Genentech: Publications

August 1, 2016

The Prevalence of Myopic Choroidal Neovascularization in the United States: Analysis of the IRIS® Data Registry and NHANES

Ophthalmology, ISSN: 15494713 01616420

Jeffrey R. Willis; Susan Vitale; Lawrence S. Morse; David W. Parke; William L. Rich; Flora Lum; Ronald A. Cantrell

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August 1, 2016

Pathway analysis by randomization incorporating structure - Paris: An update

Bioinformatics, ISSN: 14602059 13674803

Mariusz Butkiewicz; Jessica Cooke Bailey; Alex Frase; Scott Dudek; Brian L. Yaspan; Marylyn Ritchie; Sarah A. Pendergrass; Jonathan L. Haines

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August 1, 2016

Relationship between tumor biomarkers and efficacy in EMILIA, a phase III study of trastuzumab emtansine in HER2-Positive metastatic breast cancer

Clinical Cancer Research, ISSN: 15573265 10780432

Baselga; Gail L. Phillips; Sunil Verma; Jungsil Ro; Huober; Ellie Guardino; Meghna Samant; Steve Olsen; Sanne De Haas; Pegram

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August 1, 2016

Precision medicine and oncology: An overview of the opportunities presented by next-generation sequencing and big data and the challenges posed to conventional drug development and regulatory approval pathways

Annals of Oncology, ISSN: 15698041 09237534

Michael Doherty; Metcalfe; Ellie Guardino; Peters; Ramage

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August 1, 2016

Immune escape to PD-L1/PD-1 blockade: Seven steps to success (or failure)

Annals of Oncology, ISSN: 15698041 09237534

Kim; Daniel S. Chen

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August 1, 2016

Predicting vision gains with anti-VEGF therapy in neovascular age-related macular degeneration patients by using low-luminance vision

British Journal of Ophthalmology, ISSN: 14682079 00071161

Ronald E.P. Frenkel; Howard Shapiro; Ivaylo Stoilov

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August 1, 2016

Separation science in drug development, part 4: Quality control

LC-GC Europe, ISSN: 14716577

Dawen Kou; Larry Wigman; Peter M. Yehl; Michael W. Dong

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August 1, 2016

Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases

Cytokine and Growth Factor Reviews, ISSN: 18790305 13596101

Sascha Rutz; Celine Eidenschenk; James R. Kiefer; Wenjun Ouyang

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August 1, 2016

Medicare Expenditures of Individuals with Alzheimer's Disease and Related Dementias or Mild Cognitive Impairment Before and After Diagnosis

Journal of the American Geriatrics Society, ISSN: 15325415 00028614

Pei-Jung Lin; Yue Zhong; Howard Fillit; Er Chen; Peter J. Neumann

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August 1, 2016

Predicting vision gains with anti-VEGF therapy in neovascular age-related macular degeneration patients by using low-luminance vision

British Journal of Ophthalmology, ISSN: 00071161

Ronald E.P. Frenkel; Howard Shapiro; Ivaylo Stoilov

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August 1, 2016

Validation of a biotherapeutic immunoaffinity-LC-MS/MS assay in monkey serum: 'plug-And-play' across seven molecules

Bioanalysis, ISSN: 17576199 17576180

Surinder Kaur; Luna Liu; Diego F. Cortes; Junlong Shao; Rand Jenkins; William R. Mylott; Keyang Xu

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August 1, 2016

Scientific and Regulatory Policy Committee Points to Consider Review: Inclusion of Reproductive and Pathology End Points for Assessment of Reproductive and Developmental Toxicity in Pharmaceutical Drug Development

Toxicologic Pathology, ISSN: 15331601 01926233

Wendy Halpern; Mehrdad Ameri; Christopher J. Bowman; Michael R. Elwell; Michael L. Mirsky; Julian Oliver; Karen S. Regan; Amera K. Remick; Vicki L. Sutherland; Kary E. Thompson; Claudine Tremblay; Midori Yoshida; Lindsay Tomlinson

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August 1, 2016

Interpolymer Complexation Between Polyox and Carbopol, and Its Effect on Drug Release From Matrix Tablets

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Feng Zhang; Joseph W. Lubach; Watson Na; Samad Momin

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August 1, 2016

Disease, treatment, and outcome differences between men and women with follicular lymphoma in the United States

American Journal of Hematology, ISSN: 10968652 03618609

Chadi Nabhan; Zhou; Bann-Mo Day; Keith Dawson; Zelenetz; Jonathan W. Friedberg; James R. Cerhan; Brian K. Link; Christopher R. Flowers

