Genentech: Publications

October 1, 2016

Quantitative Prediction of Drug-Drug Interactions Involving Inhibitory Metabolites in Drug Development: How Can Physiologically Based Pharmacokinetic Modeling Help?

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Ian E. Templeton; Yuan Chen; Jialin Mao; Jian Lin; Hongbin Yu; Peters; Shebley; Varma

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October 1, 2016

Corticosteroid-related adverse events in patients with giant cell arteritis: A claims-based analysis

Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172

Michael S. Broder; Khaled Sarsour; Eunice Chang; Neil Collinson; Katie Tuckwell; Pavel Napalkov; Micki Klearman

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October 1, 2016

Peripheral blood gene expression predicts clinical benefit from anti–IL-13 in asthma

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

David F. Choy; Guiquan Jia; Abbas Alexander; Katrina B. Morshead; Nicholas Lewin-Koh; Rajiv Dua; Pauline Rivera; Priscilla Moonsamy; Marcel Fontecha; Aarthi Balasubramanyam; Chris Santini; Ekaterina Bassett; Jill M. Ray; Christopher R. Cabanski; Mary S. Bradley; Romeo MacIuca; Mosesova; Heleen Scheerens; Joseph R. Arron

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October 1, 2016

Regulation of interleukin-10 expression

Advances in Experimental Medicine and Biology, ISSN: 22148019 00652598

Sascha Rutz; Wenjun Ouyang

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October 1, 2016

Clinical endpoints for the study of geographic atrophy secondary to age-related macular degeneration

Retina, ISSN: 15392864 0275004X

Srinivas Sadda; Usha Chakravarthy; David G. Birch; Giovanni Staurenghi; Erin C. Henry; Christopher Brittain

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October 1, 2016

Metabolic response to NAD depletion across cell lines is highly variable

PLoS ONE, ISSN: 19326203

Yang Xiao; Mandy Kwong; Anneleen Daemen; Marcia Belvin; Xiaorong Liang; Georgia Hatzivassiliou; Thomas O'Brien

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October 1, 2016

Ranibizumab Treatment for Pigment Epithelial Detachment Secondary to Neovascular Age-Related Macular Degeneration: Post Hoc Analysis of the HARBOR Study

Ophthalmology, ISSN: 15494713 01616420

David Sarraf; Nikolas J.S. London; Rahul N. Khurana; Pravin U. Dugel; Shamika Gune; Lauren Hill; Lisa Tuomi

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October 1, 2016

Non-cytochrome P450-mediated bioactivation and its toxicological relevance

Drug Metabolism Reviews, ISSN: 10979883 03602532

Jinping Gan; Shuguang Ma; Donglu Zhang

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October 1, 2016

Isolating the Role of Bevacizumab in Elderly Patients with Previously Untreated Nonsquamous Non-Small Cell Lung Cancer

American Journal of Clinical Oncology: Cancer Clinical Trials, ISSN: 1537453X 02773732

Corey Langer; Mark A. Socinski; Jyoti D. Patel; Alan Sandler; Joan H. Schiller; Larry Leon; Sebastien J. Hazard; Suresh Ramalingam

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October 1, 2016

Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials

The Lancet Respiratory Medicine, ISSN: 22132619 22132600

Nicola A. Hanania; Phillip Korenblat; Kenneth R Chapman; Eric D Bateman; Petr Kopecky; Pierluigi Paggiaro; Akihito Yokoyama; Julie Olsson; Sarah Gray; Cécile T.J. Holweg; Mark D. Eisner; Charles Asare; Saloumeh Kadkhodayan Fischer; Kun Peng; Wendy Putnam; Matthews

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October 1, 2016

An automated high-throughput metabolic stability assay using an integrated high-resolution accurate mass method and automated data analysis software

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Pranav Shah; Edward Kerns; Dac-Trung Nguyen; R. Scott Obach; Amy Q. Wang; Alexey Zakharov; John C. McKew; Anton Simeonov; Cornelis E. Hop; Xin Xu

