzaskoma; Henry N. Hulter; Karin Rosén; Patricia M. Sterba; Jean-Paul Courneya; Alan Lackey; Hubert Chen
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Reversible phosphorylation of the 26S proteasome
Protein and Cell, ISSN: 16748018 1674800X
Xing Guo; Xiuliang Huang; Mark J. Chen
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From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
Nature Reviews Drug Discovery, ISSN: 14741784 14741776
Avi Ashkenazi; Wayne J. Fairbrother; Joel D. Leverson; Andrew J. Souers
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Control Strategies for Drug Product Continuous Direct Compression—State of Control, Product Collection Strategies, and Startup/Shutdown Operations for the Production of Clinical Trial Materials and Commercial Products
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Ahmad Almaya; Lawrence De Belder; Robert Meyer; Karthik Nagapudi; Hung-Ren Homer Lin; Ian Leavesley; Jayanthy Jayanth; Gurjit Bajwa; James DiNunzio; Anthony Tantuccio; Dan Blackwood; Admassu Abebe
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Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions
Trends in Immunology, ISSN: 14714981 14714906
Robin A. Aglietti; Erin C. Dueber
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Characterization of PD-L1 expression and immune cell infiltration in nasopharyngeal cancer
Oral Oncology, ISSN: 18790593 13688375
Oscar Siu Hong Chan; Marcin Kowanetz; Wai Tong Ng; Koeppen; Lai Kwan Chan; Rebecca Mei Wan Yeung; Haiyan Wu; Lukas Amler; Christoph Mancao
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Challenges in Determining Intrinsic Viscosity Under Low Ionic Strength Solution Conditions
Pharmaceutical Research, ISSN: 1573904X 07248741
Mariya Pindrus; Steven J. Shire; Sandeep Yadav; Devendra S. Kalonia
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Newly diagnosed vs. relapsing giant cell arteritis: Baseline data from the GiACTA trial
Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172
Katie Tuckwell; Neil Collinson; Sophie Dimonaco; Micki Klearman; Daniel Blockmans; Elisabeth Brouwer; Maria C. Cid; Bhaskar Dasgupta; Juergen Rech; Carlo Salvarani; Sebastian Unizony; John H. Stone
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