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August 1, 2016

Going beyond common drug metabolizing enzymes: Case studies of biotransformation involving aldehyde oxidase, γ-glutamyl transpeptidase, cathepsin B, flavin-containing monooxygenase, and ADP-ribosyltransferase

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Peter W. Fan; Donglu Zhang; Jason S Halladay; James Driscoll; S. Cyrus Khojasteh

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August 1, 2016

Population pharmacokinetics of bevacizumab in cancer patients with external validation

Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704

Kelong Han; Thomas Peyret; Mathilde Marchand; Angelica Quartino; Nathalie H. Gosselin; Sandhya Girish; David E. Allison; Jin Y. Jin

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August 1, 2016

Properties and mechanisms of drug release from matrix tablets containing poly(ethylene oxide) and poly(acrylic acid) as release retardants

European Journal of Pharmaceutics and Biopharmaceutics, ISSN: 18733441 09396411

Feng Zhang; Fan Meng; Joseph W. Lubach; Joseph Koleng; Watson

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August 1, 2016

Predictors of Diabetic Macular Edema Treatment Frequency with Ranibizumab During the Open-Label Extension of the RIDE and RISE Trials

Ophthalmology, ISSN: 15494713 01616420

Charles C. Wykoff; Michael J. Elman; Carl D. Regillo; Beiying Ding; Na Lu; Ivaylo Stoilov

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August 1, 2016

Expression, purification, and characterization of recombinant human and murine milk fat globule-epidermal growth factor-factor 8

Protein Expression and Purification, ISSN: 10465928

Erick R. Castellanos; Claudio Ciferri; Wilson Phung; Wendy N. Sandoval; Marissa L. Matsumoto

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August 1, 2016

Comparison of BALB/c and B6-albino mouse strain blastocysts as hosts for the injection of C57BL6/N-derived C2 embryonic stem cells

Transgenic Research, ISSN: 15739368 09628819

Tuija M. Alcantar; Rhonda Wiler; Xin Y. Rairdan

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July 29, 2016

Reducing the risk of failure: Biomarker-guided trial design

Nature Reviews Drug Discovery, ISSN: 14741784 14741776

Michael J. Townsend; Joseph R. Arron

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July 29, 2016

A high-throughput hydrophilic interaction liquid chromatography coupled with a charged aerosol detector method to assess trisulfides in IgG1 monoclonal antibodies using tris(2-carboxyethyl)phosphine reaction products: Tris(2-carboxyethyl)phosphine-oxide and tris(2-carboxyethyl)phosphine-sulfide

Journal of Chromatography A, ISSN: 18733778 00219673

Christopher Cornell; Amish Karanjit; Yan Chen; Fred Jacobson

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July 27, 2016

Comment on "nRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis"

Science Translational Medicine, ISSN: 19466242 19466234

Jérémie Decalf; Rosa Barreira da Silva; Scott Werneke; Matthew L. Albert

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July 20, 2016

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

Neuron, ISSN: 10974199 08966273

Felix L. Yeh; Yuanyuan Wang; Irene Tom; Lino C. Gonzalez Jr.; Morgan Sheng

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July 20, 2016

Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates

Bioconjugate Chemistry, ISSN: 15204812 10431802

Jose Ponte; Xiuxia Sun; Nicholas C. Yoder; Nathan Fishkin; Rassol Laleau; Jennifer A. Coccia; Leanne Lanieri; Megan Bogalhas; Lintao Wang; Sharon Wilhelm; Wayne C. Widdison; Jan Pinkas; Thomas A. Keating; Ravi Chari; Hans Erickson; John M. Lambert

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July 19, 2016

The Itch to degrade ROR-γt

Nature Immunology, ISSN: 15292916 15292908

Sascha Rutz; Wenjun Ouyang

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July 15, 2016

Green Chemistry Articles of Interest to the Pharmaceutical Industry

Organic Process Research and Development, ISSN: 1520586X 10836160

Rakeshwar Bandichhor; Apurba Bhattacharya; Marian C. Bryan; Andrew Cosbie; Alba Díaz-Rodríguez; Louis Diorazio; Zhongbo Fei; Kenneth Fraunhoffer; John Hayler; Matthew Hickey; Luke Humphreys; Paul Richardson; Scott Roberts; Timothy White; Stijn Wuyts; Jingjun Yin

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July 15, 2016

A sensitive mutation screening method supporting cell line development for biotherapeutics

Analytical Biochemistry, ISSN: 10960309 00032697

Ildana Valisheva; Reed J. Harris; Judith Zhu-Shimoni

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July 15, 2016

Validation and determination of taselisib, a β-sparing phosphoinositide 3-kinase (PI3K) inhibitor, in human plasma by LC-MS/MS