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October 1, 2016

Clinical development of new drug-radiotherapy combinations

Nature Reviews Clinical Oncology, ISSN: 17594782 17594774

Ricky A. Sharma; Ruth Plummer; Julie K. Stock; Tessa A. Greenhalgh; Ozlem Ataman; Stephen Kelly; Robert Clay; Richard A. Adams; Richard Baird; Lucinda Billingham; Sarah R. Brown; Sean Buckland; Helen Bulbeck; Anthony J. Chalmers; Glen Clack; Aaron N. Cranston; Lars Damstrup; Roberta Ferraldeschi; Martin D. Forster; Julian Golec; Russell M. Hagan; Emma Hall; Axel-R. Hanauske; Kevin J. Harrington; Tom Haswell; Maria A. Hawkins; Tim Illidge; Hazel Jones; Andrew S. Kennedy; Fiona Mcdonald; Thorsten Melcher; James P.B. O'Connor; John R. Pollard; Mark P. Saunders; David Sebag-Montefiore; Melanie Smitt; John Staffurth; Ian J. Stratford; Stephen R. Wedge

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October 1, 2016

Reference ranges for serum periostin in a population without asthma or chronic obstructive pulmonary disease

Clinical and Experimental Allergy, ISSN: 13652222 09547894

Caswell-Smith; Hosking; Cripps; Cécile T.J. Holweg; Matthews; Holliday; Maillot; James Fingleton; Mark Weatherall; Irene Braithwaite; Beasley; Thomas Charles; Leonie Eastlake; Denise Fabian; Tony Mallon; Claire Munro; Janine Pilcher; Alison Pritchard; Michael Richards; Judith Riley; Philippa Shirtcliffe; Maureen Stretch; Mathew Williams; Jochen Brumm; Meghana Handigol; Julie Olsen; Karl Yen

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October 1, 2016

Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells

Biotechnology and Bioengineering, ISSN: 10970290 00063592

Zhilan Hu; Henry Zhang; Benjamin Haley; Frank D. Macchi; Feng Yang; Shahram Misaghi; Joseph Elich; Renee Yang; Yun Tang; John C. Joly; Snedecor; Amy Shen

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October 1, 2016

1H, 13C and 15N backbone resonance assignment for the 40.5 kDa catalytic domain of Ubiquitin Specific Protease 7 (USP7)

Biomolecular NMR Assignments, ISSN: 1874270X 18742718

Paola Di Lello; Lionel Rouge; Borlan Pan; Till Maurer

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October 1, 2016

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Nature Chemical Biology, ISSN: 15524469 15524450

Aaron Boudreau; Hans E. Purkey; Anna Hitz; Kirk D. Robarge; David Peterson; Sharada Labadie; Mandy Kwong; Rebecca Hong; Min Gao; Christopher J. Del Nagro; Raju V. Pusapati; Shuguang Ma; Laurent Salphati; Jodie Pang; Aihe Zhou; Tommy Lai; Yingjie Li; Zhongguo Chen; Binqing Wei; Ivana Yen; Steve Sideris; Mark L. McCleland; Ron Firestein; Laura B. Corson; Alexander N. Vanderbilt; Simon P. Williams; Anneleen Daemen; Marcia Belvin; Eigenbrot; Peter K Jackson; Shiva Malek; Georgia Hatzivassiliou; Deepak Sampath; Marie Evangelista; Thomas O'Brien

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October 1, 2016

Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232

Tao Chen; Yan Chen; Cinzia Stella; Colin D. Medley; Jason Gruenhagen; Kelly Zhang

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October 1, 2016

Angioedema in the omalizumab chronic idiopathic/spontaneous urticaria pivotal studies

Annals of Allergy, Asthma and Immunology, ISSN: 15344436 10811206

James L. Zazzali; Allen P. Kaplan; Marcus Maurer; Karina Raimundo; Benjamin L. Trzaskoma; Paul G. Solari; Evgeniya Antonova; Meryl Mendelson; Karin Rosén

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October 1, 2016

A first-in-human phase I study to evaluate the MEK1/2 inhibitor, cobimetinib, administered daily in patients with advanced solid tumors

Investigational New Drugs, ISSN: 15730646 01676997

Lee Rosen; Patricia M. LoRusso; Wen Wee Ma; Jonathan W. Goldman; Amy Weise; A. Dimitrios Colevas; Alex Adjei; Salim Yazji; Angela Shen; Stuart H. Johnston; Hsin-Ju Hsieh; Iris Chan; Branimir I. Sikic

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October 1, 2016

Tocilizumab use in pregnancy: Analysis of a global safety database including data from clinical trials and post-marketing data

Seminars in Arthritis and Rheumatism, ISSN: 1532866X 00490172

Maria Hoeltzenbein; Evelin Beck; Richa Rajwanshi; Carina Gøtestam Skorpen; Erhan Berber; Christof Schaefer; Monika Østensen

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October 1, 2016

Investigation of low recovery in the free drug assay for antibody drug conjugates by size exclusion—reversed phase two dimensional-liquid chromatography

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232

Yi Li; Cinzia Stella; Laura Zheng; Charity Bechtel; Jason Gruenhagen; Fred Jacobson; Colin D. Medley

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October 1, 2016

Probing the Distribution of Water in a Multi-Component System by Solid-State NMR Spectroscopy

Pharmaceutical Research, ISSN: 1573904X 07248741

Pinal Mistry; Paroma Chakravarty; Joseph W. Lubach

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October 1, 2016

Development of a rapid RP-UHPLC–MS method for analysis of modifications in therapeutic monoclonal antibodies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232

Bing Zhang; Justin Jeong; Braydon Burgess; Mansour Jazayri; Yun Tang; Taylor Zhang

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October 1, 2016

Characterization of therapeutic antibodies and related products by two-dimensional liquid chromatography coupled with UV absorbance and mass spectrometric detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232

Dwight R. Stoll; John Danforth; Kelly Zhang; Alain Beck

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October 1, 2016

Neoadjuvant Systemic Therapy for Breast Cancer: Factors Influencing Surgeons’ Referrals

Annals of Surgical Oncology, ISSN: 15344681 10689265

Eleftherios P. Mamounas; Christine Poulos; Hans-Peter Goertz; Juan Marcos González; Amy Pugh; Vincent Antao

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September 22, 2016

Developing HSCs become Notch independent by the end of maturation in the AGM region

Blood, ISSN: 15280020 00064971

Céline Souilhol; Javier G. Lendinez; Stanislav Rybtsov; Fiona Murphy; Heather Wilson; David Hills; Antoniana Batsivari; Anahí Binagui-Casas; Alison C. McGarvey; H. Robson MacDonald; Kageyama; Christian W. Siebel; Suling Zhao; Alexander Medvinsky

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September 22, 2016

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Mark Zak; Po-Wai Yuen; Xiongcai Liu; Snahel Patel; Deepak Sampath; Jason Oeh; Bianca M. Liederer; Weiru Wang; Thomas O'Brien; Yang Xiao; Nicholas J. Skelton; Rongbao Hua; Jasleen K. Sodhi; Yunli Wang; Lei Zhang; Guiling Zhao; Xiaozhang Zheng; Yen-Ching Ho; Kenneth W. Bair; Peter Dragovich

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September 21, 2016

Interfering with the chronic immune response rescues chronic degeneration after traumatic brain injury

Journal of Neuroscience, ISSN: 15292401 02706474

Ali Ertürk; Susanne Mentz; Erik E. Stout; Maj Hedehus; Sara L. Dominguez; Lisa Neumaier; Franziska Krammer; Gemma Llovera; Karpagam Srinivasan; David V. Hansen; Arthur Liesz; Kimberly Scearce-Levie; Morgan Sheng

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September 21, 2016

Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla)

Bioconjugate Chemistry, ISSN: 15204812 10431802

Yan Chen; Michael Kim; Laura Zheng; Galahad Deperalta; Fred Jacobson

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September 19, 2016

Preparation of 2-Azabicyclo[21.1]hexane Hydrochloride

Synlett, ISSN: 14372096 09365214

Haili Liao; Aimin Li; Xingsong Chen; Kun Liang; Yang Shen; Qingfeng Liang; Kewei Xu; Daniel G. Shore; Elisia Villemure; Michael Siu; Malcolm P. Huestis

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September 16, 2016

Synthesis of Fused Imidazole-Containing Ring Systems via Dual Oxidative Amination of C(sp3)-H Bonds