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Xiao Ding; Faber; Shi; McKnight; Dorshorst; Joseph A. Ware; Brian J. Dean

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July 15, 2016

A simple and sensitive method to analyze genotoxic impurity hydrazine in pharmaceutical materials

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Jennifer Wang; Samuel H. Yang; Kelly Zhang

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July 15, 2016

Treatment with a human recombinant monoclonal IgG antibody against oxidized LDL in atherosclerosis-prone pigs reduces cathepsin S in coronary lesions

International Journal of Cardiology, ISSN: 18741754 01675273

Christian Bo Poulsen; Ahmed Ludvigsen Al-Mashhadi; Karin von Wachenfeldt; Jacob Fog Bentzon; Lars Bo Nielsen; Rozh H. Al-Mashhadi; Jesper Thygesen; Lars Tolbod; Jens Rolighed Larsen; Jørgen Frøkiær; Ahmed Tawakol; Esad Vucic; Jill Fredrickson; Amos Baruch; Björn Frendéus; Anna-Karin Robertson; Søren Kragh Moestrup; Ludovic Drouet; Erling Falk

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July 14, 2016

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality

PLoS Biology, ISSN: 15457885 15449173

Mario Novkovic; Lucas Onder; Jovana Cupovic; Jun Abe; David Bomze; Viviana Cremasco; Elke Scandella; Jens V. Stein; Gennady Bocharov; Shannon J. Turley; Burkhard Ludewig

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July 14, 2016

Topological Small-World Organization of the Fibroblastic Reticular Cell Network Determines Lymph Node Functionality

PLoS Biology, ISSN: 15449173

Mario Novkovic; Lucas Onder; Jovana Cupovic; Jun Abe; David Bomze; Viviana Cremasco; Elke Scandella; Jens V. Stein; Gennady Bocharov; ShannonJ. Turley; Burkhard Ludewig

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July 13, 2016

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

eLife, ISSN: 2050084X

James D. Joseph; Beatrice Darimont; Wei Zhou; Alfonso Arrazate; Amy Young; Ellen Ingalla; Kimberly Walter; Robert A. Blake; Jim Nonomiya; Zhengyu Guan; Kategaya; Steven P. Govek; Andiliy G. Lai; Mehmet Kahraman; Dan Brigham; John Sensintaffar; Nhin Lu; Gang Shao; Jing Qian; Kate Grillot; Michael Moon; Rene Prudente; Eric Bischoff; Kyoung-Jin Lee; Celine Bonnefous; Karensa L. Douglas; Jackaline D. Julien; Johnny Y. Nagasawa; Anna Aparicio; Josh Kaufman; Benjamin Haley; Jennifer M. Giltnane; Ingrid E. Wertz; Lackner; Michelle Nannini; Deepak Sampath; Luis J. Schwarz; H. Charles Manning; Mohammed Noor Tantawy; Carlos L. Arteaga; Richard A. Heyman; Peter J. Rix; Lori S. Friedman; Nicholas D. Smith; Ciara Metcalfe; Jeffrey H. Hager

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July 13, 2016

Modeling and simulation of maintenance treatment in first-line non-small cell lung cancer with external validation

BMC Cancer, ISSN: 14712407

Kelong Han; Laurent Claret; Alan Sandler; Asha Das; Jin Y. Jin; Rene Bruno

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July 12, 2016

NeuCode Proteomics Reveals Bap1 Regulation of Metabolism

Cell Reports, ISSN: 22111247

Joshua M. Baughman; Christopher M. Rose; Ganesh Kolumam; Webster; Emily M. Wilkerson; Anna E Merrill; Timothy W. Rhoads; Rajkumar Noubade; Paula Katavolos; Justin Lesch; Donald S. Stapleton; Mary E. Rabaglia; Kathy L. Schueler; Raymond Asuncion; Melanie Domeyer; Jose Zavala-Solorio; Michael Reich; Jason Devoss; Mark P. Keller; Alan D. Attie; Alexander S. Hebert; Michael S. Westphall; Joshua J Coon; Donald S. Kirkpatrick; Anwesha Dey

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July 12, 2016

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Robin A. Aglietti; Alberto Estevez; Aaron Gupta; Monica Gonzalez Ramirez; Peter S. Liu; Nobuhiko Kayagaki; Claudio Ciferri; Vishva M. Dixit; Erin C. Dueber

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July 7, 2016

Length Matters: MINDY Is a New Deubiquitinase Family that Preferentially Cleaves Long Polyubiquitin Chains