Journal of Organic Chemistry, ISSN: 15206904 00223263

Georgette M. Castanedo; Yanzhou Liu; James J. Crawford; Marie-Gabrielle Braun

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September 15, 2016

A phase i dose-escalation study evaluating the safety tolerability and pharmacokinetics of CUDC-427, a potent, oral, monovalent IAP antagonist, in patients with refractory solid tumors

Clinical Cancer Research, ISSN: 15573265 10780432

Anthony W. Tolcher; Bendell; Kyriakos P. Papadopoulos; Howard A. Burris; Amita Patnaik; Wayne J. Fairbrother; Harvey Wong; Nageshwar Budha; Darbonne; Franklin V. Peale Jr.; Michael Mamounas; Stephanie Royer-Joo; Ron Yu; Chia C. Portera; Jeffery R. Infante

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September 15, 2016

Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge

Journal of Infectious Diseases, ISSN: 15376613 00221899

Sinthujan Jegaskanda; Catherine Luke; Heather D. Hickman; Mark Y. Sangster; Wendy F. Wieland-Alter; Jacqueline McBride; Jon W. Yewdell; Peter Wright; John Treanor; Carrie M. Rosenberger; Kanta Subbarao

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September 15, 2016

Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Sharada Labadie; Peter Dragovich; Richard T Cummings; Gauri Deshmukh; Amy Gustafson; Ning Han; Jean-Christophe Harmange; James R. Kiefer; Yue Li; Jun Liang; Bianca M. Liederer; Yichin Liu; Wanda Manieri; Weifeng Mao; Lesley J. Murray; Daniel F. Ortwine; Patrick Trojer; Erica Vanderporten; Maia Vinogradova; Li Wen

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September 15, 2016

Recent progress on nuclear receptor RORγ modulators

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Patrick Cyr; Sarah M. Bronner; James J. Crawford

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September 15, 2016

Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X

Olivier René; Benjamin P. Fauber; Adrian Barnard; Kerry Chapman; Yuzhong Deng; Celine Eidenschenk; Christine Everett; Alberto Gobbi; Adam R. Johnson; Hank La; Maxine Norman; Gary Salmon; Susan Summerhill; Harvey Wong

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September 13, 2016

Validation of a treatment satisfaction questionnaire in non-hodgkin lymphoma: Assessing the change from intravenous to subcutaneous administration of rituximab

Patient Preference and Adherence, ISSN: 1177889X

Christina Theodore-Oklota; Louise Humphrey; Christof Wiesner; Gabriel Schnetzler; Stacie Hudgens; Alicyn K. Campbell

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September 10, 2016

Fast and Efficient non-reduced Lys-C digest using pressure cycling technology for antibody disulfide mapping by LC–MS

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Ying Cheng; Yonghong Chen; X. Christopher Yu

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September 8, 2016

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression

Oncogene, ISSN: 14765594 09509232

Franciosa; Diluvio; Del Gaudio; Giuli; Palermo; Grazioli; Campese; Talora; Bellavia; D'Amati; Besharat; Nicoletti; Christian W. Siebel; Lisa Choy; Rustighi; G Del Sal; Screpanti; Checquolo

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September 8, 2016

Rapid, semi-automated protein terminal characterization using ISDetect

Nature Biotechnology, ISSN: 15461696 10870156

Corey Bakalarski; Yutian Gan; Ingrid E. Wertz; Jennie R. Lill; Wendy N. Sandoval

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September 7, 2016

High cell-surface density of HER2 deforms cell membranes

Nature Communications, ISSN: 20411723

Inhee Chung; Mike Reichelt; Lily Shao; Robert W. Akita; Koeppen; Linda Rangell; Gabriele Schaefer; Ira Mellman; Mark X. Sliwkowski

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September 6, 2016

Ocular therapeutics: Drug delivery and pharmacology

Molecular Pharmaceutics, ISSN: 15438392 15438384

Leslie Dickmann

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September 6, 2016

Contribution of antibody hydrodynamic size to vitreal clearance revealed through rabbit studies using a species-matched fab