Molecular Cell, ISSN: 10974164 10972765

Till Maurer; Ingrid E. Wertz

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July 3, 2016

Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A

mAbs, ISSN: 19420870 19420862

Priyanka Gupta; Amrita Kamath; Summer Park; Chiu; Jeff Lutman; Mauricio Maia; Man-Wah Tan; Min Xu; Lee R. Swem; Rong Deng

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July 2, 2016

Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop

OncoImmunology, ISSN: 2162402X 21624011

Roch Houot; Philippe Gaulard; Schreiber; Ira Mellman; Olivier Lambotte; Pierre G. Coulie; Thierry Fest; Alan Korman; Ronald Levy; Margaret A. Shipp; Karin Tarte; Holbrook E. K. Kohrt; Aurélien Marabelle; Stephen Ansell; Hervé Watier; Andrea van Elsas; Arun Balakumaran; Frederick Arce Vargas; Sergio A. Quezada; Gilles Salles; Daniel Olive

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July 1, 2016

Protective and detrimental effects of neuroectodermal cell–derived tissue factor in mouse models of stroke

JCI insight,

Shaobin Wang; Brandi Reeves; Erica Sparkenbaugh; Janice Russell; Zbigniew Soltys; Hua Zhang; James E. Faber; Nigel S. Key; Daniel Kirchhofer; D. Neil Granger; Nigel Mackman; Rafal Pawlinski

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July 1, 2016

Validation of a spectral method for quantitative measurement of color in protein drug solutions

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Jian Yin; Trevor E. Swartz; Jian Zhang; Thomas W. Patapoff; Bartolo Chen; Joseph C. Marhoul; Norman Shih; Bruce Kabakoff; Kimia Rahimi

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July 1, 2016

Hydrolysis of polysorbate 20 and 80 by a range of carboxylester hydrolases

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Andrew C. McShan; Pervina Kei; Junyan A. Ji; Daniel C. Kim; Y. John Wang

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July 1, 2016

A spectral method for color quantitation of a protein drug solution

PDA Journal of Pharmaceutical Science and Technology, ISSN: 19482124 10797440

Trevor E. Swartz; Jian Yin; Thomas W. Patapoff; Travis A. Horst; Susan M. Skieresz; Gordon Leggett; Charles Morgan; Kimia Rahimi; Joseph C. Marhoul; Bruce Kabakoff

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July 1, 2016

Preclinical safety profile of a depleting antibody against CRTh2 for asthma: Well tolerated despite unexpected CRTh2 expression on vascular pericytes in the central nervous system and gastric mucosa

Toxicological Sciences, ISSN: 10960929 10966080

Kathila S. Rajapaksa; Tao Huang; Neeraj Sharma; Shannon Liu; Margaret Solon; Arthur Reyes; Sarah Paul; Angie Yee; Janet Tao; Sreedevi Chalasani; Nga Bien-Ly; Kai H. Barck; Richard A. D. Carano; Jianyong Wang; Linda Rangell; Meire C. Bremer; Dimitry Danilenko; Paula Katavolos; Isidro Hötzel; Karin Reif; Cary D. Austin

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July 1, 2016

Reply

Gastroenterology, ISSN: 15280012 00165085

Mary E. Keir; Tew; Jason A. Hackney

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July 1, 2016

Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling

PLoS Computational Biology, ISSN: 15537358 1553734X

Javier Estrada; Natalie Andrew; Daniel Gibson; Frederick Chang; Florian Gnad; Jeremy Gunawardena

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July 1, 2016

Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms

Proteomics, ISSN: 16159861 16159853

Florian Gnad; Sophia Doll; Kyung Song; Matthew P. Stokes; John Moffat; Bonnie Liu; David Arnott; Jeffery J. Wallin; Lori S. Friedman; Georgia Hatzivassiliou; Marcia Belvin

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July 1, 2016

Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network

Proteomics, ISSN: 16159861 16159853

Florian Gnad; Jeffery J. Wallin; Kyle A. Edgar; Sophia Doll; David Arnott; Liliane Robillard; Donald S. Kirkpatrick; Matthew P. Stokes; Ulka Vijapurkar; Georgia Hatzivassiliou; Lori S. Friedman; Marcia Belvin

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July 1, 2016

Simulations to Predict Clinical Trial Outcome of Bevacizumab Plus Chemotherapy vs. Chemotherapy Alone in Patients With First-Line Gastric Cancer and Elevated Plasma VEGF-A

CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306

Kelong Han; Laurent Claret; Piao; Priti Hegde; Amita Joshi; Powell; Jin Y. Jin; Rene Bruno

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