Molecular Pharmaceutics, ISSN: 15438392 15438384

Whitney Shatz; Hass; Mary Mathieu; Hok Seon Kim; Kimberly D. Leach; Michelle Zhou; Yongping Crawford; Amy Shen; Kathryn Wang; Debby P. Chang; Mauricio Maia; Susan R. Crowell; Leslie Dickmann; Justin M. Scheer; Robert F. Kelley

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September 6, 2016

Characterization of the pH and temperature in the rabbit, pig, and monkey eye: Key parameters for the development of long-acting delivery ocular strategies

Molecular Pharmaceutics, ISSN: 15438392 15438384

Florence Lorget; Audrey Parenteau; Michel Carrier; Daniel Lambert; Ana Gueorguieva; Chris Schuetz; Vlad Bantseev; Evan A Thackaberry

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September 5, 2016

Mixed-mode chromatography in pharmaceutical and biopharmaceutical applications

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Kelly Zhang; Xiaodong Liu

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September 1, 2016

Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant

Nature Communications, ISSN: 20411723

Jill M. Spoerke; Steven Gendreau; Kimberly Walter; Jiaheng Qiu; Wilson; Heidi Savage; Junko Aimi; Mika K. Derynck; Meng Chen; Iris Chan; Lukas Amler; Garret M. Hampton; Stephen Johnston; Ian E. Krop; Schmid; Lackner

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September 1, 2016

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

Cell Reports, ISSN: 22111247

Alejandra Urrutia; Darragh Duffy; Vincent Rouilly; Céline Posseme; Raouf Djebali; Gabriel Illanes; Valentina Libri; Benoit Albaud; David Gentien; Barbara Piasecka; Milena Hasan; Magnus Fontes; Laurent Abel; Andres Alcover; Kalla Astrom; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Jacques Fellay; Antonio Freitas; Odile Gelpi; Ivo Gomperts-Boneca; Serge Hercberg; Olivier Lantz; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Stanislas Pol; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Vassili Soumelis; Frédéric Tangy; Eric Tartour; Antoine Toubert; Marie-Noëlle Ungeheuer; Lluis Quintana-Murci; Matthew L. Albert

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September 1, 2016

First-Line Treatment with Bevacizumab and Platinum Doublet Combination in Non-Squamous Non-Small Cell Lung Cancer: A Retrospective Cohort Study in US Oncology Community Practices

Drugs - Real World Outcomes, ISSN: 21989788 21991154

Orsolya Lunacsek; Arliene Ravelo; Anna D. Coutinho; Sebastien J. Hazard; Mark R. Green; Joanne Willey; Michael Eaddy; Hans-Peter Goertz

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September 1, 2016

Application of 19F quantitative NMR to pharmaceutical analysis

Concepts in Magnetic Resonance Part A: Bridging Education and Research, ISSN: 15525023 15466086

Allison O. Mattes; David J. Russell; Evgeny Tishchenko; Yanzhou Liu; Robert H. Cichewicz; Sarah J. Robinson

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September 1, 2016

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

Cell Reports, ISSN: 22111247

Alejandra Urrutia; Darragh Duffy; Vincent Rouilly; Céline Posseme; Raouf Djebali; Gabriel Illanes; Valentina Libri; Benoit Albaud; David Gentien; Barbara Piasecka; Milena Hasan; Magnus Fontes; Matthew L. Albert; Laurent Abel; Andres Alcover; Kalla Astrom; Philippe Bousso; Pierre Bruhns; Ana Cumano; Caroline Demangel; Ludovic Deriano; James P. Di Santo; Françoise Dromer; Gérard Eberl; Jost Enninga; Jacques Fellay; Antonio Freitas; Odile Gelpi; Ivo Gomperts-Boneca; Serge Hercberg; Olivier Lantz; Claude Leclerc; Hugo Mouquet; Sandra Pellegrini; Stanislas Pol; Lars Rogge; Anavaj Sakuntabhai; Olivier Schwartz; Benno Schwikowski; Spencer Shorte; Vassili Soumelis; Frédéric Tangy; Eric Tartour; Antoine Toubert; Marie-Noëlle Ungeheuer; Lluis Quintana-Murci; Matthew L. Albert

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